First and second pregnancy outcomes in women with class III obesity: An observational cohort study

Background Ongoing technological advancements have allowed the resolution of ultrasound imaging in the first trimester to evolve to a level at which early fetal development can be assessed and monitored in detail. Objective To find a relation between first-trimester ultrasound fetal measurements and adverse pregnancy outcomes. Subjects and Methods A prospective observational cohort study conducted on 500 pregnant women at 1st trimester attending ANC clinic of obs& gyne. department of Al-Azhar university hospital (Assiut -Egypt). Ultrasound measurements of early fetal parameter GSD, CRL and YSD at 5-12 weeks of gestation were done. Results of measurements were classified into three classes, class A<10th centile, class B 10th-90th centile and Class C>90th centile. Patients were followed up throughout pregnancy to determine normal and abnormal outcomes in each class. Comparison between different classes was made to show association with abnormal pregnancy outcomes. Results Early fetal ultrasonographic parameters class A & C were significantly associated with 1st, 2nd-trimester abortions, IUFD, APH and PROM (p<0.001) with no significant association between these parameters and other pregnancy outcomes (p>0.05). Conclusion Our study emphasizes the role of early ultrasound in predicting abnormal pregnancy outcomes it could be useful to obstetricians to anticipate adverse outcomes and being warned to manage prenatal care and delivery more appropriately. Recommendation Early fetal ultrasound should be used as a tool to predict pregnancy outcome so as to manage prenatal care and delivery more efficiently

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Impact of prepregnancy body mass index on pregnancy outcomes, incidence of urinary incontinence and quality of life during pregnancy - An observational cohort study

Biomedical Journal ◽

10.1016/j.bj.2019.11.001 ◽

2020 ◽

Author(s):

Ching-Chung Liang ◽

Minston Chao ◽

Shuenn-Dhy Chang ◽

Sherry Yueh-Hsia Chiu

Keyword(s):

Quality Of Life ◽

Body Mass Index ◽

Urinary Incontinence ◽

Cohort Study ◽

Body Mass ◽

Pregnancy Outcomes ◽

Observational Cohort Study ◽

Prepregnancy Body Mass Index ◽

Observational Cohort

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Serum 25-hydroxyvitamin D levels in relation to lipids and clinical outcomes in pregnant women with gestational diabetes mellitus: an observational cohort study

BMJ Open ◽

10.1136/bmjopen-2020-039905 ◽

2020 ◽

Vol 10 (11) ◽

pp. e039905

Author(s):

Wenqing Chen ◽

Yuan Li ◽

Bo Gao ◽

Jie Li ◽

Mingming Zheng ◽

...

Keyword(s):

Diabetes Mellitus ◽

Cohort Study ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnancy Outcomes ◽

Density Lipoprotein ◽

Observational Cohort Study ◽

Hydroxyvitamin D ◽

Observational Cohort ◽

25 Hydroxyvitamin D

ObjectiveThe aim of the present study was to investigate whether 25-hydroxyvitamin D (25(OH)D) status at 24–28 weeks is associated with blood lipids and pregnancy outcomes in patients with gestational diabetes mellitus (GDM).DesignWe performed an observational cohort study.SettingThe study was conducted in China.ParticipantsA total of 261 pregnant women diagnosed with GDM at 24–28 weeks of gestation in our hospital were included between June 2015 and December 2017. According to the levels of 25(OH)D, the women were divided into the G1 (<20 ng/mL) and G2 (≥20 ng/mL) groups. The levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), TG/HDL-c and TC/HDL-c ratios were obtained from medical records. Pregnancy outcomes included gestational weeks of birth and delivery mode. Newborn information included birth weight and body length. Differences between groups were tested with adjusted multiple linear regression.ResultsThe serum levels of 25(OH)D (14.1±3.4 ng/mL vs 28.5±6.5 ng/mL, p<0.001), TC (5.3±0.9 vs 5.6±0.8, p=0.006), HDL-c (1.8±0.4 vs 1.9±0.4, p=0.046) and LDL-c (2.5±0.6 vs 2.7±0.7, p=0.015) in the G2 group were significantly higher than those in G1 group, while TG/HDL-c ratios (1.43±0.7 vs 1.26±0.7, p=0.035) were significantly higher in the G1 group. Moreover, we failed to find a significant difference in pregnancy outcomes of mothers and newborns among the two groups (p>0.05). In models adjusting for maternal age, parity, height, blood pressure, socioeconomic status, educational attainment, pre-pregnancy body mass index, season and gestational age, maternal 25(OH)D was associated with TG/HDL-c ratios (B=−0.016; 95% CI= −0.025 to –0.006).ConclusionWe found that there was no relationship between vitamin D and pregnancy/neonatal outcomes in our study. Maternal 25(OH)D at 24–28 weeks was inversely associated with TG/HDL-c ratios.

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