Source and Filter Acoustic Measures of Young, Middle-Aged and Elderly Adults for Application in Vowel Synthesis

Background. Traumatic spinal cord injury (SCI) is a lesion that can affect several spinal structures, including the vertebrae, spinal cord, ligaments, and other adjacent parts of the spine. Traumatic spinal cord injury (SCI) can cause functional changes in patients of different ages. Material and methods. The study aims to determine whether there are social, clinical, and radiological differences between young, middle-aged, and elderly adults with SCI caused by a ground-level fall. This retrospective study analyzed the records of patients with a clinical diagnosis of SCI. It enrolled patients with traumatic spinal cord injury after a ground-level fall divided as follows: young aged adults 18–35 years of age (G1); middle-aged adults aged 36–60 years (G2); and elderly adults aged over 60 years (G3). Their clinical, social, and radiological variables were analyzed. Results. It is observed that low schooling level, being widowed, and being a homemaker were more frequently encountered among elderly adults, whereas being single was more common in middle-aged adults. The morphologic diagnosis of compression fracture and the associated injury of facial trauma occurred more frequently in elderly adults, with an increasing tendency with age. Conservative therapeutic management was most commonly encountered in elderly adults, compared to surgery from a posterior approach in middle-aged adults. Listhesis was better identified in middle-aged adults by computed tomography (CT). Spinal cord contusion and injury to the C1 vertebra were demonstrated in young adults by magnetic resonance imaging (MRI). Conclusions. 1. Elderly adults with low education level, widowed, and homemakers were more susceptible to SCI caused by a fall. 2. Single marital status was more frequently noted in young adults. 3. The most frequent clinical aspects were the morphological aspect of compression fracture and facial trauma as an associated injury in elderly adults, with the occurrence of facial trauma increasing with age. 4. Conservative therapeutic management was more common in elderly adults than surgery from a posterior approach in middle-aged adults. 5. Regarding the radiological aspects of CT, listhesis was better identified in middle-aged adults. Spinal cord contusions and C1 vertebra lesions were better identified in young adults by MRI.

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The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults

Cardiovascular Therapeutics ◽

10.1155/2021/4626062 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Xianpeng Xu ◽

Jinke Huang ◽

Simin Wu ◽

Qingjie Ji ◽

Xuguang Guo ◽

...

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Turning Point ◽

Serum Uric Acid Level ◽

Recursive Algorithm ◽

Multiple Logistic Regression Analysis ◽

Elderly Adults ◽

Middle Aged ◽

Health And Nutrition ◽

The Relationship

Background. Studies on serum uric acid (sUA) levels and hypertension (HTN) are controversial. To investigate the association between the sUA level and the incident of HTN in middle-aged and elderly adults, we performed this study. Methods. 6399 participants aged ≥40 years from the National Health and Nutrition Examination Survey (NHANES) were included. Weighted multiple logistic regression analysis was carried out to evaluate the relationship between the sUA level and the incident of HTN, exploring the potential nonlinear relationship using the fitted smoothing curves. If nonlinearity was observed, the inflection point was further calculated by a recursive algorithm. Results. A positive relationship between the sUA level and the incident of HTN was found. However, it may differ in different race groups, nor between male and female. Moreover, the association between the sUA level and the incident of HTN followed a U-shaped curve in male (turning point: sUA 4.1 mg/dL) and Whites (turning point: sUA 7.9 mg/dL). Conclusions. The results revealed that the sUA level is positively correlated with the incident of HTN, in middle-aged and elderly adults. However, it followed a U-shaped curve in males and Whites.

