Delivery of therapeutic agents and cells to pancreatic islets: Towards a new era in the treatment of diabetes

2021 ◽  
pp. 101063
Author(s):  
Elnaz Zeynaloo ◽  
Logan D. Stone ◽  
Emre Dikici ◽  
Camillo Ricordi ◽  
Sapna K. Deo ◽  
...  
Keyword(s):  
Pancreatic Islets ◽  
Therapeutic Agents ◽  
New Era ◽  
Treatment Of Diabetes

Flavonoids as Potential Therapeutic Agents for the Management of Diabetic Neuropathy

2020 ◽  
Vol 26 (42) ◽  
pp. 5468-5487 ◽  
Author(s):  
Ankita Sood ◽  
Bimlesh Kumar ◽  
Sachin Kumar Singh ◽  
Pankaj Prashar ◽  
Anamika Gautam ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Diabetic Neuropathy ◽  
Glucose Utilization ◽  
Antioxidant Properties ◽  
Therapeutic Agents ◽  
Secondary Complications ◽  
Naturally Occurring ◽  
Glycation End Products ◽  
Treatment Of Diabetes ◽  
Pharmaceutical Industries

Flavonoids are secondary metabolites that are widely distributed in plants. These phenolic compounds are classified into various subgroups based on their structures: flavones, flavonols, isoflavones, flavanones, and anthocyanins. They are known to perform various pharmacological actions like antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic and antiallergic, etc. Diabetes is a chronic progressive metabolic disorder that affects several biochemical pathways and leads to secondary complications such as neuropathy, retinopathy, nephropathy, and cardiomyopathy. Among them, the management of diabetic neuropathy is one of the major challenges for physicians as well as the pharmaceutical industries. Naturally occurring flavonoids are extensively used for the treatment of diabetes and its related complications due to their antioxidant properties. Moreover, flavonoids inhibit various pathways that are involved in the progression of diabetic neuropathy like the reduction of oxidative stress, decrease in glycogenolysis, increase glucose utilization, decrease in the formation of advanced glycation end products, and inhibition of the α-glucosidase enzyme. This review entails current updates on the therapeutic perspectives of flavonoids in the treatment of neuropathic pain. This manuscript explains the pathological aspects of neuropathic pain, the chemistry of flavonoids, and their application in amelioration of neuropathic pain through preclinical studies either alone or in combination with other therapeutic agents.

Anti-inflammatory Glycosylated Flavonoids as Therapeutic Agents for Treatment of Diabetes-Impaired Wounds

2015 ◽  
Vol 15 (23) ◽  
pp. 2456-2463 ◽  
Author(s):  
Marilena Antunes-Ricardo ◽  
Janet Gutierrez-Uribe ◽  
Sergio Serna-Saldivar
Keyword(s):  
Therapeutic Agents ◽  
Treatment Of Diabetes ◽  
Anti Inflammatory

scholarly journals Nanopolyphenols: a review of their encapsulation and anti-diabetic effects

2020 ◽  
Vol 2 (8) ◽  
Author(s):  
Theresa F. Rambaran
Keyword(s):  
Functional Food ◽  
Encapsulation Efficiency ◽  
Water Solubility ◽  
Drug Loading ◽  
Therapeutic Agents ◽  
Low Ph ◽  
Free Form ◽  
Pharmaceutical Development ◽  
Curcumin Nanoparticles ◽  
Treatment Of Diabetes

AbstractPolyphenols are believed to possess numerous health benefits and can be grouped as phenolic acids, flavonoids or non-flavonoids. Research involving the synthesis of nanopolyphenols has attracted interest in the areas of functional food, nutraceutical and pharmaceutical development. This is in an effort to overcome current challenges which limit the application of polyphenols such as their rapid elimination, low water-solubility, instability at low pH, and their particle size. In the synthesis of nanopolyphenols, the type of nanocarrier used, the nanoencapsulation technique employed and the type of polymers that constitute the drug delivery system are crucial. For this review, all mentioned factors which can influence the therapeutic efficacy of nanopolyphenols were assessed. Their efficacy as anti-diabetic agents was also evaluated in 33 publications. Among these were phenolic acid (1), flavonoids (13), non-flavonoids (17) and polyphenol-rich extracts (2). The most researched polyphenols were quercetin and curcumin. Nanoparticles were the main nanocarrier and the size of the nanopolyphenols ranged from 15 to 333 nm with encapsulation efficiency and drug loading capacities of 56–97.7% and 4.2–53.2%, respectively. The quantity of nanomaterial administered orally ranged from 1 to 300 mg/kg/day with study durations of 1–70 days. Most studies compared the effect of the nanopolyphenol to its free-form and, in all but three cases, significantly greater effects of the former were reported. Assessment of the polyphenol to understand its properties and the subsequent synthesis of its nanoencapsulated form using suitable nanocarriers, polymers and encapsulation techniques can result in effective therapeutic agents for the treatment of diabetes.

