Coxiella burnetii (Q fever) in Rattus norvegicus and Rattus rattus at livestock farms and urban locations in the Netherlands; could Rattus spp. represent reservoirs for (re)introduction?

2011 ◽  
Vol 101 (1-2) ◽  
pp. 124-130 ◽  
Author(s):  
Chantal Reusken ◽  
Rozemarijn van der Plaats ◽  
Marieke Opsteegh ◽  
Arnout de Bruin ◽  
Arno Swart
Keyword(s):  
The Netherlands ◽  
Coxiella Burnetii ◽  
Rattus Norvegicus ◽  
Q Fever ◽  
Rattus Rattus ◽  
Livestock Farms

Coxiella burnetii infections (Q fever)

2010 ◽  
pp. 923-926
Author(s):  
T.J. Marrie
Keyword(s):  
The Netherlands ◽  
Coxiella Burnetii ◽  
Rattus Norvegicus ◽  
Q Fever ◽  
Gram Negative ◽  
Sheep And Goats ◽  
Large Outbreak ◽  
The Common ◽  
Animal Reservoirs

Q fever is a zoonosis caused by Coxiella burnetii, an intracellular Gram-negative spore-forming bacterium, the common animal reservoirs of which are cattle, sheep, and goats, although in a large outbreak in the Netherlands it appears that rats, Rattus norvegicus and R. rattus, may have played a role in the spread of the condition. ...

scholarly journals Detection of Coxiella burnetii DNA in the environment during and after a large Q fever epidemic in the Netherlands

2013 ◽  
Vol 114 (5) ◽  
pp. 1395-1404 ◽  
Author(s):  
A. de Bruin ◽  
I. Janse ◽  
M. Koning ◽  
L. de Heer ◽  
R.Q.J. van der Plaats ◽  
...  
Keyword(s):  
The Netherlands ◽  
Coxiella Burnetii ◽  
Q Fever

scholarly journals Serological survey of antibodies to Toxoplasma gondii and Coxiella burnetii in rodents in north-western African islands (Canary Islands and Cape Verde)

2015 ◽  
Vol 82 (1) ◽  
Author(s):  
Pilar Foronda ◽  
Josué Plata-Luis ◽  
Borja Del Castillo-Figueruelo ◽  
Ángela Fernández-Álvarez ◽  
Aarón Martín-Alonso ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Coxiella Burnetii ◽  
Canary Islands ◽  
Q Fever ◽  
Rattus Rattus ◽  
Cape Verde ◽  
Farm Animals ◽  
Economic Losses ◽  
Enzyme Linked Immunosorbent Assay ◽  
North Western

Coxiella burnetii and Toxoplasma gondii are intracellular parasites that cause important reproductive disorders in animals and humans worldwide, resulting in high economic losses. The aim of the present study was to analyse the possible role of peridomestic small mammals in the maintenance and transmission of C. burnetii and T. gondii in the north-western African archipelagos of the Canary Islands and Cape Verde, where these species are commonly found affecting humans and farm animals. Between 2009 and 2013, 108 black rats (Rattus rattus) and 77 mice (Mus musculus) were analysed for the presence of Coxiella and Toxoplasma antibodies by enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence (IFA), respectively. Our results showed a wide distribution of C. burnetii and T. gondii, except for T. gondii in Cape Verde, in both rodent species. The overall seroprevalence of C. burnetii antibodies was 12.4%; 21.1% for Cape Verde and 10.2% for the Canary Islands. With respect to T. gondii, seropositive rodents were only observed in the Canary Islands, with an overall seroprevalence of 15%. Considering the fact that both pathogens can infect a large range of hosts, including livestock and humans, the results are of public health and veterinary importance and could be used by governmental entities to manage risk factors and to prevent future cases of Q fever and toxoplasmosis.

scholarly journals Genotypic Diversity of Coxiella burnetii in the 2007-2010 Q Fever Outbreak Episodes in The Netherlands

2011 ◽  
Vol 50 (3) ◽  
pp. 1076-1078 ◽  
Author(s):  
J. J. H. C. Tilburg ◽  
J. W. A. Rossen ◽  
E. J. van Hannen ◽  
W. J. G. Melchers ◽  
M. H. A. Hermans ◽  
...  
Keyword(s):  
The Netherlands ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Genotypic Diversity

Coxiella burnetii infection among blood donors during the 2009 Q-fever outbreak in the Netherlands

Transfusion ◽  
2011 ◽  
Vol 52 (1) ◽  
pp. 144-150 ◽  
Author(s):  
Boris M. Hogema ◽  
Ed Slot ◽  
Michel Molier ◽  
Peter M. Schneeberger ◽  
Mirjam H. Hermans ◽  
...  
Keyword(s):  
The Netherlands ◽  
Coxiella Burnetii ◽  
Blood Donors ◽  
Q Fever

scholarly journals Detection of Coxiella burnetii in Complex Matrices by Using Multiplex Quantitative PCR during a Major Q Fever Outbreak in The Netherlands

