scholarly journals Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure

Redox Biology ◽  
2014 ◽  
Vol 2 ◽  
pp. 148-155 ◽  
Author(s):  
Caroline Asselin ◽  
Anique Ducharme ◽  
Thierry Ntimbane ◽  
Matthieu Ruiz ◽  
Annik Fortier ◽  
...  
Keyword(s):  
Heart Failure ◽  
Linoleic Acid ◽  
Hdl Cholesterol ◽  
Protein Adducts ◽  
Patients With Heart Failure ◽  
Circulating Levels

Effect of cardiac resynchronization therapy on cardiotrophin-1 circulating levels in patients with heart failure

2011 ◽  
Vol 9 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Giuseppe Limongelli ◽  
Teo Roselli ◽  
Giuseppe Pacileo ◽  
Paolo Calabró ◽  
Valeria Maddaloni ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Resynchronization Therapy ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Patients With Heart Failure ◽  
Circulating Levels

scholarly journals Impaired High‐Density Lipoprotein Function in Patients With Heart Failure

2021 ◽  
Author(s):  
Johanna E. Emmens ◽  
Congzhuo Jia ◽  
Leong L. Ng ◽  
Dirk J. van Veldhuisen ◽  
Kenneth Dickstein ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cholesterol Efflux ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cholesterol Concentration ◽  
Hdl Function ◽  
Patients With Heart Failure ◽  
Hdl Functionality ◽  
Anti Inflammatory

Background We recently showed that, in patients with heart failure, lower high‐density lipoprotein (HDL) cholesterol concentration was a strong predictor of death or hospitalization for heart failure. In a follow‐up study, we suggested that this association could be partly explained by HDL proteome composition. However, whether the emerging concept of HDL function contributes to the prognosis of patients with heart failure has not been addressed. Methods and Results We measured 3 key protective HDL function metrics, namely, cholesterol efflux, antioxidative capacity, and anti‐inflammatory capacity, at baseline and after 9 months in 446 randomly selected patients with heart failure from BIOSTAT‐CHF (A Systems Biology Study to Tailored Treatment in Chronic Heart Failure). Additionally, the relationship between HDL functionality and HDL proteome composition was determined in 86 patients with heart failure. From baseline to 9 months, HDL cholesterol concentrations were unchanged, but HDL cholesterol efflux and anti‐inflammatory capacity declined (both P <0.001). In contrast, antioxidative capacity increased ( P <0.001). Higher HDL cholesterol efflux was associated with lower mortality after adjusting for BIOSTAT‐CHF risk models and log HDL cholesterol (hazard ratio, 0.81; 95% CI, 0.71–0.92; P =0.001). Other functionality measures were not associated with outcome. Several HDL proteins correlated with HDL functionality, mainly with cholesterol efflux. Apolipoprotein A1 emerged as the main protein associated with all 3 HDL functionality measures. Conclusions Better HDL cholesterol efflux at baseline was associated with lower mortality during follow‐up, independent of HDL cholesterol. HDL cholesterol efflux and anti‐inflammatory capacity declined during follow‐up in patients with heart failure. Measures of HDL function may provide clinical information in addition to HDL cholesterol concentration in patients with heart failure.

Effects of Vesnarinone on Peripheral Circulating Levels of Cytokines and Cytokine Receptors in Patients With Heart Failure

CHEST Journal ◽  
2001 ◽  
Vol 120 (2) ◽  
pp. 453-459 ◽  
Author(s):  
Anita Deswal ◽  
Nancy J. Petersen ◽  
Arthur M. Feldman ◽  
Bill G. White ◽  
Douglas L. Mann
Keyword(s):  
Heart Failure ◽  
Cytokine Receptors ◽  
Patients With Heart Failure ◽  
Circulating Levels

scholarly journals Association of HDL cholesterol and triglycerides with mortality in patients with heart failure

2009 ◽  
Vol 42 (5) ◽  
pp. 420-425 ◽  
Author(s):  
H.F.G. Freitas ◽  
E.A. Barbosa ◽  
F.H.F.P. Rosa ◽  
A.C.P. Lima ◽  
A.J. Mansur
Keyword(s):  
Heart Failure ◽  
Hdl Cholesterol ◽  
Patients With Heart Failure

scholarly journals Enlarged waist combined with elevated triglycerides (hypertriglyceridemic waist phenotype) and HDL-cholesterol in patients with heart failure

