A high-performance enzyme-activated near-infrared probe for the sensing and tracking of tumor-related NQO1 in cells and in vivo

2022 ◽  
Vol 354 ◽  
pp. 131129
Author(s):  
Yong Zhang ◽  
Xueqian Chen ◽  
Qing Yuan ◽  
Yongning Bian ◽  
Mingrui Li ◽  
...  
Keyword(s):  
High Performance ◽  
Near Infrared ◽  
In Cells

Ultrathin carbon layer coated MoO2 nanoparticles for high-performance near-infrared photothermal cancer therapy

2015 ◽  
Vol 51 (49) ◽  
pp. 10054-10057 ◽  
Author(s):  
Qin Liu ◽  
Chunyang Sun ◽  
Qun He ◽  
Daobin Liu ◽  
Adnan Khalil ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
High Performance ◽  
Near Infrared ◽  
Solvothermal Method ◽  
Carbon Layer

Uniform MoO2 nanoparticles coated with ultrathin carbon layers, synthesized by a solvothermal method, were demonstrated as a promising NIR photothermal agent by in vitro and in vivo tests.

A new chloro-substituted dicyanoisophorone-based near-infrared fluorophore with a larger Stokes shift and its application for detecting cysteine in cells and in vivo

2020 ◽  
Vol 44 (36) ◽  
pp. 15432-15438
Author(s):  
Yu Wang ◽  
Wenda Zhang ◽  
Ting Ma ◽  
Duolu Li ◽  
Yubing Zhou ◽  
...  
Keyword(s):  
Near Infrared ◽  
Stokes Shift ◽  
Hydroxyl Group ◽  
Molecular Fluorescence ◽  
Fluorescence Bioimaging ◽  
In Cells

Many dicyanoisophorone-based fluorophores with an optical hydroxyl group have been explored to meet different imaging needs along with the rapid and wide development of molecular fluorescence bioimaging in recent years.

scholarly journals A near-infrared fluorescent probe for evaluating endogenous hydrogen peroxide during ischemia/reperfusion injury

The Analyst ◽  
2019 ◽  
Vol 144 (8) ◽  
pp. 2556-2564 ◽  
Author(s):  
Runfeng Xu ◽  
Yue Wang ◽  
Huiyan You ◽  
Liangwei Zhang ◽  
Yunqing Wang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Reperfusion Injury ◽  
Real Time ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Real Time Monitoring ◽  
In Cells

A fluorescent probe, Cy-ArB, is developed for real-time monitoring of H2O2 fluctuations in cells and in vivo during ischemia/reperfusion processes.

Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo

2019 ◽  
Vol 55 (17) ◽  
pp. 2477-2480 ◽  
Author(s):  
Zhengmin Yang ◽  
Wenxiu Li ◽  
Hua Chen ◽  
Qingyuan Mo ◽  
Jun Li ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Living Cells ◽  
Monoamine Oxidase A ◽  
Specific Detection ◽  
Design And Synthesis ◽  
Mao A ◽  
In Cells

A series of near-infrared fluorescent probes based on inhibitor (clorgyline) structure-guided design were synthesized for the specific detection of MAO-A in cells and in vivo.

scholarly journals FT-NIRS Coupled with PLS Regression as a Complement to HPLC Routine Analysis of Caffeine in Tea Samples

Foods ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 827
Author(s):  
Najeeb Ur Rehman ◽  
Ahmed Al-Harrasi ◽  
Ricard Boqué ◽  
Fazal Mabood ◽  
Muhammed Al-Broumi ◽  
...  
Keyword(s):  
Least Squares ◽  
Partial Least Squares ◽  
High Performance ◽  
Near Infrared ◽  
Pls Regression ◽  
Least Squares Regression ◽  
Daily Consumption ◽  
Limit Of Quantification ◽  
Scientific Attention

