An insight to therapeutic potential and phytochemical profile of Solanum villosum (L)

Rhipsalis baccifera (Sol.) Stearn is a typical cactus from tropical regions with wide geographic distribution, and its therapeutic potential is not yet fully understood, such as antitumoral property. Thus, this study evaluated the cytotoxic ethanolic extract of R. baccifera (EERB) and its antitumor activity against Erlich's tumor in mice. The EERB was obtained, and its phytochemical profile was filed by thin-layer chromatography. The toxicity was evaluated in vitro and in vivo using the microcrustacean Artemia salina Leach and mice. The lethal dose was determined after implantation of a tumor cell suspension, with subsequent treatment with EERB (200 mg/kg and 100 mg/kg) 48h after implantation. These values represent the tenth part of the DL50 and CL50, respectively. The presence of phenols, tannins and triterpenes were demonstrated in the phytochemical results. Toxicity was dose-dependent, and the tumor inhibition was 84.1% and 75.8% at doses of 200 mg/kg and 100 mg/kg, respectively. We can highlight that the growth of Erlich's carcinoma suffered inhibitory effects against the EERB. EERB was found to have low acute toxicity and a high potential for use in antitumor therapy. Thus, new studies involving pre-clinical and clinical analyses of the extract are essential to determine the safe dose.

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PHYTOCHEMICAL PROFILE AND GASTROPROTECTIVE ACTIVITY OF EUGENIA MATTOSII FRUITS

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201800000-24 ◽

2018 ◽

Vol 55 (2) ◽

pp. 138-141 ◽

Cited By ~ 1

Author(s):

Luana dos SANTOS ◽

Adriana CAMPOS ◽

Valdir CECHINEL FILHO ◽

Luciane Angela Nottar NESELLO

Keyword(s):

Therapeutic Potential ◽

Conventional Medicine ◽

Gastrointestinal Diseases ◽

Experimental Models ◽

Phytochemical Analysis ◽

Gastroprotective Activity ◽

Lesion Area ◽

Acute Ulcer ◽

Ulcer Model ◽

Phytochemical Profile

ABSTRACT BACKGROUND: Extracts obtained from plants and fruits provide a relatively safe and practical alternative for the conventional medicine of gastrointestinal diseases. The specie Eugenia mattosii, popularly known in Brazil as “cerejinha”, belongs to Myrtaceae family. Species of this family present pharmacological properties, and can be used in the treatment of gastrointestinal disorders. OBJECTIVE: The aim of this study was to determine the phytochemical profile and evaluate the gastroprotective activity of Eugenia mattosii fruits. METHODS: Phytochemical analysis was carried out by thin layer chromatography and gastroprotective assays were performed using two experimental models: acute ulcer model induced by ethanol/HCl and acute ulcer model induced by non-steroidal anti-inflammatory drug (indomethacin). Total lesion area (mm2) and relative lesion area (%) were determined. RESULTS: The results of the phytochemical analysis indicated that the bark and pulp and seeds of E. mattosii present phenolic compounds, terpenes and/or steroids. In gastric ulcer model induced by ethanol was evidenced significant reduction of damaged areas for doses of 50 and 250 mg/ kg of seeds methanol extract, while in the indomethacin-induced ulcer model, all parts of the fruit presented defense capability of the gastric mucosa by reducing lesions at doses of 50, 125 and 250 mg/kg. CONCLUSION: The results demonstrate that the specie E. mattosii has bioactive compounds that provide gastroprotective activity, presenting possible therapeutic potential.

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Phytochemical profile and therapeutic potential of white horehound (Marrubium vulgare) – a review of the current state of knowledge

Farmacja Polska ◽

10.32383/farmpol/119180 ◽

2018 ◽

Vol 74 (4) ◽

pp. 210-222

Author(s):

Anna Magiera ◽

Anna Marchelak ◽

Aleksandra Owczarek ◽

Monika Olszewska

Keyword(s):

Therapeutic Potential ◽

Current State ◽

Marrubium Vulgare ◽

Phytochemical Profile

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Perspectives on the Combined Effects of Ocimum basilicum and Trifolium pratense Extracts in Terms of Phytochemical Profile and Pharmacological Effects

Plants ◽

10.3390/plants10071390 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1390

Author(s):

Andreea-Ina Antonescu (Mintas) ◽

Florina Miere (Groza) ◽

Luminita Fritea ◽

Mariana Ganea ◽

Mihaela Zdrinca ◽

...

