Preparation of Chitosan-Based Fiber Reticulated Medical Dressing and Its Application in Wound Care

2020 ◽  
Vol 12 (6) ◽  
pp. 921-931
Author(s):  
Peiying Han ◽  
Jie Ma ◽  
Min Lin ◽  
Xiaoyan Cai ◽  
Fang Fang
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Antibacterial Properties ◽  
Biological Properties ◽  
Wound Area ◽  
Cell Compatibility ◽  
Wound Recovery ◽  
Liquid Absorption ◽  
Healing Of Wounds ◽  
Chitosan Fiber

With the continuous development of medical dressings, patients start to focus on how to take care of wounds caused by different reasons. Therefore, there is a need for medical dressings that can stop the bleeding and promote the healing of wounds with excellent biological properties. This study produced seven different dressing samples by combining chitosan fiber and hydroentanglement technique. The different dressings were characterized and analyzed for biological properties. At the same time, 60 New Zealand rabbits were selected for wound care experiments. Respectively, the wounds were constructed and were treated with sample 1 and sample 3, which were selected as experimental materials from the prepared dressing samples. Besides, the polyacrylate (SAP) and common gauze were taken as the control materials. Then, different dressings were used to cover the wounds of rabbits. Three days later, the dressings were changed every few days to observe the wounds. At the same time, the wound area and wound healing scores of the sample 1 group, sample 3 group, and SAP group were counted at 7 days, 14 days and 21 days after the operations. During the experiment, the chitosan fiber-based fiber web dressing showed excellent hygroscopicity and rigidity. For the comparison of biological properties, different samples all had excellent cell compatibility and antibacterial properties. Meanwhile, the antibacterial properties of sample 1 and sample 3 were all above 90%. For the wound care experiment, the adsorbent rate of sample 1 dressing was the fastest in the first 8 min, reaching 70% of the maximum liquid absorption. For the comparison of the wound recovery area and wound healing scores, compared with SAP and common gauze, the medical dressings based on composite chitosan fiber-hydroentanglement technique had better wound recovery performance. This has proved that the medical dressings proposed in this study have better wound care performances.

scholarly journals PENGARUH PENGGUNAAN ASI PADA PERAWATAN LUKA PERINIEM DENGAN LAMA WAKTU PENYEMBUHAN LUKA PERINIUM

2019 ◽  
Vol 7 (2) ◽  
pp. 67-73
Author(s):  
Annisa Ul Mutmainnah ◽  
Siti Noorbaya
Keyword(s):  
Wound Healing ◽  
Data Analysis ◽  
Random Sampling ◽  
Wound Care ◽  
Healing Time ◽  
Natural Process ◽  
Control Group ◽  
P Value ◽  
Research Subjects ◽  
Wound Area

Childbirth is a natural process, but sometimes labor can also cause birth canaltrauma, especially in the aluminum region, this trauma can be injuries to the periniumarea, the cause can be intentional biases such as episiotomy or unintentional actions such as spontaneous tears in the process of removing the baby. Injury to the perineum if not treated properly can cause postpartum infection because the wound area will be a medium for developing germs. The purpose of this study was to analyze the effect of the use of breast milk in the treatment of periniem wounds with the duration of perinium wound healing at the Ramlah Parjib Clinic in Samarinda. The method used in this study was Posttest Only Control Group Desigen research subjects were postpartum motherswith a sample of 60 respondents taken by random sampling and grouped based on treatment using ASI. Data analysis using ANOVA test. The results showed that the use of ASI had a significant effect on the treatment of periniem wounds with a healing time seen from the P value of 0,000. Conclusion: Periniuem wound care techniques are factors that influence the duration of perinieum wound healing

scholarly journals Manfaat Olesan Madu Pada Penyembuhan Luka Kulit

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Arantsa Lomban ◽  
Sonny J. R. Kalangi ◽  
Taufiq F. Pasiak
Keyword(s):  
Wound Healing ◽  
Literature Review ◽  
Wound Care ◽  
Antibacterial Properties ◽  
Review Literature ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Clinical Observations ◽  
Healing Of Skin Wounds ◽  
Ancient Times

