scholarly journals Haemophilus spp., an emerging multidrug-resistant sexually transmitted pathogen

2020 ◽  
Vol 50 (8) ◽  
pp. 734-737
Author(s):  
M. Ducours ◽  
M. Puges ◽  
A. Desclaux ◽  
L. Barthod ◽  
O. Peuchant ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Sexually Transmitted

scholarly journals In Vitro Activity of Lefamulin against Sexually Transmitted Bacterial Pathogens

2018 ◽  
Vol 62 (5) ◽  
Author(s):  
Susanne Paukner ◽  
Astrid Gruss ◽  
Jørgen Skov Jensen
Keyword(s):  
Chlamydia Trachomatis ◽  
Bacterial Pathogens ◽  
Mycoplasma Genitalium ◽  
Standard Of Care ◽  
Multidrug Resistant ◽  
In Vitro Activity ◽  
First Line ◽  
Content Type ◽  
Sexually Transmitted

ABSTRACT The pleuromutilin antibiotic lefamulin demonstrated in vitro activity against the most relevant bacterial pathogens causing sexually transmitted infections (STI), including Chlamydia trachomatis (MIC 50/90 , 0.02/0.04 mg/liter; n = 15), susceptible and multidrug-resistant Mycoplasma genitalium (MIC range, 0.002 to 0.063 mg/liter; n = 6), and susceptible and resistant Neisseria gonorrhoeae (MIC 50/90 , 0.12/0.5 mg/liter; n = 25). The results suggest that lefamulin could be a promising first-line antibiotic for the treatment of STI, particularly in populations with high rates of resistance to standard-of-care antibiotics.

scholarly journals Transcriptomic Data Sets To Determine Gene Expression Changes Mediated by the Presence of PBT2 in Growth Medium of Multidrug-Resistant Neisseria gonorrhoeae WHO Z

2020 ◽  
Vol 9 (21) ◽  
Author(s):  
Freda E.-C. Jen ◽  
Ibrahim M. El-Deeb ◽  
John M. Atack ◽  
Mark von Itzstein ◽  
Michael P. Jennings
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Transcriptome Sequencing ◽  
Multidrug Resistant ◽  
Data Sets ◽  
Sequencing Data ◽  
Transmitted Infection ◽  
High Coverage ◽  
Content Type ◽  
Sexually Transmitted ◽  
Transcriptomic Data

ABSTRACT Neisseria gonorrhoeae causes the sexually transmitted infection gonorrhea. High-coverage (∼3,300-fold) transcriptome sequencing data have been collected from multidrug-resistant N. gonorrhoeae strain WHO Z grown in the presence and absence of PBT2.

scholarly journals Shigella sonnei, an emerging multidrug-resistant sexually transmitted pathogen in Franche-Comté, France

2021 ◽  
pp. 1-13
Author(s):  
Souheil Zayet ◽  
Timothée Klopfenstein ◽  
Alix Pierron ◽  
Pierre-Yves Royer ◽  
Lynda Toko ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Shigella Sonnei ◽  
Sexually Transmitted

scholarly journals Multidrug-resistant Neisseria gonorrhoeae with reduced cefotaxime susceptibility is increasingly common in men who have sex with men, Amsterdam, the Netherlands

2009 ◽  
Vol 14 (37) ◽  
Author(s):  
H JC de Vries ◽  
J J van der Helm ◽  
M F Schim van der Loeff ◽  
A P van Dam
Keyword(s):  
The Netherlands ◽  
Neisseria Gonorrhoeae ◽  
Treatment Options ◽  
Multidrug Resistant ◽  
Considerable Proportion ◽  
Third Generation ◽  
Sexually Transmitted ◽  
Sex With Men ◽  
Third Generation Cephalosporins ◽  
Multiple Antibiotics

Antimicrobial resistance is an increasing problem in Neisseria gonorrhoeae (NG) treatment. Presently, third-generation parenteral cephalosporins, like ceftriaxone and cefotaxime, are the first option. Resistance to oral, but not to parenteral, third-generation cephalosporins has been reported previously. We analysed the microbial susceptibility (as minimum inhibitory concentration - MIC) of NG cultures obtained from high-risk visitors of the largest Dutch outpatient clinic for sexually transmitted infections (STI) in Amsterdam, the Netherlands. Among 1,596 visitors, we identified 102 patients with at least one NG isolate with reduced susceptibility to cefotaxime (0.125 μg/ml < MIC ≤ 0.5 μg/ml). The percentage of NG isolates with reduced susceptibility to cefotaxime rose from 4.8% in 2006 to 12.1% in 2008 (chi2 17.5, p<0.001). With multivariate logistic regression, being a man who has sex with men (MSM) was significantly associated with reduced susceptibility to cefotaxime (p<0.001). Compared to susceptible NG isolates, those with decreased susceptiblity to cefotaxime were more often resistant also to penicillin (16.5% vs. 43.3%), tetracycline (21.5% vs. 68.9%) and ciprofloxacin (44.4% vs. 90.0%, all p<0.001). The increased prevalence of NG strains with reduced susceptibility to cefotaxime among MSM may herald resistance to third-generation parenteral cephalosporins. A considerable proportion of these strains show resistance to multiple antibiotics which could limit future NG treatment options.

