Osteosarcopenia in chronic pancreatitis

Aim. To determine clinical features and some mechanisms of osteosarcopenia development in patients with chronic pancreatitis (CP). Materials and methods. A casecontrol study was conducted on the basis of the Saratov State Clinical Hospital 5 in 20152018 of patients with CP. In a study of 161 patients with CP included, the control group 30 healthy individuals. Patients were divided into groups according to the etiology of CP: 79 with toxic-metabolic CP, 82 with biliary CP. To determine the risks of low-energy fractures, 154 patients were tested with the Fracture risk assessment tool (FRAX). Along with the standard examination, 30 patients with CP dual-energy X-ray absorptiometry was performed. To assess the state of skeletal muscles, body mass index was determined, hand-held dynamometry was performed, and a set of Short Physical Performance Battery (SPPB) tests was used. Along with the assessment of traditional risk factors for osteosarcopenia gender, age, state of reproductive function in women, body mass index, functional state of the pancreas (pancreas) the quantitative content of interleukins (IL)-2, 6, 8 in in colonic biopsies was analyzed by enzyme-linked immunosorbent assay (ELISA). Results. Bone disorders, according to densitometry, was detected in 70.0% of patients with CP, in 13.3% of the control group. Presarcopenia was detected in 62 (38.5%) patients with CP, sarcopenia in 34 (21.1%), in the control group presarcopenia and sarcopenia were not detected. Sarcopenia was statistically significantly more common in toxic-metabolic CP than in biliary CP (2=11.6; p0.001). Correlations of the lumbar spine T-score and IL-6 (r=-0.29; p=0.03), IL-8 (r=-0.29; p=0.04) were revealed. Correlations between sarcopenia and the concentration of cytokines in the in the colon mucosa in CP were determined (IL-2: r=0.44; p0.001; IL-6: r=0.48; p0.001; IL-8: r=0.42; p0.001). Conclusion. The development of osteopenia and sarcopenia syndromes in CP is interrelated and associated with both traditional risk factors and an increased concentration of cytokines in the in the colon mucosa.

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APOA5 genetic and epigenetic variability jointly regulate circulating triacylglycerol levels

Clinical Science ◽

10.1042/cs20160433 ◽

2016 ◽

Vol 130 (22) ◽

pp. 2053-2059 ◽

Cited By ~ 7

Author(s):

Iris Oliva ◽

Montse Guardiola ◽

Joan-Carles Vallvé ◽

Daiana Ibarretxe ◽

Núria Plana ◽

...

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Body Mass ◽

Cpg Island ◽

Epigenetic Variability ◽

Traditional Risk Factors ◽

Capacity Prediction

The sum of APOA5 polymorphisms (S19W, -1131T>C and 724C>G) and methylation information of the CpG island in APOA5 exon3 to traditional risk factors (age, sex and body mass index), improves ∼7% the gene capacity prediction of plasma triacylglycerols.

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Risk factors and AGTR1 gene polymorphism (1166A>C) in patients with essential hypertension

Bukovinian Medical Herald ◽

10.24061/2413-0737.xxiv.4.96.2020.109 ◽

2020 ◽

Vol 24 (4 (96)) ◽

pp. 99-104

Author(s):

