Preparation and properties study of F-SiO2@MPDA-AuNPs drug nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

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Co-delivery of 5-fluorodeoxyuridine and doxorubicin via gold nanoparticle equipped with affibody-DNA hybrid strands for targeted synergistic chemotherapy of HER2 overexpressing breast cancer

Scientific Reports ◽

10.1038/s41598-020-79125-0 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Chao Zhang ◽

Fanghua Zhang ◽

Mengnan Han ◽

Xuming Wang ◽

Jie Du ◽

...

Keyword(s):

Breast Cancer ◽

Antitumor Activity ◽

Solid Phase ◽

Clinical Care ◽

Drug Loading ◽

Her2 Positive ◽

Apoptosis Pathway ◽

Phase Synthesis ◽

Drug Nanocarriers ◽

Dual Drug

AbstractCombination chemotherapy is still of great importance as part of the standard clinical care for patients with HER2 positive breast cancer. As an attractive component, gold nanoparticles (AuNPs) have been extensively studied as biosafety nanomaterials, but they are rarely explored as drug nanocarriers for targeted co-delivery of multiple chemotherapeutics. Herein, a novel affibody-DNA hybrid strands modified AuNPs were fabricated for co-loading nucleoside analogue (5-fluorodeoxyuridine, FUdR) and anthracycline (doxorubicin, Dox). FUdRs were integrated into DNA hybrid strands decorated on AuNPs by DNA solid phase synthesis, and Dox molecules were intercalated into their duplex regions. Affibody molecules coupled to the DNA hybrid strands were distributed the surface of AuNPs, giving them targeting for HER2. The new dual-drug-containing affibody-DNA-AuNPs (Dox@affi-F/AuNPs) owned compact and stable spherical nanostructures, and precise drug loading. Cytotoxicity tests demonstrated that these nanoparticles caused a higher inhibition in HER2 overexpressing breast cancer cells, and showed better synergistic antitumor activity than simple mixture of the two drugs. The related mechanistic studies proved that Dox@affi-F/AuNPs achieved a remarkable combined antitumor activity of Dox and FUdR by promoting more cells to enter apoptosis pathway. Our work provided a nanomedicine platform for targeted co-delivery of nucleoside analog therapeutics and anthracycline anticancer drugs to achieve synergistic treatment of HER2+ cancer.

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A nanoselenium-coating biomimetic cytomembrane nanoplatform for mitochondrial targeted chemotherapy- and chemodynamic therapy through manganese and doxorubicin codelivery

Journal of Nanobiotechnology ◽

10.1186/s12951-021-00971-9 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Jianmin Xiao ◽

Miao Yan ◽

Ke Zhou ◽

Hui Chen ◽

Zhaowei Xu ◽

...

Keyword(s):

Cell Membrane ◽

Cancer Cells ◽

High Yield ◽

Ros Generation ◽

Superoxide Dismutase 1 ◽

Nuclear Targeting ◽

Dual Mode ◽

Red Cell Membrane ◽

Cancer Cell Death ◽

Drug Nanocarriers

Abstract The cell membrane is widely considered as a promising delivery nanocarrier due to its excellent properties. In this study, self-assembled Pseudomonas geniculate cell membranes were prepared with high yield as drug nanocarriers, and named BMMPs. BMMPs showed excellent biosafety, and could be more efficiently internalized by cancer cells than traditional red cell membrane nanocarriers, indicating that BMMPs could deliver more drug into cancer cells. Subsequently, the BMMPs were coated with nanoselenium (Se), and subsequently loaded with Mn2+ ions and doxorubicin (DOX) to fabricate a functional nanoplatform (BMMP-Mn2+/Se/DOX). Notably, in this nanoplatform, Se nanoparticles activated superoxide dismutase-1 (SOD-1) expression and subsequently up-regulated downstream H2O2 levels. Next, the released Mn2+ ions catalyzed H2O2 to highly toxic hydroxyl radicals (·OH), inducing mitochondrial damage. In addition, the BMMP-Mn2+/Se nanoplatform inhibited glutathione peroxidase 4 (GPX4) expression and further accelerated intracellular reactive oxygen species (ROS) generation. Notably, the BMMP-Mn2+/Se/DOX nanoplatform exhibited increased effectiveness in inducing cancer cell death through mitochondrial and nuclear targeting dual-mode therapeutic pathways and showed negligible toxicity to normal organs. Therefore, this nanoplatform may represent a promising drug delivery system for achieving a safe, effective, and accurate cancer therapeutic plan.

