Cardiometabolic Health Outcomes Associated With Discordant Visceral and Liver Fat Phenotypes: Insights From the Dallas Heart Study and UK Biobank

2021 ◽  
Author(s):  
Sanaa Tejani ◽  
Cody McCoy ◽  
Colby R. Ayers ◽  
Tiffany M. Powell-Wiley ◽  
Jean-Pierre Després ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Liver Fat ◽  
Cardiometabolic Health ◽  
Uk Biobank ◽  
Heart Study ◽  
Dallas Heart Study

scholarly journals Profiling the Discordant Visceral Adipose Tissue–Ectopic Liver Fat Phenotype: Results from the Dallas Heart Study

2020 ◽  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Fat Deposition ◽  
Liver Fat ◽  
Heart Study ◽  
Dallas Heart Study ◽  
Ectopic Liver ◽  
Visceral Adipose ◽  
Cardiometabolic Profile

The accumulation of visceral adipose tissue (VAT) and ectopic liver fat (ELF) generally parallel each other, but a proportion of individuals have discordant fat deposition. The cardiometabolic profile of individuals with a discordant phenotype is unknown.

Abstract MP35: Discordant Visceral and Liver Fat Phenotypes are Differentially Associated With Incident Cardiovascular Disease and Type 2 Diabetes

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Sanaa Tejani
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Health Outcomes ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Liver Fat ◽  
Cardiometabolic Health ◽  
Study Cohort ◽  
Incident Cardiovascular Disease

Background: Visceral adipose tissue (VAT) and ectopic liver fat (ELF) are linked with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) but little is known about their joint associations when they are discordant in an individual. Objective and Hypothesis: This study aims to evaluate cardiometabolic health outcomes associated with discordant VAT-ELF phenotypes in a multi-ethnic, population-based cohort of adults. We hypothesized that high VAT-low ELF, but not low VAT-high ELF, would be associated with incident cardiovascular disease, but both would be associated with incident T2DM. Methods: Participants of the Dallas Heart Study with no history of CVD or T2DM had assessments of VAT and ELF by MRI and MRS, respectively, between 2000 and 2002 and were followed for a median (IQR) of 12.0 (11.5-12.7) years for the incidence of CVD or T2DM. Associations between VAT-ELF phenotypes (high/low based on sex- and race-specific median values) and outcomes were evaluated using multivariable adjusted Cox proportional hazards and logistic regression models, as appropriate. Results: The study cohort included 1731 participants (mean age 43, 54% female, 44% black, 18% Hispanic, 41% obese). 128 (7.4%) participants had incident CVD and 95 (5.5%) had incident T2DM during follow-up. In unadjusted models, those with high VAT-low ELF had the highest hazard for CVD ( Table ), but associations were attenuated after multivariable adjustment. In both unadjusted and adjusted models, high VAT and/or high ELF phenotypes were associated with T2DM, with the high VAT-high ELF phenotype demonstrating the highest odds for T2DM ( Table ). Conclusions: In conclusion, we found that the heterogeneous manifestations of abdominal obesity impact cardiometabolic health outcomes. Elevated liver fat in the presence of low or normal VAT is associated with incident T2DM but not CVD.

scholarly journals Assessing Cardiometabolic Health Risk Among U.S. Children Who Live in Grandparent-Headed Households

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 524-524
Author(s):  
MinKyoung Song ◽  
Karen Lyons ◽  
Laura Hayman ◽  
Nathan Dieckmann ◽  
Carol Musil
Keyword(s):  
Health Outcomes ◽  
Insurance Coverage ◽  
Change Agents ◽  
Indirect Evidence ◽  
Health Insurance Coverage ◽  
Cardiometabolic Health ◽  
Steady Increase ◽  
Childhood Experiences ◽  
Grandparent Caregivers ◽  
Age Appropriate

Abstract Many interventions have been designed to leverage parent-caregivers as change agents for improving children’s cardiometabolic health (CMH), however very few have been designed to leverage grandparent-caregivers for that purpose. This is surprising since there has been a steady increase in children living in grandparent-headed households. As a first step in assessing the potential impact of interventions with grandparent-caregivers, we used data from the National Survey of Children’s Health (2018) to compare CMH measures in children living in grandparent-headed households with CMH measures in children living in parent-headed households. Our hypothesis was that CMH risk might be higher in grandparent households – given that research shows that grandparents taking over caregiving from parents is associated with worse overall health outcomes for both grandparents and their grandchildren. Additionally, since research indicates that children who experience ≥ 4 adverse childhood experiences (ACEs) have significantly worse health outcomes, we assessed levels of ACEs. Our analytic sample included children aged 10-17 years (n=14,941). Adjusting for age, sex, race/ethnicity, and health insurance coverage status, children living in grandparent households were more likely to be obese (Adjusted Odds Ratio [95% confidence interval]= 2.04 [1.02, 4.09]), exposed to secondhand smoke (2.32 [1.49, 3.59]), and less likely to meet recommended age-appropriate standards for sleep (0.42 [0.27, 0.67]). The children living in grandparent households were more likely to experience ≥ 4 ACEs (8.59 [5.42, 13.62]). Our results provide indirect evidence that interventions with grandparent-caregivers may be particularly critical for improving CMH risk in families.

