scholarly journals Perioperative SARS-CoV-2 infections increase mortality, pulmonary complications, and thromboembolic events: A Dutch, multicenter, matched-cohort clinical study

Surgery ◽  
2020 ◽  
Author(s):  
Pascal K.C. Jonker ◽  
Willemijn Y. van der Plas ◽  
Pieter J. Steinkamp ◽  
Ralph Poelstra ◽  
Marloes Emous ◽  
...  
Keyword(s):  
Clinical Study ◽  
Pulmonary Complications ◽  
Thromboembolic Events ◽  
Matched Cohort

scholarly journals Pulmonary complications in toxic epidermal necrolysis: a prospective clinical study

1997 ◽  
Vol 23 (12) ◽  
Author(s):  
F. Lebargy ◽  
P. Wolkenstein ◽  
M. Gisselbrecht ◽  
F. Lange ◽  
J. Fleury-Feith ◽  
...  
Keyword(s):  
Clinical Study ◽  
Toxic Epidermal Necrolysis ◽  
Pulmonary Complications ◽  
Prospective Clinical Study

scholarly journals Comparison of outcomes of neurosurgical operations performed before and during the COVID-19 pandemic: a matched cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e047063
Author(s):  
Emma Toman ◽  
Wai Cheong Soon ◽  
Gopiga Thanabalasundaram ◽  
Daniel Burns ◽  
Vladimir Petrik ◽  
...  
Keyword(s):  
Major Trauma ◽  
Final Analysis ◽  
Trauma Centre ◽  
Pulmonary Complications ◽  
Matched Cohort ◽  
University Hospitals ◽  
Major Trauma Centre ◽  
Neurosurgical Patients ◽  
Significant Difference ◽  
Discharge Length

ObjectiveTo determine how the first wave of the COVID-19 pandemic affected outcomes for all operatively managed neurosurgical patients, not only those positive for SARS-CoV-2.DesignMatched cohort (pairwise method).SettingA single tertiary neurosurgical referral centre at a large UK Major Trauma Centre.ParticipantsDuring the first COVID-19 wave, 231 neurosurgical cases were performed. These cases were matched to cases from 2019. Cases were matched for age (±10 years), primary pathology and surgical procedure. Cases were excluded from analysis if either the age could not be matched to within 10 years, or the primary pathology or procedure was too unique. After exclusions, 191 cases were included in final analysis.Outcome measuresPrimary outcomes were 30-day mortality and postoperative pulmonary complications. Secondary outcomes included Glasgow Outcome Score (GOS) on discharge, length of stay (LoS), operative and anaesthetic times and grade of primary surgeon. An exploratory outcome was the SARS-CoV-2 status of patients.ResultsThere was no significant difference between the pandemic and matched cohorts in 30-day mortality, pulmonary complications, discharge GOS, LoS, operative or anaesthetic times. There was a significant difference in the variation of grade of primary surgeon. Only 2.2% (n=5) of patients had a SARS-CoV-2 positive swab.ConclusionDuring the first UK wave of the COVID-19 pandemic, the mortality, morbidity and functional outcomes of operatively managed neurosurgical patients at University Hospitals Birmingham were not significantly affected compared with normal practice. The grade of primary surgeon was significantly more senior and adds to the growing body of evidence that demonstrates how the pandemic has negatively impacted UK surgical training. Mixing COVID-19 positive, unknown and negative cases did not significantly impact on outcomes and indicates that further research is required to support the implementation of evidence-based surgical pathways, such as COVID-light sites, throughout the next stage of the pandemic.

scholarly journals Influence of Body Mass Index on Outcomes of Patients Undergoing Surgery for Acute Aortic Dissection: A Propensity-Matched Analysis

2019 ◽  
Vol 46 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Antonio Lio ◽  
Emanuele Bovio ◽  
Francesca Nicolò ◽  
Guglielmo Saitto ◽  
Antonio Scafuri ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Aortic Dissection ◽  
Body Mass ◽  
Acute Aortic Dissection ◽  
Survival Rates ◽  
Type A ◽  
Pulmonary Complications ◽  
Obese Group ◽  
Matched Cohort ◽  
Low Cardiac Output Syndrome

To determine whether body mass index ≥30 kg/m2 affects morbidity and mortality rates in patients undergoing surgery for type A acute aortic dissection, we conducted a retrospective study of 201 patients with type A dissection. Patients were divided into 2 groups according to body mass index (BMI): nonobese (BMI, <30 kg/m2; 158 patients) and obese (BMI, ≥30 kg/m2; 43 patients). Propensity score matching was used to reduce selection bias. The overall mortality rate was 19% (38/201 patients). The perioperative mortality rate was higher in the obese group, both in the overall cohort (33% vs 15%; P=0.01) and in the propensity-matched cohort (32% vs 12%; P=0.039). In the propensity-matched cohort, patients with obesity had higher rates of low cardiac output syndrome (26% vs 6%; P=0.045) and pulmonary complications (32% vs 9%; P=0.033) than those without obesity. The overall 5-year survival rates were 52.5% ± 7.8% in the obese group and 70.3% ± 4.4% in the nonobese group (P=0.036). In the propensity-matched cohort, the 5-year survival rates were 54.3% ± 8.9% in the obese group and 81.6% ± 6.8% in the nonobese group (P=0.018). Patients with obesity (BMI, ≥30 kg/m2) who underwent surgery for type A acute aortic dissection had higher operative mortality rates and an increased risk of low cardiac output syndrome, pulmonary complications, and other postoperative morbidities than did patients without obesity. Additional extensive studies are needed to confirm our findings.

