Construction of a TiO2/Cu2O multifunctional coating on Ti-Cu alloy and its influence on the cell compatibility and antibacterial properties

Acalypha indica (A. indica) possesses antibacterial properties and has capability to accelerate wound healing due to its active therapeutic compounds of flavonoid and alkaloid. The incorporation of A. indica extracts in polymer hydrogels is useful for wound treatment, despite the advancement in synthetic medicines and drugs. In this study, polyvinyl alcohol (PVA) hydrogels with different concentrations of A. indica extract (0.5, 1.0, 1.5 and 2.0 mg) were fabricated. The ATR-FTIR spectra testified the presence of A. indica in the hydrogels. More enormous spotted agglomerations were visualized on the higher concentrations of A. indica hydrogels. The A. indica hydrogels became less moisture, more hydrophobic and has low water uptake ability compared to the control hydrogel (without A. indica). The antibacterial activities of the hydrogels against Escherichia coli and Staphylococcus aureus were acted in a dose-dependent manner where higher inhibition zones and higher bacterial retardations were recorded on the hydrogels with higher concentrations of A. indica. The incorporation of A. indica (1.0 - 1.5 mg/mL) has also induced cell viability, cell migration, and proliferation of the human skin fibroblasts. Therefore, optimization of the A. indica hydrogels is crucial in accommodating the bi-functional properties of antibacterial and biocompatibility for wound treatment.

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Optimization of mechanical and antibacterial properties of Ti-3wt%Cu alloy through cold rolling and annealing

Rare Metals ◽

10.1007/s12598-021-01841-x ◽

2021 ◽

Author(s):

Hai-Lin Yang ◽

Meng-Zhen Zhu ◽

Jian-Ying Wang ◽

Chen-Xu Ma ◽

Xiong-Wen Zhou ◽

...

Keyword(s):

Cold Rolling ◽

Antibacterial Properties ◽

Cu Alloy ◽

Cold Rolling And Annealing

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Vancomycin Hydrochloride Loaded Hydroxyapatite Mesoporous Microspheres with Micro/Nano Surface Structure to Increase Osteogenic Differentiation and Antibacterial Ability

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2021.3128 ◽

2021 ◽

Vol 17 (8) ◽

pp. 1668-1678

Author(s):

Beizhi Zhang ◽

Yunhui Chai ◽

Kai Huang ◽

Xuejie Wei ◽

Zhiqing Mei ◽

...

Keyword(s):

Osteogenic Differentiation ◽

Bone Repair ◽

Drug Loading ◽

Antibacterial Properties ◽

Precipitation Method ◽

Cell Compatibility ◽

Antibacterial Ability ◽

Vancomycin Hydrochloride ◽

Mesoporous Microspheres

As infection induced by the implant will lead to operation failure, the implant material must be endowed with certain antibacterial properties. Hydroxyapatite (HA) mesoporous microspheres have been widely used in bone repair due to their advantages, including simple synthesis, good osteogenic properties and drug loading capacity. In this study, vancomycin hydrochloride-loaded mesoporous hydroxyapatite microspheres with micro/nanosurface structures were synthesized to increase osteogenic differentiation and antibacterial ability. Phytic acid (IP6) was used as a template to prepare mesoporous hydroxyapatite microspheres composed of fibres, flakes and smooth surfaces by the hydrothermal homogeneous precipitation method, and the corresponding specific surface areas were 65.20 m2/g, 75.13 m2/g and 71.27 m2/g, respectively. Vancomycin hydrochloride (Van) was used as the drug model to study the drug loading and release characteristics of the microspheres, as well as the in vitro antibacterial properties after treatment. In addition, during cocultivation with MC3T3-E1 preosteoblasts, HA microspheres assembled via flakes exhibited better cell compatibility, which promoted cell proliferation, alkaline phosphatase (ALP) activity, and the formation of calcium nodules and increased the expression of osteogenic differentiation-related proteins such as Runx-2, osteopontin (OPN) and collagen I (COL I). These results indicated that the HA microspheres prepared in this experiment have broad application prospects in drug delivery systems and bone repair.

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In VitroAssessment of Antibacterial Activity and Cytocompatibility of Quercetin-Containing PLGA Nanofibrous Scaffolds for Tissue Engineering

Journal of Nanomaterials ◽

10.1155/2012/202608 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 15

Author(s):

Zhi-Cai Xing ◽

Wan Meng ◽

Jiang Yuan ◽

Sungmo Moon ◽

Yongsoo Jeong ◽

...

