CLINICOPATHOLOGIC PROFILE OF NONNEOPLASTIC AND NEOPLASTIC LESIONS OF SALIVARY GLANDS

2020 ◽  
Vol 129 (1) ◽  
pp. e154-e155
Author(s):  
JULIANNA MENDES SALES ◽  
JOSÉ WITTOR DE MACÊDO SANTOS ◽  
MANOEL PEREIRA DE LIMA ◽  
MANUEL ANTONIO GORDÓN-NÚÑEZ
Keyword(s):  
Salivary Glands ◽  
Neoplastic Lesions ◽  
Clinicopathologic Profile

scholarly journals Intraoperative frozen section as a reliable ancillary technique in salivary gland surgery: A cross sectional study

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 231 ◽  
Author(s):  
Andrea Marzullo ◽  
Gabriella Serio ◽  
Luigi Madami ◽  
Federica Pezzuto ◽  
Francesco Fortarezza ◽  
...  
Keyword(s):  
Decision Making ◽  
Salivary Glands ◽  
Frozen Section ◽  
Definitive Diagnosis ◽  
Malignant Neoplasms ◽  
Malignant Tumours ◽  
Benign Lesions ◽  
Cross Sectional ◽  
Good Ability ◽  
Neoplastic Lesions

Background.Salivary glands tumours are uncommon, frequently benign lesions, prevalently located in the parotid gland (80%). Surgical decision making is based on the patient’s history, examination findings, imaging and fine needle aspiration (FNA). FNA is a pre-operative method with good ability in detecting malignancy.  During surgery, therefore, Frozen section (FS) can differentiate benign lesions from malignant tumours, to reduce incorrect treatments, to increase the chances of conservative surgery and to better evaluate surgical margins. The aim of our study is to demonstrate the accuracy of the FS procedure in surgery of the salivary glands and to stress the need for dedicated pathology units specialized in lesions of the oral cavity.Methods.  The study included 499 patients who underwent surgery from May 2005 and October 2014. An intra-operative frozen section procedure was done for 288 of them. All frozen sections were compared with the final results. The cases were classified by site, nature of the lesion and histotype, according to the WHO classification. Comparison was made between the intra-operative and the definitive diagnosis.Results.Of the 288 FS procedures, 259 were for neoplastic lesions, 199 of which benign and 60 malignant, and 29 for non-neoplastic lesions.  Of the 259 neoplastic FS results, 2 were shown to be false positives and 2 were diagnosed as different malignant types.  Of the 29 non-neoplastic FS results, 4 were false negatives.Conclusions.Our results showed that the accuracy of frozen section procedure is 98% for salivary glands tumors. The highest concordance between frozen section and the definitive diagnosis was for inflammatory processes (99%), pleomorphic adenoma (98%), Warthin’s tumor (97%) and malignant neoplasms (96%). In conclusion, based on these findings, frozen section of the salivary glands may be proposed as a routine procedure and should be used in decision-making.

scholarly journals The role of ultrasound in evaluating salivary glands swellings

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Abd El-latif Ibrahim El-Rasheedy ◽  
Alaa Mohamed Abdel Rasoul Abdalla ◽  
Shaimaa Abdel-hamid Hassanein ◽  
Tarek Abdel Rahman Abdel Hafez ◽  
Heba Abdel-rehem Aboel-naga
Keyword(s):  
Computed Tomography ◽  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Diagnostic Tool ◽  
Parotid Glands ◽  
Neoplastic Lesion ◽  
Special Cases ◽  
Neoplastic Lesions

Abstract Background Viral infection is the most common cause of salivary gland swelling as mumps which mainly affects the parotid glands. Sialolithiasis is another cause of obstruction of the salivary duct. A tumor is another cause of swelling. Around 70% of salivary gland tumors arise from the parotid glands. Benign lesions represent 57% of these tumors. Three to 5% of all tumors affecting the head and neck are represented in the salivary gland. Ultrasonography is considered a basic diagnostic tool in all salivary gland swellings. Our study is to evaluate the role of ultrasound in the evaluation of salivary glands swellings in comparison with a computed tomography scan. Results A total of 80 patients aged more than 1 year old with swellings affecting the salivary glands were collected from the out-patient clinic during the period from February 2020 to February 2021. All patients underwent ultrasonography and computed tomography examination of the neck. All submandibular gland lesions presented with sialolithiasis (40 cases) (100%), and 20 cases (50%) of parotid gland swellings presented as inflammation without stone (16 cases (40%) of acute inflammation and 4 cases (10%) with recurrent inflammation), while 4 patients only presented as sialolithiasis. Neoplastic lesions were diagnosed in 16 cases of the parotid gland group. Stones less than 3 mm were detected only by computed tomography in 5 patients (12.5%) of the submandibular group. Twenty-eight cases (70%) with stones ranged in size between 3 and 6 mm. Only 11 cases (27.5%) with stones ranged in size more than 6 mm. Of the 16 parotid swellings diagnosed with neoplastic lesions, 14 parotid cases (87%) showed well-defined margins by computed tomography and ultrasonography. Conclusions Sonography is the basic diagnostic tool in salivary glands swellings. Ultrasonography should be the initial imaging modality. Only in special cases, such as stones that could not be detected by ultrasonography or a neoplastic lesion in a deep location, or bone infiltration, computed tomography neck should be performed.

