Evaluation of hepato and renal protective effect of synthesized nanoparticles using Tinospora cordifolia leaf extract

2022 ◽  
pp. 131642
Author(s):  
Muniyandi Biruntha ◽  
Balan Karunai Selvi ◽  
James Arockia John Paul ◽  
Pethanan Sivakumar ◽  
Sundararaj Rajamanikandan ◽  
...  
Keyword(s):  
Protective Effect ◽  
Leaf Extract ◽  
Tinospora Cordifolia

scholarly journals In vitro anti-bacterial activity of Tinospora cordifolia leaf extract and its phytochemical screening

2019 ◽  
Vol 5 (2) ◽  
pp. 10-17
Author(s):  
B. Praiwala ◽  
S. Priyanka ◽  
N. Raghu ◽  
N. Gopenath ◽  
A. Gnanasekaran ◽  
...  
Keyword(s):  
Cell Division ◽  
Leaf Extract ◽  
Antibacterial Property ◽  
Standard Procedure ◽  
Tinospora Cordifolia ◽  
Diffusion Method ◽  
Main Concern ◽  
Phytochemical Screening ◽  
Leaf Extracts ◽  
Screening Assay

Background: Antimicrobial resistance is the main concern worldwide to combat infectious. Over the years studies on leaf extracts Tinospora cordifolia have demonstrated the potent role its antibacterial property. The current study is an attempt to test its antibacterial property against Escherichia coli cell division. Material and methods: Phytochemical screening assay of T. cordifolia leaf extract was done using standard procedure and the results showed the presence of alkaloid, carbohydrate, terpenoid, steroid, tannin, amino acid, flavonoid and glycoside components. Results: HPLC analysis revealed the presence of berberine in T. cordifolia leaf extract. Further E. coli cells were treated with berberine to study its efficacy in inhibiting cell division. Antibacterial assay was performed by using disc diffusion method. Conclusion: Among aqueous, methanolic, ethanolic, chloroform, hexane and acetone extract only methanolic extract showed zone of inhibition.

scholarly journals Evaluation of Antioxidant Potential of Stem and Leaf Extracts of Himalayan Tinospora cordifolia Hook.f. & Thomson

2021 ◽  
Vol 9 (1) ◽  
pp. 2-8
Author(s):  
Geetanjali Upadhyay ◽  
Lalit M. Tewari ◽  
Geeta Tewari ◽  
Neha Chopra ◽  
Naveen C. Pandey ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Leaf Extract ◽  
Radical Scavenging ◽  
Aluminium Chloride ◽  
Tinospora Cordifolia ◽  
Total Phenolic ◽  
Flavonoid Content ◽  
Leaf Extracts ◽  
The Family ◽  
Stem Extract

Background: Medicinal plants are considered a rich source of ingredients, which can be used in drug development and synthesis. Tinospora cordifolia (Wild.) Hook.f. & Thomson, commonly known as guduchi, heart-leaved moonseed and giloya is a herbaceous vine of the family Menispermaceae, has several beneficial properties including antioxidant activity. Aim: The present study was carried out to analyze the antioxidant activity of leaf and stem extracts of Tinospora cordifolia by using DPPH (1,1-Diphenyl-2-picrylhydrazyl) and ABTS (2,2´-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)) free radical scavenging assays. Materials and Methods: Dried and powdered leaves and stem of T. cordifolia were extracted with methanol. Ascorbic acid was taken as standard. Total phenolic content was estimated by using Folin-ciocalteu's reagent while total flavonoid content by aluminium chloride reagent to find the correlation of polyphenols with antioxidant activity. ABTS assay of methanolic leaf and stem extracts showed the highest scavenging activity as compared to the DPPH assay. Results: Methanolic stem extract showed higher phenolic and flavonoid content along with antioxidant activity as compared to the methanolic leaf extract. Conclusion: The stem extract exhibited more antioxidant activity than the leaf extract with regards to the all parameters analyzed.

Some Indian herbs have protective effects against deleterious effects of ochratoxin A in broiler chicks

2021 ◽  
pp. 1-14
Author(s):  
S.D. Stoev ◽  
K. Dimitrov ◽  
I. Zarkov ◽  
T. Mircheva ◽  
D. Zapryanova ◽  
...  
Keyword(s):  
Body Weight ◽  
Protective Effect ◽  
Ochratoxin A ◽  
Relative Weight ◽  
Fine Powder ◽  
Inhibitory Effect ◽  
Feed Additives ◽  
Tinospora Cordifolia ◽  
Broiler Chicks ◽  
Protective Effects

A protective effect of two herbs, Glycyrrhiza glabra and Tinospora cordifolia, given as feed additives was observed against the growth inhibitory effect of ochratoxin A (OTA) and associated immunosuppression and biochemical or pathomorphological changes. The feed levels of 3 mg/kg OTA and fine powder of one of both herbs were given during a period of 32 days to female broiler chicks divided into 3 experimental and 1 control groups (14 chicks per group). The observed pathological and biochemical changes, the changes in relative organs’ weight and body weight, and the decrease of antibody titer against Newcastle disease were more pronounced in the OTA-treated chicks without herbal supplementation, and less pronounced in the chicks treated additionally with G. glabra or T. cordifolia as was shown by the better feed performance and the higher body weight in the chicks treated with the herbs. The higher relative weight of lymphoid organs of the chicks supplemented with both herbs revealed their beneficial effects on the immune system. The hepatoprotective effect of both herbs was evident, being stronger in the chicks additionally supplemented with G. glabra shown by the pathomorphological findings and by the lower levels of aspartate transaminase (131.1 U/l) compared to chicks given only OTA (156.0 U/l). A protective effect of T. cordifolia on the bone marrow and kidneys was found as was shown by the lower levels of uric acid (382.9 μmol/l) compared to chicks given only OTA (466.9 μmol/l).

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