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Self-assembly of Cyclic Grafted Copolymers with Rigid Rings and Their Potential as Drug Nanocarriers

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2021.03.139 ◽

2021 ◽

Author(s):

Jianchang Xu ◽

Liyang Wen ◽

Fusheng Zhang ◽

Wenjing Lin ◽

ijuan Zhang

Keyword(s):

Self Assembly ◽

Drug Nanocarriers

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Nano-Assemblies from Amphiphilic PnBA-b-POEGA Copolymers as Drug Nanocarriers

Polymers ◽

10.3390/polym13071164 ◽

2021 ◽

Vol 13 (7) ◽

pp. 1164

Author(s):

Angeliki Chroni ◽

Thomas Mavromoustakos ◽

Stergios Pispas

Keyword(s):

Molecular Weight ◽

Chain Transfer ◽

Raft Polymerization ◽

Polymeric Nanocarriers ◽

Reversible Addition ◽

2D Noesy ◽

Drug Nanocarriers ◽

Glycol Methyl Ether ◽

Different Molecular Weight

The focus of this study is the development of highly stable losartan potassium (LSR) polymeric nanocarriers. Two novel amphiphilic poly(n-butyl acrylate)-block-poly(oligo(ethylene glycol) methyl ether acrylate) (PnBA-b-POEGA) copolymers with different molecular weight (Mw) of PnBA are synthesized via reversible addition fragmentation chain transfer (RAFT) polymerization, followed by the encapsulation of LSR into both PnBA-b-POEGA micelles. Based on dynamic light scattering (DLS), the PnBA30-b-POEGA70 and PnBA27-b-POEGA73 (where the subscripts denote wt.% composition of the components) copolymers formed micelles of 10 nm and 24 nm in water. The LSR-loaded PnBA-b-POEGA nanocarriers presented increased size and greater mass nanostructures compared to empty micelles, implying the successful loading of LSR into the inner hydrophobic domains. A thorough NMR (nuclear magnetic resonance) characterization of the LSR-loaded PnBA-b-POEGA nanocarriers was conducted. Strong intermolecular interactions between the biphenyl ring and the butyl chain of LSR with the methylene signals of PnBA were evidenced by 2D-NOESY experiments. The highest hydrophobicity of the PnBA27-b-POEGA73 micelles contributed to an efficient encapsulation of LSR into the micelles exhibiting a greater value of %EE compared to PnBA30-b-POEGA70 + 50% LSR nanocarriers. Ultrasound release profiles of LSR signified that a great amount of the encapsulated LSR is strongly attached to both PnBA30-b-POEGA70 and PnBA27-b-POEGA73 micelles.

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How can aggregation-caused quenching based bioimaging of drug nanocarriers be improved?

Therapeutic Delivery ◽

10.4155/tde-2019-0082 ◽

2020 ◽

Vol 11 (1) ◽

pp. 809-812 ◽

Cited By ~ 3

Author(s):

Hailong Yuan ◽

Weili Zhao ◽

Wei Wu

Keyword(s):

Drug Nanocarriers

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Supramolecular cyclodextrin-based drug nanocarriers

Chemical Communications ◽

10.1039/c4cc10388b ◽

2015 ◽

Vol 51 (29) ◽

pp. 6275-6289 ◽

Cited By ~ 98

Author(s):

Susana M. N. Simões ◽

Ana Rey-Rico ◽

Angel Concheiro ◽

Carmen Alvarez-Lorenzo

Keyword(s):

Stimuli Responsive ◽

Drug Conjugates ◽

Drug Nanocarriers

Hosting of polymers, lipids and drug conjugates makes cyclodextrins suitable to prepare biocompatible, targetable and stimuli-responsive supramolecular drug nanocarriers.