Keyword(s):

Tissue Engineering ◽

Epithelial Cells ◽

Biological Activities ◽

Antibacterial Properties ◽

Bacterial Strains ◽

Antibacterial Effects ◽

Electrospinning Technique ◽

Cell Compatibility ◽

Nanofibrous Scaffolds ◽

Wide Range

Flavonoids, such as quercetin, have been reported to exhibit a wide range of biological activities related to their antioxidant capacity. The aim of this study was to investigate the protective effect of quercetin on cell adhesion, and the viability and proliferation of KB epithelial cells. Quercetin- (1, 5 wt%)-containing poly (l-lactide-co-glycolide) (PLGA) nanofibrous scaffolds (PLGA/Q 1, PLGA/Q 5) were prepared by electrospinning technique and their antibacterial properties were examined. Two types of bacteria strains,Staphylococcus aureus(SA) andKlebsiella pneumoniae(KP), were used to evaluate the antibacterial properties of the scaffolds. The results showed that the quercetin-containing PLGA nanofibrous scaffolds exhibited significant antibacterial effects against the two bacterial strains. KB epithelial cells were also used to evaluate the cytocompatibility of the scaffolds. From the results, it was found that the PLGA nanofibrous scaffolds with 1 wt% of quercetin had good cell compatibility. It is considered that the PLGA nanofibrous scaffolds with 1 wt% quercetin have potential to be used in tissue engineering.

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Synthesis of TiO2 nanotubes with ZnO nanoparticles to achieve antibacterial properties and stem cell compatibility

Nanoscale ◽

10.1039/c4nr01531b ◽

2014 ◽

Vol 6 (15) ◽

pp. 9050-9062 ◽

Cited By ~ 59

Author(s):

Wenwen Liu ◽

Penglei Su ◽

Su Chen ◽

Na Wang ◽

Yuanping Ma ◽

...

Keyword(s):

Stem Cell ◽

Streptococcus Mutans ◽

Zno Nanoparticles ◽

Bacterial Adhesion ◽

Tio2 Nanotubes ◽

Antibacterial Properties ◽

Cell Compatibility

ZnO incorporated Ti samples inhibited the expression of Streptococcus mutans bacterial adhesion genes and also inhibited P. gingivalis proliferation. (a) S. mutans and (b) P. gingivalis on the sample of TNT–Zn0.075.

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Preparation of Chitosan-Based Fiber Reticulated Medical Dressing and Its Application in Wound Care

Science of Advanced Materials ◽

10.1166/sam.2020.3770 ◽

2020 ◽

Vol 12 (6) ◽

pp. 921-931

Author(s):

Peiying Han ◽

Jie Ma ◽

Min Lin ◽

Xiaoyan Cai ◽

Fang Fang

Keyword(s):

Wound Healing ◽

Wound Care ◽

Antibacterial Properties ◽

Biological Properties ◽

Wound Area ◽

Cell Compatibility ◽

Wound Recovery ◽

Liquid Absorption ◽

Healing Of Wounds ◽

Chitosan Fiber

With the continuous development of medical dressings, patients start to focus on how to take care of wounds caused by different reasons. Therefore, there is a need for medical dressings that can stop the bleeding and promote the healing of wounds with excellent biological properties. This study produced seven different dressing samples by combining chitosan fiber and hydroentanglement technique. The different dressings were characterized and analyzed for biological properties. At the same time, 60 New Zealand rabbits were selected for wound care experiments. Respectively, the wounds were constructed and were treated with sample 1 and sample 3, which were selected as experimental materials from the prepared dressing samples. Besides, the polyacrylate (SAP) and common gauze were taken as the control materials. Then, different dressings were used to cover the wounds of rabbits. Three days later, the dressings were changed every few days to observe the wounds. At the same time, the wound area and wound healing scores of the sample 1 group, sample 3 group, and SAP group were counted at 7 days, 14 days and 21 days after the operations. During the experiment, the chitosan fiber-based fiber web dressing showed excellent hygroscopicity and rigidity. For the comparison of biological properties, different samples all had excellent cell compatibility and antibacterial properties. Meanwhile, the antibacterial properties of sample 1 and sample 3 were all above 90%. For the wound care experiment, the adsorbent rate of sample 1 dressing was the fastest in the first 8 min, reaching 70% of the maximum liquid absorption. For the comparison of the wound recovery area and wound healing scores, compared with SAP and common gauze, the medical dressings based on composite chitosan fiber-hydroentanglement technique had better wound recovery performance. This has proved that the medical dressings proposed in this study have better wound care performances.

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Preparation of graphene oxide with silver nanowires to enhance antibacterial properties and cell compatibility

RSC Advances ◽

10.1039/c5ra16371d ◽

2015 ◽

Vol 5 (104) ◽

pp. 85748-85755 ◽

Cited By ~ 17

Author(s):

Jianghu Cui ◽

Yingliang Liu

Keyword(s):

Graphene Oxide ◽

Hydrothermal Method ◽

Antibacterial Effect ◽

Silver Nanowires ◽

Antibacterial Properties ◽

Cell Compatibility ◽

Good Cell ◽

Graphene Oxide Sheets

Ag NWs were evenly distributed on the surface of graphene oxide sheets via a hydrothermal method. The prepared composites exhibited an enhanced antibacterial effect and good cell compatibility.

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