scholarly journals Design and synthesis of 3, 5- hetero diesters of 4-deoxy quinic acid and their aphicidal activity against Acyrthosiphon pisum

Tetrahedron ◽  
2021 ◽  
pp. 131982
Author(s):  
Xiubin Li ◽  
Catherine Sivignon ◽  
Pedro da Silva ◽  
Yvan Rahbé ◽  
Yves Queneau ◽  
...  
Peptides ◽  
2011 ◽  
Vol 32 (3) ◽  
pp. 587-594 ◽  
Author(s):  
Ronald J. Nachman ◽  
Kamran Mahdian ◽  
Dick R. Nässel ◽  
R. Elwyn Isaac ◽  
Nan Pryor ◽  
...  

2020 ◽  
Vol 12 (21) ◽  
pp. 1891-1910
Author(s):  
Akshaya Murugesan ◽  
Suvi Holmstedt ◽  
Kenna C Brown ◽  
Alisa Koivuporras ◽  
Ana S Macedo ◽  
...  

Aim: Quinic acid (QA) is a cyclic polyol exhibiting anticancer properties on several cancers. However, potential role of QA derivatives against glioblastoma is not well established. Methodology & results: Sixteen novel QA derivatives and QA-16 encapsulated poly (lactic-co-glycolic acid) nanoparticles (QA-16-NPs) were screened for their anti-glioblastoma effect using standard cell and molecular biology methods. Presence of a tertiary hydroxy and silylether groups in the lead compound were identified for the antitumor activity. QA-16 have 90% inhibition with the IC50 of 10.66 μM and 28.22 μM for LN229 and SNB19, respectively. The induction of apoptosis is faster with the increased fold change of caspase 3/7 and reactive oxygen species. Conclusion: QA-16 and QA-16-NPs shows similar cytotoxicity effect, providing the opportunity to use QA-16 as a potential chemotherapeutic agent.


2016 ◽  
Vol 14 (8) ◽  
pp. 2487-2497 ◽  
Author(s):  
Xiubin Li ◽  
Lucie Grand ◽  
Thomas Pouleriguen ◽  
Yves Queneau ◽  
Pedro da Silva ◽  
...  

Syntheses of seven new di-hydroxycinnamoyl 4-deoxy quinic acid derivatives and insecticidal bioassays against a pea aphid are reported.


1997 ◽  
Vol 7 (21) ◽  
pp. 2729-2734 ◽  
Author(s):  
Stephen Hanessian ◽  
Gurijala V. Reddy ◽  
Hoan K. Huynh ◽  
Jingwen Pan ◽  
Silvana Pedatella ◽  
...  

Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.


Author(s):  
Mehmet Sarikaya ◽  
Ilhan A. Aksay

Biomimetics involves investigation of structure, function, and methods of synthesis of biological composite materials. The goal is to apply this information to the design and synthesis of materials for engineering applications.Properties of engineering materials are structure sensitive through the whole spectrum of dimensions from nanometer to macro scale. The goal in designing and processing of technological materials, therefore, is to control microstructural evolution at each of these dimensions so as to achieve predictable physical and chemical properties. Control at each successive level of dimension, however, is a major challenge as is the retention of integrity between successive levels. Engineering materials are rarely fabricated to achieve more than a few of the desired properties and the synthesis techniques usually involve high temperature or low pressure conditions that are energy inefficient and environmentally damaging.In contrast to human-made materials, organisms synthesize composites whose intricate structures are more controlled at each scale and hierarchical order.


Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
B Kang ◽  
YJ Jung ◽  
R Jeon
Keyword(s):  

Planta Medica ◽  
2016 ◽  
Vol 82 (05) ◽  
Author(s):  
KY Orabi ◽  
MS Abaza ◽  
KA ElSayed ◽  
AY Elnagar ◽  
SI Faggal ◽  
...  

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