Platypus venom genes expressed in non-venom tissues

2009 ◽  
Vol 57 (4) ◽  
pp. 199 ◽  
Author(s):  
Camilla M. Whittington ◽  
Katherine Belov
Keyword(s):  
Tissue Expression ◽  
Therapeutic Agents ◽  
New Era ◽  
Functional Studies ◽  
Ornithorhynchus Anatinus ◽  
Pharmacological Studies ◽  
Platypus Genome ◽  
Insight Into ◽  
Novel Therapeutic ◽  
The Way

The venom of the platypus (Ornithorhynchus anatinus) has been poorly studied to date. The recent publication of the platypus genome heralds a new era for mammalian venom research and is a useful starting tool for functional studies of venom components. We report here the patterns of tissue expression of two venom genes, OvNGF and OvCNP, in order to provide some insight into the functions of the proteins they produce and to pave the way for further functional and pharmacological studies, which may lead to the development of novel therapeutic agents.

scholarly journals Design and Estimation of Fast Dissolving Tablet by using Novel Techniques for Effective Treatment of Diabetes

2020 ◽  
Vol 9 (3) ◽  
pp. 2345-2349
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Pancreatic Islets ◽  
Protein Digestion ◽  
Lipid Digestion ◽  
Diabetes Mellitus Type Ii ◽  
Insulin Reaction ◽  
Patients With Diabetes ◽  
Treatment Of Diabetes ◽  
Postprandial Insulin

Diabetes mellitus is a metabolic issue it is brought about by a flat out or relative absence of insulin that, among different outcomes, increments in plasma glucose fixation related to change hyperglycemia and unsettling influence of lipid digestion, starch digestion, additionally protein digestion. Glipizide, a secondgen sulfonylurea, is utilized with diet to bring down blood glucose in patients with diabetes mellitus type II. The essential method of activity of glipizide in exploratory creatures seems, by all accounts, to be the incitement of insulin emission from the beta cells of pancreatic islet tissue and is in this way reliant on working -cells in the pancreatic islets. In human's glipizide seems to bring down the blood glucose intensely by invigorating the arrival of insulin from the pancreas, an impact subordinate after working -cells in the pancreatic islets. In man, incitement of insulin discharge by glipizide because of a feast is undoubtedly vital. Fasting insulin levels are not raised even on long haul glipizide organization, yet the postprandial insulin reaction keeps on being upgraded after at any rate a half year of treatment.

Naringenin Scaffold As A Template For Drug Designing

2019 ◽  
Vol 05 ◽  
Author(s):  
Yogesh Murti ◽  
Bhupesh Chander Semwal ◽  
Ahsas Goyal ◽  
Pradeep Mishra
Keyword(s):  
Health Care ◽  
Natural Products ◽  
Molecular Mechanisms ◽  
Therapeutic Agents ◽  
Lead Compound ◽  
Enhancer Activity ◽  
New Era ◽  
The Family ◽  
Drug Designing ◽  
Memory Enhancer

: Natural products provides cornucopia of heterocyclic systems. 2-Phenyl chromane nucleus is one of the important and well known heterocycles present in natural products. Naringenin, a plant-derived flavanone (2-phenyl chroman-4-one) belongs to the family of flavanoids. It possesses diverse biologic activities such as antidiabetic, antiatherogenic, antidepressant, antiandrogenic, antiestrogenic, immunomodulatory, antitumor, antimicrobial, anti-inflammatory, antiviral, hypolipidemic, antihypertensive, antioxidant, neuroprotective, anti-obesity, anti-Alzheimer, and memory enhancer activity. It has potential to be used as an active pharmacophore. A number of molecular mechanisms underlying its beneficial activities have been reported. With emerging interest in the traditional medicine and exploit their potentials based on different health care system, it was thought to explore literature on naringenin. Further, this review aims to provide newer insights of naringenin and its derivatives as lead compound in drug design to a new era of flavonoid based therapeutic agents.

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