Stages of reproductive aging: Effects on sleep, physical activity, and connectedness with nature

Maturitas ◽  
2021 ◽  
Vol 152 ◽  
pp. 82
Author(s):  
Andreia Teixeira ◽  
Ronaldo Gabriel ◽  
Graça Pinto ◽  
Mário Santos ◽  
Aurélio Faria ◽  
...  
Author(s):  
Michal Nissim ◽  
Abigail Livny ◽  
Caroline Barmatz ◽  
Galia Tsarfaty ◽  
Yitshal Berner ◽  
...  

Background: Normal aging is associated with balance and working memory decline. From a neurobiological standpoint, changes in cerebellar functional plasticity may mediate the decline in balance and working memory for older adults. Mounting evidence suggests that physical activity is beneficial for decreasing aging effects. Previous studies have focused on land-based physical activity and research concerning the aquatic environment is scarce. This study investigated the effectiveness of Ai-Chi on balance abilities and cerebral activation during a high working memory load task among community-dwelling older people. Methods: A total of 19 people aged 65–86 years were allocated to receive Ai-Chi practice (n = 6), structured on-land Ai-Chi practice (n = 7) or guided-imagery of Ai-Chi practice (n = 6) for a bi-weekly, 30-min exercise session for 12 weeks. Balance was measured by the Tinetti balance sub-test and working memory was measured by the N-back test during functional-MRI scan. Results: The Ai-Chi practice group presented a significant change in balance between pre and post intervention (balance t = −4.8, p < 0.01). In the whole-brain analysis, during high working memory load task, the Ai-Chi practice group presented a decrease in left cerebellar activation. Region of interest analyses yielded similar results by which pre-cerebellar activation was higher than post-intervention (t = 2.77, p < 0.05). Conclusions: Ai-Chi is an available, non-invasive intervention method that may serve as a tool to improve cerebellar activation that in turn might improve balance. In addition, our findings may provide new insights into the neuronal mechanisms that underlie both motor and cognitive abilities.


2020 ◽  
Author(s):  
Michal Nissim ◽  
Abigail Livny ◽  
Caroline Barmatz ◽  
Galia Tsarfaty ◽  
Yitshal Berner ◽  
...  

Abstract Background: Normal aging is associated with balance, mobility and working memory decline that increase fall risk and influence activity of daily living functions. Mounting evidence suggests that physical activity is beneficial for decreasing aging effects. Previous studies have focused on land-based physical activity. Research concerning the aquatic environment is scarce. The primary objectives of this three arm intervention pilot study were to examine the effects of an aquatic physical intervention program on balance, gait, fall risk and working memory among community-dwelling older individuals. The secondary objective was to examine the effects of an aquatic physical intervention program on safety of street–crossing among community-dwelling older individuals. Methods: Forty-two healthy participants aged 65 or older were enrolled into one of three intervention groups: aquatic physical intervention (API) (N=13), on-land physical intervention (OLPI) (N=14) or non-physical intervention (NPI) (N=15). The intervention took place from 2018 until 2019 at Tel-Aviv University, Sheba medical center and Reich Center. The protocol included 30-minute sessions twice a week for 12 weeks. Balance, gait and fall risk were assessed by the Tinneti test, working memory abilities were assessed by digit span and Corsi blocks tests and simulated safe streets-crossing was assessed by the hazard perception test for pedestrians.Testing and data collection was conducted at baseline, after six weeks and 12 weeks of intervention. All members of the professional team involved in evaluating participants were blind to the intervention group to which participants were allocated. Results: The differences in Tinetti balance (F(2,39)=10.03, p<0.01), fall risk (F(2,39)=5.62, p0>.05), digit span forward (F(2,39)=8.85, p<0.01) and Corsi blocks forward (F(2,39)=3.54, p<0.05) and backward (F(2,39)=6.50, p<0.05) scores after 12 weeks between the groups were significant. The API group showed improved scores. The differences in hazard perception test for pedestrians scores after 12 weeks of intervention between the groups were marginally significant (F(2,39)=3.13, p=0.055). The API group showed improved scores. Conclusions: These findings may affect experts working with the elderly population when making decisions concerning therapeutic prevention interventions for the deficiencies of elderly patients. Older adults practicing aquatic physical activity could contribute to their increased safety. Trial registrationTrial registration number: ClinicalTrials.gov Registry NCT03510377. Date of registration: 10/31/2017