2017 ◽  
Vol 135 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Camila Weschenfelder ◽  
Aline Marcadenti ◽  
Airton Tetelbom Stein ◽  
Catarina Bertaso Andreatta Gottschall
Keyword(s):  
Heart Failure ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Hdl Cholesterol ◽  
Hypertriglyceridemic Waist ◽  
Significant Difference ◽  
Patients With Heart Failure ◽  
The Mean ◽  
Hypertriglyceridemic Waist Phenotype

ABSTRACT CONTEXT AND OBJECTIVE: The association of serum triglycerides plus waist circumference seems to be a good marker of cardiovascular risk and has been named the “hypertriglyceridemic waist” phenotype. The aim of our study was to investigate the association between the hypertriglyceridemic waist phenotype and HDL-cholesterol among patients with heart failure. DESIGN AND SETTING: Cross-sectional study in a tertiary-level hospital in southern Brazil. METHODS: We included patients with heart failure aged > 40 years. Anthropometric assessment (weight, height, waist and hip circumferences) was performed; body mass index (BMI) and waist-hip ratio were calculated and lipid measurements (serum total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides) were collected. In men and women, respectively, waist circumference ≥ 94 cm and ≥ 80 cm, and triglycerides ≥ 150 mg/dl were considered abnormal and were used to identify the hypertriglyceridemic waist phenotype. Analyses of covariance were used to evaluate possible associations between levels of HDL-cholesterol and the hypertriglyceridemic waist phenotype, according to sex. RESULTS: 112 participants were included, of whom 62.5% were men. The mean age was 61.8 ± 12.3 years and the mean ejection fraction was 40.1 ± 14.7%. Men and woman presented mean HDL-cholesterol of 40.5 ± 14.6 and 40.9 ± 12.7 mg/dl, respectively. The prevalence of the hypertriglyceridemic waist phenotype was 25%. There was a significant difference in mean HDL-cholesterol between men with and without the hypertriglyceridemic waist phenotype (32.8 ± 14.2 versus 42.1 ± 13.7 mg/dl respectively; P = 0.04), even after adjustment for age, body mass index, type 2 diabetes mellitus, use of statins and heart failure etiology. CONCLUSIONS: The hypertriglyceridemic waist phenotype is significantly associated with lower HDL-cholesterol levels in men with heart failure.

Cardiac natriuretic hormones, neuro-hormones, thyroid hormones and cytokines in normal subjects and patients with heart failure

2004 ◽  
Vol 42 (6) ◽  
Author(s):  
Michele Emdin ◽  
Claudio Passino ◽  
Concetta Prontera ◽  
Annalisa Iervasi ◽  
Andrea Ripoli ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Thyroid Hormones ◽  
Natriuretic Peptide ◽  
Nyha Class ◽  
Normal Subjects ◽  
Clinical Severity ◽  
Tnf Α ◽  
Patients With Heart Failure ◽  
Circulating Levels

AbstractThe derangement of neuro-endocrine control of circulation influences both disease evolution and response to treatment in patients with heart failure, but little data are available about the complex relationships between the degree of neuro-hormonal activation and clinical severity. We studied the relationships between cardiac natriuretic hormones (CNHs) and several neuro-hormones and immunological markers in a prospective cohort of 105 consecutive patients with cardiomyopathy (77 men and 28 women, mean age 66.7±12.4 years, range 33–89 years). We assayed the circulating levels of CNHs (atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP)), plasma renin activity (PRA), aldosterone, cortisol, adrenaline, noradrenaline, thyroid hormones and thyroid stimulating hormone (TSH), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The concentrations of all CNHs and neuro-hormones were higher in patients with heart failure compared to normal subjects, except for free triiodothyronine (FT3), which was below normal values. ANP was positively related to NYHA class, IL-6, adrenaline, noradrenaline and cortisol, while negatively with ejection fraction and FT3. BNP was positively related to age, NYHA class, IL-6, TNF-α, adrenaline, noradrenaline and cortisol, while negatively with ejection fraction and FT3. A stepwise multiple linear regression indicated that plasma ANP depended only on ejection fraction, adrenaline and noradrenaline values, while for plasma BNP variation NYHA class contributed too. Our data confirm a progressive activation of hormonal and immunological systems in patients with heart failure. Furthermore, CNH circulating levels in heart failure are affected not only by cardiac function and disease severity, but also by activation of neuro-hormonal and stress-related cytokine systems, as well as by the thyroid hormones, even on usual medical treatment.

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