Indian ayurvedic herb, Boerhaavia diffusa as BCPR inhibitor: The story behind the curtains

2022 ◽  
Vol 1249 ◽  
pp. 131564
Author(s):  
Nataša Milošević ◽  
Maja Milanović ◽  
Nebojša Pavlović ◽  
Larisa Đurić ◽  
Nunzio Antonio Cacciola ◽  
...  
2012 ◽  
Vol 3 (6) ◽  
pp. 780-782
Author(s):  
Dattatrya Nikam ◽  
Shreekant Mundada ◽  
Dayashankar Mishra
Keyword(s):  

2018 ◽  
Vol 29 ◽  
pp. ix110
Author(s):  
J.K. Acharya ◽  
S. Beniwal ◽  
S. Jakhar ◽  
N. Mohta

Author(s):  
Pravalika Arunkumar ◽  
R. V. Geetha ◽  
S. Rajesh Kumar

Introduction: The extract of Boerhaavia diffusa root, a plant used in Indian traditional medicine, has significant immunomodulatory Potential. Selenium, a nutrient element that has a massive function in biological systems, is one of the interesting compounds to integrate with antibacterial agents. Recently several studies have pointed out the ability of selenium nanoparticles to exhibit anticancer, antioxidant, antibacterial and antibiofilm properties. Aim: To analyze the antimicrobial and cytotoxic activity of Boerhaavia diffusa mediated selenium nanoparticles based mouthwash. Materials and Methods:   1 g of Boerhavia diffusa was added in 100 ml of distilled water. It was boiled; the plant extract was filtered using Whatman’s no.1 filter paper. In 250 ml conical flask, 60 ml of 20 millimolar sodium selenite was prepared and 40 ml of the filtered plant extract was mixed. This flask was kept in a magnetic stirrer. The nanoparticle solution was centrifuged at 8000rpm to prepare nanoparticle pellets. The nanoparticle pellet was dried in a hot air oven at 80 degree celsius. The dried powder was sent for Characterization. A mouthwash is prepared. The prepared mouthwash was tested for cytotoxic activity by brine shrimp lethality assay and antimicrobial activity evaluated the zone of inhibition of agar well diffusion method. Results and Discussion: It was proved that cytotoxic activity of selenium bound mouthwash was less compared to the commercial mouthwash. The antibacterial activity of the selenium bound mouthwash against C. albicans and S. mutans was significant when compared to the standard antimicrobial agent. Conclusion: Based on the results, this mouthwash has the required qualities to be commercially be used. Therefore further studies can be done to prove that this mouthwash can be used commercially.


2021 ◽  
Vol 9 (8) ◽  
pp. 1778-1788
Author(s):  
Bargale Sushant Sukumar

Ayurveda is successfully implemented as a primary healthcare system in India, and it is flourishing in the promotion of health around the world. Ayurveda aims to create a society happily, healthy, and peaceful. In general, the simple regimes mentioned in Ayurveda texts are of immense use faced by the present world today regarding health pro- motion. Ashwagandha (Withania Somnifera) is usually referred to as 'Indian winter cherry' or 'Indian Ginseng'. It is a shrub grown in India and North America whose roots have been used by Ayurvedic practitioners for thousands of years. Ashwagandha is one of Ayurveda's most essential herbs, used as Rasayana for its wide range of health benefits for centuries. Chemicals constitute of Ashwagandha (Withania Somnifera)- The chemistry of Ashwagan- dha (Withania Somnifera) has been widely studied and numerous categories of chemical constituents have been described, extracted, and isolated, such as steroidal lactones, alkaloids, flavonoids, tannin, etc. More than 12 alka- loids, 40 withanolides and several sitoindosides have currently been isolated from the aerial parts, roots, and berries of the Withania species and have been recorded. The principal biochemical element of Ashwagandha (WS) root is withanolides, which are steroidal alkaloids and steroidal lactones. The pharmacological activity of Ashwagan- dha- It has been shown to have pharmacological importance as an Adaptogen, Antibiotic, abortifacient, aphrodisiac, Astringent, Anti-inflammatory, deobstructive, diuretic, narcotic, sedative, and tonic through centuries of Ayurvedic medicinal practice using Ashwagandha (Withania Somnifera). Along with these Ashwagandha acts as Anti-stress,Anticarcinogenic activity, Anti-inflammatory activity, Anti-aging activity, Cardioprotective activity, hypothyroid activity and Immunomodulatory activity. Keywords: Ashwagandha, Withania Somnifera, Alkaloids, Withanoids, sitoindosides


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