PD45-09 EARLY DETECTION OF CARDIOVASCULAR DISEASE (CVD) RISK IN MEN WITH ERECTILE DYSFUNCTION (ED) IS FACILITATED USING NEXT GENERATION IMMUNODIAGNOSTICS

Abstract: Erectile dysfunction (ED) is common among cardiovascular disease (CVD) patients. It is an important component of the quality of life. Moreover, it also confers an independent risk for future CV events. There is usual a 3-year time frame between the onset of ED symptoms and a CV event which offers an opportunity for risk mitigation. Thus, sexual function should be incorporated into CVD risk assessment for all males. Algorithms for the management of patient with ED have been proposed according to the risk for sexual activity and future (comprising of both lifestyle changes and pharmacological treatment) improve overall vascular health, including sexual function. Proper sexual counselling improves the quality of life and increase adherence to medication. Testosterone assessment may be useful for both diagnosis of ED, risk stratification, and further management. There are issues to be addressed, such as whether PDE5 inhibitors reduce CV risk. Management of ED requires a collaborative approach and the role of the cardiologist is pivotal.Keywords: cardiovascular disease, erectile dysfunction, sexual functionAbstrak: Disfungsi ereksi (DE) umumnya ditemukan pada pasien dengan penyakit kardiovaskular. DE merupakan komponen penting terhadap penurunan kualitas hidup pada laki-laki dan merupakan indikator terhadap risiko kejadian penyakit kardiovaskular di masa depan. Terdapat jangka waktu sekitar 3 tahun antara munculnya DE dan kejadian penyakit kardiovaskular, sehingga masih ada kesempatan untuk mencegah risiko yang akan terjadi. Dengan demikian fungsi seksual harus dimasukkan dalam penilaian risiko penyakit kardiovaskular pada semua laki-laki. Algoritma untuk penanganan pasien DE telah dirumuskan sesuai dengan risiko aktivitas seksual dan kejadian penyakit kardiovaskular di masa depan. Beberapa pendekatan untuk mengurangi resiko penyakit kardiovaskular terdiri dari perubahan gaya hidup dan pengobatan farmakologi dapat meningkatkan kesehatan termasuk fungsi seksual. Konseling seksual yang tepat dapat meningkatkan kualitas hidup dan meningkatkan kepatuhan terhadap pengobatan. Penggunaan testosteron dan inhibitor PDE5 dapat bermanfaat dalam pengobatan DE. Penanganan DE memerlukan kerjasama dari berbagai bidang spesialistik termasuk peran dari kardiologis.Kata kunci: disfungsi ereksi, fungsi seksual, penyakit kardiovaskular

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The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis

Vascular Medicine ◽

10.1177/1358863x17725809 ◽

2017 ◽

Vol 23 (1) ◽

pp. 9-20 ◽

Cited By ~ 17

Author(s):

Chukwuemeka U Osondu ◽

Bryan Vo ◽

Ebenezer T Oni ◽

Michael J Blaha ◽

Emir Veledar ◽

...

Keyword(s):

Cardiovascular Disease ◽

Erectile Dysfunction ◽

Vascular Function ◽

Meta Analysis ◽

Ankle Brachial Index ◽

Intima Media Thickness ◽

Publication Date ◽

Cvd Risk ◽

The Relationship ◽

Subclinical Cvd

Erectile dysfunction (ED) is associated with cardiovascular disease (CVD) and CVD mortality. However, the relationship between ED and subclinical CVD is less clear. We synthesized the available data on the association of ED and measures of subclinical CVD. We searched multiple databases for published literature on studies examining the association of ED and measures of subclinical CVD across four domains: endothelial dysfunction measured by flow-mediated dilation (FMD), carotid intima–media thickness (cIMT), coronary artery calcification (CAC), and other measures of vascular function such as the ankle–brachial index, toe–brachial index, and pulse wave velocity. We conducted random effects meta-analysis and meta-regression on studies that examined an ED relationship with FMD (15 studies; 2025 participants) and cIMT (12 studies; 1264 participants). ED was associated with a 2.64 percentage-point reduction in FMD compared to those without ED (95% CI: –3.12, −2.15). Persons with ED also had a 0.09-mm (95% CI: 0.06, 0.12) higher cIMT than those without ED. In subgroup meta-analyses, the mean age of the study population, study quality, ED assessment questionnaire (IIEF-5 or IIEF-15), or the publication date did not significantly affect the relationship between ED and cIMT or between ED and FMD. The results for the association of ED and CAC were inconclusive. In conclusion, this study confirms an association between ED and subclinical CVD and may shed additional light on the shared mechanisms between ED and CVD, underscoring the importance of aggressive CVD risk assessment and management in persons with ED.