M. Semianiv

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Body Mass Index ◽

Essential Hypertension ◽

Diastolic Blood Pressure ◽

Body Mass ◽

Control Group ◽

Blood Pressure Elevation ◽

A1166c Polymorphism ◽

Gender And Age

Objective – to analyze the association of risk factors with the 1666 A>C polymorphism of the AGTR1 gene in patients with essential hypertension.Material and methods. 100 patients were screened, 72 of whom were genotyped. The control group consisted of 48 healthy individuals who did not differ in gender and age, and with the group of patients.Results. The obtained data confirmed that the level of blood pressure elevation is associated, to some extent, with modified (diabetes mellitus 2, smoking, body mass index) and unmodified factors (family history, gender) the risk of essential hypertension. The results of the analysis of blood pressure levels considering the A1166C polymorphism of the AGTR1 gene showed that the values of systolic and diastolic blood pressure in the group of patients with C-allele carriers were higher than in carriers of AA genotype: SBP – by 5.38% (p<0.05), DBP – by 5.15% (p<0.05). Conclusions. The level of blood pressure in patients with essential hypertension depends on body mass index and smoking. In carriers of the C-allele of the AGTR1 gene (A1166C), the level of systolic and diastolic blood pressure exceeds the ones of the carriers of the AA genotype. The presence of the C-allele of the AGTR1 gene (A1166C) almost doubles the risk of severe essential hypertension [OR = 2.75; p = 0.037].

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Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study

BioMed Research International ◽

10.1155/2017/4875026 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Wei Yang ◽

Yun Li ◽

Tian Tian ◽

Li Wang

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Weight Control ◽

Normal Glucose Tolerance ◽

Normal Weight ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Diabetic Patients ◽

Clinical Trial Registration ◽

Cross Sectional

Aims. This study was to evaluate the association of serum vaspin concentrations with body mass index (BMI) among elderly patients (>60 years old). Methods. A total of 227 elderly individuals included 76 healthy with normal glucose tolerance, which divided into normal weight control (BMI < 25, n=38) and overweight or obese control (BMI ≥ 25, n=38) subgroups, and 150 T2DM patients, which divided into normal weight diabetes (BMI < 25, n=55), overweight diabetes (30 > BMI ≥ 25, n=52), and obese diabetes (BMI ≥ 30, n=43) subgroups. Relevant parameters were matched for age and gender ratio. Serum vaspin concentrations were measured by enzyme-linked immunosorbent assay. Results. Serum vaspin concentration was significantly higher in the T2DM than the healthy (451.9±32.6 versus 284.2±21.7, P<0.01). In the diabetic patients, the vaspin concentration was significantly higher in the obese group than the normal weight group (498.2±17.1 versus 382.1±21.3, P<0.05). In addition, the concentration of vaspin in normal weight T2DM was higher than in healthy control group with normal weight (382.1±21.3 versus 192.5±45.2, P<0.05). Multiple regression analysis revealed that BMI was independent factors influencing the serum vaspin concentration in all participants. Conclusion. Vaspin may play an important compensatory role in obesity and insulin resistance in elderly people. The clinical trial registration number is ChiCTR-OPC-14005698.

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EVALUATION OF GALECTIN-3 LEVELS IN OBESE ADOLESCENTS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i3.130 ◽

2019 ◽

Vol 3 (3) ◽

Author(s):

Hüseyin Dag ◽

Nevin Cetin Dag ◽

Emine Turkkan ◽

Ebru Misirli Ozdemir ◽

Okan Dikker

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Obese Adolescent ◽

Adolescent Group ◽

Obese Adolescents ◽

Significant Difference ◽

Galectin 3 ◽

Healthy Control

Background: Galectin-3 is a member of the family of soluble beta-galactoside binding lectins, which is involved in inflammation, cell differentiation, adhesion, proliferation, angiogenesis and cancer cell invasion. Increased galectin-3 levels in obese patients have been shown in previous studies. In our study; we aimed to investigate the galectin-3 levels in obese adolescents for the first time in the literature. Materials and methods: A total of 85 adolescent patients who were admitted to our pediatrics outpatient clinic between December 19th of 2018 and January 31st of 2019 were included in our study. Among those patients 52 were obese and 33 were normal-weighted. Adolescents having body mass index (BMI) 95% percentile and above according to their age and sex were defined as obese. Enzyme-Linked Immunosorbent Assay kit was used for the measurement of galectin-3 in serum. Laboratory tests (Galectin-3, HbA1c, glucose, insulin, HOMA-IR), sex, age and BMI were statistically compared between groups. Results: We found no statistically significant difference in terms of gender distribution rates, age, glucose or galectin-3 levels among obese adolescent and healthy control groups (p> 0.05). The BMI, HbA1c, HOMA-IR and insulin levels of the obese adolescent group were found to be significantly higher than the healthy control group (p <0.05). We found no statistically significant correlation between galectin-3 levels and other parameters in obese adolescent group (p> 0.05). Conclusion: In our study, we did not find any relationship between serum galectin-3 levels and obesity in adolescents. We believe that the effects of galectin-3 levels on obesity in adolescents should be more clearly explained by further investigations, which also measures other biomarkers of the mechanism of action. Keywords: Galectin-3, obesity, adolescent List of abbreviations: BMI: Body-Mass Index, CV: Variation coefficient, ELISA: Enzyme linked immunoassay, HOMA-IR: Homeostatic model of assessment-insulin resistance, IL: Interleukin, r: Correlation coefficient, SD: Standard deviation.