2011 ◽  
Vol 77 (18) ◽  
pp. 6516-6523 ◽  
Author(s):  
A. de Bruin ◽  
A. de Groot ◽  
L. de Heer ◽  
J. Bok ◽  
P. R. Wielinga ◽  
...  
Keyword(s):  
Bacillus Thuringiensis ◽  
The Netherlands ◽  
Quantitative Pcr ◽  
Coxiella Burnetii ◽  
Internal Control ◽  
Q Fever ◽  
Qpcr Assay ◽  
Environmental Matrices ◽  
Content Type ◽  
Control Target

ABSTRACTQ fever, caused byCoxiella burnetii, is a zoonosis with a worldwide distribution. A large rural area in the southeast of the Netherlands was heavily affected by Q fever between 2007 and 2009. This initiated the development of a robust and internally controlled multiplex quantitative PCR (qPCR) assay for the detection ofC. burnetiiDNA in veterinary and environmental matrices on suspected Q fever-affected farms. The qPCR detects threeC. burnetiitargets (icd,com1, and IS1111) and oneBacillus thuringiensisinternal control target (cry1b).Bacillus thuringiensisspores were added to samples to control both DNA extraction and PCR amplification. The performance of the qPCR assay was investigated and showed a high efficiency; a limit of detection of 13.0, 10.6, and 10.4 copies per reaction for the targetsicd,com1, and IS1111, respectively; and no cross-reactivity with the nontarget organisms tested. Screening forC. burnetiiDNA on 29 suspected Q fever-affected farms during the Q fever epidemic in 2008 showed that swabs from dust-accumulating surfaces contained higher levels ofC. burnetiiDNA than vaginal swabs from goats or sheep. PCR inhibition by coextracted substances was observed in some environmental samples, and 10- or 100-fold dilutions of samples were sufficient to obtain interpretable signals for both theC. burnetiitargets and the internal control. The inclusion of an internal control target and threeC. burnetiitargets in one multiplex qPCR assay showed that complex veterinary and environmental matrices can be screened reliably for the presence ofC. burnetiiDNA during an outbreak.

scholarly journals Screening of post-mortem tissue donors for Coxiella burnetii infection after large outbreaks of Q fever in The Netherlands

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Marja J van Wijk ◽  
D Willemijn Maas ◽  
Nicole HM Renders ◽  
Mirjam HA Hermans ◽  
Hans L Zaaijer ◽  
...  
Keyword(s):  
The Netherlands ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Post Mortem ◽  
Tissue Donors

scholarly journals Antibodies against Coxiella burnetii and pregnancy outcome during the 2007-2008 Q fever outbreaks in the Netherlands

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Wim van der Hoek ◽  
Jamie CE Meekelenkamp ◽  
Alexander CAP Leenders ◽  
Nancy Wijers ◽  
Daan W Notermans ◽  
...  
Keyword(s):  
The Netherlands ◽  
Pregnancy Outcome ◽  
Coxiella Burnetii ◽  
Q Fever

Screening for Coxiella burnetii seroprevalence in chronic Q fever high-risk groups reveals the magnitude of the Dutch Q fever outbreak

2012 ◽  
Vol 141 (4) ◽  
pp. 847-851 ◽  
Author(s):  
L. M. KAMPSCHREUR ◽  
J. C. J. P. HAGENAARS ◽  
C. C. H. WIELDERS ◽  
P. ELSMAN ◽  
P. J. LESTRADE ◽  
...  
Keyword(s):  
High Risk ◽  
The Netherlands ◽  
Confidence Interval ◽  
Coxiella Burnetii ◽  
Catchment Area ◽  
Q Fever ◽  
Risk Groups ◽  
Chronic Q Fever ◽  
Epidemic Area ◽  
Acute Q Fever

SUMMARYThe Netherlands experienced an unprecedented outbreak of Q fever between 2007 and 2010. The Jeroen Bosch Hospital (JBH) in 's-Hertogenbosch is located in the centre of the epidemic area. Based on Q fever screening programmes, seroprevalence of IgG phase II antibodies to Coxiella burnetii in the JBH catchment area was 10·7% [785 tested, 84 seropositive, 95% confidence interval (CI) 8·5–12·9]. Seroprevalence appeared not to be influenced by age, gender or area of residence. Extrapolating these data, an estimated 40 600 persons (95% CI 32 200–48 900) in the JBH catchment area have been infected by C. burnetii and are, therefore, potentially at risk for chronic Q fever. This figure by far exceeds the nationwide number of notified symptomatic acute Q fever patients and illustrates the magnitude of the Dutch Q fever outbreak. Clinicians in epidemic Q fever areas should be alert for chronic Q fever, even if no acute Q fever is reported.

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