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Cardiovascular Disease, Hypogonadism and Erectile Dysfunction: Early Detection, Prevention and the Positive Effects of Long-Term Testosterone Treatment: Prospective Observational, Real-Life Data

Vascular Health and Risk Management ◽

10.2147/vhrm.s309714 ◽

2021 ◽

Vol Volume 17 ◽

pp. 497-508

Author(s):

Mustafa Alwani ◽

Aksam Yassin ◽

Raidh Talib ◽

Ahmad Al-Qudimat ◽

Omar Aboumarzouk ◽

...

Keyword(s):

Cardiovascular Disease ◽

Erectile Dysfunction ◽

Early Detection ◽

Real Life ◽

Testosterone Treatment ◽

Positive Effects ◽

Life Data ◽

Real Life Data

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Key Potentials of mHealth for Community-Based Early Detection of Cardiovascular Disease During the COVID-19 Pandemic

10.21203/rs.3.rs-233630/v1 ◽

2021 ◽

Author(s):

Kemal Nazarudin Siregar ◽

Rico Kurniawan ◽

Ryza Jazid BaharuddinNur ◽

Dion Zein Nuridzin ◽

Yolanda Handayani ◽

...

Keyword(s):

Cardiovascular Disease ◽

Early Detection ◽

Communicable Disease ◽

Age Groups ◽

The Elderly ◽

Cvd Risk ◽

Community Based ◽

Detection Mechanism ◽

Control Programs ◽

Personalized Health

Abstract Background The epidemiological transition from infectious to non-communicable disease (NCD) is characterized by an increasing incidence of cardiovascular disease (CVD). The Coronavirus Disease 2019 (COVID-19) pandemic has led to a significant decline in NCD screening and treatment activities in health centers. This study aims to revive and expand the coverage of NCD control programs, from the elderly to productive age groups, through the use of mHealth for the early detection of CVD, which is also provides health promotion media that is easily accessible. Methods This research is an operational study to develop a community-based early detection mechanism for CVD using mHealth during the COVID-19 pandemic in the Babakan Madang sub-district, Bogor district. Results The use of the mHealth application supported by community participation is proven to be able to reach the productive age population significantly (87.1%) in the Babakan Madang sub-district. The mHealth application simplifies CVD risk predictions so that it can be used by the public during the COVID-19 pandemic. Conclusion This application is also very well accepted by the community and is able to provide personalized health promotions.

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Management of a patient with erectile dysfunction with or without known cardiovascular disease

ESC CardioMed ◽

10.1093/med/9780198784906.003.0138 ◽

2018 ◽

pp. 1039-1044

Author(s):

Charalambos Vlachopoulos ◽

Nikolaos Ioakeimidis ◽

Dimitris Tousoulis

Keyword(s):