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The role of «hunger hormone» in the regulation of eating behavior in patients with Parkinson’s disease

Ukrainian Neurological Journal ◽

10.30978/unj2021-1-2-25 ◽

2021 ◽

Author(s):

K. A. Tarianyk

Keyword(s):

Parkinson’S Disease ◽

Body Mass Index ◽

Parkinson's Disease ◽

Body Mass ◽

Eating Behavior ◽

Disease Duration ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Clear Correlation ◽

Group 2

Objective — to evaluate the correlation between ghrelin levels, body mass index and the course of the disease in patients with Parkinson’s disease Methods and subjects. We examined 40 patients with Parkinson’s disease and 20 patients without signs of neurodegenerative disease (control group), who were examined and admitted to the neurological department. Patients were distributed into groups: 1 group — 20 patients with a disease duration of 12.1 ± 2.3 years, group 2 — 20 patients with a disease duration of 7.3 ± 1.6 years, group 3 — control, 20 patients without signs of morbidity. The diagnosis was made according to the criteria of the World Brain Bank of Great Britain. The severity of the disease was determined by the Hen and Yar scale. All patients, after signing the consent agreement, underwent a general clinical, neurological examination with assessment of anthropometric parameters: height, weight, body mass index. Also, patients underwent laboratory determination of serum ghrelin levels using the method of enzyme‑linked immunosorbent assay (ELISA) on the basis of the Research Institute of Genetic, Immunological Basis of Pathology and Pharmacogenetics of the Ukrainian Medical Dental Academy. Results. Studies indicate that in the group of patients with a longer course of the disease (group 1) there was an increase in BMI, which can be interpreted as obesity or overweight, compared with group 2 and control, where the rate was normal. In group 2, where the duration of the disease was shorter, there was a decrease in BMI, accompanied by weight loss of patients. In each group of examined patients there were patients with different forms of the disease, but in the second group patients with akinetic‑rigid form of the disease prevailed, so these patients in neurological status suffered more from stiffness, immobility. Normally, ghrelin level rises in the morning during hunger and decreases after eating. A similar picture was observed in the control group of patients, where the rate of morning ghrelin was elevated. When assessing fasting plasma ghrelin levels in groups of patients, there is a slight decrease in the indicator compared with the control group. Conclusions. There is a clear correlation between the duration of the disease, body mass index and hunger hormone levels in patients with Parkinson’s disease. In patients with the initial stages of the disease there is a decrease in body mass index, which is a prognostically unfavorable sign. Fluctuations in ghrelin levels may be associated with decreased energy intake due to gastrointestinal dysfunction, increased energy expenditure caused by motor manifestations of the disease, or increased glucose metabolism with the use of drugs and changes in the eating behavior of patients.

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Circulating ErbB3/HER3 Levels are Associated with Increased Risk of Hypertension with Overweight: A Cross-Sectional Study

10.21203/rs.3.rs-70059/v1 ◽

2020 ◽

Author(s):

Lijun Zhu ◽

Zhengmei Fang ◽

Yuelong Jin ◽

Weiwei Chang ◽

Mengyun Huang ◽

...

