Impact of the whey protein/casein ratio on the reconstitution and flow properties of spray-dried dairy protein powders

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

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Modification of molecular conformation of spray-dried whey protein microparticles improving digestibility and release characteristics

Food Chemistry ◽

10.1016/j.foodchem.2018.12.074 ◽

2019 ◽

Vol 280 ◽

pp. 255-261 ◽

Cited By ~ 5

Author(s):

Qianyu Ye ◽

Meng Wai Woo ◽

Cordelia Selomulya

Keyword(s):

Whey Protein ◽

Molecular Conformation ◽

Spray Dried ◽

Protein Microparticles

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Properties of partially denatured whey protein products 2: Solution flow properties

Food Hydrocolloids ◽

10.1016/j.foodhyd.2015.12.012 ◽

2016 ◽

Vol 56 ◽

pp. 218-226 ◽

Cited By ~ 14

Author(s):

Zhuo Zhang ◽

Valeria Arrighi ◽

Lydia Campbell ◽

Julien Lonchamp ◽

Stephen R. Euston

Keyword(s):

Whey Protein ◽

Flow Properties ◽

Solution Flow

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Spray-dried whey protein/lactose/soybean oil emulsions. 1. Surface composition and particle structure

Food Hydrocolloids ◽

10.1016/s0268-005x(96)80020-8 ◽

1996 ◽

Vol 10 (4) ◽

pp. 421-429 ◽

Cited By ~ 97

Author(s):

Pia Fäldt ◽

Björn Bergenståhl

Keyword(s):

Soybean Oil ◽

Whey Protein ◽

Surface Composition ◽

Particle Structure ◽

Oil Emulsions ◽

Spray Dried

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Repurposing Butenafine as An Oral Nanomedicine for Visceral Leishmaniasis

Pharmaceutics ◽

10.3390/pharmaceutics11070353 ◽

2019 ◽

Vol 11 (7) ◽

pp. 353 ◽

Cited By ~ 5

Author(s):

Adriana Bezerra-Souza ◽

Raquel Fernandez-Garcia ◽

Gabriela F. Rodrigues ◽

Francisco Bolas-Fernandez ◽

Marcia Dalastra Laurenti ◽

...

Keyword(s):

Drug Stability ◽

Drug Loading ◽

Cost Effective ◽

Angle Of Repose ◽

Proof Of Concept ◽

Flow Properties ◽

Non Invasive ◽

Long Duration ◽

Effective Drugs ◽

Spray Dried

Leishmaniasis is a neglected tropical disease affecting more than 12 million people worldwide, which in its visceral clinical form (VL) is characterised by the accumulation of parasites in the liver and spleen, and can lead to death if not treated. Available treatments are not well tolerated due to severe adverse effects, need for parenteral administration and patient hospitalisation, and long duration of expensive treatments. These treatment realities justify the search for new effective drugs, repurposing existing licensed drugs towards safer and non-invasive cost-effective medicines for VL. In this work, we provide proof of concept studies of butenafine and butenafine self-nanoemulsifying drug delivery systems (B-SNEDDS) against Leishmania infantum. Liquid B-SNEDDS were optimised using design of experiments, and then were spray-dried onto porous colloidal silica carriers to produce solid-B-SNEDDS with enhanced flow properties and drug stability. Optimal liquid B-SNEDDS consisted of Butenafine:Capryol 90:Peceol:Labrasol (3:49.5:24.2:23.3 w/w), which were then sprayed-dried with Aerosil 200 with a final 1:2 (Aerosil:liquid B-SNEDDS w/w) ratio. Spray-dried particles exhibited near-maximal drug loading, while maintaining excellent powder flow properties (angle of repose <10°) and sustained release in acidic gastrointestinal media. Solid-B-SNEDDS demonstrated greater selectivity index against promastigotes and L. infantum-infected amastigotes than butenafine alone. Developed oral solid nanomedicines enable the non-invasive and safe administration of butenafine as a cost-effective and readily scalable repurposed medicine for VL.

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Soy-Dairy Protein Blend or Whey Protein Isolate Ingestion Induces Similar Postexercise Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis Responses in Older Men

Journal of Nutrition ◽

10.3945/jn.116.231159 ◽

2016 ◽

Vol 146 (12) ◽

pp. 2468-2475 ◽

Cited By ~ 25

Author(s):

Michael S Borack ◽

Paul T Reidy ◽

Syed H Husaini ◽

Melissa M Markofski ◽

Rachel R Deer ◽

...

Keyword(s):

Protein Synthesis ◽

Whey Protein ◽

Older Men ◽

Whey Protein Isolate ◽

Protein Isolate ◽

Target Of Rapamycin ◽

Mechanistic Target Of Rapamycin ◽

Dairy Protein

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Correlation between flow properties of silica‐PVA aqueous slurries and spray‐dried granules

Journal of Rheology ◽

10.1122/1.550661 ◽

1995 ◽

Vol 39 (4) ◽

pp. 792-792

Author(s):

Toshihiro Ishimori ◽

Mamoru Senna

Keyword(s):

Flow Properties ◽

Spray Dried

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SPRAY DRIED LACTOSE BASED PRONIOSOMES AS STABLE PROVESICULAR DRUG DELIVERY CARRIERS: SCREENING, FORMULATION, AND PHYSICOCHEMICAL CHARACTERIZATION

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2018v10i5.27732 ◽

2018 ◽

Vol 10 (5) ◽

pp. 125 ◽

Cited By ~ 2

Author(s):

Ali Nasr ◽

Mona Qushawy ◽

Shady Swidan

Keyword(s):

Drug Delivery ◽

Particle Size ◽

Zeta Potential ◽

Oral Drug Delivery ◽

Physicochemical Characterization ◽

Water Soluble ◽

Oral Drug ◽

Flow Properties ◽

Poorly Water Soluble ◽

Spray Dried

Objective: In the present investigation efforts were considered to optimize the different conditions for the preparation of spray dried lactose based proniosomes. The aim of this research was to investigate the feasibility of proniosomes as stable precursors for the development of niosomes as oral drug delivery system for poorly water-soluble drugs.Methods: A total of twenty-eight plain proniosomal formulae were prepared with various surfactant-cholesterol loading ratios in each formula using spray dried lactose as a carrier. Span 20, 40, 60 and 80 were used in various molar ratios with cholesterol. Different evaluation techniques were performed to study the performance of the prepared proniosomes. The micromeritic properties of the prepared proniosomes were analyzed. The reconstituted niosomes were further evaluated for morphological characterization using transmission electron microscope (TEM), particle size analysis, zeta potential, and polydispersity index (PDI). Finally, selected proniosomal formulae were tested for stability study.Results: The proniosomal formulae prepared using span 40 and span 60 exhibited excellent flowability while those prepared with span 20 and span 80 showed poor flow properties. TEM photographs revealed that the vesicles were discrete, spherical without aggregation. The mean vesicle size of reconstituted niosomes was found to be in the range between (252.9±0.43–624.3±0.23 nm) with perfect PDI values (0.387±0.05–0.835±0.03). The negative values of zeta potential indicated that all prepared formulae were stabilized by electrostatic repulsion forces. Stability studies confirmed that proniosomes give a more stable system that could overcome the problems of standard niosomes. Formulae with the smallest particle size, higher surface charge values and best flow properties were selected to be loaded with poorly soluble drugs for further study.Conclusion: The obtained results offered evidence that spray-dried lactose based proniosomes are promising stable drug delivery carriers and ready to incorporate various poorly water-soluble drugs in order to improve their limited oral bioavailability.

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