Oxidative stress and decreased dopamine levels induced by imidacloprid exposure cause behavioral changes in a neurodevelopmental disorder model in Drosophila melanogaster

2021 ◽  
Author(s):  
Dieniffer Espinosa Janner ◽  
Nathalie Savedra Gomes ◽  
Márcia Rósula Poetini ◽  
Kétnne Hanna Poleto ◽  
Elize Aparecida Santos Musachio ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Neurodevelopmental Disorder ◽  
Behavioral Changes

Melatonin improves cognitive behavior, oxidative stress, and metabolism in tumor‐prone lethal giant larvae mutant of Drosophila melanogaster

2021 ◽  
Author(s):  
Kar‐Cheng Wong ◽  
Srivani Sankaran ◽  
Jaime J. Jayapalan ◽  
Perumal Subramanian ◽  
Puteri S. Abdul‐Rahman
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Cognitive Behavior ◽  
Lethal Giant Larvae

scholarly journals Effects of sodium fluoride and Ocimum sanctum extract on the lifespan and climbing ability of Drosophila melanogaster

2021 ◽  
Vol 82 (1) ◽  
Author(s):  
Sidra Perveen ◽  
Shalu Kumari ◽  
Himali Raj ◽  
Shahla Yasmin
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Drosophila Melanogaster ◽  
Sodium Fluoride ◽  
Ocimum Sanctum ◽  
Activity Assay ◽  
Lipid Peroxidation Assay ◽  
Climbing Ability ◽  
The Impact ◽  
Sublethal Concentrations

Abstract Background Fluoride may induce oxidative stress and apoptosis. It may also lead to neurobehavioural defects including neuromuscular damage. The present study aimed to explore the effects of sub lethal concentrations of sodium fluoride (NaF) on the lifespan and climbing ability of Drosophila melanogaster. In total, 0.6 mg/L and 0.8 mg/L of NaF were selected as sublethal concentrations of NaF for the study. Lifespan was measured and climbing activity assay was performed. Results The study showed significant decrease in lifespan of flies treated with fluoride. With increasing age, significant reduction in climbing activity was observed in flies treated with sodium fluoride as compared to normal (control) flies. Flies treated with tulsi (Ocimum sanctum) and NaF showed increase in lifespan and climbing activity as compared to those treated with NaF only. Lipid peroxidation assay showed significant increase in malondialdehyde (MDA) values in the flies treated with NaF as compared to control. The MDA values decreased significantly in flies treated with tulsi mixed with NaF. Conclusions The results indicate that exposure to sub lethal concentration of NaF may cause oxidative stress and affect the lifespan and climbing activity of D. melanogaster. Tulsi extract may help in reducing the impact of oxidative stress and toxicity caused by NaF.

scholarly journals SHR/NCrl rats as a model of ADHD can be discriminated from controls based on their brain, blood, or urine metabolomes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Camille Dupuy ◽  
Pierre Castelnau ◽  
Sylvie Mavel ◽  
Antoine Lefevre ◽  
Lydie Nadal-Desbarats ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Attention Deficit Hyperactivity Disorder ◽  
Animal Model ◽  
Metabolic Pathways ◽  
Neurodevelopmental Disorder ◽  
Hyperactivity Disorder ◽  
Pathophysiological Condition ◽  
The Brain ◽  
And Oxidative Stress ◽  
Peripheral Samples

AbstractAttention-Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorder characterized by inattention, impulsivity, and hyperactivity. The neurobiological mechanisms underlying ADHD are still poorly understood, and its diagnosis remains difficult due to its heterogeneity. Metabolomics is a recent strategy for the holistic exploration of metabolism and is well suited for investigating the pathophysiology of diseases and finding molecular biomarkers. A few clinical metabolomic studies have been performed on peripheral samples from ADHD patients but are limited by their access to the brain. Here, we investigated the brain, blood, and urine metabolomes of SHR/NCrl vs WKY/NHsd rats to better understand the neurobiology and to find potential peripheral biomarkers underlying the ADHD-like phenotype of this animal model. We showed that SHR/NCrl rats can be differentiated from controls based on their brain, blood, and urine metabolomes. In the brain, SHR/NCrl rats displayed modifications in metabolic pathways related to energy metabolism and oxidative stress further supporting their importance in the pathophysiology of ADHD bringing news arguments in favor of the Neuroenergetic theory of ADHD. Besides, the peripheral metabolome of SHR/NCrl rats also shared more than half of these differences further supporting the importance of looking at multiple matrices to characterize a pathophysiological condition of an individual. This also stresses out the importance of investigating the peripheral energy and oxidative stress metabolic pathways in the search of biomarkers of ADHD.

scholarly journals The tamas Gene, Identified as a Mutation That Disrupts Larval Behavior in Drosophila melanogaster, Codes for the Mitochondrial DNA Polymerase Catalytic Subunit (DNApol-γ125)