Keyword(s):

Blood Pressure ◽

Cardiovascular Disease ◽

Body Mass Index ◽

Body Mass ◽

Conditional Logistic Regression ◽

Cross Sectional Study ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Cross Sectional ◽

Increased Risk

Abstract Background: Hypertension and overweight are both independent risk factors for cardiovascular disease，and being overweight can more likely to develop high blood pressure. Recent research has shown that ErbB3/HER3 played a considerable role in the development of cardiovascular disease. However, ErbB3 levels effects in the hypertensive overweight patients are unknown. This study aimed to assess the association between ErbB3 levels and hypertension with overweight in Chinese population. Methods: 128 Chinese adults aged 33-79 years, both sexes, underwent evaluation of height and weight, blood pressure, biochemical indicators and ErbB3 levels. Plasma ErbB3 levels was assessed by the Enzyme-linked immunosorbent assay (ELISA), and body mass index (BMI) was calculated as body weight divided by height squared. Participants were allocated in three groups according to blood pressure and BMI: healthy control group (CNT; n = 31; normotensive and nonoverweight), hypertension group (HT; n = 33; hypertension and nonoverweight) and hypertension with overweight group (HTO; n = 64; hypertension and overweight). A 2-tailed P<0.05 was defined to be statistically significant. Results: The difference in mean of ErbB3 levels in three groups was not significant, but had a linear decrease in males, in CNT (1.13±0.36), HT (1.03±0.36) and HTO (0.84±0.26) ng/ml, with P was 0.007. In drinking population, the ErbB3 was significantly reduced in the HTO group as compared with the CNT and HT groups (0.76±0.23 versus 1.18±0.37 and 1.20±0.30, respectively). ErbB3 levels was negatively correlated with DBP in males(r=-0.293, P=0.012), in smoking populations (r=-0.47, P=0.004) and drinking populations (r=-0.387, P=0.008). Besides, BMI in males and in drinking populations and UA in males presented negatively correlations with ErbB3 (p＜0.05). The multivariate conditional logistic regression showed that plasma ErbB3 levels was associated with reduced risk for HTO in males (OR 0.054; 95% CI: 0.007-0.412) and drink group(OR 0.002; 95% CI: 0.000-0.101). Conclusions：The apparent association between lower ErbB3 levels and overweight hypertensive patients suggested that ErbB3 may contribute to the pathogenesis to hypertension with overweight, with BMI, gender, and drinking all potentially modulating the process.Keywords: ErbB3; Hypertension; Overweight; Body mass index.

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Abstract T P158: Prolonged Atrial Electrical Mechanical Delay on Echocardiography in Patients With Cryptogenic Stroke

Stroke ◽

10.1161/str.45.suppl_1.tp158 ◽

2014 ◽

Vol 45 (suppl_1) ◽

Author(s):

Dae-Hyun Kim ◽

Seong-HO Choi ◽

Jong-Seong Park ◽

Hyun-Wook Nagh ◽

Jae-Kwan Cha

Keyword(s):