2001 ◽  
Vol 11 (s1) ◽  
pp. S208-S217 ◽  
Author(s):  
Raymond D. Starling

Aging is associated with a decline in daily energy expenditure that is disproportionately greater than the decline in daily energy intake. Collectively, these events can create a “positive” energy balance, secondary gains in central and total body fat, and a subsequently higher risk of morbidity and mortality. Participation in regular physical activity is a logical strategy to attenuate the decline in energy expenditure with aging, as physical activity can comprise between 10–50% of an older person’s daily energy expenditure. Understanding the influence of regular physical activity on energy expenditure with advancing age is clinically relevant, particularly since estimates predict that nearly 25% of the population will be ≥ 65 years of age by the year 2030. This brief review will focus on the current state of aging, energy expenditure, and physical activity literature. Topics to be addressed include: (a) measurement of physical activity in older adults; (b) aging and physical inactivity; and (c) influence of regular aerobic exercise on resting metabolic rate (RMR), thermic effect of food (TEF), and non-exercising physical activity.


2019 ◽  
Author(s):  
Michal Nissim ◽  
Abigail Livny ◽  
Caroline Barmatz ◽  
Galia Tsarfaty ◽  
Yitshal Berner ◽  
...  

Abstract Background: Normal aging is associated with balance, mobility and working memory decline that increase fall risk and influence activity of daily living functions. Mounting evidence suggests that physical activity is beneficial for decreasing aging effects. The environment in which the physical activity occurs influences the results of the activity. Previous studies have focused on land-based physical activity. Research concerning the aquatic environment is scarce. The purpose of this study was to examine the effects of an aquatic physical intervention program on fall risk, working memory and safety of streets–crossing among community-dwelling older individuals.Methods: Forty-two healthy participants aged 65 or older were divided into one of three intervention groups: aquatic physical intervention (API), on-land physical intervention (OLPI) or non-physical intervention (NPI). The intervention took place from 2018 until 2019 and the protocol included 30-minute sessions twice a week for 12 weeks. Balance, gait and fall risk, working memory abilities and simulated safe streets-crossing were tested. Testing and data collection was conducted at baseline, after six weeks and 12 weeks of intervention. Results: After six and 12 weeks of intervention, the API group achieved higher improvement on fall-risk score as compared to the NPI group, and both OLPI and NPI groups achieved less improvement on balance score compared to the API group. Additionally, after 12 weeks of intervention, both OLPI and NPI groups scored significantly lower than the API group in verbal and visuospatial working memory tests. Finally, a trend of improvement was found on the hazard-perception as pedestrians test after 12 weeks of intervention only among the API group. Conclusions: These findings may affect experts working with the elderly population when making decisions concerning therapeutic prevention interventions for the deficiencies of elderly patients. Such interventions may help reduce falling and cognitive deficits, which can lead to decreased injuries and fatalities of older pedestrians. Older adults practicing aquatic physical activity could contribute to their increased safety. Trial registration Trial registration number: ClinicalTrials.gov Registry NCT03510377. Date of registration: 10/31/2017 https://clinicaltrials.gov/ct2/show/NCT03510377


Author(s):  
Paweł Kordowitzki ◽  
Amin Haghani ◽  
Joseph A. Zoller ◽  
Caesar Z. Li ◽  
Ken Raj ◽  
...  