Abstract: The use of honey in wound care has been used since ancient times. Honey has been shown to have antibacterial properties, as well as low pH levels making environmental conditions unfavorable for bacterial growth. Clinical observations from human trials report that honey helps granulation tissue formation, increases epithelialization, and reduces inflammation which affects the acceleration of wound healing. The aims of this study is to determine the effect of honey toward wound healing. This study is in the form of a literature review. Literature is taken from one database, namely PubMed. The keywords used are honey and wound healing. After being selected by inclusion and exclusion criteria, ten literature will be reviewed. Honey gave good results and affected the healing of skin wounds, including several types of honey that were studied in experimental animals and in experimental people. In conclusion, honey has an effect on healing skin wounds.Key words: Honey, wound healing  Abstrak: Penggunaan madu dalam perawatan luka telah digunakan sejak saat zaman kuno. Madu telah terbukti memiliki sifat antibakteri, juga kadar pH rendah membuat kondisi lingkungan yang tidak mendukung untuk pertumbuhan bakteri. Pengamatan klinis dari uji coba pada manusia melaporkan bahwa madu membantu pembentukan jaringan granulasi, meningkatkan epitelisasi, dan mengurangi peradangan yang mempengaruhi percepatan penyembuhan luka. Tujuan penelitian ini untuk mengetahui pengaruh madu terhadap penyembuhan luka. Penelitian ini dalam bentuk literature review. Literatur diambil dari satu database yaitu PubMed. Kata kunci yang digunakan yaitu honey and wound healing. Setelah diseleksi dengan kriteria inklusi dan eksklusi didapatkan sepuluh literatur yang akan direview. Madu memberikan hasil yang baik dan berpengaruh terhadap penyembuhan luka kulit, di antaranya ada beberapa jenis madu yang diteliti pada hewan percobaan maupun pada orang coba. Sebagai simpulan, madu mempunyai pengaruh terhadap penyembuhan luka kulit.Kata kunci: Madu, penyembuhan luka

scholarly journals Application of Nanomaterial in Hydrogels Related to Wound Healing

2022 ◽  
Vol 2022 ◽  
pp. 1-11
Author(s):  
Yangyang Liu ◽  
Shurui Song ◽  
Shuangyong Liu ◽  
Xiaoyan Zhu ◽  
Peige Wang
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Wound Repair ◽  
Antibacterial Properties ◽  
Sustained Drug Release ◽  
Broad Application ◽  
Wound Recovery ◽  
Swelling Rate ◽  
Good Biocompatibility ◽  
Application Prospects

Traditional dressings used for wound repair, such as gauze, have shortcomings; for example, they cannot provide a suitable microenvironment for wound recovery. Therefore, it is necessary to find a better dressing to overcome shortcomings. Hydrogel provides a suitable wet environment, has good biocompatibility, and has a strong swelling rate to absorb exudate. Nanomaterial in hydrogels has been used to improve their performance and overcome the shortcomings of current hydrogel dressings. Hydrogel dressing can also be loaded with nanodrug particles to exert a better therapeutic effect than conventional drugs and to make the dressing more practical. This article reviews the application of nanotechnology in hydrogels related to wound healing and discusses the application prospects of nanohydrogels. After searching for hydrogel articles related to wound healing, we found that nanomaterial can not only enhance the mechanical strength, antibacterial properties, and adhesion of hydrogels but also achieve sustained drug release. From the perspective of clinical application, these characteristics are significant for wound healing. The combination of nanomaterial and hydrogel is an ideal dressing with broad application prospects for wound healing in the future.