Risk Factors ◽

Atrial Fibrillation ◽

Body Mass Index ◽

Logistic Regression ◽

Regression Analysis ◽

Body Mass ◽

Cryptogenic Stroke ◽

Control Group ◽

Lower Body ◽

Stroke Group

Backgrounds and Purpose: One quarter of strokes are cryptogenic, and subclinical atrial fibrillation may be a common etiologic factor. Prolonged atrial electrical-mechanical delay was known as a predictor of paroxysmal atrial fibrillation (AF). We evaluated whether the prevalence of prolonged atrial electrical-mechanical delay suggesting the presence of atrial substrates for paroxysmal AF may be higher in patients with cryptogenic stroke. Methods: We retrospectively reviewed data from patients with ischemic stroke who were admitted to our hospital between January 2011 and December 2012, and selected patients with cryptogenic stroke who underwent echocardiography. Patients who underwent echocardiography for health care examination were enrolled in control group. Age, sex and underlying risk factors were matched in two groups. Atrial electrical-mechanical delay (PA interval) was defined as the time interval (msec) from the initiation of P wave on surface electrocardiogram to the initiation of trans-mitral inflow on pulse wave Doppler echocardiogram during late diastole. Clinical significance of PA interval was evaluated. Results: Total 130 patients in cryptogenic stroke group and 130 persons in control group were enrolled. Mean age was 63 ± 11 years and 176 (68%) were male. The PR interval (178 ± 27 vs. 165 ± 27 msec, p < 0.0001) and PA interval (74 ± 15 vs. 61 ± 13 msec, p < 0.0001) were longer in cryptogenic stroke patients. The body mass index (23 ± 3 vs. 24 ± 3, p = 0.043) was lower and mitral E/E’ ratio (8.8 ± 3.0 vs. 8.0 ± 2.6 msec, p < 0.0001) was higher in cryptogenic stroke group. Prolonged PR (OR: 1.019, CI: 1.009 - 1.029, p < 0.0001) and PA (OR: 1.068, CI: 1.045 - 1.093, p < 0.0001) intervals, and lower body mass index (OR: 0.919, CI: 0.846 - 0.998) were risk factors for cryptogenic stroke in univariate logistic regression analysis. Prolonged PA (OR: 1.060, CI: 1.035 - 1.086, p < 0.0001) and PR (OR: 1.019, CI: 1.004 - 1.034, p = 0.011) intervals, and lower body mass index (OR: 0.845, CI: 0.764 - 0.935, p = 0.001) were risk factors for cryptogenic stroke in multivariate logistic regression analysis. Conclusion: The prevalence of prolonged atrial electrical-mechanical delay suggesting atrial substrates for paroxysmal AF was higher in patients with cryptogenic stroke.

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Elastin Expression is the Strongest Risk Factor for Developing Pelvic Organ Prolapse

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v1i4.367 ◽

2016 ◽

Author(s):

Djusiana Cessaria

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Risk Factor ◽

Body Mass ◽

Menopausal Status ◽

Clinical History ◽

Vaginal Wall ◽

Anterior Vaginal Wall ◽

Control Group ◽

Pelvic Prolapse

Objective: To compare elastin expression in the anterior vaginal wall of women with and with no pelvic prolapse. Methods: The research was conducted in RS Dr. Wahidin Sudirohusodo and other network hospitals of Obstetrics and Gynecology Department of Hasanuddin University, Makassar. Full-thickness specimens were obtained from the anterior vaginal wall of women having a large prolapse repaired (stage III or IV; prolapse group, 34) and the same location in patients with no prolapse having abdominal and vaginal hysterectomy (control group, 35). The expression of elastin was measured by immunohistochemistry on tissue sectioned. The examiner was unaware of sample identity and the patients’ clinical history. The result then analyzed with p 4000 gr weight (p=0.572); age, parity, menopausal status, and body mass index were significantly different between the groups (0.001; 0.035; 0.011; 0.002; respectively). Immunohistochemical staining indicated that elastin expression in the prolapse group was lower (p=0.009). Elastin expression appeared to be stable with increasing of age, parity, menopausal status, history of bearing baby 4000 gr. weight and Body mass Index in the prolapse group. But multiple logistic regression revealed that elastin have the highest influence to prolapse among the risk factors mentioned (Exp.B =6.252). Conclusion: In this case-control study, the elastin expression were significantly lower in the vaginal wall of patients with a large prolapse. Instead of influence by other risk factors, elastin is the strongest risk factor for developing prolapse among other risk factors. This result is expected to be able to give explanation for the development of prolapse in women without risk factors such is young women and nullipara. [Indones J Obstet Gynecol 2013; 1-4: 204-8] Keywords: elastin, prolapse, women

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Preterm birth is not associated with asymptomatic/mild SARS-CoV-2 infection per se: Pre-pregnancy state is what matters

PLoS ONE ◽

10.1371/journal.pone.0254875 ◽

2021 ◽

Vol 16 (8) ◽

pp. e0254875

Author(s):

Stefano Cosma ◽

Andrea Roberto Carosso ◽

Jessica Cusato ◽

Fulvio Borella ◽

Marco Carosso ◽

...