Keyword(s):

Wound Healing ◽

Trifolium Pratense ◽

Therapeutic Potential ◽

Ocimum Basilicum ◽

Dermal Fibroblasts ◽

Antioxidant Compounds ◽

Phytochemical Profile ◽

Skin Conditions ◽

Ethanol Extracts ◽

Scratch Tests

Nowadays, the tendency in pharmaceutical and food industries is to replace synthetic antioxidants with the natural ones. For this reason, there is a growing interest in analyzing natural, healthy and non-toxic additives as potential antioxidants. Some plants, which contain high levels of phenolic compounds, present an increasing interest for medicine due to their ability to scavenge free radicals, along with other pharmacological activities, such as antibacterial activity, wound healing and anti-inflammatory effect, to mention only a few. The aim of this review is to explore the therapeutic potential of Ocimum basilicum and Trifolium pratense in relation with their phytochemical profile and to highlight the pharmacological activity of aqueous or ethanol extracts. Special attention was devoted to the dermal pathology and wound healing effects, in the context of multiple skin conditions such as acne, eczema boils, psoriasis and rashes. Additionally, both extracts (Trifolium sp. and Ocimum sp.) are characterized by high content of antioxidant compounds, which are responsible for the radiance and resistance of the skin and slowing down of the aging process by maintaining estrogen levels. Moreover, the potential combined effect of the mixed extract is pointed out in terms of future applications for wound healing, based on some preliminary results obtained from a “scratch tests” assay performed with respect to human dermal fibroblasts.

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Phytochemical Profile and Investigation of the Spasmolytic Activity of Hydroalcoholic Extract of Syzygium cumini (L.) Skeels Seeds

European Journal of Medicinal Plants ◽

10.9734/ejmp/2020/v31i330220 ◽

2020 ◽

pp. 27-38

Author(s):

F. S. Monteiro ◽

A. F. S. Carvalho ◽

R. M. Ribeiro ◽

A. C. R. Borges ◽

M. O. R. Borges

Keyword(s):

Saline Solution ◽

Therapeutic Potential ◽

Smooth Muscles ◽

Phytochemical Analysis ◽

Spasmolytic Activity ◽

Tonic Component ◽

Hydroalcoholic Extract ◽

Phytochemical Profile ◽

Value Effect ◽

Stabilization Period

Aims: Perform the phytochemical analysis and investigate the spasmolytic activity of the hydroalcoholic extract obtained from S. cumini seeds (EHS-SC). Study Design: Qualitative phytochemical analysis and test of the EHS-SC on isolated smooth muscles (aorta, trachea, jejunum and uterus) of rat, to value effect relaxant and/or inhibitor. Place and Duration of Study: Pharmacognosy Laboratory II (Pharmacy course) and Pharmacology Research and Post-Graduate Laboratory (Department of Physiological Sciences) of the Federal University of Maranhão, between January 2017 and July 2018. Methodology: EHS-SC was submitted to phytochemical analysis and changes in color, fluorescence and absence or presence of precipitate were observed. The smooth muscle segments were suspended (tension of 1 g) in glass vats containing specific saline solution, at an appropriate temperature and after stabilization period, was stimulated by a suitable contractile agent to observe the effect of EHS-SC in the phasic and/or tonic component. Results: EHS-SC showed the majority presence of phenols, steroids, alkaloids and flavonoids (flavones, xanthones, flavonols) and was more potent in inhibiting phasic contractions induced by 10-6 M carbachol (CCh) in isolated rat jejunum (Emax: 83.5 ± 6.7%; n = 3). In addition, the EHS-SC (81.0; 243.0 and 729 µg/mL) antagonized the CCh effect (n = 4), increasing the EC50 (6.5 ± 1.3 x 10-7 M) of the CCh to 8.5 ± 1.1; 18.5 ± 3.4 and 40.5 ± 7.4 x 10-7 M and reducing the Emax (100%) of the CCh to 82.9 ± 10.5; 67.6 ± 6.0 and 10.1 ± 8.3%. Conclusion: Spasmolytic activity may be combined with antimicrobial and antidiarrheal activity according to literature data, where they show that the seeds have the same secondary metabolites, signaling the therapeutic potential for the treatment of colic and/or diarrhea.

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