In vitro Cytotoxicity, MMP and ROS activity of green synthesized nickel oxide nanoparticles using extract of Terminalia chebula against MCF-7 cells

2019 ◽  
Vol 234 ◽  
pp. 129-133 ◽  
Author(s):  
Fatima Ibraheem ◽  
Muhammad Hammad Aziz ◽  
Mahvish Fatima ◽  
Fozia Shaheen ◽  
Syed Mansoor Ali ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
In Vitro Cytotoxicity ◽  
Oxide Nanoparticles ◽  
Terminalia Chebula ◽  
Nickel Oxide Nanoparticles ◽  
Mcf 7

scholarly journals The inhibitory role of synthesized Nickel oxide nanoparticles against Hep-G2, MCF-7, and HT-29 cell lines: the inhibitory role of NiO NPs against Hep-G2, MCF-7, and HT-29 cell lines

2021 ◽  
Vol 14 (3) ◽  
pp. 443-453
Author(s):  
Mohammad Amin Jadidi Kouhbanani ◽  
Yasin Sadeghipour ◽  
Mina Sarani ◽  
Erfan Sefidgar ◽  
Saba Ilkhani ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Cell Lines ◽  
Oxide Nanoparticles ◽  
Hep G2 ◽  
Nickel Oxide Nanoparticles ◽  
Inhibitory Role ◽  
Nio Nps ◽  
Ht 29 ◽  
Mcf 7

Evaluation of the genotoxic properties of nickel oxide nanoparticles in vitro and in vivo

2018 ◽  
Vol 836 ◽  
pp. 47-53 ◽  
Author(s):  
Raíne F. De Carli ◽  
Débora dos S. Chaves ◽  
Tatiane R. Cardozo ◽  
Ana Paula de Souza ◽  
Allan Seeber ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Oxide Nanoparticles ◽  
Nickel Oxide Nanoparticles

scholarly journals In Vitro Evaluation of Cytotoxic Effects of Nickel Oxide Nanoparticles on Human Neuroblastoma Cell Line (SH-SY5Y)

2021 ◽  
Vol 14 (11) ◽  
pp. 20-29
Author(s):  
Mozhdeh Hajimohammadjafar tehrania ◽  
Mahsa Ale-Ebrahim ◽  
Mojtaba Falahati ◽  
Shahram Zarabiyan ◽  
◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Oxide Nanoparticles ◽  
Human Neuroblastoma Cell ◽  
Nickel Oxide Nanoparticles ◽  
Human Neuroblastoma ◽  
Cytotoxic Effects ◽  
Human Neuroblastoma Cell Line

scholarly journals Phytogenic Synthesis of Nickel Oxide Nanoparticles (NiO) Using Fresh Leaves Extract of Rhamnus triquetra (Wall.) and Investigation of Its Multiple In Vitro Biological Potentials

Biomedicines ◽  
2020 ◽  
Vol 8 (5) ◽  
pp. 117 ◽  
Author(s):  
Javed Iqbal ◽  
Banzeer Ahsan Abbasi ◽  
Riaz Ahmad ◽  
Mahboobeh Mahmoodi ◽  
Akhtar Munir ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Nickel Oxide ◽  
Biological Activities ◽  
Radical Scavenging ◽  
New Drugs ◽  
In Vivo Studies ◽  
Oxide Nanoparticles ◽  
Nickel Oxide Nanoparticles ◽  
X Ray

Chemically nickel oxide nanoparticles (NiONPs) involve the synthesis of toxic products, which restrict their biological applications. Hence, we developed a simple, eco-friendly, and cost-efficient green chemistry method for the fabrication of NiONPs using fresh leaf broth of Rhamnus triquetra (RT). The RT leaves broth was used as a strong reducing, capping, and stabilizing agent in the formation of RT-NiONPs. The color change in solution from brown to greenish black suggests the fabrication of RT-NiONPs which was further confirmed by absorption band at 333 nm. The synthesis and different physicochemical properties of RT-NiONPs were investigated using different analytical techniques such as UV-Vis (ultraviolet−visible spectroscopy), XRD (X-ray powder diffraction), FT-IR (Fourier-transform infrared spectroscopy), SEM (scanning electron microscopy), TEM (transmission electron microscopy), EDS (energy-dispersive X-ray spectroscopy), DLS (dynamic light scattering) and Raman. Further, RT-NiONPs were subjected to different in vitro biological activities and revealed distinctive biosafe and biocompatibility potentials using erythrocytes and macrophages. RT-NiONPs exhibited potential anticancer activity against liver cancer cell lines HUH7 (IC50: 11.3 µg/mL) and HepG2 (IC50: 20.73 µg/mL). Cytotoxicity potential was confirmed using Leishmanial parasites promastigotes (IC50: 27.32 µg/mL) and amastigotes (IC50: 37.4 µg/mL). RT-NiONPs are capable of rendering significant antimicrobial efficacy using various bacterial and fungal strains. NiONPs determined potent radical scavenging and moderate enzyme inhibition potencies. Overall, this study suggested that RT-NiONPs can be an attractive and eco-friendly candidate. In conclusion, current study showed potential in vitro biological activities and further necessitate different in vivo studies in various animal models to develop leads for new drugs to treat several chronic diseases.