scholarly journals Characteristics and Dissemination of Mosaic Penicillin-Binding Protein 2-Harboring Multidrug-Resistant Neisseria gonorrhoeae Isolates with Reduced Cephalosporin Susceptibility in Northern Taiwan

2010 ◽  
Vol 54 (11) ◽  
pp. 4893-4895 ◽  
Author(s):  
Chung-Ter Huang ◽  
Muh-Yong Yen ◽  
Wing-Wai Wong ◽  
Lan-Hui Li ◽  
Kun-Yen Lin ◽  
...  
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Multidrug Resistant ◽  
Bisexual Men ◽  
Penicillin Binding Protein ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Sex With Men ◽  
Sequence Types ◽  
Northern Taiwan ◽  
Major Sequence

ABSTRACT Among 254 Neisseria gonorrhoeae isolates from a sexually transmitted infection (STI) clinic in northern Taiwan, 69 isolates were found to contain the mosaic penA (MA) gene and were associated with elevated cefixime and ceftriaxone MICs. Most of these MA gene-harboring isolates were also resistant to penicillin (71.4%) and ciprofloxacin (100%) and were from men who have sex with men (MSM) or from bisexual men (81.2%). Three major sequence types (ST835, ST2180, and ST2253) constituted 55.7% of these isolates. The major sequence types harboring the mosaic penA gene may represent major sexual networks responsible for the emergence/introduction and the spread of the multidrug-resistant clones in Taiwan.

scholarly journals Emergence of novel strains of Shigella flexneri associated with sexual transmission in adult men in England, 2019–2020

2021 ◽  
Vol 70 (10) ◽  
Author(s):  
Timothy J Dallman ◽  
Hannah Charles ◽  
Mateo Prochazka ◽  
Katy Sinka ◽  
Gwenda Hughes ◽  
...  
Keyword(s):  
Type Species ◽  
Sexual Transmission ◽  
Shigella Flexneri ◽  
Multidrug Resistant ◽  
National Surveillance ◽  
Adult Males ◽  
Content Type ◽  
Sexually Transmitted ◽  
Adult Men ◽  
Link Type

National surveillance of shigellosis in England revealed an increase in sexually transmitted Shigella flexneri in adult males in 2019 that persisted throughout 2020. We observed a resurgence of azithromycin-resistant S. flexneri serotype 3a, and the emergence of two novel multidrug-resistant clades of S. flexneri 2a and S. flexneri 1b.

Adherence to the 2012 European gonorrhoea guideline in the WHO European Region according to the 2018–19 International Union against Sexually Transmitted Infections European Collaborative Clinical Group gonorrhoea survey

2019 ◽  
Vol 31 (1) ◽  
pp. 69-76 ◽  
Author(s):  
M Unemo ◽  
E Clarke ◽  
I Boiko ◽  
C Patel ◽  
R Patel ◽  
...  
Keyword(s):  
Sexually Transmitted Infections ◽  
Clinical Care ◽  
Public Health Problem ◽  
Developed Countries ◽  
Multidrug Resistant ◽  
Antimicrobial Treatment ◽  
Clinical Group ◽  
Major Public Health Problem ◽  
International Union ◽  
Sexually Transmitted

Gonorrhoea is a major public health problem globally. Increasing incidence in many particularly developed countries and the emergence of resistance to the extended-spectrum cephalosporin ceftriaxone, the last option for empiric first-line monotherapy, are of serious concern. This paper evaluates the results of the 2018–19 International Union against Sexually Transmitted Infections European Collaborative Clinical Group survey on the diagnosis and treatment of gonorrhoea in Europe. Although high quality clinical care was reported in many European settings, in several countries the testing, diagnostics, antimicrobial treatment, and follow-up of gonorrhoea patients were evidently suboptimal. Increased adherence to evidence-based European and/or nationally-adapted management guidelines is essential in controlling the increasing incidence of gonorrhoea in many European settings and the spread of ceftriaxone-resistant, multidrug-resistant, and extensively drug-resistant gonorrhoea.

scholarly journals Culture-free genotyping of Neisseria gonorrhoeae revealed distinct strains at different anatomical sites in a quarter of patients, the Netherlands, 2012 to 2016