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Preterm Birth ◽

Body Mass ◽

Cumulative Incidence ◽

Control Group ◽

Case Group ◽

Chronic Hypertension ◽

The Real ◽

Significant Difference

Evidence for the real impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is unclear, as available series report composite pregnancy outcomes and/or do not stratify patients according to disease severity. The purpose of the research was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on preterm birth not due to maternal respiratory failure. This case-control study involved women admitted to Sant Anna Hospital, Turin, for delivery between 20 September 2020 and 9 January 2021. The cumulative incidence of Coronavirus disease-19 was compared between preterm birth (case group, n = 102) and full-term delivery (control group, n = 127). Only women with spontaneous or medically-indicated preterm birth because of placental vascular malperfusion (pregnancy-related hypertension and its complications) were included. Current or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and detection of IgM/IgG antibodies in blood samples. A significant difference in the cumulative incidence of Coronavirus disease-19 between the case (21/102, 20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed, although the case group was burdened by a higher prevalence of three known risk factors (body mass index > 24.9, asthma, chronic hypertension) for severe Coronavirus disease-19. Logistic regression analysis showed that asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of spontaneous and medically-indicated preterm birth due to pregnancy-related hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43). Pregnant patients without comorbidities need to be reassured that asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm delivery. Preterm birth and severe Coronavirus disease-19 share common risk factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which may explain the high rate of indicated preterm birth due to maternal conditions reported in the literature.

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Abstract 3560: Obstructive Sleep Apnea Exacerbates Endothelial Dysfunction In Patients With Metabolic Syndrome

Circulation ◽

10.1161/circ.116.suppl_16.ii_805-d ◽

2007 ◽

Vol 116 (suppl_16) ◽

Author(s):

Masahiro Akishita ◽

Yumiko Ohike ◽

Masayoshi Hashimoto ◽

Katsuya Iijima ◽

Masato Eto ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Body Mass Index ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Endothelial Dysfunction ◽

Body Mass ◽

Hdl Cholesterol ◽

Control Group ◽

Obstructive Sleep

Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) are well known as the risk factor of cardiovascular diseases, and are prevalent among obese patients. However, whether OSA deteriorates endothelial dysfunction in MS patients has not been determined. We therefore examined flow-mediated vasodilation (FMD) in MS patients with or without OSA. Methods: We enrolled 49 overweight patients (body mass index ≥25, aged 35–69 years) and categorized into the 3 groups; patients with MS but not OSA (MS group, n=21), Group 2: patients with both MS and OSA (MS+OSA group, n=14), Group 3: patients with no risk factors but overweight (control group, n=14). MS was defined using the IDF criteria and OSA using polysomnography. FMD was measured using ultrasound as the percent change of the brachial artery diameter. Results: Compared with the control group, MS group showed significantly lower %FMD (6.8±2.4 [mean±SD] vs 5.0±2.7, p<0.001) and HDL cholesterol, and higher triglycerides and hemoglobin A1c. Although there were no significant differences in classical risk factors between MS group and MS+OSA group, %FMD was significantly lower in MS+OSA group than in MS group (3.0±1.3 vs 5.0±2.7, p<0.001). On multiple regression analysis, OSA was significantly related to %FMD, independent of age, body mass index, blood pressure, LDL cholesterol, HDL cholesterol, triglycerides, fasting plasma glucose, and smoking (β=−0.328, p=0.02). Conclusion: OSA exacerbates endothelial dysfunction in patients with MS, possibly leading to the increased risk of cardiovascular disease.

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