Positive oxidative stress in aging and aging-related disease tolerance

Severe oxidative stress is a relevant risk factor for major deleterious health-related events in olderpeople and is thought to be an important contributor to age-related disease. Literature has suggested oxidativestress as a therapeutic target for mitigating the biological decline and attenuating the occurrence of adverseclinical events in aged individuals. However, definitive treatments are not known. Regular and moderate physicalactivity has been proposed as possible intervention for slowing age-related decline. This healthy strategy presentsa wide range of beneficial aspects for elderly, from the reduction of morbidity, disability, frailty and mortalityrates to treatment of many age-related disorders. Importantly, the global benefits on health are not shared by anyother strategies. Nevertheless, the physiological basis by which exercise produces its benefits to the organism isnot fully understood. This review summarizes the evidence for the role of physical activity as potential healthyintervention for mitigating the negative aspects of aging through the modulation of the oxidative mechanisms.

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Screening of lysyl oxidase (LOX) and lysyl oxidase like (LOXL) enzyme expression and activity in preterm prelabor rupture of fetal membranes

Journal of Perinatal Medicine ◽

10.1515/jpm-2014-0337 ◽

2015 ◽

Vol 0 (0) ◽

Cited By ~ 1

Author(s):

Jossimara Polettini ◽

Marcia G. Silva ◽

Marian Kacerovsky ◽

Tariq A. Syed ◽

George R. Saade ◽

...

Keyword(s):

Oxidative Stress ◽

Reactive Oxygen Species ◽

Lysyl Oxidase ◽

Fetal Membranes ◽

Oxygen Species ◽

Enzyme Expression ◽

Antioxidant Treatment ◽

Related Disease ◽

Prelabor Rupture Of Membranes ◽

Expression And Activity

AbstractLysyl oxidase (LOX) and LOX like enzymes (LOXL1–4) physiologically remodel extracellular matrix and pathologically contribute to cellular senescence under oxidative stress (OS). We characterized LOX and LOXL expressions and activity in human fetal membranes.Human fetal membranes from women with uncomplicated pregnancies at term, preterm birth with intact membranes (PTB) or preterm prelabor rupture of membranes (pPROM), andIncrease of LOX expression in pPROM, an OS-related disease, and the apparent inhibition of LOX activity by CSE restored by antioxidant treatment suggest that reactive oxygen species might influence LOX-mediated tissue remodeling in fetal membranes. Balanced antioxidant supplementation during pregnancy may reduce the risk of pPROM by increasing LOX activity.

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Power of Proteomics in Linking Oxidative Stress and Female Infertility

BioMed Research International ◽

10.1155/2014/916212 ◽

2014 ◽

Vol 2014 ◽

pp. 1-26 ◽

Cited By ~ 35

Author(s):

Sajal Gupta ◽

Jana Ghulmiyyah ◽

Rakesh Sharma ◽

Jacques Halabi ◽

Ashok Agarwal

Keyword(s):

Oxidative Stress ◽

Cell Cycle ◽

Molecular Mechanisms ◽

Unexplained Infertility ◽

Female Infertility ◽

Related Disease ◽

Large Numbers ◽

The One ◽

Related Proteins ◽

Potential Biomarkers

Endometriosis, PCOS, and unexplained infertility are currently the most common diseases rendering large numbers of women infertile worldwide. Oxidative stress, due to its deleterious effects on proteins and nucleic acids, is postulated to be the one of the important mechanistic pathways in differential expression of proteins and in these diseases. The emerging field of proteomics has allowed identification of proteins involved in cell cycle, as antioxidants, extracellular matrix (ECM), cytoskeleton, and their linkage to oxidative stress in female infertility related diseases. The aim of this paper is to assess the association of oxidative stress and protein expression in the reproductive microenvironments such as endometrial fluid, peritoneal fluid, and follicular fluid, as well as reproductive tissues and serum. The review also highlights the literature that proposes the use of the fertility related proteins as potential biomarkers for noninvasive and early diagnosis of the aforementioned diseases rather than utilizing the more invasive methods used currently. The review will highlight the power of proteomic profiles identified in infertility related disease conditions and their linkage with underlying oxidative stress. The power of proteomics will be reviewed with regard to eliciting molecular mechanisms for early detection and management of these infertility related conditions.