scholarly journals Relations of liver fat with prevalent and incident chronic kidney disease in the Framingham Heart Study: A secondary analysis

2019 ◽  
Vol 39 (8) ◽  
pp. 1535-1544 ◽  
Author(s):  
Robert M. Wilechansky ◽  
Alison Pedley ◽  
Joseph M. Massaro ◽  
Udo Hoffmann ◽  
Emelia J. Benjamin ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Framingham Heart Study ◽  
Secondary Analysis ◽  
Liver Fat ◽  
Heart Study ◽  
Incident Chronic Kidney Disease

Association of Lipoprotein-Associated Phospholipase A2 Mass and Activity with Coronary and Aortic Atherosclerosis: Findings from the Dallas Heart Study

2008 ◽  
Vol 54 (12) ◽  
pp. 1975-1981 ◽  
Author(s):  
Emmanouil S Brilakis ◽  
Amit Khera ◽  
Bilal Saeed ◽  
Subhash Banerjee ◽  
Darren K McGuire ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Large Population ◽  
Population Based ◽  
Aortic Atherosclerosis ◽  
Standard Deviation Increase ◽  
Plaque Instability ◽  
Aortic Plaque ◽  
Heart Study ◽  
Atherosclerosis Risk Factors ◽  
Dallas Heart Study

Abstract Background: Our aim was to characterize the association of lipoprotein-associated phospholipase A2 (Lp-PLA2) with coronary and aortic atherosclerosis in a large population-based study. Methods: Lp-PLA2 mass and activity were measured in 2171 subjects 30–65 years old participating in the Dallas Heart Study. We examined the association of Lp-PLA2 levels with 3 atherosclerosis phenotypes: coronary artery calcium (CAC) measured by electron-beam computed tomography and abdominal aortic plaque (AAP) and aortic wall thickness (AWT) measured by magnetic resonance imaging. Results: CAC and AAP were detected in 21% and 40% of subjects, respectively, and mean AWT (SD) was 1.70 (0.32) mm. In univariable analyses, Lp-PLA2 mass (but not activity) was higher in both men (P = 0.04) and women (P = 0.02) with detectable CAC. Lp-PLA2 mass and activity were higher (P = 0.004 and P = 0.01, respectively) and AWT was greater (P < 0.001 and P = 0.02, respectively) in women with aortic atheroma, but not in men. After adjustment for traditional atherosclerosis risk factors and C-reactive protein concentrations, Lp-PLA2 mass and activity were not associated with AAP or AWT in either sex, but Lp-PLA2 mass remained modestly associated with detectable CAC only in men (odds ratio 1.20 per 1 standard deviation increase, 95% CI 1.01–1.42, P = 0.04). Conclusions: Although Lp-PLA2 mass was independently associated with CAC in men, it was not associated with AAP or AWT in men or with any of the atherosclerosis phenotypes in women. These findings suggest that if Lp-PLA2 independently influences clinical events, it does so by promoting atherosclerotic plaque instability rather than by stimulating atherogenesis.

Abstract 003: Change in Cardiovascular Risk Factors Associated with Weight Gain in the Dallas Heart Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Tiffany M Powell ◽  
Colby R Ayers ◽  
James A de Lemos ◽  
Amit Khera ◽  
Susan G Lakoski ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Weight Gain ◽  
Cardiovascular Risk Factors ◽  
Average Weight ◽  
Men And Women ◽  
Significant Weight Gain ◽  
Heart Study ◽  
Dallas Heart Study ◽  
The Impact