Cardiovascular Disease ◽

Erectile Dysfunction ◽

Cardiovascular Risk ◽

Cardiovascular Events ◽

Risk Estimation ◽

Subclinical Atherosclerosis ◽

Intermediate Risk ◽

Cvd Risk ◽

Practical Algorithms ◽

Framingham Risk

Erectile dysfunction (ED) is common in subjects with cardiovascular risk factors and in patients with cardiovascular disease (CVD); it also confers an independent risk for future cardiovascular events. Thus, sexual function should be incorporated into CVD risk assessment for all men. Algorithms for the management of patients with ED have been proposed according to the risk for sexual activity and future cardiovascular events. This chapter recommends that initial cardiovascular risk stratification be based on the SCORE risk estimation tool or Framingham Risk Score. Management of men with ED who are at low risk for CVD should focus on risk factor control; men at high/very high risk, including those with CVD, should be referred to a cardiologist. Intermediate-risk men should undergo non-invasive evaluation for subclinical atherosclerosis and functional CVD status. This chapter provides practical algorithms for the evaluation and management of these patients. The clinical use of biomarkers has the ability to provide the clinician with a tool to gauge residual risk and chart a course for optimal management of the patient with ED. Testosterone and biomarkers of generalized vascular disease serve this purpose specifically in intermediate-risk ED patients even though most of them do not fulfil all the stringent criteria to adequately predict cardiovascular risk in this specific population.

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Abstract P346: Cohort Identification to Harness the Electronic Health Record for Cardiovascular Disease Prediction

Circulation ◽

10.1161/circ.141.suppl_1.p346 ◽

2020 ◽

Vol 141 (Suppl_1) ◽

Author(s):

Sheila M Manemann ◽

Jennifer St Sauver ◽

Janet E Olson ◽

Nicholas B Larson ◽

Paul Y Takahashi ◽

...

Keyword(s):

Blood Pressure ◽

Cardiovascular Disease ◽

Heart Rate ◽

Electronic Health Record ◽

Risk Prediction ◽

Health Record ◽

Next Generation ◽

Cvd Risk ◽

Electronic Health

Background: Current cardiovascular disease (CVD) risk scores are derived from research cohorts and are particularly inaccurate in women, older adults, and those with missing data. To overcome these limitations, we aimed to develop a cohort to capitalize on the depth and breadth of clinical data within electronic health record (EHR) systems in order to develop next-generation sex-specific risk prediction scores for incident CVD. Methods: All individuals 30 years of age or older residing in Olmsted County, Minnesota on 1/1/2006 were identified. We developed and validated algorithms to define a variety of risk factors, thus building a comprehensive risk profile for each patient. Outcomes including myocardial infarction (MI), percutaneous intervention (PCI), coronary artery bypass graft (CABG), and CVD death were ascertained through 9/30/2017. Results: We identified 73,069 individuals without CVD (Table). We retrieved a total of 14,962,762 lab results; 14,534,466 diagnoses; 17,062,601 services/procedures; 1,236,998 outpatient prescriptions; 1,079,065 heart rate measurements; and 1,320,115 blood pressure measurements. The median number of blood pressure and heart rate measurements ascertained per individuals were 11 and 9, respectively. The five most prevalent conditions were: hypertension, hyperlipidemia, arthritis, depression, and cardiac arrhythmias. During follow-up 1,455 MIs, 1,581 PCI, 652 CABG, and 2,161 CVD-related deaths occurred. Conclusions: We developed a cohort with comprehensive risk profiles and follow-up for each patient. Using sophisticated machine learning approaches, this electronic cohort will be utilized to develop next-generation sex-specific CVD risk prediction scores. These approaches will allow us to address several challenges with use of EHR data including the ability to 1) deal with missing values, 2) assess and utilize a large number of variables without over-fitting, 3) allow non-linear relationships, and 4) use time-to-event data.

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Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk

Journal of Nutritional Science ◽

10.1017/jns.2021.73 ◽

2021 ◽

Vol 10 ◽

Author(s):

Bryant H. Keirns ◽

Christina M. Sciarrillo ◽

Nicholas A. Koemel ◽

Sam R. Emerson

Keyword(s):

Cardiovascular Disease ◽

At Risk ◽

Early Detection ◽

Cardiometabolic Risk ◽

Distinct Advantage ◽

Cvd Risk ◽

Postprandial Triglycerides

Abstract Fasting triacylglycerols have long been associated with cardiovascular disease (CVD) and other cardiometabolic conditions. Evidence suggests that non-fasting triglycerides (i.e. measured within 8 h of eating) better predict CVD than fasting triglycerides, which has led several organisations to recommend non-fasting lipid panels as the new clinical standard. However, unstandardised assessment protocols associated with non-fasting triglyceride measurement may lead to misclassification, with at-risk individuals being overlooked. A third type of triglyceride assessment, postprandial testing, is more controlled, yet historically has been difficult to implement due to the time and effort required to execute it. Here, we review differences in assessment, the underlying physiology and the pathophysiological relevance of elevated fasting, non-fasting and postprandial triglycerides. We also present data suggesting that there may be a distinct advantage of postprandial triglycerides, even over non-fasting triglycerides, for early detection of CVD risk and offer suggestions to make postprandial protocols more clinically feasible.