scholarly journals Diagnostic Accuracy of Fine Needle Aspiration Cytology in Lesions of Oral Cavity and Salivary Glands: A Clinico-Pathological Study

2018 ◽  
Vol 12 (1) ◽  
pp. 782-790 ◽  
Author(s):  
Shubhangi Shalley ◽  
Nasib Chand ◽  
Amit Aggarwal ◽  
Laxmi Narayan Garg ◽  
Varuni Yadav ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Oral Cavity ◽  
Salivary Glands ◽  
Hard Palate ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Neoplastic Lesions ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity

Objective: Fine Needle Aspiration Cytology (FNAC) is a rapid, reliable and safe diagnostic tool used for various lesions of the oral cavity and salivary glands. The present study was undertaken to categorize the cytomorphology of the oral cavity and salivary gland lesions on FNAC and to assess the accuracy of FNAC in arriving at a diagnosis. Materials and Methods: A prospective study on oral cavity swellings and salivary gland aspirates was done during a 2 year period from August 2015 to July 2017 in which a total of 70 FNAC’s were performed. There were 12 aspirates obtained from oral cavity swellings and 58 aspirates were obtained from salivary glands. Histopathological evaluation of 65 lesions was done and was considered as gold standard. Only the lesions undergoing histopathological confirmation were included in the study. The sensitivity, specificity, diagnostic accuracy and clinical utility index were evaluated for accuracy of FNAC. Results: Hard palate (33.33%) was the predominantly aspirated site in the oral cavity. Parotid gland was the predominant gland aspirated (60.32%) among the involved salivary glands. Non-neoplastic lesions constituted 18.47% cases whereas neoplastic lesions were 81.53% (60.00% benign and 21.53% malignant). Pleomorphic adenoma (28.65%) was the most common benign lesion in the oral cavity involving hard palate and as salivary gland neoplasm (70.54%). Squamous cell carcinoma (60%) was the most common malignant lesion of oral cavity involving the tongue and buccal mucosa and adenoid cystic carcinoma (44.45%) was the commonest malignancy in salivary gland malignant neoplasms. The overall sensitivity, specificity and accuracy of FNAC in the present study were 89.5%, 100% and 85% respectively. Conclusion: FNAC is a safe, cost-effective and reliable technique effective in diagnosing the spectrum of different lesions in the oral and maxillofacial region.

scholarly journals CLINICOPATHOLOGICAL STUDY OF SALIVARY GLAND SWELLING

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Akshay Akulwar ◽  
Akshay Bavikatte
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Inflammatory Diseases ◽  
Late Presentation ◽  
Final Decision ◽  
X Rays ◽  
Sublingual Gland ◽  
The World ◽  
Neoplastic Lesions

