Lesion symptom mapping of domain-specific cognitive impairments using routine imaging in stroke

AbstractBackground and PurposeThis large-scale lesion-symptom mapping study aimed to investigate the necessary neuro-anatomical substrates of 5 cognitive domains frequently affected post stroke: Language, Attention, Praxis, Number, and Memory. This study aims to demonstrate the validity of using routine clinical brain imaging from a large, real-world patient cohort for lesion-symptom mapping.MethodsBehavioural cognitive screening data from the Oxford Cognitive Screen and routine clinical neuroimaging from 573 acute patients was used in voxel-based lesion-symptom mapping analyses. Patients were classed as impaired or not on each of the subtests within 5 cognitive domains.ResultsDistinct patterns of lesion damage were associated with different domains. Language functions were associated with damage to left hemisphere fronto-temporal areas. Visuo-spatial functions were associated with damage to posterior occipital areas (Visual Field) and the right temporo-parietal region (Visual Neglect). Different memory impairments were linked to distinct voxel clusters within the left insular and opercular cortices. Deficits which were not associated with localised voxels (e.g. praxis, executive function) represent distributed functions.ConclusionThe standardised, brief Oxford Cognitive Screen was able to reliably differentiate distinct neural correlates critically involved in supporting domain-specific cognitive abilities. By demonstrating and replicating known brain anatomy correlates within real-life clinical cohorts using routine CT scans, we open up VLSM techniques to a wealth of clinically relevant studies which can capitalise on using existing clinical brain imaging.

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Domain-Specific Cognitive Impairments in Humans and Flies With Reduced CYFIP1 Dosage

Biological Psychiatry ◽

10.1016/j.biopsych.2019.04.008 ◽

2019 ◽

Vol 86 (4) ◽

pp. 306-314 ◽

Cited By ~ 4

Author(s):

Young Jae Woo ◽

Alexandros K. Kanellopoulos ◽

Parisa Hemati ◽

Jill Kirschen ◽

Rebecca A. Nebel ◽

...

Keyword(s):

Cognitive Impairments ◽

Domain Specific

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Cognitive impairments are independently associated with shorter survival in diffuse glioma patients

Journal of Neurology ◽

10.1007/s00415-020-10303-w ◽

2020 ◽

Author(s):

Emma van Kessel ◽

Irene M. C. Huenges Wajer ◽

Carla Ruis ◽

Tatjana Seute ◽

Susanne Fonville ◽

...

Keyword(s):

Executive Functioning ◽

Cognitive Functioning ◽

Neuropsychological Assessment ◽

Cognitive Impairments ◽

Awake Surgery ◽

Diffuse Glioma ◽

Who Grade ◽

Diffuse Infiltration ◽

Domain Specific ◽

Diffuse Gliomas

Abstract Background Diffuse gliomas (WHO grade II–IV) are progressive primary brain tumors with great variability in prognosis. Cognitive deficits are of important prognostic value for survival in diffuse gliomas. Until now, few studies focused on domain-specific neuropsychological assessment and rather used MMSE as a measure for cognitive functioning. Additionally, these studies did not take WHO 2016 diagnosis into account. We performed a retrospective cohort study with the aim to investigate the independent relationship between cognitive functioning and survival in treatment-naive patients undergoing awake surgery for a diffuse glioma. Methods In patients undergoing awake craniotomy between 2010 and 2017, we performed pre-operative neuropsychological assessments in five cognitive domains, with special attention for the domains executive functioning and memory. We evaluated the independent relation between these domains and survival, in a Cox proportional hazards model that included state-of-the-art integrated histomolecular (‘layered’ or WHO-2016) classification of the gliomas and other known prognostic factors. Results We included 197 patients. Cognitive impairments (Z-values ≦ − 2.0) were most frequent in the domains memory (18.3%) and executive functioning (25.9%). Impairments in executive functioning and memory were significantly correlated with survival, even after correcting for the possible confounders. Analyses with the domains language, psychomotor speed, and visuospatial functioning yielded no significant results. Extensive domain-specific neuropsychological assessment was more strongly correlated to survival than MMSE. Conclusion Cognitive functioning is independently related to survival in diffuse glioma patients. Possible mechanisms underlying this relationship include the notion of cognitive functioning as a marker for diffuse infiltration of the tumor and the option that cognitive functioning and survival are determined by overlapping genetic pathways and biomarkers.

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Distinct Neural Substrates Support Phonological and Orthographic Working Memory: Implications for Theories of Working Memory

Frontiers in Neurology ◽

10.3389/fneur.2021.681141 ◽

2021 ◽

Vol 12 ◽

Author(s):

Jeremy Purcell ◽

Brenda Rapp ◽

Randi C. Martin

Keyword(s):

Working Memory ◽

Neural Substrates ◽

Angular Gyrus ◽

Long Term Memory ◽

Neural Basis ◽

Domain Specific ◽

Memory Representations ◽

Attentional System ◽

Lesion Symptom Mapping

Prior behavioral and neuroimaging evidence supports a separation between working memory capacities in the phonological and orthographic domains. Although these data indicate distinct buffers for orthographic and phonological information, prior neural evidence does indicate that nearby left inferior parietal regions support both of these working memory capacities. Given that no study has directly compared their neural substrates based on data from the same individuals, it is possible that there is a common left inferior parietal region shared by both working memory capacities. In fact, those endorsing an embedded processes account of working memory might suggest that parietal involvement reflects a domain-general attentional system that directs attention to long-term memory representations in the two domains, implying that the same neural region supports the two capacities. Thus, in this work, a multivariate lesion-symptom mapping approach was used to assess the neural basis of phonological and orthographic working memory using behavioral and lesion data from the same set of 37 individuals. The results showed a separation of the neural substrates, with regions in the angular gyrus supporting orthographic working memory and with regions primarily in the supramarginal gyrus supporting phonological working memory. The results thus argue against the parietal involvement as supporting a domain-general attentional mechanism and support a domain-specific buffer account of working memory.

