scholarly journals Neuro-Otological Paraneoplastic Syndromes: A New Neuroimmunological Differential Diagnosis

2021 ◽  
pp. 100049
Author(s):  
Marcelo Henrique De Moura Campos ◽  
André Eduardo De Almeida Franzoi ◽  
Matheus Fellipe Nascimento De Souza ◽  
Guilherme Zini Dos Reis ◽  
Daniel Collares ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Paraneoplastic Syndromes

scholarly journals PARANEOPLASTIC SYNDROMES IN THE PRACTICE OF A NEUROLOGIST (CLINICAL CASES)

2019 ◽  
pp. 44-51
Author(s):  
N. L. Bozhenko ◽  
M. I. Bozhenko ◽  
S. Y. Кyrylyuk ◽  
I. M. Bozhenko ◽  
A. O. Tyutko
Keyword(s):  
Differential Diagnosis ◽  
Clinical Case ◽  
Careful Analysis ◽  
Paraneoplastic Syndromes ◽  
Systemic Effects ◽  
Malignant Diseases ◽  
The Future ◽  
Clinical Cases

Paraneoplastic syndromes are the rare states caused by a change in the immune system's response to neoplasms. These include non-metastatic systemic effects that accompaniy malignant diseases. Diagnosis of these syndromes has some difficulties. In this article clinical cases of patients with paraneoplastic syndromes are analyzed and differential diagnosis is performed. Careful analysis of each clinical case is extremely important for the accumulation of experience, improvement of diagnostics and avoiding mistakes in the future.

Pulmonary Malignancy

2019 ◽  
pp. 166-170
Author(s):  
Ali A. Zaied ◽  
Margaret M. Johnson
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Cushing Syndrome ◽  
Superior Vena ◽  
Vena Cava ◽  
Paraneoplastic Syndromes ◽  
Advanced Stage ◽  
Intensive Care Admission ◽  
Myasthenic Syndrome ◽  
Vena Cava Syndrome

Although the number of new lung cancer cases has decreased, most are diagnosed at an advanced stage owing to the asymptomatic nature of the disease. Furthermore, patients may need intensive care admission for paraneoplastic syndromes such as hypercalcemia, Lambert-Eaton myasthenic syndrome (LEMS), syndrome of inappropriate secretion of antidiuretic hormone (SIADH), Cushing syndrome, and superior vena cava syndrome (SVCS). Pulmonary infections must be considered in the differential diagnosis of chemotherapy-related lung toxicity.

scholarly journals Paraneoplastic neuromuscular syndromes at the outpatient level

2019 ◽  
Vol 10 (3) ◽  
pp. 72-82
Author(s):  
A. E. Chertousova ◽  
I. V. Chernikova
Keyword(s):  
Differential Diagnosis ◽  
Paraneoplastic Syndromes ◽  
Sensory Nerves ◽  
Control Group ◽  
Diagnostic Center ◽  
Group A ◽  
Outpatient Practice ◽  
And Control ◽  
Experimental Group ◽  
Serological Diagnostics

Objective: to develop tactics for the differential diagnosis of paraneoplastic neuromuscular syndromes in patients at the outpatient level.Materials and methods: the study included 50 patients with classical neuromuscular paraneoplastic syndromes (experimental group) and 50 patients with neuromuscular syndromes of non-paraneoplastic nature (control group). All patients underwent a comprehensive laboratory and instrumental examination at the Regional Consultative and Diagnostic Center of the Ministry of Health of the Rostov Region from 2014 to 2018.Results: the evaluation of clinical differences in patients of the experimental and control groups was created. When comparing the laboratory parameters, it was revealed that the SFMC, D-dimer, CRP-2 levels significantly increased in patients with paraneoplastic lesions (p <0.05). In the experimental group, a significant increase in the amplitude of the M-response from the sensory nerves (> 5.25 mV) was noted. Based on obtained data, differential diagnosis algorithms for patients with studied neuromuscular lesions at the outpatient level have been developed.Conclusions: the conducted study allows the implementation of non-serological diagnostics algorithms for classical neuromuscular paraneoplastic syndromes in outpatient practice.

scholarly journals PARANEOPLASTIC SYNDROMES IN THE PRACTICE OF A NEUROLOGIST (CLINICAL CASES)

2019 ◽  
pp. 44-51
Author(s):  
N. L. Bozhenko ◽  
M. I. Bozhenko ◽  
S. Y. Кyrylyuk ◽  
I. M. Bozhenko ◽  
A. O. Tyutko
Keyword(s):  
Differential Diagnosis ◽  
Clinical Case ◽  
Careful Analysis ◽  
Paraneoplastic Syndromes ◽  
Systemic Effects ◽  
Malignant Diseases ◽  
The Future ◽  
Clinical Cases

Paraneoplastic syndromes are the rare states caused by a change in the immune system's response to neoplasms. These include non-metastatic systemic effects that accompaniy malignant diseases. Diagnosis of these syndromes has some difficulties. In this article clinical cases of patients with paraneoplastic syndromes are analyzed and differential diagnosis is performed. Careful analysis of each clinical case is extremely important for the accumulation of experience, improvement of diagnostics and avoiding mistakes in the future.