Introduction: Although the salivary, sweat, apocrine, and mammary glands all have similar phylogeny and cellular phenotypes, many lesions are unique to the salivary glands.  Various studies around the world reported incidence for all salivary glands tumors to be between 0.4 and 13.5 cases/100,000. Salivary gland swellings can be broadly classified into inflammatory, non- inflammatory and neoplastic swellings. Acute inflammatory conditions generally can be diagnosed by history and physical examination alone, whereas chronic inflammatory diseases and granulomatous disorders require supplemental diagnostic information including lab tests, imaging studies and biopsy. Accurate pathological diagnosis is necessary for proper management of neoplastic disorders. In this part of the world, the problem of these tumours is more troublesome in management because of their late presentation due to poor economic condition and lack of awareness of health among the general population. It is important to note that diffuse swellings usually signify disease of inflammatory nature. Discrete swelling within the gland usually indicates neoplasia and rarely replace entire gland until very late. Submandibular gland tumours are twice as likely to be malignant, compared to parotid. Sublingual gland tumours are unusual, 80% are malignant.  Material and Methods: Patients included were those admitted to surgical wards with salivary gland swellings due to obstructions of the salivary duct and neoplasia and were willing to participate in the study for investigation and treatment. Patients, hemoglobin level, bleeding time, clotting time, urine, sugar albumin, microscopy, chest screening, ECG, Blood urea, serum Creatinine, RBS was estimated. Specific investigations like FNAC, X-rays of Mandible were done for all patients in the study group. After evaluation of the swellings by clinical examination and by specific investigations, a surgical plan was formulated. The final decision was taken per operatively by the surgeon. The required specimen was sent for histopathologocal examinations. Different modalities of treatment adopted in this study were, surgery or surgery and post-operative radiotherapy. Results: Age of the patients varied from 9 years to 80 years. Average age of the patient was 40.6 years. Out of 40 cases 15(35%) cases was of male and 25(65%) cases of female. 62.5% (25 cases) were found in the parotid gland, 30% cases (12) in submandibular gland and 7.5% cases (3) in the sublingual gland. Out of 40 cases, neoplastic lesions of 65.0 %( 25 cases) and non-inflammatory non neoplastic lesions of 37.5% (15 cases) were seen. Out of 25 salivary gland Keywords: SALIVARY GLAND, TUMOUR, MALIGNANT, BENIGN, FNAC, HISTOPATHOLOGY

Ultrastructural Analysis of the Salivary Glands of Gromphadorhina Portentosa (Schaum)

1977 ◽  
Vol 35 ◽  
pp. 638-639
Author(s):  
P.J. Dailey
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Salivary Glands ◽  
Secretory Vesicles ◽  
The Past ◽  
Transmission Electron ◽  
Means Of Transmission ◽  
Gromphadorhina Portentosa ◽  
Scanning Electron ◽  
Topographical Relief

The structure of insect salivary glands has been extensively investigated during the past decade; however, none have attempted scanning electron microscopy (SEM) in ultrastructural examinations of these secretory organs. This study correlates fine structure by means of SEM cryofractography with that of thin-sectioned epoxy embedded material observed by means of transmission electron microscopy (TEM).Salivary glands of Gromphadorhina portentosa were excised and immediately submerged in cold (4°C) paraformaldehyde-glutaraldehyde fixative1 for 2 hr, washed and post-fixed in 1 per cent 0s04 in phosphosphate buffer (4°C for 2 hr). After ethanolic dehydration half of the samples were embedded in Epon 812 for TEM and half cryofractured and subsequently critical point dried for SEM. Dried specimens were mounted on aluminum stubs and coated with approximately 150 Å of gold in a cold sputtering apparatus.Figure 1 shows a cryofractured plane through a salivary acinus revealing topographical relief of secretory vesicles.

Automated Image Analysis Of Nuclear And Cytoplasmic Changes In Exfoliated Cells From Tracheas Treated With Carcinogen

1977 ◽  
Vol 35 ◽  
pp. 220-221
Author(s):  
S.F. Stinson ◽  
J.C. Lilga ◽  
M.B. Sporn
Keyword(s):  
Image Analysis ◽  
Pattern Analysis ◽  
Relative Proportion ◽  
Automated Image Analysis ◽  
Image Analyzer ◽  
Cross Sectional ◽  
Exfoliated Cells ◽  
Neoplastic Lesions ◽  
Analysis System ◽  
Morphologic Criterion

Increased nuclear size, resulting in an increase in the relative proportion of nuclear to cytoplasmic sizes, is an important morphologic criterion for the evaluation of neoplastic and pre-neoplastic cells. This paper describes investigations into the suitability of automated image analysis for quantitating changes in nuclear and cytoplasmic cross-sectional areas in exfoliated cells from tracheas treated with carcinogen.Neoplastic and pre-neoplastic lesions were induced in the tracheas of Syrian hamsters with the carcinogen N-methyl-N-nitrosourea. Cytology samples were collected intra-tracheally with a specially designed catheter (1) and stained by a modified Papanicolaou technique. Three cytology specimens were selected from animals with normal tracheas, 3 from animals with dysplastic changes, and 3 from animals with epidermoid carcinoma. One hundred randomly selected cells on each slide were analyzed with a Bausch and Lomb Pattern Analysis System automated image analyzer.

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