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The Analysis of Foot-Eye Coordination Strategies Among Middle-Aged and Elderly Adults: An Example of Foot Positioning Tasks

Advances in Intelligent Systems and Computing - Proceedings of the 20th Congress of the International Ergonomics Association (IEA 2018) ◽

10.1007/978-3-319-96089-0_85 ◽

2018 ◽

pp. 777-785

Author(s):

Yi-Chen Wang ◽

Jun-Ming Lu

Keyword(s):

Elderly Adults ◽

Middle Aged ◽

Coordination Strategies

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Left atrial diameter as an independent predictor of first clinical cardiovascular events in middle-aged and elderly adults: The Strong Heart Study (SHS)

American Heart Journal ◽

10.1016/j.ahj.2005.04.031 ◽

2006 ◽

Vol 151 (2) ◽

pp. 412-418 ◽

Cited By ~ 245

Author(s):

Jorge R. Kizer ◽

Jonathan N. Bella ◽

Vittorio Palmieri ◽

Jennifer E. Liu ◽

Lyle G. Best ◽

...

Keyword(s):

Left Atrial ◽

Cardiovascular Events ◽

Independent Predictor ◽

Elderly Adults ◽

Middle Aged ◽

Strong Heart Study ◽

Left Atrial Diameter ◽

Heart Study

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Serum gamma glutamyltransferase as a marker of metabolic syndrome and coronary disease likelihood in nondiabetic middle-aged and elderly adults

Preventive Medicine ◽

10.1016/j.ypmed.2006.04.005 ◽

2006 ◽

Vol 43 (2) ◽

pp. 136-139 ◽

Cited By ~ 30

Author(s):

Altan Onat ◽

Gülay Hergenç ◽

Ahmet Karabulut ◽

Serdar Türkmen ◽

Yüksel Doğan ◽

...

Keyword(s):

Metabolic Syndrome ◽

Coronary Disease ◽

Elderly Adults ◽

Middle Aged ◽

Gamma Glutamyltransferase

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Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations

Journal of Molecular Medicine ◽

10.1007/s00109-020-01976-x ◽

2020 ◽

Vol 98 (11) ◽

pp. 1603-1613 ◽

Cited By ~ 1

Author(s):

Paula J. Martinez ◽

Marta Agudiez ◽

Dolores Molero ◽

Marta Martin-Lorenzo ◽

Montserrat Baldan-Martin ◽

...

Keyword(s):

Young Adults ◽

Cardiovascular Risk ◽

Age Groups ◽

Gamma Aminobutyric Acid ◽

Elderly Adults ◽

Middle Aged ◽

Metabolic Signature ◽

Metabolic Fingerprint ◽

Elderly Populations ◽

Metabolic Signatures

Abstract The predictive value of traditional cardiovascular risk estimators is limited, and young and elderly populations are particularly underrepresented. We aimed to investigate the urine metabolome and its association with cardiovascular risk to identify novel markers that might complement current estimators based on age. Urine samples were collected from 234 subjects categorized into three age-grouped cohorts: 30–50 years (cohort I, young), 50–70 years (cohort II, middle-aged), and > 70 years (cohort III, elderly). Each cohort was further classified into three groups: (a) control, (b) individuals with cardiovascular risk factors, and (c) those who had a previous cardiovascular event. Novel urinary metabolites linked to cardiovascular risk were identified by nuclear magnetic resonance in cohort I and then evaluated by target mass spectrometry quantification in all cohorts. A previously identified metabolic fingerprint associated with atherosclerosis was also analyzed and its potential risk estimation investigated in the three aged cohorts. Three different metabolic signatures were identified according to age: 2-hydroxybutyrate, gamma-aminobutyric acid, hypoxanthine, guanidoacetate, oxaloacetate, and serine in young adults; citrate, cyclohexanol, glutamine, lysine, pantothenate, pipecolate, threonine, and tyramine shared by middle-aged and elderly adults; and trimethylamine N-oxide and glucuronate associated with cardiovascular risk in all three cohorts. The urinary metabolome contains a metabolic signature of cardiovascular risk that differs across age groups. These signatures might serve to complement existing algorithms and improve the accuracy of cardiovascular risk prediction for personalized prevention. Key messages • Cardiovascular risk in the young and elderly is underestimated. • The urinary metabolome reflects cardiovascular risk across all age groups. • Six metabolites constitute a metabolic signature of cardiovascular risk in young adults. • Middle-aged and elderly adults share a cardiovascular risk metabolic signature. • TMAO and glucuronate levels reflect cardiovascular risk across all age groups.

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