2018 ◽  
Vol 23 (50) ◽  
Author(s):  
Brian MJW van der Veer ◽  
Petra FG Wolffs ◽  
Christian JPA Hoebe ◽  
Nicole HTM Dukers-Muijrers ◽  
Lieke B van Alphen
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Multidrug Resistant ◽  
Cross Reactivity ◽  
Analytical Sensitivity ◽  
Sexually Transmitted ◽  
Paired Samples ◽  
Genotyping Method ◽  
Resistant Strains ◽  
Sex With Men ◽  
Culture Dependent

Background Genotyping of Neisseria gonorrhoeae (NG) is essential for surveillance to monitor NG transmission and dissemination of resistant strains. Current genotyping methods rely on bacterial culture which frequently fails. Aim Our aim was to develop a culture-free genotyping method that is compatible with the widely used N. gonorrhoeae multi-antigen sequence typing (NG-MAST) database, which facilitates genotyping of NG detected at separate anatomical sites in individual patients. Methods Specific primers for both PCR targets porB and tbpB were designed and technically validated by assessing the analytical sensitivity, cross-reactivity with 32 non-gonoccocal Neisseria species, and concordance with NG-MAST. Clinical application was assessed on 205 paired samples from concurrent NG infections at different anatomical sites of 98 patients (81 men who have sex with men and 17 women) visiting our sexually transmitted infections clinic. Results Typing could be consistently performed on samples with a PCR quantification cycle (Cq) value <35. Furthermore, the method showed no cross-reactivity and was concordant with NG-MAST. Culture-free NG-MAST improved the typing rate from 62% (59/95) for cultured samples to 94% (89/95) compared with culture-dependent NG-MAST. Paired samples of 80 of 98 patients were genotyped, revealing distinct NG strains in separate anatomical sites in 25% (20/80) of the patients. Conclusions This NG-specific genotyping method can improve NG surveillance as it facilitates genotyping of non-culturable and extra-genital samples. Furthermore, 25% of patients were infected with multiple NG strains, which is missed in current culture-dependent surveillance. Including non-culturable and concurrent NG infections in surveillance informs actions on dissemination of multidrug-resistant NG strains.

scholarly journals In Vitro and In Vivo Activities of TP0480066, a Novel Topoisomerase Inhibitor, against Neisseria gonorrhoeae

2021 ◽  
Author(s):  
Aiko Masuko ◽  
Iichiro Takata ◽  
Kiyoko Fujita ◽  
Hirotoshi Okumura ◽  
Fumihito Ushiyama ◽  
...  
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Antimicrobial Agent ◽  
Transmitted Disease ◽  
Dna Gyrase ◽  
Multidrug Resistant ◽  
Cross Resistance ◽  
Topoisomerase Iv ◽  
Sexually Transmitted

Gonorrhea is a common, sexually transmitted disease caused by Neisseria gonorrhoeae. Multidrug-resistant N. gonorrhoeae is an urgent threat, and the development of a new antimicrobial agent that functions via a new mechanism is strongly desired. We evaluated the in vitro and in vivo activities of a DNA gyrase/topoisomerase IV inhibitor, TP0480066, which is a novel 8-(methylamino)-2-oxo-1,2-dihydroquinoline derivative. The MICs of TP0480066 were substantially lower than those of other currently or previously used antimicrobials against gonococcal strains demonstrating resistance to fluoroquinolones, macrolides, β-lactams and aminoglycosides (MICs, ≤0.0005 μg/mL). Additionally, no cross-resistance was observed between TP0480066 and ciprofloxacin. The frequencies of spontaneous resistance to TP0480066 for N. gonorrhoeae ATCC 49226 were below the detection limit (<2.4 × 10−10) at concentrations equivalent to 32 × MIC. TP0480066 also showed potent in vitro bactericidal activity and in vivo efficacy in a mouse model of N. gonorrhoeae infection. These data suggest that TP0480066 is a candidate antimicrobial agent for gonococcal infections.

Two cases of multidrug-resistant genitourinary Mycoplasma genitalium infection successfully eradicated with minocycline

2019 ◽  
Vol 30 (5) ◽  
pp. 512-514 ◽  
Author(s):  
Allison M Glaser ◽  
William M Geisler ◽  
Amy E Ratliff ◽  
Li Xiao ◽  
Ken B Waites ◽  
...  
Keyword(s):  
Public Health ◽  
Antimicrobial Resistance ◽  
Mycoplasma Genitalium ◽  
Multidrug Resistant ◽  
Health Concern ◽  
Public Health Concern ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Nongonococcal Urethritis ◽  
Extended Course

Mycoplasma genitalium (MG) infection is a sexually transmitted infection that causes up to 25% of nongonococcal urethritis (NGU). MG strains carrying genetic markers of antimicrobial resistance that may affect treatment outcomes are increasingly recognized as a public health concern. We present two cases of persistent MG NGU with strains carrying both macrolide and quinolone resistance-associated mutations that were eradicated successfully by an extended course of minocycline.

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