Pancreatic calcifications associate with diverse aetiological risk factors in patients with chronic pancreatitis: A multicentre study of 1500 cases

Aim. To determine clinical features and some mechanisms of osteosarcopenia development in patients with chronic pancreatitis (CP). Materials and methods. A casecontrol study was conducted on the basis of the Saratov State Clinical Hospital 5 in 20152018 of patients with CP. In a study of 161 patients with CP included, the control group 30 healthy individuals. Patients were divided into groups according to the etiology of CP: 79 with toxic-metabolic CP, 82 with biliary CP. To determine the risks of low-energy fractures, 154 patients were tested with the Fracture risk assessment tool (FRAX). Along with the standard examination, 30 patients with CP dual-energy X-ray absorptiometry was performed. To assess the state of skeletal muscles, body mass index was determined, hand-held dynamometry was performed, and a set of Short Physical Performance Battery (SPPB) tests was used. Along with the assessment of traditional risk factors for osteosarcopenia gender, age, state of reproductive function in women, body mass index, functional state of the pancreas (pancreas) the quantitative content of interleukins (IL)-2, 6, 8 in in colonic biopsies was analyzed by enzyme-linked immunosorbent assay (ELISA). Results. Bone disorders, according to densitometry, was detected in 70.0% of patients with CP, in 13.3% of the control group. Presarcopenia was detected in 62 (38.5%) patients with CP, sarcopenia in 34 (21.1%), in the control group presarcopenia and sarcopenia were not detected. Sarcopenia was statistically significantly more common in toxic-metabolic CP than in biliary CP (2=11.6; p0.001). Correlations of the lumbar spine T-score and IL-6 (r=-0.29; p=0.03), IL-8 (r=-0.29; p=0.04) were revealed. Correlations between sarcopenia and the concentration of cytokines in the in the colon mucosa in CP were determined (IL-2: r=0.44; p0.001; IL-6: r=0.48; p0.001; IL-8: r=0.42; p0.001). Conclusion. The development of osteopenia and sarcopenia syndromes in CP is interrelated and associated with both traditional risk factors and an increased concentration of cytokines in the in the colon mucosa.

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Risk Factors for Distal Contegra Stenosis: Results of a Prospective European Multicentre Study

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0031-1298062 ◽

2012 ◽

Vol 60 (03) ◽

pp. 195-204 ◽

Cited By ~ 14

Author(s):

Dietmar Boethig ◽

Christian Schreiber ◽

Mark Hazekamp ◽

Ute Blanz ◽

Rene Prêtre ◽

...

Keyword(s):

Risk Factors ◽

Multicentre Study

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Risk factors for fecal carriage of IMP-6-producing Enterobacteriaceae at a long-term care hospital in Japan: A follow-up report from the northern Osaka multicentre study group

Journal of Infection and Chemotherapy ◽

10.1016/j.jiac.2018.03.009 ◽

2018 ◽

Vol 24 (9) ◽

pp. 769-772 ◽

Cited By ~ 7

Author(s):

Hideharu Hagiya ◽

Norihisa Yamamoto ◽

Ryuji Kawahara ◽

Yukihiro Akeda ◽

Rathina Kumar Shanmugakani ◽

...

Keyword(s):

Risk Factors ◽

Multicentre Study ◽

Long Term Care ◽

Study Group ◽

Care Hospital ◽

Term Care ◽

Fecal Carriage

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Risk factors for intensive care admission in children with severe acute asthma in the Netherlands: a prospective multicentre study

ERJ Open Research ◽

10.1183/23120541.00126-2020 ◽

2020 ◽

Vol 6 (3) ◽

pp. 00126-2020 ◽

Cited By ~ 1

Author(s):

Shelley A. Boeschoten ◽

Annemie L. Boehmer ◽

Peter J. Merkus ◽

Joost van Rosmalen ◽

Johan C. de Jongste ◽

...

Keyword(s):

Risk Factors ◽

Intensive Care ◽

The Netherlands ◽

Multicentre Study ◽

Tobacco Smoke ◽

Acute Asthma ◽

Significant Risk ◽

General Ward ◽

Tobacco Smoke Exposure ◽

Severe Acute Asthma

RationaleSevere acute asthma (SAA) can be fatal, but is often preventable. We previously observed in a retrospective cohort study, a three-fold increase in SAA paediatric intensive care (PICU) admissions between 2003 and 2013 in the Netherlands, with a significant increase during those years of numbers of children without treatment of inhaled corticosteroids (ICS).ObjectivesTo determine whether steroid-naïve children are at higher risk of PICU admission among those hospitalised for SAA. Furthermore, we included the secondary risk factors tobacco smoke exposure, allergic sensitisation, previous admissions and viral infections.MethodsA prospective, nationwide multicentre study of children with SAA (2–18 years) admitted to all Dutch PICUs and four general wards between 2016 and 2018. Potential risk factors for PICU admission were assessed using logistic regression analyses.Measurements and main results110 PICU and 111 general ward patients were included. The proportion of steroid-naïve children did not differ significantly between PICU and ward patients. PICU children were significantly older and more exposed to tobacco smoke, with symptoms >1 week prior to admission. Viral susceptibility was not a significant risk factor for PICU admission.ConclusionsChildren with SAA admitted to a PICU were comparable to those admitted to a general ward with respect to ICS treatment prior to admission. Preventable risk factors for PICU admission were >7 days of symptoms without adjustment of therapy and exposure to tobacco smoke. Physicians who treat children with asthma must be aware of these risk factors.

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