Daily consumption of caffeine in coffee, tea, chocolate, cocoa, and soft drinks has gained wide and plentiful public and scientific attention over the past few decades. The concentration of caffeine in vivo is a crucial indicator of some disorders—for example, kidney malfunction, heart disease, increase of blood pressure and alertness—and can cause some severe diseases including type 2 diabetes mellitus (DM), stroke risk, liver disease, and some cancers. In the present study, near-infrared spectroscopy (NIRS) coupled with partial least-squares regression (PLSR) was proposed as an alternative method for the quantification of caffeine in 25 commercially available tea samples consumed in Oman. This method is a fast, complementary technique to wet chemistry procedures as well as to high-performance liquid chromatography (HPLC) methods for the quantitative analysis of caffeine in tea samples because it is reagent-less and needs little or no pre-treatment of samples. In the current study, the partial least-squares (PLS) algorithm was built by using the near-infrared NIR spectra of caffeine standards prepared in tea samples scanned by a Frontier NIR spectrophotometer (L1280034) by PerkinElmer. Spectra were collected in the absorption mode in the wavenumber range of 10,000–4000 cm−1, using a 0.2 mm path length and CaF2 sealed cells with a resolution of 2 cm−1. The NIR results for the contents of caffeine in tea samples were also compared with results obtained by HPLC analysis. Both techniques provided good results for predicting the caffeine contents in commercially available tea samples. The results of the proposed study show that the suggested FT-NIRS coupled with PLS regression algorithun has a high potential to be routinely used for the quick and reproducible analysis of caffeine contents in tea samples. For the NIR method, the limit of quantification (LOQ) was estimated as 10 times the error of calibration (root mean square error of calibration (RMSECV)) of the model; thus, RMSEC was calculated as 0.03 ppm and the LOQ as 0.3 ppm.

scholarly journals Evaluation of VCAM-1 Targeted Naringenin/Indocyanine Green-Loaded Lipid Nanoemulsions as Theranostic Nanoplatforms in Inflammation

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1066
Author(s):  
Elena Valeria Fuior ◽  
Cristina Ana Mocanu ◽  
Mariana Deleanu ◽  
Geanina Voicu ◽  
Maria Anghelache ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
High Performance ◽  
Large Scale ◽  
Near Infrared ◽  
Water Solubility ◽  
Mrna Levels ◽  
Efficient Delivery ◽  
Anti Inflammatory ◽  
Reduced Water

Naringenin, an anti-inflammatory citrus flavonoid, is restrained from large-scale use by its reduced water solubility and bioavailability. To overcome these limitations, naringenin was loaded into lipid nanoemulsions directed towards vascular cell adhesion molecule (VCAM)-1, exposed by activated endothelium, and delivered intravenously in a murine model of lipopolysaccharide (LPS)-induced inflammation. To follow the in vivo bio-distribution, naringenin-loaded nanoemulsions were labeled with near-infrared probe Indocyanine Green (ICG). Based on ICG fluorescence, a VCAM-1-dependent retention of nanoemulsions was detected in the heart and aorta, while ultra-high-performance liquid chromatography (UHPLC) measurements showed a target-selective accumulation of naringenin in the heart and lungs. Correlated, fluorescence and UHPLC data indicated a mixed behavior of the VCAM-1 directed nanoparticles, which were driven not only by the targeting moiety but also by passive retention. The treatment with naringenin-loaded nanoemulsions reduced the mRNA levels of some inflammatory mediators in organs harvested from mice with acute inflammation, indicative of their anti-inflammatory potential. The data support a novel theranostic nanoplatform for inflammation, the naringenin/ICG-loaded nanoparticles that either by passive accumulation or effective targeting of the activated endothelium can be employed for imaging inflamed vascular areas and efficient delivery of the encapsulated therapeutic agent.

BODIPY-based near-infrared fluorescent probe for diagnosis drug-induced liver injury via imaging of HClO in cells and in vivo

2021 ◽  
pp. 110073
Author(s):  
Guanwen Fan ◽  
Nannan Wang ◽  
Jian Zhang ◽  
Xin Ji ◽  
Shuchun Qin ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
In Cells
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