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Lessons learned from the porcine CARPA model: constant and variable responses to different nanomedicines and administration protocols

European Journal of Nanomedicine ◽

10.1515/ejnm-2015-0011 ◽

2015 ◽

Vol 7 (3) ◽

Cited By ~ 17

Author(s):

Rudolf Urbanics ◽

Péter Bedőcs ◽

János Szebeni

Keyword(s):

Inflammatory Mediator ◽

Lessons Learned ◽

Bolus Administration ◽

Variable Parameters ◽

Skin Changes ◽

Wide Range ◽

Slow Infusion ◽

Technical Details ◽

Drug Nanocarriers ◽

Preclinical Safety

AbstractPigs provide a sensitive and quantitative animal model of complement (C) activation-related pseudoallergy (CARPA) caused by liposomes and a wide range of nanoparticulate drugs or drug nanocarriers (nanomedicines). The tetrad of symptoms (hemodynamic, hematological, laboratory and skin changes) that arise within minutes after i.v. injection of reactogenic nanomedicines (RNMs) are highly reproducible among different pigs but the presence, direction and relative severity of symptoms are very different with different RNMs and their administration schedule. Bolus administration of RNMs usually trigger pulmonary hypertension with or without various degrees of systemic hyper- or hypotension, tachy-or bradycardia, arrhythmia, blood cell and inflammatory mediator changes and skin rash. These reactions can be rapid or protracted, and fully tachyphylactic, semi-tachyphylactic or non-tachyphylactic. Slow infusion usually diminishes the reactions and/or entail delayed, protracted and less severe hemodynamic and other changes. The goal of this review is to present some technical details of the porcine CARPA model, point out its constant and variable parameters, show examples of different reactions, highlight the unique features and capabilities of the model and evaluate its utility in preclinical safety assessment. The information obtained in this model enables the understanding of the complex pathomechanism of CARPA involving simultaneous anaphylatoxin and inflammatory mediator actions at multiple sites in different organs.

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From Residues to Added-Value Bacterial Biopolymers as Nanomaterials for Biomedical Applications

Nanomaterials ◽

10.3390/nano11061492 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1492

Author(s):

Francisco G. Blanco ◽

Natalia Hernández ◽

Virginia Rivero-Buceta ◽

Beatriz Maestro ◽

Jesús M. Sanz ◽

...

Keyword(s):

Biomedical Applications ◽

Carbon Sources ◽

Structural Diversity ◽

Added Value ◽

Nanoscale Systems ◽

Chemical Structures ◽

Wide Range ◽

Peptide Functionalization ◽

Metabolic Strategies ◽

Drug Nanocarriers

Bacterial biopolymers are naturally occurring materials comprising a wide range of molecules with diverse chemical structures that can be produced from renewable sources following the principles of the circular economy. Over the last decades, they have gained substantial interest in the biomedical field as drug nanocarriers, implantable material coatings, and tissue-regeneration scaffolds or membranes due to their inherent biocompatibility, biodegradability into nonhazardous disintegration products, and their mechanical properties, which are similar to those of human tissues. The present review focuses upon three technologically advanced bacterial biopolymers, namely, bacterial cellulose (BC), polyhydroxyalkanoates (PHA), and γ-polyglutamic acid (PGA), as models of different carbon-backbone structures (polysaccharides, polyesters, and polyamides) produced by bacteria that are suitable for biomedical applications in nanoscale systems. This selection models evidence of the wide versatility of microorganisms to generate biopolymers by diverse metabolic strategies. We highlight the suitability for applied sustainable bioprocesses for the production of BC, PHA, and PGA based on renewable carbon sources and the singularity of each process driven by bacterial machinery. The inherent properties of each polymer can be fine-tuned by means of chemical and biotechnological approaches, such as metabolic engineering and peptide functionalization, to further expand their structural diversity and their applicability as nanomaterials in biomedicine.

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