Functional Imaging in Wounds: Imaging Modalities of Today and Tomorrow

2021 ◽  
Author(s):  
Scott Stratman ◽  
Caralin Schneider ◽  
Hadar Lev-Tov ◽  
Robert Kirsner
Keyword(s):  
Wound Healing ◽  
Healthcare System ◽  
Wound Care ◽  
Significant Risk ◽  
Area Measurement ◽  
Imaging Modalities ◽  
Wound Area ◽  
Wound Assessment ◽  
Risk Of Mortality ◽  
The Us

Wound care is a multidisciplinary field with significant economic burden to our healthcare system. Not only does wound care cost the US healthcare system $20 billion annually, but wounds also remarkably impact the quality of life of patients; wounds pose significant risk of mortality, as the five-year mortality rate for diabetic foot ulcers (DFUs) and ischemic ulcers is notably higher compared to commonly encountered cancers such as breast and prostate. Although it is important to measure how wounds may or may not be improving over time, the only relative “marker” for this is wound area measurement—area measurements can help providers determine if a wound is on a healing or non-healing trajectory. Because wound area measurements are currently the only readily available “gold standard” for predicting healing outcomes, there is a pressing need to understand how other relative biomarkers may play a role in wound healing. Currently, wound care centers across the nation employ various techniques to obtain wound area measurements; length and width of a wound can be measured with a ruler, but this carries a high amount of inter- and intrapersonal error as well as uncertainty. Acetate tracings could be used to limit the amount of error but do not account for depth, thereby making them inaccurate. Here, we discuss current imaging modalities and how they can serve to accurately measure wound size and serve as useful adjuncts in wound assessment. Moreover, new imaging modalities are also discussed and how up-and-coming technologies can provide important information on “biomarkers” for wound healing.

scholarly journals Optimal Support of Wound Healing: New Insights

Dermatology ◽  
2020 ◽  
Vol 236 (6) ◽  
pp. 593-600 ◽  
Author(s):  
Jens Malte Baron ◽  
Martin Glatz ◽  
Ehrhardt Proksch
Keyword(s):  
Wound Healing ◽  
Best Practices ◽  
Wound Closure ◽  
Wound Care ◽  
Clinical Approach ◽  
Visual Appearance ◽  
Rapid Repair ◽  
Wound Recovery ◽  
Scar Management ◽  
Three Phases

<b><i>Background:</i></b> The ultimate goal of wound healing following minor injury is to form a tissue regenerate that has functionality and visual appearance as close to the original skin as possible. The body’s physiological response to any wound is traditionally characterised by three distinct steps: inflammation, proliferation and remodelling. <b><i>Summary:</i></b> New insights suggest that the three phases overlap (and even occur in parallel) in both time and space in the wound, necessitating a clinical approach that targets each stage simultaneously to ensure rapid repair and wound closure without further complications. Ingredients that exhibit activity across each of the three phases, such as dexpanthenol, are of value in the context of minor wound care and scar management. <b><i>Key Messages:</i></b> In addition to treatment and ingredient selection, it is also important to consider broader clinical best practices and self-care options that can be used to optimise the management of minor wounds. An individualised approach that can account for a patient’s unique requirements and preferences is critical in achieving effective wound recovery.

Novel alginate, chitosan, and psyllium composite fiber for wound-care applications

2016 ◽  
Vol 47 (1) ◽  
pp. 20-37 ◽  
Author(s):  
Rashid Masood ◽  
Tanveer Hussain ◽  
Mohsen Miraftab ◽  
Azeem Ullah ◽  
Zulfiqar Ali Raza ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Sodium Alginate ◽  
Wound Care ◽  
Antibacterial Properties ◽  
Coagulation Bath ◽  
Composite Fibers ◽  
Absorption Properties ◽  
Swelling Properties ◽  
Liquid Absorption ◽  
Dope Solution