Randomized clinical study of the prevention of pulmonary complications after thoracoabdominal resection by two different breathing techniques

2002 ◽  
Vol 89 (10) ◽  
pp. 1228-1234 ◽  
Author(s):  
M. Fagevik Olsén ◽  
E. Wennberg ◽  
E. Johnsson ◽  
K. Josefson ◽  
H. Lönroth ◽  
...  
Keyword(s):  
Clinical Study ◽  
Pulmonary Complications ◽  
Randomized Clinical Study ◽  
Breathing Techniques

scholarly journals National Rugby League athletes and tendon tap reflex assessment: a matched cohort clinical study

2016 ◽  
Vol 17 (1) ◽  
Author(s):  
James Maurini ◽  
Paul Ohmsen ◽  
Greg Condon ◽  
Rodney Pope ◽  
Wayne Hing
Keyword(s):  
Clinical Study ◽  
Rugby League ◽  
Matched Cohort ◽  
Tendon Tap

scholarly journals COVID-19 in trauma: a propensity-matched analysis of COVID and non-COVID trauma patients

2021 ◽  
Author(s):  
Eric O. Yeates ◽  
Areg Grigorian ◽  
Morgan Schellenberg ◽  
Natthida Owattanapanich ◽  
Galinos Barmparas ◽  
...  
Keyword(s):  
Injury Severity ◽  
Pulmonary Complications ◽  
Surgical Patients ◽  
Trauma Patients ◽  
Matched Cohort ◽  
Trauma Centers ◽  
Propensity Score Model ◽  
Trauma Population ◽  
Level I ◽  
Score Model

Abstract Purpose There is mounting evidence that surgical patients with COVID-19 have higher morbidity and mortality than patients without COVID-19. Infection is prevalent amongst the trauma population, but any effect of COVID-19 on trauma patients is unknown. We aimed to evaluate the effect of COVID-19 on a trauma population, hypothesizing increased mortality and pulmonary complications for COVID-19-positive (COVID) trauma patients compared to propensity-matched COVID-19-negative (non-COVID) patients. Methods A retrospective analysis of trauma patients presenting to 11 Level-I and II trauma centers in California between 1/1/2019–6/30/2019 and 1/1/2020–6/30/2020 was performed. A 1:2 propensity score model was used to match COVID to non-COVID trauma patients using age, blunt/penetrating mechanism, injury severity score, Glasgow Coma Scale score, systolic blood pressure, respiratory rate, and heart rate. Outcomes were compared between the two groups. Results A total of 20,448 trauma patients were identified during the study period. 53 COVID trauma patients were matched with 106 non-COVID trauma patients. COVID patients had higher rates of mortality (9.4% vs 1.9%, p = 0.029) and pneumonia (7.5% vs. 0.0%, p = 0.011), as well as a longer mean length of stay (LOS) (7.47 vs 3.28 days, p < 0.001) and intensive care unit LOS (1.40 vs 0.80 days, p = 0.008), compared to non-COVID patients. Conclusion This multicenter retrospective study found increased rates of mortality and pneumonia, as well as a longer LOS, for COVID trauma patients compared to a propensity-matched cohort of non-COVID patients. Further studies are warranted to validate these findings and to elucidate the underlying pathways responsible for higher mortality in COVID trauma patients.

scholarly journals Anticoagulation Prior to COVID-19 Infection Has No Impact on 6 Months Mortality: A Propensity Score–Matched Cohort Study

2022 ◽  
Vol 11 (2) ◽  
pp. 352
Author(s):  
Marcin Protasiewicz ◽  
Konrad Reszka ◽  
Wojciech Kosowski ◽  
Barbara Adamik ◽  
Wojciech Bombala ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Mortality Rate ◽  
Propensity Score ◽  
Medical Records ◽  
Thromboembolic Events ◽  
Matched Cohort ◽  
Anticoagulant Treatment ◽  
Antithrombotic Treatment ◽  
Bleeding Rate ◽  
High Incidence

The coronavirus disease 2019 (COVID-19) shows high incidence of thromboembolic events in humans. In the present study, we aimed to evaluate if anticoagulation prior to COVID-19 infection may impact clinical profile, as well as mortality rate among patients hospitalized with COVID-19. The study was based on retrospective analysis of medical records of patients with laboratory confirmed SARS-CoV-2 infection. After propensity score matching (PSM), a group of 236 patients receiving any anticoagulant treatment prior to COVID-19 infection (AT group) was compared to 236 patients without previous anticoagulation (no AT group). In 180 days, the observation we noted comparable mortality rate in AT and no AT groups (38.5% vs. 41.1%, p = 0.51). Similarly, we did not observe any statistically significant differences in admission in the intensive care unit (14.1% vs. 9.6%, p = 0.20), intubation and mechanical ventilation (15.0% vs. 11.6%, p = 0.38), catecholamines usage (14.3% vs. 13.8%, p = 0.86), and bleeding rate (6.3% vs. 8.9%, p = 0.37) in both groups. Our results suggest that antithrombotic treatment prior to COVID-19 infection is unlikely to be protective for morbidity and mortality in patients hospitalized with COVID-19.

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