scholarly journals Protective effects of syringic acid, resveratrol and their combination against isoprenaline administered cardiotoxicity in wistar rats

2019 ◽  
Vol 26 (7) ◽  
pp. 1429-1435 ◽  
Author(s):  
Manjunatha Sammeturi ◽  
Althaf Hussain Shaik ◽  
Sasi Bhusana Rao Bongu ◽  
Srinivasulu Cheemanapalli ◽  
Altaf Mohammad ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Syringic Acid ◽  
Protective Effects

scholarly journals Co-Treatment of Purified Annatto Oil (Bixa orellana L.) and Its Granules (Chronic®) Improves the Blood Lipid Profile and Bone Protective Effects of Testosterone in the Orchiectomy-Induced Osteoporosis in Wistar Rats

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4720
Author(s):  
Arlindo César Matias Pereira ◽  
Helison de Oliveira Carvalho ◽  
Danna Emanuelle Santos Gonçalves ◽  
Karyny Roberta Tavares Picanço ◽  
Abrahão Victor Tavares de Lima Teixeira dos dos Santos ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Wistar Rats ◽  
Calcium Concentration ◽  
Calcium Content ◽  
Blood Lipid ◽  
Atomic Absorption Spectrophotometry ◽  
Protective Effects ◽  
Blood Lipid Profile ◽  
Bone Calcium ◽  
Weight Structure

This study aimed to evaluate and compare the effects of co-treatment with purified annatto oil (PAO) or its granules (GRA, Chronic®) with that of testosterone on the orchiectomy-induced osteoporosis in Wistar rats. After surgery, rats were treated from day 7 until day 45 with testosterone only (TES, 7 mg/kg, IM) or TES + PAO or GRA (200 mg/kg, p.o.). The following parameters were evaluated: food/water intake, weight, HDL, LDL, glucose, triglycerides (TG), total cholesterol (TC), alkaline phosphatase levels, blood phosphorus and calcium contents, femur weight, structure (through scanning electron microscopy), and calcium content (through atomic absorption spectrophotometry). Our results show that orchiectomy could significantly change the blood lipid profile and decrease bone integrity parameters. Testosterone reposition alone could improve some endpoints, including LDL, TC, bone weight, and bone calcium concentration. However, other parameters were not significantly improved. Co-treatment with PAO or GRA improved the blood lipid profile and bone integrity more significantly and improved some endpoints not affected by testosterone reposition alone (such as TG levels and trabeculae sizes). The results suggest that co-treatment with annatto products improved the blood lipid profile and the anti-osteoporosis effects of testosterone. Overall, GRA had better results than PAO.

scholarly journals Safety evaluation of syringic acid: subacute oral toxicity studies in Wistar rats

Heliyon ◽  
2019 ◽  
Vol 5 (8) ◽  
pp. e02129 ◽  
Author(s):  
Anwarbaig C. Mirza ◽  
Shital S. Panchal
Keyword(s):  
Wistar Rats ◽  
Safety Evaluation ◽  
Syringic Acid ◽  
Oral Toxicity ◽  
Toxicity Studies

scholarly journals Effect of curcumin in the acute phase of ischemia in chronic cerebral hypoperfusion in rats

2018 ◽  
Vol 17 (1) ◽  
pp. 69-73
Author(s):  
N. S. Shcherbak ◽  
M. A. Popovetskiy ◽  
G. Yu. Yukina ◽  
M. M. Galagudza
Keyword(s):  
Brain Injury ◽  
Acute Phase ◽  
Wistar Rats ◽  
Neuroprotective Effect ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Ischemic Brain Injury ◽  
Protective Effects ◽  
Single Application ◽  
Ischemic Brain

Curcumin presents antioxidant and anti-inflammatory properties and can be considered as a neuroprotector. Data on doses and duration of application of curcumin to achieve protective effects in various types of ischemic brain injury is controversial. The purpose was to study the neuroprotective properties of curcumin in the acute phase of ischemia in chronic cerebral hypoperfusion in rats. It is shown that a single application of curcumin (300 mg/kg, i.p.) is not has neuroprotective effect in the acute phase of ischemia in chronic hypoperfusion in Wistar rats. The results allow to conclude that the neuroprotective effect of a single application of curcumin.

scholarly journals Evaluation of analgesic activity of the methanol extract from the galls of Quercus infectoria alone and as an adjuvant in wistar rats

2020 ◽  
Vol 9 (5) ◽  
pp. 701
Author(s):  
Abishek P. Raichurkar ◽  
Shashikala Gowdara Hanumanth Reddy
Keyword(s):  
Analgesic Activity ◽  
Wistar Rats ◽  
Methanolic Extract ◽  
Inflammatory Diseases ◽  
Syringic Acid ◽  
Tail Flick ◽  
Hot Plate ◽  
Anti Inflammatory ◽  
Group 2 ◽  
Quercus Infectoria

Background: Non-steroidal anti-inflammatory drugs and opioids are the most preferred drugs for pain relief. Considering the gastrointestinal toxicity, dependence and other side effects, search for better analgesic drug continues. Quercus infectoria (QI) is from the family Fagaceae. The galls of QI are comprised of tannin (36 to 60%), gallic acid, ellagic acid, and syringic acid. They possess antioxidant, anti-inflammatory, antimicrobial, and anti-diabetic properties. In India, galls of QI have been used for the treatment of toothache, diarrhoea, sore throat and inflammatory diseases as a home remedy. This study was conducted to evaluate the analgesic activity of methanolic extract of galls of QI on wistar rats using tail-flick and Eddy’s hot-plate methods. The objective of the study was to evaluate the analgesic activity of methanolic extract of galls of QI alone and as an adjuvant with tramadol on Wistar rats.Methods: Total of 24 wistar rats were included in the study and divided into 4 groups. They received drugs intra-peritoneally as follows. In group 1, normal saline, in group 2, tramadol, in group 3, methanolic extract of galls of QI and in group 4, tramadol with methanolic extract of galls of QI was available.Results: Methanolic extract of galls of QI produced significant maximal possible analgesia (<0.001) at 30 and 60 minutes in tail-flick method whereas it failed to produce analgesia in hot-plate method during all time intervals.Conclusions: Methanolic extract of galls of QI showed analgesic activity in tail-flick method indicating that its possible mechanism of action is spinally mediated.

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