Chemical-based risk assessment and in vitro models of human health effects induced by organic pollutants in soils from the Olona valley

2013 ◽  
Vol 463-464 ◽  
pp. 790-801 ◽  
Author(s):  
Diego Baderna ◽  
Andrea Colombo ◽  
Giorgia Amodei ◽  
Stefano Cantù ◽  
Federico Teoldi ◽  
...  
2017 ◽  
Vol 579 ◽  
pp. 1929-1939 ◽  
Author(s):  
Federico Teoldi ◽  
Marco Lodi ◽  
Emilio Benfenati ◽  
Andrea Colombo ◽  
Diego Baderna

2013 ◽  
Vol 726-731 ◽  
pp. 175-178
Author(s):  
Zhi Min Cao ◽  
Zhen Zhen Wu ◽  
Zhi Fen Lin

There is an essential need to use computation-based quantitative structureactivity relationship (QSAR) modeling for providing information about the physicochemical properties of chemicals and their environmental fate as well as their human health effects. The major aims of this paper is to explore ways to predict and to identify hazardous combinations of chemicals relevant to humans and the environment. So we use QSAR modeling for toxicological predictions determine the potential adverse effects of reactive organic compounds in risk assessment.


2018 ◽  
Vol 16 (10) ◽  
pp. 805-816
Author(s):  
Rithy KAN ◽  
Thaniya KAOSOL ◽  
Perapong TEKASAKUL ◽  
Surajit TEKASAKUL

Risk assessment of emitted particle polycyclic aromatic hydrocarbons (PAHs) from lignite-biomass pelletization burning focusing on size distribution and human health effects are investigated. The particles and PAHs are experimented by a tube furnace and high performance liquid chromatography coupled diode array and fluorescence detectors (HPLC-DAD/FLD), respectively. The carcinogenic, mutagenic, and toxic potencies of PAHs are also discussed in relative to the size distribution of emitted particle PAHs. The results indicate that the carcinogenic, mutagenic, and toxic potencies of PAHs are like to accumulate in the ultrafine particles finer than 0.65 µm. The ultrafine particles contribute the largest PAHs existences of carcinogenic, mutagenic and toxic substances; even though they register in the small mass fraction of PAHs.  Moreover, the co-pellets burning can reduce the values of carcinogenic PAHs, carcinogenic equivalency quotients (BaP-TEQ), mutagenic equivalency quotients (BaP-MEQ), and toxic equivalency quotients (TCDD-TEQ) by more than 60%.


Author(s):  
PA Ganichev

Introduction: Polymer products have become inexpensive, convenient and widely used in all spheres of everyday life recently. Microplastics are found in seawater, wastewater, fresh water, foodstuffs, and air. Over the past few years, the presence of microplastics in treated tap and bottled water has been reported, raising questions and concerns about their potential human health effects. Objective: To summarize and systematize the results of studying health effects of exposure to microplastics in potable water. Materials and methods: A literature review was done based on ten topical articles and reviews published in 2014–2021 out of 64 sources found in the PubMed and Scopus international databases and the Russian Science Citation Index (RSCI). Results and conclusions: Generalization and systematization of the published research data demonstrated the lack of strong evidence to draw conclusions about human health effects of microplastics. Information on toxicokinetics and toxicodynamics of ingested microplastic particles is absent just like the studies of the most common shapes and sizes of plastic particles and health risks from exposure to such particles in drinking water.


2018 ◽  
Vol 2 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Tee L. Guidotti

On 16 October 1996, a malfunction at the Swan Hills Special Waste Treatment Center (SHSWTC) in Alberta, Canada, released an undetermined quantity of persistent organic pollutants to the atmosphere. An ecologically based, staged health risk assessment was conducted to evaluate the human health risk, the findings of which are presented in Part 2, on Ecotoxicology and Human Health Risk. The incident resulted in the largest fine for an environmental infraction in Alberta history up to that time. Despite the incident, the province of Alberta has continued to subsidize the facility and has kept it in operation, with changes in management. The policy rationale is that if the facility were not available, accumulation and possible diversion of hazardous waste into illegal disposal alternatives would threaten the environment much more than operation of the plant. This case study illustrates an ecological approach to risk assessment and an attempted culturally sensitive approach to risk management. Incidents in which people are exposed to toxic substances do not occur in a social vacuum. Risk management strategies must be adapted to groups with different cultural values and expectations. Community and individual responses to such incidents, and the development of health advisory messages, may depend on presenting information on exposure and risk in terms consistent with cultural patterns among subpopulations in the community.


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