Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility

2021 ◽  
Author(s):  
Jiri Forejt ◽  
Petr Jansa ◽  
Emil Parvanov
Keyword(s):  
Mus Musculus ◽  
Hybrid Sterility ◽  
Peculiar Case ◽  
Sterility Genes

scholarly journals The Origin of Weedy Rice Ludao in China Deduced by Genome Wide Analysis of Its Hybrid Sterility Genes

2005 ◽  
Vol 55 (4) ◽  
pp. 409-414 ◽  
Author(s):  
Susong Zhu ◽  
Ling Jiang ◽  
Chunming Wang ◽  
Huqu Zhai ◽  
Danting Li ◽  
...  
Keyword(s):  
Hybrid Sterility ◽  
Weedy Rice ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Sterility Genes

The genetics of hybrid sterility between subspecies of the complex of Glossina morsitans Westwood (Diptera: Glossinidae)

1985 ◽  
Vol 75 (4) ◽  
pp. 689-699 ◽  
Author(s):  
P. Rawlings
Keyword(s):  
Hybrid Sterility ◽  
Autosomal Gene ◽  
Glossina Morsitans ◽  
Hybrid Male ◽  
Hybrid Female ◽  
Hybrid Male Sterility ◽  
Tsetse Control ◽  
Y Chromosomes ◽  
Control Programmes ◽  
Sterility Genes

AbstractCrosses were made between the three subspecies of the complex of Glossina morsitans Westwood and the hybrid females backcrossed. Hybrid female fecundity was highly ‘reactive’ to foreign male genes when the mother was G. morsitans centralis Machado compared with the reciprocal crosses and backcrosses. Hybrid F1 males were unable to inseminate females successfully, and although in nearly a quarter of the dissections sperm was transferred to the uterus, it did not migrate to the spermathecae. Heterozygosity between the X- and Y-chromosomes and most of the autosomes led to high frequencies of sterile males, but homozygosity between the X- and Y-chromosomes could still yield 30–50% sterility. Successive backcrosses of hybrid females between G. m. morsitans and G. m. centralis to the latter subspecies continued to increase the frequency of fertile males. Interactions between X-chromosome and autosomal gene seemed to be responsible for hybrid male sterility, and the number of sterility genes involved appeared to be very few. Crosses involving G. morsitans submorsitans Newstead generally agreed with those between the other two subspecies, but the distortion in the sex ratio of emergent adults limited the application of the data to this subspecies. Competition experiments using sterile hybrid males and fertile males in population cages (30 cm cube) showed that suppression was possible, especially when the ratio of sterile:fertile males was 2:1. The value of stetile hybrid males in tsetse control programmes and the evolution of reproductive isolation in the complex is discussed.

Evaluation of Drosophila chromosomal segments proposed by means of simulations of possessing hybrid sterility genes from reproductive isolation

2020 ◽  
Vol 99 (1) ◽  
Author(s):  
Francisco García-Franco ◽  
Lilian Milena Barandica-Cañon ◽  
Jannitza Arandia-Barrios ◽  
Ezel Jacome Galindo-Pérez ◽  
Gilberto Sven Binnqüist Cervantes ◽  
...  
Keyword(s):  
Reproductive Isolation ◽  
Hybrid Sterility ◽  
Sterility Genes

scholarly journals Chromosome-wide characterization of meiotic noncrossovers (gene conversions) in mouse hybrids

Genetics ◽  
2020 ◽  
Vol 217 (1) ◽  
pp. 1-14
Author(s):  
Vaclav Gergelits ◽  
Emil Parvanov ◽  
Petr Simecek ◽  
Jiri Forejt
Keyword(s):  
Mus Musculus ◽  
Hybrid Sterility ◽  
Wide Distribution ◽  
Mus Musculus Domesticus ◽  
Dna Double Strand Breaks ◽  
Mus Musculus Musculus ◽  
Significant Deficit ◽  
Chromosome Substitution Strains ◽  
Gene Conversions