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Association Between Erectile Dysfunction and Cardiovascular Disease: A Systematic Review

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v18i2.47779 ◽

2020 ◽

Vol 18 (2) ◽

pp. 59-66

Author(s):

Sumon Rahman Chowdhury ◽

Masud Karim ◽

SM Amanat Ullah ◽

Muhammed Abu Bakar

Keyword(s):

Cardiovascular Disease ◽

Erectile Dysfunction ◽

Arterial Disease ◽

Cvd Risk ◽

Risk Factor Modification ◽

The Metabolic Syndrome ◽

Artery Disease ◽

Peripheral Arterial ◽

Independent Marker

Erectile Dysfunction (ED) describes the persistent inability to achieve or maintain a penile erection for adequate sexual performance. ED is thought to be a vascular disease affecting more than 70% of men with (Cardiovascular Disease) CVD and sharing a myriad of risk factors like hypertension, smoking, diabetes, obesity, ageing and the metabolic syndrome. Diabetes increases the risk of both ED and CVD with the latter being the leading cause of death. Endothelial dysfunction and its role in the development of atherosclerosis may be the common link between ED, CVD and diabetes. With the current epidemic of type 2 diabetes, diabetes related CVD will increase in tandem. Early identification of this risk group is therefore paramount. Evidence has shown that ED is an independent marker of increased CVD risk and heralds the onset of coronary artery disease, peripheral arterial disease and stroke thereby providing a window of opportunity for risk factor modification. In our paper we shall explore the correlation of ED and CVD with a view to formulation of intervention strategies. Chatt Maa Shi Hosp Med Coll J; Vol.18 (2); July 2019; Page 59-66

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Potentials of community-based early detection of cardiovascular disease risk during the COVID-19 pandemic

BMC Public Health ◽

10.1186/s12889-021-11384-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Kemal Nazarudin Siregar ◽

Rico Kurniawan ◽

Ryza Jazid BaharuddinNur ◽

Dion Zein Nuridzin ◽

Yolanda Handayani ◽

...

Keyword(s):

Cardiovascular Disease ◽

Early Detection ◽

Health Workers ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Screening Tools ◽

Cvd Risk ◽

Community Based ◽

Community Activities ◽

Community Acceptance

Abstract Background The Coronavirus Disease 2019 (COVID-19) pandemic has led to a significant decline in Non Communicable Diseases (NCD) screening and early detection activities, especially Cardiovascular Disease (CVD). This study aims to assess the potential of community-based self-screening of CVD risk through the mhealth application. Methods This is operational research by actively involving the community to carry out self-screening through the mHealth application. Community health workers were recruited as facilitators who encourage the community to carry out self-screening. To evaluate the potential of community-based self-screening of CVD risk, we use several indicators: responses rate, level of CVD risk, and community acceptance. Results Of the 846 individuals reached by the cadres, 53% or 442 individuals carried out self-screening. Based on the results of self-screening of CVD risk, it is known that around 21.3% are at high risk of developing CVD in the next 10 years. The results of the evaluation of semi-structured questions showed that about 48% of the people had positive impressions, 22% assessed that this self-screening could increase awareness and was informative, 3% suggested improvements to self-screening tools. Conclusion Cadres play an important role in reaching and facilitating the community in their environment to remain aware of their health conditions by conducting self-screening of CVD risk. The availability of the mHealth application that the public can easily access can simplify CVD risk prediction and expand screening coverage, especially during the COVID-19 pandemic, where there are social restrictions policies and community activities.

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