Tumor Diagnosis

1982 ◽  
Vol 40 ◽  
pp. 262-265
Author(s):  
Bruce Mackay
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Differential Diagnosis ◽  
Light Microscopy ◽  
Clinical Examination ◽  
Ultrastructural Study ◽  
Diagnostic Procedures ◽  
Specific Diagnosis ◽  
Transmission Electron ◽  
Microscopic Diagnosis

The broadest application of transmission electron microscopy (EM) in diagnostic medicine is the identification of tumors that cannot be classified by routine light microscopy. EM is useful in the evaluation of approximately 10% of human neoplasms, but the extent of its contribution varies considerably. It may provide a specific diagnosis that can not be reached by other means, but in contrast, the information obtained from ultrastructural study of some 10% of tumors does not significantly add to that available from light microscopy. Most cases fall somewhere between these two extremes: EM may correct a light microscopic diagnosis, or serve to narrow a differential diagnosis by excluding some of the possibilities considered by light microscopy. It is particularly important to correlate the EM findings with data from light microscopy, clinical examination, and other diagnostic procedures.

The Preschool Stuttering Screen for Health Care Professionals

2011 ◽  
Vol 21 (2) ◽  
pp. 59-62
Author(s):  
Joseph Donaher ◽  
Christina Deery ◽  
Sarah Vogel
Keyword(s):  
Risk Factors ◽  
Health Care ◽  
Differential Diagnosis ◽  
Preschool Children ◽  
Health Care Professionals ◽  
Healthcare Professionals ◽  
Evidence Based ◽  
Developmental Profile

Healthcare professionals require a thorough understanding of stuttering since they frequently play an important role in the identification and differential diagnosis of stuttering for preschool children. This paper introduces The Preschool Stuttering Screen for Healthcare Professionals (PSSHP) which highlights risk factors identified in the literature as being associated with persistent stuttering. By integrating the results of the checklist with a child’s developmental profile, healthcare professionals can make better-informed, evidence-based decisions for their patients.

The Effect of Sensori-Neural Hearing Loss on Threshold-Duration Functions

1968 ◽  
Vol 11 (4) ◽  
pp. 842-852 ◽  
Author(s):  
H. N. Wright
Keyword(s):  
Hearing Loss ◽  
Differential Diagnosis ◽  
Time Constant ◽  
Present Series ◽  
Auditory Disorders ◽  
Threshold Duration

Previous findings on the threshold for tones as a function of their duration have suggested that such functions may be systematically affected by sensori-neural hearing losses of cochlear origin. The present series of investigations was designed to explore this relation further and to determine also whether the amount of hearing loss present has any effect upon the results which are obtained. Preliminary studies were also carried out on a conductively impaired listener to indicate whether hearing losses of this type affect the threshold-duration function. The results indicate that the threshold-duration function is systematically affected by sensori-neural hearing losses of cochlear origin. This effect is manifested by a progressive shortening of the time constant relating threshold to duration and is not uniquely related to the amount of hearing loss present. The results obtained from the conductively impaired listener suggested that this type of hearing loss has no effect on the threshold-duration function, thereby implying that such functions may contribute significantly to the differential diagnosis of auditory disorders.

POST-TRANSFUSION PURPURA VS. HEPARIN-INDUCED THROMBOCYTOPENIA: DIFFERENTIAL DIAGNOSIS IN CLINICAL PRACTICE

2000 ◽  
Vol 10 (4) ◽  
pp. 323-324 ◽  
Author(s):  
F. Araujo ◽  
J. J. Sa ◽  
V. Araujo ◽  
M. Lopes ◽  
L. M. Cunha-Ribeiro
Keyword(s):  
Differential Diagnosis ◽  
Clinical Practice ◽  
Heparin Induced Thrombocytopenia

A Historical Review of Complex Regional Pain Syndrome in the “Guides Library”

2009 ◽  
Vol 14 (6) ◽  
pp. 1-9
Author(s):  
Robert J. Barth
Keyword(s):  
Differential Diagnosis ◽  
Complex Regional Pain Syndrome ◽  
Reflex Sympathetic Dystrophy ◽  
International Association ◽  
Historical Review ◽  
Pain Syndrome ◽  
Sixth Edition

Abstract Complex regional pain syndrome (CRPS) is a controversial, ambiguous, unreliable, and unvalidated concept that, for these very reasons, has been justifiably ignored in the “AMA Guides Library” that includes the AMAGuides to the Evaluation of Permanent Impairment (AMA Guides), the AMA Guides Newsletter, and other publications in this suite. But because of the surge of CRPS-related medicolegal claims and the mission of the AMA Guides to assist those who adjudicate such claims, a discussion of CRPS is warranted, especially because of what some believe to be confusing recommendations regarding causation. In 1994, the International Association for the Study of Pain (IASP) introduced a newly invented concept, CRPS, to replace the concepts of reflex sympathetic dystrophy (replaced by CRPS I) and causalgia (replaced by CRPS II). An article in the November/December 1997 issue of The Guides Newsletter introduced CRPS and presciently recommended that evaluators avoid the IASP protocol in favor of extensive differential diagnosis based on objective findings. A series of articles in The Guides Newsletter in 2006 extensively discussed the shortcomings of CRPS. The AMA Guides, Sixth Edition, notes that the inherent lack of injury-relatedness for the nonvalidated concept of CRPS creates a dilemma for impairment evaluators. Focusing on impairment evaluation and not on injury-relatedness would greatly simplify use of the AMA Guides.

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