Background and Objective:
This study was designed to estimate the long-term effects of
zinc oxide nanoparticles/green tea (ZnONPs/GTE) complex against monosodium glutamate (MSG).
The antioxidant/oxidative status, testosterone levels, DNA damage, and histopathological changes of
testis were evaluated.
Methods:
The rats were divided into eight groups that were treated as follows: saline, the lower dosage
of MSG (6.0 mg/kg), the higher dosage of MSG (17.5 mg/Kg), GTE, ZnONPs, ZnONPs/GTE and the
last two groups were treated with the lower dosage of MSG or the higher dosage of MSG with
ZnONPs/GTE complex. The data showed minimal toxicity in testicular tissue after the administration
of ZnONPs.
Results:
The MSG treatment in the adult male rats reduced testosterone levels and disrupted testicular
histology, which revealed dose-dependence of MSG. Also, ZnONPs induced testicular dysfunction
through the interference of antioxidant/oxidant balance and suppression of testosterone levels as well
as induction of cellular damage of testis. The combination of ZnONPs with GTE complex significantly
protects against MSG or ZnONPs toxicity by decreasing the DNA damage, oxidative stress, and enhancement
of antioxidant as well as histological structure of testis.
Conclusion:
We could recommend using ZnONPs/GTE complex to reduce the toxicity of ZnONPs
and MSG on the testis at the cellular and oxidative stress levels.
The Radiosensitizing Effect of Zinc Oxide Nanoparticles in Sub-Cytotoxic Dosing Is Associated with Oxidative Stress In Vitro