Abstract During meiosis, the recombination-initiating DNA double-strand breaks (DSBs) are repaired by crossovers or noncrossovers (gene conversions). While crossovers are easily detectable, noncrossover identification is hampered by the small size of their converted tracts and the necessity of sequence polymorphism. We report identification and characterization of a mouse chromosome-wide set of noncrossovers by next-generation sequencing of 10 mouse intersubspecific chromosome substitution strains. Based on 94 identified noncrossovers, we determined the mean length of a conversion tract to be 32 bp. The spatial chromosome-wide distribution of noncrossovers and crossovers significantly differed, although both sets overlapped the known hotspots of PRDM9-directed histone methylation and DNA DSBs, thus supporting their origin in the standard DSB repair pathway. A significant deficit of noncrossovers descending from asymmetric DSBs proved their proposed adverse effect on meiotic recombination and pointed to sister chromatids as an alternative template for their repair. The finding has implications for the molecular mechanism of hybrid sterility in mice from crosses between closely related Mus musculus musculus and Mus musculus domesticus subspecies.

scholarly journals Independent domestications shape the genetic pattern of a reproductive isolation system in rice

2020 ◽  
Author(s):  
Xun Xu ◽  
Song Ge ◽  
Fu-Min Zhang
Keyword(s):  
Reproductive Isolation ◽  
Hybrid Sterility ◽  
Cost Savings ◽  
Isolation System ◽  
Bottleneck Effect ◽  
In The Wild ◽  
History Of ◽  
On Line ◽  
Selection For ◽  
Sterility Genes

AbstractSevere reproductive isolation (RI) exists between the two subspecies of rice, Indica and Japonica, but in the wild ancestors no post-zygotic RI was found. The studies about the establishment of the interspecies RI of rice are still rear. A pair of rice hybrid sterility genes, DOPPELGANGER 1 (DPL1) and DOPPELGANGER 2 (DPL2), offers a convenient example to study the evolutionary history of RI genes. Either of the two loci has one non-functional allele (DPL1- and DPL2-). The hybrid pollen carrying both DPL1- and DPL2- will be sterility.We collected 811 individuals: Oryza sativa (132), the two wild ancestors O. nivara (296) and O. rufipogon (383) as well as 20 DPL1 and 34 DPL2 sequences of O. sativa from on-line databases. We analysed the genetic and geographic pattern of DPLs in all three species to determine the origination regions of DPL1- and DPL2-. The neutral test as well as the diversities of nucleotide and haplotype were used to detect if selection shaped the pattern of DPLs.We found that DPL1- and DPL2- of rice emerged from wild ancestor populations in South Asia and South China through two respective domestications. Comparing with the ancestral populations, DPL1- and DPL2- both showed reduce of diversities, however their frequencies increased in rice. We assume that the reduce of diversities due to the bottleneck effect of domestication while the loss of one copy was preferred by artificial selection for cost savings.

Discord Between the Phylogenies Inferred From Molecular Versus Functional Data: Uneven Rates of Functional Evolution or Low Levels of Gene Flow?

Genetics ◽  
1996 ◽  
Vol 144 (3) ◽  
pp. 1321-1328
Author(s):  
Michael F Palopoli ◽  
Andrew W Davis ◽  
Chung-I Wu
Keyword(s):  
Gene Flow ◽  
Functional Data ◽  
Hybrid Sterility ◽  
Species Boundaries ◽  
Negative Effects ◽  
Functional Evolution ◽  
Sterility Gene ◽  
Molecular Divergence ◽  
Low Levels ◽  
Sterility Genes