ABSTRACTCattle are an attractive animal model of fertility in women due to their high degree of similarity relative to follicle selection, embryo cleavage, blastocyst formation, and gestation length. To facilitate future studies of the epigenetic underpinnings of aging effects in the female reproductive axis, several DNA methylation-based biomarkers of aging (epigenetic clocks) for bovine oocytes are presented. One such clock was germane to only oocytes, while a dual-tissue clock was highly predictive of age in both oocytes and blood. Dual species clocks that apply to both humans and cattle were also developed and evaluated. These epigenetic clocks can be used to accurately estimate the chronological age of the oocyte donor. Both epigenetic clock studies and epigenome wide association studies revealed that blood and oocytes differ substantially with respect aging and the underlying epigenetic signatures that potentially influence the aging process. The rate of epigenetic aging was found to be slower in oocytes compared to blood, however, oocytes appeared to begin at an older epigenetic age. The epigenetic clocks for oocytes are expected to address questions in the field of reproductive aging, including the central question: how to slow aging of oocytes.


Circulation ◽  
2020 ◽  
Vol 141 (13) ◽  
Author(s):  
Barry A. Franklin ◽  
Paul D. Thompson ◽  
Salah S. Al-Zaiti ◽  
Christine M. Albert ◽  
Marie-France Hivert ◽  
...  

Epidemiological and biological plausibility studies support a cause-and-effect relationship between increased levels of physical activity or cardiorespiratory fitness and reduced coronary heart disease events. These data, plus the well-documented anti-aging effects of exercise, have likely contributed to the escalating numbers of adults who have embraced the notion that “more exercise is better.” As a result, worldwide participation in endurance training, competitive long distance endurance events, and high-intensity interval training has increased markedly since the previous American Heart Association statement on exercise risk. On the other hand, vigorous physical activity, particularly when performed by unfit individuals, can acutely increase the risk of sudden cardiac death and acute myocardial infarction in susceptible people. Recent studies have also shown that large exercise volumes and vigorous intensities are both associated with potential cardiac maladaptations, including accelerated coronary artery calcification, exercise-induced cardiac biomarker release, myocardial fibrosis, and atrial fibrillation. The relationship between these maladaptive responses and physical activity often forms a U- or reverse J-shaped dose-response curve. This scientific statement discusses the cardiovascular and health implications for moderate to vigorous physical activity, as well as high-volume, high-intensity exercise regimens, based on current understanding of the associated risks and benefits. The goal is to provide healthcare professionals with updated information to advise patients on appropriate preparticipation screening and the benefits and risks of physical activity or physical exertion in varied environments and during competitive events.


2018 ◽  
Vol 15 (7) ◽  
pp. 537-542 ◽  
Author(s):  
Declan J. Ryan ◽  
Jorgen A. Wullems ◽  
Georgina K. Stebbings ◽  
Christopher I. Morse ◽  
Claire E. Stewart ◽  
...  

Background: The aim of the study was to provide an isotemporal substitution model to predict how changes in physical behavior may affect the cardiovascular parameters (CVPs) of older adults. Methods: Participants wore a thigh-mounted accelerometer for 7 days. Phenotype of the carotid, brachial, and popliteal artery was conducted using ultrasound. Isotemporal substitution was used to simulate the degree to which replacing 1 hour of physical behavior with another would affect CVP. Results: Substitution of sedentary behavior with Standing and sporadic moderate- to vigorous-intensity physical activity (MVPA accumulated in bouts <10 min) would reduce resting heart rate [−6.20 beats per minute (−12.1 to −0.22) and −3.72 beats per minute (−7.01 to −0.44), respectively]. Substitution of sedentary behavior with light-intensity physical activity would reduce carotid artery diameter [−0.54 mm (−1.00 to −0.07)]. Substitution of Standing with sporadic MVPA would increase popliteal artery diameter [1.31 mm (0.11 to 2.51)]. Conclusions: Our modeling suggests that an accumulation of MVPA bouts that are shorter than the recommended 10-minute minimum may still improve CVP, with lower intensity physical activity also influencing CVP. Our findings are a promising avenue for lifestyle interventions in older adults to reduce the aging effects on CVP for those who cannot engage or sustain sufficient MVPA.


1997 ◽  
Vol 9 (1-2) ◽  
pp. 73-79 ◽  
Author(s):  
R. J. M. McCarter ◽  
I. Shimokawa ◽  
Y. Ikeno ◽  
Y. Higami ◽  
G. B. Hubbard ◽  
...  

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