Alginate/psyllium and alginate/chitosan fibers have great potential for wound-care applications. However, alginate/psyllium fibers have poor tensile strength and alginate/chitosan fibers comparatively have low liquid absorption properties. The main aim was to develop a tri-component fiber with comparatively better tensile strength and liquid absorption properties using three different natural polysaccharides. Alginate, chitosan, and psyllium composite fibers were made by using two different coagulation bath compositions. In method A, psyllium-containing sodium alginate dope solution was extruded into a bath containing CaCl2 and subsequently passed through hydrolyzed chitosan bath, whereas in method B: psyllium-containing sodium alginate dope solution was directly extruded into hydrolyzed chitosan and subsequently passed through CaCl2 bath. The produced fibers were rinsed using 25–100% acetone solutions and dried in air. Tensile, antibacterial, swelling, and absorption properties of these fibers were measured. The study showed that homogeneous fibers can be extruded by using both methods. The fibers produced showed good antibacterial, absorption, and swelling properties. Antibacterial activity of the controlled and composite fibers was more or less the same. However, tensile properties of fibers produced by method A and method B were less than the control alginate–chitosan fibers. The composite fibers produced by method A showed better absorption of saline and solution A than control fiber and composite fibers produced by method B. Therefore, method A is recommended for producing the psyllium-containing alginate chitosan fibers for wound-dressing applications. The fibers produced by this method showed comparable tensile and antibacterial properties, superior absorbency, and swelling properties.

Use of a bacterial fluorescence imaging system to target wound debridement and accelerate healing: a pilot study

2020 ◽  
Vol 29 (Sup7) ◽  
pp. S44-S52 ◽  
Author(s):  
Windy Cole ◽  
Stacey Coe
Keyword(s):  
Wound Healing ◽  
Fluorescence Imaging ◽  
Imaging System ◽  
Wound Care ◽  
Point Of Care ◽  
Bacterial Load ◽  
Case Series ◽  
Wound Area ◽  
Wound Debridement ◽  
Wound Bed Preparation

Objective: Optimal wound-bed preparation consists of regular debridement to remove devitalised tissues, reduce bacterial load, and to establish an environment that promotes healing. However, lack of diagnostic information at point-of-care limits effectiveness of debridement. Method: This observational case series investigated use of point-of-care fluorescence imaging to detect bacteria (loads >104CFU/g) and guide wound bed preparation. Lower extremity hard-to-heal wounds were imaged over a 12-week period for bacterial fluorescence and wound area. Results: A total of 11 wounds were included in the study. Bacterial fluorescence was present in 10 wounds and persisted, on average, for 3.7 weeks over the course of the study. The presence of red or cyan fluorescent signatures from bacteria correlated with an average increase in wound area of 6.5% per week, indicating stalled or delayed wound healing. Fluorescence imaging information assisted in determining the location and extent of wound debridement, and the selection of dressings and/or antimicrobials. Elimination of bacterial fluorescence signature with targeted debridement and other treatments correlated with an average reduction in wound area of 27.7% per week (p<0.05), indicative of a healing trajectory. Conclusion: These results demonstrate that use of fluorescence imaging as part of routine wound care enhances assessment and treatment selection, thus facilitating improved wound healing.

scholarly journals Electrospun Medicated Nanofibers for Wound Healing: Review

Membranes ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 770
Author(s):  
Xinkuan Liu ◽  
Haixia Xu ◽  
Mingxin Zhang ◽  
Deng-Guang Yu
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Wound Care ◽  
Electrospun Fiber ◽  
Antibacterial Properties ◽  
Biologically Active ◽  
Wound Dressings ◽  
Future Research ◽  
Manufacturing Method ◽  
Active Substances

With the increasing demand for wound care and treatment worldwide, traditional dressings have been unable to meet the needs of the existing market due to their limited antibacterial properties and other defects. Electrospinning technology has attracted more and more researchers’ attention as a simple and versatile manufacturing method. The electrospun nanofiber membrane has a unique structure and biological function similar to the extracellular matrix (ECM), and is considered an advanced wound dressing. They have significant potential in encapsulating and delivering active substances that promote wound healing. This article first discusses the common types of wound dressing, and then summarizes the development of electrospun fiber preparation technology. Finally, the polymers and common biologically active substances used in electrospinning wound dressings are summarized, and portable electrospinning equipment is also discussed. Additionally, future research needs are put forward.