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Hot Topics and Challenges of Regenerative Nanoceria in Application of Antioxidant Therapy

Journal of Nanomaterials ◽

10.1155/2018/4857461 ◽

2018 ◽

Vol 2018 ◽

pp. 1-12 ◽

Cited By ~ 8

Author(s):

Changyan Li ◽

Xiangcheng Shi ◽

Qiudi Shen ◽

Chen Guo ◽

Zepeng Hou ◽

...

Keyword(s):

Oxidative Stress ◽

Drug Delivery ◽

Tissue Engineering ◽

Free Radical ◽

Radiation Protection ◽

Free Radical Scavenger ◽

Radical Scavenger ◽

Redox Cycle ◽

Related Disease ◽

Resistance To Oxidation

As a new antioxidant, nanoceria is of significant importance in applications of medical and biological fields. In comparison with conventional organic antioxidants, nanoceria has multienzyme mimetic activity by Ce4+/Ce3+ redox cycle. This unique regenerative/autocatalytic property has been widely used in the aspects of free-radical scavenger, radiation protection, oxidative-stress-related disease, drug delivery, biosensor, tissue engineering, cancer biomarker, and anti-inflammatory. This paper reviews the latest breakthrough of nanoceria as an antioxidant in applications of medical and biological fields on the base of the authors’ research works on resistance to oxidation and cytotoxicity. The challenges of nanoceria encountered in applications in medical and biological fields are commented as well.

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Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease

Biomolecules ◽

10.3390/biom9080377 ◽

2019 ◽

Vol 9 (8) ◽

pp. 377 ◽

Cited By ~ 11

Author(s):

Aleksandrina Volobueva ◽

Andrey Grechko ◽

Shaw-Fang Yet ◽

Igor Sobenin ◽

Alexander Orekhov

Keyword(s):

Oxidative Stress ◽

Mitochondrial Dna ◽

Molecular Markers ◽

Cardiovascular Diseases ◽

Mitochondrial Genome ◽

Therapeutic Intervention ◽

Molecular Mechanisms ◽

Disease Pathogenesis ◽

Mtdna Mutations ◽

Related Disease

Atherosclerosis-related cardiovascular diseases remain the leading cause of morbidity and mortality, and the search for novel diagnostic and therapeutic methods is ongoing. Mitochondrial DNA (mtDNA) mutations associated with atherosclerosis represent one of the less explored aspects of the disease pathogenesis that may bring some interesting opportunities for establishing novel molecular markers and, possibly, new points of therapeutic intervention. Recent studies have identified a number of mtDNA mutations, for which the heteroplasmy level was positively or negatively associated with atherosclerosis, including the disease at its early, subclinical stages. In this review, we summarize the results of these studies, providing a list of human mtDNA mutations potentially involved in atherosclerosis. The molecular mechanisms underlying such involvement remain to be elucidated, although it is likely that some of them may be responsible for the increased oxidative stress, which plays an important role in atherosclerosis.

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Novel insights on the pulmonary vascular consequences of COVID-19

AJP Lung Cellular and Molecular Physiology ◽

10.1152/ajplung.00195.2020 ◽

2020 ◽

Vol 319 (2) ◽

pp. L277-L288 ◽

Cited By ~ 14

Author(s):

François Potus ◽

Vicky Mai ◽

Marius Lebret ◽

Simon Malenfant ◽

Emilie Breton-Gagnon ◽

...

Keyword(s):

Oxidative Stress ◽

Vascular Diseases ◽

Pulmonary Vasculature ◽

Imaging Studies ◽

Related Disease ◽

Increased Risk ◽

The Status ◽

Early Imaging ◽

Coronavirus Infection ◽

Pulmonary Vascular Diseases

In the last few months, the number of cases of a new coronavirus-related disease (COVID-19) rose exponentially, reaching the status of a pandemic. Interestingly, early imaging studies documented that pulmonary vascular thickening was specifically associated with COVID-19 pneumonia, implying a potential tropism of the virus for the pulmonary vasculature. Moreover, SARS-CoV-2 infection is associated with inflammation, hypoxia, oxidative stress, mitochondrial dysfunction, DNA damage, and lung coagulopathy promoting endothelial dysfunction and microthrombosis. These features are strikingly similar to what is seen in pulmonary vascular diseases. Although the consequences of COVID-19 on the pulmonary circulation remain to be explored, several viruses have been previously thought to be involved in the development of pulmonary vascular diseases. Patients with preexisting pulmonary vascular diseases also appear at increased risk of morbidity and mortality. The present article reviews the molecular factors shared by coronavirus infection and pulmonary vasculature defects, and the clinical relevance of pulmonary vascular alterations in the context of COVID-19.

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