The integration of biodiversity conservation and public health has
gained significant traction, leading to new efforts to identify win–win
solutions for the environment and health. At the forefront of these
efforts is pin-pointing ways in which biodiversity conservation can
reduce risk of zoonotic spillover, especially given the consequences of
epidemics and pandemics of wild animal origin. However, there is
currently an incomplete understanding of the mechanisms by which
biodiversity change influences the spillover process, limiting the
application of integrated strategies aimed at achieving positive
outcomes for both conservation and disease management. Here, we review
the literature, considering a broad scope of biodiversity dimensions, to
identify cases where zoonotic pathogen spillover is mechanistically
linked to changes in biodiversity. By reframing the discussion of
biodiversity and disease using mechanistic evidence while encompassing
multiple aspects of biodiversity, including functional diversity,
landscape diversity, phenological diversity, and interaction diversity,
we work toward general principles that can guide future research and
more effectively integrate the related goals of biodiversity
conservation and spillover prevention. We conclude by summarizing how
these principles could be used to integrate spillover prevention into
ongoing biodiversity conservation initiatives.