scholarly journals Green synthesis of magnetic iron-nickel oxide nanoparticles using Terminalia chebula extract

2020 ◽  
Vol 18 (3) ◽  
pp. 74-84
Author(s):  
حدیثه اسدیان ◽  
فریبا تدین ◽  
ساناز رئیس فرشید
Keyword(s):  
Nickel Oxide ◽  
Green Synthesis ◽  
Oxide Nanoparticles ◽  
Terminalia Chebula ◽  
Nickel Oxide Nanoparticles ◽  
Iron Nickel

scholarly journals Antimycobacterial, Antioxidant and Cytotoxicity Activities of Mesoporous Nickel Oxide Nanoparticles for Healthcare

Coatings ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1242
Author(s):  
Jivan R. Kote ◽  
Ambadas S. Kadam ◽  
Mohd Ubaidullah ◽  
Abdullah M. Al-Enizi ◽  
Mohammed A. Al-Abdrabalnabi ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Nickel Oxide ◽  
Longitudinal Optical ◽  
Oxide Nanoparticles ◽  
Potential Candidate ◽  
Nickel Oxide Nanoparticles ◽  
Silar Method ◽  
Hemolysis Assay ◽  
Nio Nps

Nanobiotechnology has offered great attention in drug delivery and the development of various medicines used to treat microorganism infections. The present investigation deals with antimycobacterial activity, in-vitro hemolysis assay, and antioxidant activity of nickel oxide nanoparticles (NiO NPs). NiO NPs, with controlled size and shape, prepared by a simple and inexpensive successive ionic layer adsorption and reaction (SILAR) method was scanned using field emission scanning electron microscopy (FE-SEM) and high-resolution transmission electron microscopy (HR-TEM) digital images for surface morphology confirmation. Spherical irregular island-type NPs of about 24 nm diameter are obtained. The X-ray diffraction pattern demonstrates the synthesis of polycrystalline and cubic in phase NiO NPs. The Raman spectrum has revealed the presence of two vibration bands cantered at 550 and 1095 cm−1 for one photon longitudinal optical, and two longitudinal optical modes, respectively. The as-prepared NiO NPs endow 10 µg/mL against Mycobacterium tuberculosis (M. tuberculosis, MTCC-300) and 10 µg/mL against Mycobacterium phlei (M. phlei, MTCC-1723) inhibitory concentrations. The hemolytic activity of NiO NPs has also been explored. The antioxidant result demonstrates 63.44% for NiO NPs over 88.23% for standard, i.e., di(phenyl)-(2, 4, 6-trinitrophenyl) viminoazaniun antioxidant. Taken together, NiO NPs act as a potential candidate against mycobacteria.

scholarly journals Green Synthesis of Nickel Oxide Nanoparticles from Berberis balochistanica Stem for Investigating Bioactivities

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1548
Author(s):  
Siraj Uddin ◽  
Luqman Bin Safdar ◽  
Saeed Anwar ◽  
Javed Iqbal ◽  
Sabiha Laila ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Green Synthesis ◽  
Antioxidant Activities ◽  
Germination Rate ◽  
Oxide Nanoparticles ◽  
X Ray Diffraction ◽  
Nickel Oxide Nanoparticles ◽  
Total Antioxidant ◽  
Elemental Nature

Green synthesis of nanomaterials is advancing due to its ease of synthesis, inexpensiveness, nontoxicity and renewability. In the present study, an eco-friendly biogenic method was developed for the green synthesis of nickel oxide nanoparticles (NiONPs) using phytochemically rich Berberis balochistanica stem (BBS) extract. The BBS extract was rich in phenolics, flavonoids and berberine. These phytochemicals successfully reduced and stabilised the NiNO3 (green) into NiONPs (greenish-gray). BBS-NiONPs were confirmed by using UV-visible spectroscopy (peak at 305 nm), X-ray diffraction (size of 31.44 nm), Fourier transform infrared spectroscopy (identified -OH group and Ni-O formation), energy dispersive spectroscopy (showed specified elemental nature) and scanning electron microscopy (showed rhombohedral agglomerated shape). BBS-NiONPs were exposed to multiple in vitro bioactivities to ascertain their beneficial biological applications. They exhibited strong antioxidant activities: total antioxidant capacity (64.77%) and 2, 2-diphenyl-1-picrylhydrazyl (71.48%); and cytotoxic potential: Brine shrimp cytotoxicity assay with IC50 (10.40 µg/mL). BBS-NiONPs restricted the bacterial and fungal pathogenic growths at 1000, 500 and 100 µg/mL. Additionally, BBS-NiONPs showed stimulatory efficacy by enhancing seed germination rate and seedling growth at 31.25 and 62.5 µg/mL. In aggregate, BBS extract has a potent antioxidant activity which makes the green biosynthesis of NiONPs easy, economical and safe. The biochemical potential of BBS-NiONPs can be useful in various biomedical and agricultural fields.

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