scholarly journals RESEARCH AND DEVELOPMENT IN WOUND MANAGEMENT PRODUCTS: A BRIEF REVIEW

2018 ◽  
Vol 11 (6) ◽  
pp. 17
Author(s):  
Surya Geetha V ◽  
Vishal Gupta N ◽  
Gowda Dv ◽  
Kulkarni Pk
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Wound Management ◽  
Skin Substitutes ◽  
Wound Recovery ◽  
Surgical Wounds ◽  
Wide Range ◽  
Healing Wounds ◽  
Dressing Materials ◽  
Normal Architecture

Wound can be defined as any process which leads to the disruption of the normal architecture of a tissue. They may be closed or open, for example, abrasions, lacerations, avulsions, ballistic and excised, or surgical wounds. Successful wound care includes advancing patient local and systemic conditions in conjunction with a perfect injury healing condition. Numerous wide assortments of dressing materials are accessible both for extreme and persistent non-healing wounds. A wide range of wound healing products have been produced to impact this injury condition to give a non-pathogen, ensured, and clammy region for healing to happen. A perfect injury dressing ought to limit loss of protein, electrolytes, and liquids from twisted and to diminish pain and contamination alongside wound healing. More current products are as of now being utilized to supplant or enlarge different substrates in the injury healing period. There is a sharp complexity to prior routine of wound administration, where the injury is permitted to dry, yet the present advancement was to move forward to the idea of wet injury recovering. This review of the present wounding periphery in wound recovery occurs at the most recent utilizations of silver and the employments of negative pressure wound gadgets, propelled dressings and skin substitutes, and biologic injury items including development of hydrogels and hyperbaric oxygen as an aid in wound mending. With the advancement of accessible dressings, the objective is to locate the most proper methodology or blend of modalities to optimize wound healing.

scholarly journals Comparison of Biological Properties of Two Medicinal Extracts of the Tehuacan-Cuicatlan Valley

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Karla S. Martinez-Elizalde ◽  
Marco A. Rodriguez-Monroy ◽  
Cesar M. Flores ◽  
Luis B. Hernandez-Portilla ◽  
Elizabeth Barbosa-Cabrera ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activities ◽  
Biological Properties ◽  
Diffusion Method ◽  
Histopathological Analysis ◽  
Disc Diffusion ◽  
Bacteriostatic Effect ◽  
Disc Diffusion Method ◽  
Healing Of Wounds ◽  
Wound Healing Activity

In the Valley of Tehuacan-Cuicatlan, Cyrtocarpa procera and Bursera morelensis are located and are used in traditional medicine. In this research, several biological properties were evaluated. The methanol extracts of C. procera (MeCp) and B. morelensis (MeBm) were obtained by maceration. The antibacterial activities of the extracts were evaluated by the Kirby–Baüer disc-diffusion method. The wound healing activity was evaluated by histopathological analysis. Both extracts had a bacteriostatic effect in the Staphylococcus aureus (MeCp MIC = 0.25 mg/mL and MeBm MIC = 1 mg/mL) and the Vibrio cholerae (MeCp MIC = 1 mg/mL and MeBm MIC = 4 mg/mL). Both extracts demonstrated a wound healing efficacy similar to the reference standard (Recoveron). They also showed a high antioxidant capacity (MeCp SC50 = 5.75 μg/mL and MeBm SC50 = 4.27 μg/mL). These results are related to the concentration of phenols (MeCp = 166 and MeBm = 236.6 mg GAe/g) and flavonoids of MeCp = 16 and MeBm = 22 μg Qe/g. Both extracts, acting in a similar way in microorganisms that cause infection thanks to their antioxidant activity, favor the healing of wounds. This is the first study in which the biological properties of these two species are compared.

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