Effect of choline chloride-oxalic acid based deep eutectic solvent on the ultrasonic assisted extraction of polyphenols from Aegle marmelos

2019 ◽  
Vol 287 ◽  
pp. 110956 ◽  
Author(s):  
Suman Kumar Saha ◽  
Suhrita Dey ◽  
Runu Chakraborty
Keyword(s):  
Oxalic Acid ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Aegle Marmelos ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction

scholarly journals OPTIMIZATION OF MICROWAVE- AND ULTRASONIC-ASSISTED EXTRACTION OF MAHKOTA DEWA (PHALERIA MACROCARPA [SCHEFF.] BOERL.) FRUIT PULP

2020 ◽  
pp. 32-37
Author(s):  
ROSITA HANDAYANI ◽  
ANDRE BANGUN ◽  
PASKAH DEWI DEBORAH ◽  
ABDUL MUN’IM
Keyword(s):  
Antioxidant Activity ◽  
High Performance ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Total Phenolic ◽  
Solvent Ratio ◽  
Water Addition ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction

Objective: This work aimed to determine the optimal extraction conditions of Mahkota dewa using different extraction methods: microwave-assistedextraction with ethanol (MAE-ethanol), ultrasonic-assisted extraction using a choline chloride natural deep eutectic solvent (UAE-NADES), andSoxhlet and reflux extractions.Methods: Experimental design was performed through Box-Behnken. The efficiency of the methods was evaluated based on the total phenolic content(TPC) and antioxidant activity. The presence of relevant compounds was qualitatively assessed by high-performance liquid chromatography (HPLC).Results: For the MAE-ethanol method, optimum extraction was achieved with 65% ethanol, in 1 min under 30% microwave power, and a 1:12 sample–solvent ratio, which yielded a TPC and antioxidant activity of 62.79±0.74 mg gallic acid equivalents (GAE)/g powder and 30.48±0.32%, respectively. InUAE-NADES, the optimal conditions were choline chloride: lactic acid ratio of 1:4 with a 50% water addition, 20 min extraction (TPC and antioxidantactivity of 65.25 mg GAE/g powder and 26.45±0.02%). The Soxhlet and reflux methods gave a TPC of 49.68±0.59 and 50.98±0.54 mg GAE/g powder,and antioxidant activity of 22.87±0.13% and 25.97±0.34%, respectively. Qualitative HPLC analysis showed the presence of quercetin, mahkoside A,4,6-dihydroxy-4-methoxybenzophenone-2-O-β-D-glucopyranoside, and mangiferin.Conclusion: MAE-ethanol was more efficient than the conventional Soxhlet and reflux methods and performed similarly to UAE-NADES in terms of TPC.

scholarly journals Green and Efficient Extraction of Resveratrol from Peanut Roots Using Deep Eutectic Solvents

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Jingnan Chen ◽  
Xingxing Jiang ◽  
Guolong Yang ◽  
Yanlan Bi ◽  
Wei Liu
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Extraction Yield ◽  
Box Behnken Design ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Efficient Extraction ◽  
Ultrasonic Assisted Extraction ◽  
Solid Liquid ◽  
Total Extraction

Deep eutectic solvents (DESs), a new group of ecofriendly solvent combined with the ultrasonic-assisted extraction (UAE) technique, were first successfully used for extraction of resveratrol from peanut roots. Resveratrol in the extract was analyzed and quantified using a HPLC-UV method. A series of DESs consisting of choline chloride (ChCl) and 1,4-butanediol, citric acid, and ethylene glycol were formulated, finding ChCl/1,4-butanediol was a most proper extraction system. The optimal extraction parameters were obtained using a Box–Behnken design (BBD) test combined with response surface methodology as follows: 40% of water in ChCl/1,4-butanediol (1/3, g/g) at 55°C for 40 min and solid/liquid ratio of 1:30 g/mL. The total extraction content and extraction yield of resveratrol from peanut roots could reach 38.91 mg/kg and 88.19%, respectively, under such optimal conditions. The present study will provide a typical example for using DESs to extract natural bioactive compounds from plants.

scholarly journals ULTRASONIC-ASSISTED EXTRACTION USING A BETAINE-BASED NATURAL DEEP EUTECTIC SOLVENT FOR RESVERATROL EXTRACTION FROM MELINJO (GNETUM GNEMON) SEEDS

2020 ◽  
pp. 26-31
Author(s):  
WIDYA DWI ARYATI ◽  
KHUSNA MILLATI AZKA ◽  
ABDUL MUN’IM
Keyword(s):  
Lactic Acid ◽  
High Performance ◽  
Deep Eutectic Solvent ◽  
High Water Content ◽  
Solvent Ratio ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Gnetum Gnemon ◽  
Ultrasonic Assisted Extraction ◽  
Natural Deep Eutectic Solvent

Objective: Melinjo (Gnetum gnemon L.) seeds are known to contain resveratrol, which are classified as a phenolic compound of the stilbenoid. Melinjoseeds have high water content, making them unstable to be stored for prolonged periods with open packaging at room temperature. The present studyaimed to explore the use of ultrasonic-assisted extraction with a betaine-based natural deep eutectic solvent (NADES) for resveratrol extraction fromirradiated melinjo seeds.Methods: The best betaine-based NADES component was identified among betaine-urea, betaine-lactic acid, and betaine-malic acid. Optimization ofextraction methods was performed using the best NADES and extraction variables such as time of extraction, water percentage, and sample: solventratio. The outcome of extraction was evaluated by measuring resveratrol content using high-performance liquid chromatography and the results wereanalyzed using response surface methodology.Results: The best betaine-based NADES was found to be betaine-lactic acid, yielding a resveratrol content of 0.3344 mg/g powder. The optimumextraction was achieved in 10 min with 60% water and a sample: solvent ratio of 1:10, yielding a resveratrol content of 0.227 mg/g powder.Conclusion: Betaine-based NADES can be purposed as an alternative solvent for resveratrol extraction from irradiated melinjo seeds.

scholarly journals Optimization Studies on the Extraction of Flavone Di-C-glycosides from Premna fulva Craib by Deep Eutectic Solvents

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Yueyuan Chen ◽  
Jiaoyang Dang ◽  
Xiaojie Yan ◽  
Fenglai Lu ◽  
Dianpeng Li
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Microstructural Alterations ◽  
Solid Ratio ◽  
Macroporous Resins ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Extraction Solvents ◽  
Ultrasonic Assisted Extraction ◽  
Novel Strategy

Deep eutectic solvents (DESs) are emerging as new extraction solvents for the extraction of bioactive compounds from natural plants. In this work, a total of thirteen choline chloride-based DESs were synthesized and evaluated for the simultaneous extraction of five bioactive flavone di-C-glycosides from Premna fulva Craib. DES-F, which was composed of choline chloride and 1,3-propanediol, showed the best extraction efficiency for the flavone di-C-glycosides, exceeding that of the conventional industrial solvent (40% ethanol). Subsequently, the extraction parameters for ultrasonic-assisted extraction (liquid-solid ratio, water content (%) in the selected DES, and extraction time) were optimized using response surface methodology. Furthermore, the microstructural alterations in the samples after extraction were evaluated using scanning electron microscopy. In addition, we further verified the recovery of flavone di-C-glycosides from the DESs using macroporous resins and evaluated the reusability of the DESs as solvents. The results indicated that DES-F was an efficient and sustainable solvent for the extraction of bioactive flavone di-C-glycosides from Premna fulva Craib. Therefore, this novel strategy may represent a sustainable approach for the extraction of bioactive products and could make phytochemistry more attractive and environmentally friendly.

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