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Case Studies for Telepractice in AAC

Perspectives on Augmentative and Alternative Communication ◽

10.1044/aac23.1.42 ◽

2014 ◽

Vol 23 (1) ◽

pp. 42-54 ◽

Cited By ~ 1

Author(s):

Tanya Rose Curtis

Keyword(s):

Service Delivery ◽

Case Studies ◽

Eye Gaze ◽

Cognitive Impairments ◽

Perceived Barriers ◽

Computer Experience ◽

Access Methods ◽

Complex Communication Needs ◽

Barriers To Service ◽

Communication Needs

As the field of telepractice grows, perceived barriers to service delivery must be anticipated and addressed in order to provide appropriate service delivery to individuals who will benefit from this model. When applying telepractice to the field of AAC, additional barriers are encountered when clients with complex communication needs are unable to speak, often present with severe quadriplegia and are unable to position themselves or access the computer independently, and/or may have cognitive impairments and limited computer experience. Some access methods, such as eye gaze, can also present technological challenges in the telepractice environment. These barriers can be overcome, and telepractice is not only practical and effective, but often a preferred means of service delivery for persons with complex communication needs.

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Scientific Problem Solving in a Virtual Laboratory: A Comparison Between Individuals and Pairs

Swiss Journal of Psychology ◽

10.1024/1421-0185.67.2.71 ◽

2008 ◽

Vol 67 (2) ◽

pp. 71-83 ◽

Cited By ~ 5

Author(s):

Yolanda A. Métrailler ◽

Ester Reijnen ◽

Cornelia Kneser ◽

Klaus Opwis

Keyword(s):

Visual Search ◽

Problem Solving ◽

Process Data ◽

Scientific Problem ◽

Domain Specific ◽

Scientific Problem Solving ◽

Before And After ◽

Verbal Data ◽

Psychological Knowledge ◽

Problem Solving Task

This study compared individuals with pairs in a scientific problem-solving task. Participants interacted with a virtual psychological laboratory called Virtue to reason about a visual search theory. To this end, they created hypotheses, designed experiments, and analyzed and interpreted the results of their experiments in order to discover which of five possible factors affected the visual search process. Before and after their interaction with Virtue, participants took a test measuring theoretical and methodological knowledge. In addition, process data reflecting participants’ experimental activities and verbal data were collected. The results showed a significant but equal increase in knowledge for both groups. We found differences between individuals and pairs in the evaluation of hypotheses in the process data, and in descriptive and explanatory statements in the verbal data. Interacting with Virtue helped all students improve their domain-specific and domain-general psychological knowledge.

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Emotions and health: The impact of emotions, emotions regulation, music, and acculturation on health

Zeitschrift für Gesundheitspsychologie ◽

10.1026/0943-8149.16.3.112 ◽

2008 ◽

Vol 16 (3) ◽

pp. 112-115 ◽

Cited By ~ 1

Author(s):

Stephan Bongard ◽

Volker Hodapp ◽

Sonja Rohrmann

Keyword(s):

Stress Responses ◽

Physiological Stress ◽

Anger Expression ◽

Domain Specific ◽

Cardiovascular Stress ◽

Expression Behavior ◽

Cardio Vascular ◽

And Coping ◽

Relationship Of ◽

The Impact

Abstract. Our unit investigates the relationship of emotional processes (experience, expression, and coping), their physiological correlates and possible health outcomes. We study domain specific anger expression behavior and associated cardio-vascular loads and found e.g. that particularly an open anger expression at work is associated with greater blood pressure. Furthermore, we demonstrated that women may be predisposed for the development of certain mental disorders because of their higher disgust sensitivity. We also pointed out that the suppression of negative emotions leads to increased physiological stress responses which results in a higher risk for cardiovascular diseases. We could show that relaxation as well as music activity like singing in a choir causes increases in the local immune parameter immunoglobuline A. Finally, we are investigating connections between migrants’ strategy of acculturation and health and found e.g. elevated cardiovascular stress responses in migrants when they where highly adapted to the German culture.

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Measurement Invariance of Divergent Thinking Across Gender, Age, and School Forms

European Journal of Psychological Assessment ◽

10.1027/1015-5759.25.1.1 ◽

2009 ◽

Vol 25 (1) ◽

pp. 1-7 ◽

Cited By ~ 12

Author(s):

Jörg-Tobias Kuhn ◽

Heinz Holling

Keyword(s):

Measurement Invariance ◽

Divergent Thinking ◽

Factor Model ◽

Age Groups ◽

Thinking Skills ◽

Specific Model ◽

Confirmatory Factor Analyses ◽

Domain Specific ◽

Gender And Age ◽

Confirmatory Factor

The present study explores the factorial structure and the degree of measurement invariance of 12 divergent thinking tests. In a large sample of German students (N = 1328), a three-factor model representing verbal, figural, and numerical divergent thinking was supported. Multigroup confirmatory factor analyses revealed that partial strong measurement invariance was tenable across gender and age groups as well as school forms. Latent mean comparisons resulted in significantly higher divergent thinking skills for females and students in schools with higher mean IQ. Older students exhibited higher latent means on the verbal and figural factor, but not on the numerical factor. These results suggest that a domain-specific model of divergent thinking may be assumed, although further research is needed to elucidate the sources that negatively affect measurement invariance.

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