Detection of mtDNA with 4977bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease

2005 ◽  
Vol 570 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Nicoletta Botto ◽  
Sergio Berti ◽  
Samantha Manfredi ◽  
Anees Al-Jabri ◽  
Chiara Federici ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Blood Cells ◽  
Atherosclerotic Lesions ◽  
Artery Disease

Impact of red blood cells count and high density lipoproteins with the prevalence and extent of coronary artery disease

2015 ◽  
Vol 40 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Alon Schaffer ◽  
Monica Verdoia ◽  
Ettore Cassetti ◽  
Lucia Barbieri ◽  
Pasquale Perrone-Filardi ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Red Blood Cells ◽  
Blood Cells ◽  
High Density ◽  
High Density Lipoproteins ◽  
Artery Disease

scholarly journals Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Larisa-Diana Mocan Hognogi ◽  
Cerasela-Mihaela Goidescu ◽  
Anca-Daniela Farcaş
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Arterial Wall ◽  
Major Influence ◽  
Current Guideline ◽  
Thoracic Region ◽  
Atherosclerotic Lesions ◽  
Fat Deposits ◽  
Artery Disease

Cardiovascular disease is the leading cause of death among both women and men, but there is still a great percentage of misdiagnosis and lack of clearly defined criteria. Advances in biomolecular science have proven the crucial role of inflammation and, more importantly, the role of adipokines in mediating all stages of coronary artery disease. It has also been suggested that regional fat deposits, more precisely from thoracic region, have a major influence on the development of coronary artery disease by creating a local proatherogenic environment. The immune system closely interacts with metabolic risk factors to initiate, promote, and further aggravate the atherosclerotic lesions on the arterial wall all with the “help” of adipokines. So nowadays, research extensively focuses on uncovering biomarkers that would provide an increased chance of detecting subclinical cardiac distress and also add a consistent value to current guideline-imposed risk criteria.

Absence of atherosclerotic lesions in the thoracic aorta indicates absence of significant coronary artery disease

1996 ◽  
Vol 77 (12) ◽  
pp. 1118-1121 ◽  
Author(s):  
Fragiskos Parthenakis ◽  
Emmanuel Skalidis ◽  
Emmanuel Simantirakis ◽  
Daphne Kounali ◽  
Panos Vardas ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Thoracic Aorta ◽  
Significant Coronary Artery Disease ◽  
Atherosclerotic Lesions ◽  
Artery Disease

scholarly journals Matrix Metalloproteinase 13 Genotype in rs640198 Polymorphism Is Associated with Severe Coronary Artery Disease

2012 ◽  
Vol 33 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Anna Vašků ◽  
Jaroslav Meluzín ◽  
Jan Blahák ◽  
Vladimír Kincl ◽  
Monika Pávková Goldbergová ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Odds Ratio ◽  
Atherosclerotic Lesions ◽  
Matrix Metalloproteinase 13 ◽  
Power Of The Test ◽  
Triple Vessel Disease ◽  
Increased Risk ◽  
Severe Coronary Artery ◽  
Artery Disease

Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity.The study comprised 1071 consecutive patients with suspected or known coronary artery disease (CAD), confirmed by coronary angiography.Genotyping for the rs640198 polymorphism in MMP-13 gene was performed using Taqman® assay. The TT and TG genotypes of rs640198 polymorphism in MMP-13 gene confer the significantly increased risk of triple vessel disease compared to patients without atherosclerotic lesions in coronary arteries (odds ratio = 1.64, Pcorr = 0.05). Furthermore, an increased risk of having 5 and more stenoses (odds ratio = 1.90, Pcorr = 0.004) was observed in TT and TG carriers (sensitivity of 0.613 and a specificity of 0.544; power of the test is 0.87).The T allele of MMP-13 intron polymorphism rs640198 is associated with the severity of coronary artery disease, represented by the number of affected arteries as well as by the number of stenoses confirmed by coronarography.

scholarly journals Nitric Oxide Synthetic Pathway in Red Blood Cells Is Impaired in Coronary Artery Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e66945 ◽  
Author(s):  
Sonia Eligini ◽  
Benedetta Porro ◽  
Alessandro Lualdi ◽  
Isabella Squellerio ◽  
Fabrizio Veglia ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Synthetic Pathway ◽  
Artery Disease

scholarly journals CRP Is Transported by Monocytes and Monocyte-Derived Exosomes in the Blood of Patients with Coronary Artery Disease

Biomedicines ◽  
2020 ◽  
Vol 8 (10) ◽  
pp. 435
Author(s):  
Ivan Melnikov ◽  
Sergey Kozlov ◽  
Olga Saburova ◽  
Ekaterina Zubkova ◽  
Olga Guseva ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Healthy Volunteers ◽  
Blood Cells ◽  
Messenger Rna ◽  
Blood Monocytes ◽  
Gm Csf ◽  
Reactive Protein ◽  
Artery Disease ◽  
Macrophage Colony

The objective of this work was to study the ability of blood cells and their microparticles to transport monomeric and pentameric forms of C-reactive protein (mCRP and pCRP) in the blood of patients with coronary artery disease (CAD). Blood was obtained from 14 patients with CAD 46 ± 13 years old and 8 healthy volunteers 49 ± 13.6 years old. Blood cells and microparticles with mCRP and pCRP on their surface were detected by flow cytometry. Messenger RNA (mRNA) of CRP was extracted from peripheral blood monocytes stimulated with lipopolysaccharide (LPS) and granulocyte-macrophage colony-stimulating factor (GM-CSF). mRNA of CRP in monocytes was detected with PCR. Monocytes were predominantly pCRP-positive (92.9 ± 6.8%). mCRP was present on 22.0 ± 9.6% of monocyte-derived exosomes. mCRP-positive leukocyte-derived microparticle counts were significantly higher (8764 ± 2876/µL) in the blood of patients with CAD than in healthy volunteers (1472 ± 307/µL). LPS and GM-CSF stimulated monocytes expressed CRP mRNA transcripts levels (0.79 ± 0.73-fold), slightly lower relative to unstimulated hepatocytes of the HepG2 cell line (1.0 ± 0.6-fold), but still detectable. The ability of monocytes to transport pCRP in blood flow, and monocyte-derived exosomes to transmit mCRP, may contribute to the maintenance of chronic inflammation in CAD.

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