Abstract According to measures of molecular divergence, the three species of the Drosophila simulans clade are closely related to and essentially equidistant from each other. We introgressed 10% of the D. sechellia X chromosome into a pure D. simulans genetic background and found that males carrying this introgressed region were consistently fertile; in contrast, males carrying the same segment from D. mauritiana are sterile and suffer from incompatibilities at a minimum of four loci. Together with other recent results, these data suggest that D. simulans and D. sechellia are much more closely related to each other than either is to D. mauritiana. How can we reconcile the phylogeny inferred from the density of hybrid sterility genes with that inferred from molecular divergence? If the molecular phylogeny is correct, the discrepancy might be explained by uneven rates of functional evolution, resulting in the uneven accumulation of substitutions with corresponding negative effects in hybrids. If the functional phylogeny is correct, then low levels of gene flow across nascent species boundaries, particularly for loci not tightly linked to a hybrid sterility gene, may have erased the original pattern of lineage splitting. We propose tests that will allow us to discriminate between these hypotheses.

scholarly journals Genetic studies on male sterility of hybrids between laboratory and wild mice (Mus musculus L.)

1974 ◽  
Vol 24 (2) ◽  
pp. 189-206 ◽  
Author(s):  
J. Forejt ◽  
P. Iványi
Keyword(s):  
Mus Musculus ◽  
Hybrid Sterility ◽  
Chromosomal Rearrangements ◽  
Genetic System ◽  
Inbred Strains ◽  
Male Offspring ◽  
Chromosome 17 ◽  
Genetic Studies ◽  
Wild Mice ◽  
Chromosomal Type

SUMMARYThe genetic control of the sterility of male hybrids between certain laboratory and wild mice (Mus musculus L.) is investigated. The observed sterility is, by definition, hybrid sterility since both parental forms (i.e. wild and laboratory mice) are fully fertile, their male offspring displaying small testes with arrest of spermatogenesis at the stage of spermatogenesis or primary spermatocytes. Results of genetic analysis as well as the failure to detect any chromosomal rearrangements point to a genie rather than a chromosomal type of hybrid sterility.Fifty-three wild males were classified into three sets, after mating with C57BL/10 inbred females, according to the fertility of their male progeny (set I – only sterile sons; set II – only fertile sons; set III – both fertile and sterile sons). The wild males of set I, which yield only sterile male offspring with C57BL/10 females, sire sterile sons also with females of the following inbred strains: A/Ph, BALB/c, DBA/1, and AKR/J, whereas the same wild males produce fertile offspring with females of C3H/Di, CBA/J, P/J, I/St and F/St inbred strains.The described hybrid sterility seems to be under the control of several independently segregating genes, one of them (proposed symbol Hst-1) being localized on chromosome 17 (linkage group IX), 6 cM distally from dominant T (Brachyury). A chance to search for the mechanism of hybrid sterility is provided by the finding of two laboratory inbred strains, C57BL/10 and C3H/Di, differing with respect to the Hybrid sterility genetic system only at the Hst-1 gene.Hst-1 is closely linked but apparently not identical with the sterility factor of recessive t alleles of the T locus.

Zwei Fallberichte einer disseminierten Toxoplasmose

2012 ◽  
Vol 40 (01) ◽  
pp. 64-69
Author(s):  
C. Kiesow ◽  
C. Ellenberger ◽  
B. Stief
Keyword(s):  
Mus Musculus ◽  
Ailurus Fulgens

ZusammenfassungEs werden die Fälle einer disseminierten letalen Toxoplasmose bei einer Farbmaus (Mus musculus) und einem Roten Panda (Ailurus fulgens) vorgestellt. Es handelte sich um eine als Haustier gehaltene Farbmaus und einen Roten Panda aus einem sächsischen zoologischen Garten. Die pathologische Untersuchung ergab bei beiden Tieren eine systemische Toxoplasmeninfektion. Eine hochgradige nekrotisierende Hepatitis stellte in beiden Fällen den histologischen Hauptbefund dar. Parasitenzysten fanden sich massenhaft in der Leber, in mäßiger Zahl im Gehirn und in geringer Zahl in anderen Organen. Mittels PAS-Reaktion waren diese Zysten bei der Farbmaus kaum darstellbar, beim Roten Panda dagegen sehr deutlich. PCR bzw. Immunhistologie bestätigten die Diagnose.

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