Amino acids- based hydrophobic natural deep eutectic solvents as a green acceptor phase in two-phase hollow fiber-liquid microextraction for the determination of caffeic acid in coffee, green tea, and tomato samples

2021 ◽  
Vol 164 ◽  
pp. 106021
Author(s):  
Negar Nooraee Nia ◽  
Mohammad Reza Hadjmohammadi
Keyword(s):  
Amino Acids ◽  
Caffeic Acid ◽  
Green Tea ◽  
Hollow Fiber ◽  
Deep Eutectic Solvents ◽  
Two Phase ◽  
Natural Deep Eutectic Solvents ◽  
Liquid Microextraction ◽  
Acceptor Phase

Ionic Liquid-based Hollow Fiber Liquid–Liquid–Liquid Microextraction Combined with Capillary Electrophoresis for the Determination of Sulfonamides in Aquaculture Waters

2019 ◽  
Vol 57 (10) ◽  
pp. 950-960
Author(s):  
Youyi Wu ◽  
Jingwen Zhou ◽  
Xuedong Wang ◽  
Zhanen Zhang ◽  
Shiqian Gao
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Hollow Fiber ◽  
Water Samples ◽  
Extraction Temperature ◽  
Relative Standard ◽  
Liquid Microextraction ◽  
Acceptor Phase ◽  
Donor Phase

Abstract Ionic liquid-based hollow-fiber liquid–liquid–liquid microextraction (IL-HF-LLLME) coupled to capillary electrophoresis (CE) has been developed for the determination of six sulfonamides (SAs) in aquaculture waters. A series of extraction parameters was optimized to enhance the extraction efficiency, which included type and pore size of hollow fiber, type and composition of extraction solvent, pH value of donor phase, the concentration of acceptor phase and the mass ratio of donor phase to acceptor phase along with extraction temperature and time. Under optimal conditions, the IL-HF-LLLME-CE method provided a wide liner range for six SAs from 2 to 1,000 μg L−1 (r2 ≥ 0.9995), the limits of the detection from 0.25 to 0.48 and the enrichment factors from 122 to 230, respectively. Relative standard deviations for intra- and interday precision were 1.4–5.3% and 1.8–7.5% (n = 5), respectively. The proposed method was successfully applied for the determination of trace-level SAs in seven real-world aquaculture water samples with good recoveries (80.4–100.7%). Also, sulfamerazine and sulfamethoxazole were detected at the level of 0.52–1.60 μg L−1 in two water samples. Due to its good sensitivity, simple operation, short analysis time and eco-friendliness, the developed method has a great application potential in analysis of trace SA residues in aquaculture waters.

scholarly journals Highly Efficient Extraction Procedures Based on Natural Deep Eutectic Solvents or Ionic Liquids for Determination of 20-Hydroxyecdysone in Spinach

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4736
Author(s):  
Sylwia Bajkacz ◽  
Kornelia Rusin ◽  
Anna Wolny ◽  
Jakub Adamek ◽  
Karol Erfurt ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Extraction Procedure ◽  
Deep Eutectic Solvents ◽  
Molar Ratio ◽  
Green Extraction ◽  
Natural Deep Eutectic Solvents ◽  
Efficient Extraction ◽  
Solid Liquid ◽  
Extraction Agent

A novel, efficient extraction procedure based on natural deep eutectic solvents (NADES) and ionic liquids (ILs) for determination of 20-hydroxyecdysone (20-E) in spinach has been developed. NADES, the first green extraction agent, with different hydrogen bond donors and acceptors are screened in order to determine extraction efficiencies. NADES consisting of lactic acid and levulinic acid at a molar ratio of 1:1 exhibits the highest yields. ILs, the second green extraction agent, with various cations and anions are also investigated, where [TEA] [OAc]·AcOH, χAcOH = 0.75 displays the highest recovery. Moreover, NADES-SLE and IL-SLE (SLE, solid-liquid extraction) parameters are investigated. Using the obtained optimized method, the recoveries of the target compound in spinach are above 93% and 88% for NADES-SLE and IL-SLE procedure, respectively. The methods display good linearity within the range of 0.5–30 μg/g and LODs of 0.17 µg/g. The proposed NADES-SLE-UHPLC-UV and IL-SLE-UHPLC-UV procedures can be applied to the analysis of 20-E in real spinach samples, making it a potentially promising technique for food matrix. The main advantage of this study is the superior efficiency of the new, green extraction solvents, which results in a significant reduction of extraction time and solvents as compared to those in the literature.

scholarly journals Physicochemical Properties, Cytotoxicity, and Antioxidative Activity of Natural Deep Eutectic Solvents Containing Organic Acid

2019 ◽  
Vol 33 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Anamarija Mitar ◽  
Manuela Panić ◽  
Kristina Radošević ◽  
Ivana Radojčić Redovniković ◽  
Kristina Zagajski Kučan ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Antioxidative Activity ◽  
Deep Eutectic Solvents ◽  
Oxygen Radical ◽  
Structural Variations ◽  
Natural Deep Eutectic Solvents ◽  
Environmentally Safe ◽  
Mcf 7

Natural deep eutectic solvents (NADES) may be considered ‘designer solvents’ due to their numerous structural variations and the possibility of tailoring their physicochemical properties. Prior to their industrial application, characterization of NADES is essential, including determination of their physicochemical properties, cytotoxicity, and antioxidative activity. The most important physicochemical properties of eight prepared NADES (choline chloride:malic acid, proline:malic acid, choline chloride:proline:malic acid, betaine:malic acid, malic acid:glucose, malic acid:glucose:glycerol, choline chloride:citric acid, and betaine:citric acid) were measured as functions of temperature and water content. In general, the structure of prepared NADES greatly influences their physical properties, which could be successfully modified and adjusted by addition of water. All tested NADES were absolutely benign and noncorrosive for investigated steel X6CrNiTi18-10. Furthermore, cytotoxicity of prepared solvents was assessed toward three human cell lines (HEK-293T, HeLa, and MCF-7 cells), and antioxidative activity was measured by the Oxygen Radical Absorbance Capacity (ORAC) method. With regard to cell viability, all tested NADES containing carboxylic acid could be classified as practically harmless and considered environmentally safe. The ORAC values indicated that the tested NADES displayed antioxidative activity.

Development of continuously operated aqueous two-phase microextraction process using natural deep eutectic solvents

2020 ◽  
Vol 244 ◽  
pp. 116746 ◽  
Author(s):  
Nela Miličević ◽  
Manuela Panić ◽  
Davor Valinger ◽  
Marina Cvjetko Bubalo ◽  
Maja Benković ◽  
...  
Keyword(s):  
Deep Eutectic Solvents ◽  
Two Phase ◽  
Natural Deep Eutectic Solvents
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