Background: Concerning trends in weight gain from 2000-2009 exist in the Dallas Heart Study (DHS), a probability-based sample of Dallas County residents aged 30-65. However, the impact of significant weight gain (≥ 5% increase in body weight) on cardiovascular risk factors (CVRF) in this contemporary, multi-ethnic population is not known. Methods: We measured weight, LDL-c, blood pressure (SBP and DBP), and fasting glucose (FG) in 2,022 DHS participants (58% female) at study entry in 2000 and in 2009. Using logistic regression stratified by sex and race/ethnicity, we determined the age-adjusted odds of worsening CVRF (any increase in LDL-c, SBP, DBP or FG) for people who gained significant weight compared to those who did not. Results: Among women, 43% (N=500) gained significant weight, compared to 42% of men (N=355). Despite similar average weight gain (9.7±5.8 kg for women vs. 10±5.6 kg for men, p=0.4), women who gained significant weight had almost twice as large an increase in LDL-c (14±34 vs. 8±39 mg/dl, p=0.01) and SBP (12±18 vs. 6±19 mmHg, p<0.001) compared with men who gained significant weight. Increases in DBP (5±10 vs. 4±11 mmHg, p=0.05) and FG (4±29 vs. 2±32 mg/dl, p=0.30) were not significantly different between men and women. Among those with significant weight gain who were not on medications, SBP and LDL-c increases were higher in women compared with men (p<0.05). Differences in the amount of weight gained stratified by race and sex were modest (Table). Black women who gained significant weight were likely to have a worsening of all CVRF, while Hispanic women had the highest likelihood of having an increase in SBP associated with weight gain. In contrast, significant weight gain among men was not associated with worsening CVRF. Conclusions: Significant weight gain was associated with a deleterious impact on CVRF among women but not men. Disparate effects of weight gain between men and women highlight the importance of targeting aggressive weight control interventions toward women to help prevent adverse cardiac outcomes.

Abstract MP88: Neighborhood-Level Socioeconomic Deprivation Predicts Weight Gain in a Multi-Ethnic Population: Longitudinal Data from the Dallas Heart Study

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Priscilla Agyemang ◽  
Colby Ayers ◽  
Min Lian ◽  
Sandeep Das ◽  
Christine Hoehner ◽  
...  
Keyword(s):  
Physical Activity ◽  
Weight Gain ◽  
Weight Change ◽  
Socioeconomic Deprivation ◽  
Neighborhood Environment ◽  
Dallas County ◽  
Heart Study ◽  
Deprived Neighborhoods ◽  
Dallas Heart Study ◽  
Neighborhood Level

Background: Although neighborhood-level socioeconomic deprivation associates with prevalent obesity, its relationship to individual-level weight change over time is poorly elucidated. Few studies have evaluated the impact of behavioral and psychosocial factors on this relationship. Methods: We examined the relationship between neighborhood-level socioeconomic deprivation and weight change among those who did not move in the 7-year study period (N=955) of the Dallas Heart Study (DHS), a multi-ethnic, population-based sample of Dallas County residents aged 18-65. Baseline weight measurements were performed in 2000-02 and weight was re-measured at 7-year follow-up. Home addresses obtained at baseline and follow-up were geocoded and linked to residential census tracts in Dallas County. A neighborhood deprivation index (NDI) for DHS participants was created using factor analysis of 21 census-tract neighborhood characteristics, with higher scores indicating more socioeconomic deprivation. Repeated-measures linear mixed modeling with random effects was used to determine weight change (kg) relative to tertiles of NDI. Reported physical activity (yes/no: exercised <150 mets/min-wk) and perceptions of neighborhood environment (questionnaire-derived score with higher score = more unfavorable perceptions of neighborhood violence, aesthetics, and social cohesion) were examined as mediators. Results: DHS participants living in more socioeconomically deprived neighborhoods had lower income and education (p-trend <0.001 for both). Blacks were more likely to live in more socioeconomically deprived neighborhoods than whites and Hispanics (p<0.001). Adjusting for age, sex, race, smoking, education, and income as fixed effects, DHS participants living in the most socioeconomically deprived neighborhoods (highest NDI tertile) gained 5.8±2.5 more kilograms (p=0.02) over the 7-year period compared to those in the least deprived neighborhoods. Living in the most socioeconomically deprived neighborhoods remained associated with a 6.4±2.5 kg greater increase in weight (p=0.01) compared to living in the least deprived neighborhoods after adjustment for physical activity levels and a 6.6±2.6 kg greater increase in weight (p=0.01) after adjustment for perceptions of neighborhood environment. Conclusions: Living in more socioeconomically deprived neighborhoods is associated with greater weight gain among DHS participants over a 7-year period. This relationship does not appear to be fully explained by lower levels of physical activity or unfavorable perceptions of the neighborhood environment. In Dallas County, the high risk for greater weight gain among people living in socioeconomically deprived neighborhoods supports the need to develop targeted community-based interventions to address obesity and reduce disparities in cardiovascular risk.

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