Genetics ◽  
1999 ◽  
Vol 153 (4) ◽  
pp. 1809-1824 ◽  
Author(s):  
Balaji Iyengar ◽  
John Roote ◽  
Ana Regina Campos
Keyword(s):  
Mitochondrial Dna ◽  
Drosophila Melanogaster ◽  
Mutant Strain ◽  
Dna Polymerase ◽  
Complementation Group ◽  
Behavioral Changes ◽  
Catalytic Subunit ◽  
Primary Deficit ◽  
Mitochondrial Dna Polymerase ◽  
Food Substrate

AbstractFrom a screen of pupal lethal lines of Drosophila melanogaster we identified a mutant strain that displayed a reproducible reduction in the larval response to light. Moreover, this mutant strain showed defects in the development of the adult visual system and failure to undergo behavioral changes characteristic of the wandering stage. The foraging third instar larvae remained in the food substrate for a prolonged period and died at or just before pupariation. Using a new assay for individual larval photobehavior we determined that the lack of response to light in these mutants was due to a primary deficit in locomotion. The mutation responsible for these phenotypes was mapped to the lethal complementation group l(2)34Dc, which we renamed tamas (translated from Sanskrit as “dark inertia”). Sequencing of mutant alleles demonstrated that tamas codes for the mitochondrial DNA polymerase catalytic subunit (DNApol-γ125).

Lead (Pb) induced Oxidative Stress as a Mechanism to Cause Neurotoxicity in Drosophila melanogaster

Toxicology ◽  
2021 ◽  
pp. 152959
Author(s):  
Olakkaran Shilpa ◽  
Kizhakke Purayil Anupama ◽  
Anet Antony ◽  
Hunasanahally Puttaswamygowda Gurushankara
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster

Perinatal Exposure to the Cyanotoxin β-N-Méthylamino-l-Alanine (BMAA) Results in Long-Lasting Behavioral Changes in Offspring—Potential Involvement of DNA Damage and Oxidative Stress

2017 ◽  
Vol 33 (1) ◽  
pp. 87-112 ◽  
Author(s):  
Anthony Laugeray ◽  
Asma Oummadi ◽  
Clément Jourdain ◽  
Justyne Feat ◽  
Géraldine Meyer-Dilhet ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Behavioral Changes ◽  
Perinatal Exposure ◽  
And Oxidative Stress

Pyocyanin induces systemic oxidative stress, inflammation and behavioral changes in vivo

2018 ◽  
Vol 28 (6) ◽  
pp. 410-414 ◽  
Author(s):  
Devinder Arora ◽  
Susan Hall ◽  
Shailendra Anoopkumar-Dukie ◽  
Rachel Morrison ◽  
Amelia McFarland ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Behavioral Changes ◽  
Systemic Oxidative Stress

scholarly journals Empathy and Oxidative Stress in Healthy Adults

2020 ◽  
Vol 12 (12) ◽  
pp. 4959 ◽  
Author(s):  
Agnieszka Żelaźniewicz ◽  
Judyta Nowak ◽  
Agata Groyecka ◽  
Piotr Sorokowski ◽  
Małgorzata Dobrowolska ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Level ◽  
Oxidative Dna Damage ◽  
Behavioral Changes ◽  
Social Environments ◽  
Self Assessment ◽  
Adverse Conditions ◽  
Oxidative Stress Level ◽  
Empathy Quotient ◽  
Study Participants

Empathy is crucial for normal and effective social functioning, enabling comprehension and prediction of actions in social environments. Despite its importance for maintaining social relationships in human groups, the physiological correlates of empathy are not fully known. The aim of this study was to test whether empathy is related to oxidative stress level, that may result both from internal disturbances and influence of external adverse factors. Seventy-four healthy women (Mage = 26.23, SDage = 2.88) and one hundred and one men (Mage = 28.09, SDage = 3.03) took part in the study. Participants’ empathy was evaluated with self-assessment questionnaire—Empathy Quotient (EQ). Oxidative stress level was measured with serum 8-OH-dG, a product of oxidative DNA damage. The results showed that empathy is negatively related to oxidative stress level in men but not in women, when controlled for testosterone level. Revealed sex differences may be explained by men’s greater vulnerability to various adverse conditions and harmful factors. Men, compared to women, seem to be more susceptible to behavioral changes, induced by increased oxidative stress level. The study adds to growing evidence showing that many physiological mechanisms, other than hormonal factors, that may be also related with environmental harmful factors, are related to behavioral, affective and cognitive phenomena.

Exposure to a high dose of amoxicillin causes behavioral changes and oxidative stress in young zebrafish

2020 ◽  
Vol 35 (8) ◽  
pp. 1407-1416 ◽  
Author(s):  
Cinara L. Gonçalves ◽  
Francine F. P. Vasconcelos ◽  
Leticia B. Wessler ◽  
Isabela S. Lemos ◽  
Gabriela Candiotto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Behavioral Changes ◽  
High Dose ◽  
And Oxidative Stress
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