Titanium dioxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in human amnion epithelial (WISH) cells

2012 ◽  
Vol 26 (2) ◽  
pp. 351-361 ◽  
Author(s):  
Quaiser Saquib ◽  
Abdulaziz A. Al-Khedhairy ◽  
Maqsood A. Siddiqui ◽  
Faisal M. Abou-Tarboush ◽  
Ameer Azam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Human Amnion

scholarly journals Comparison of Oxidative Stresses Mediated by Different Crystalline Forms and Surface Modification of Titanium Dioxide Nanoparticles

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Karim Samy El-Said ◽  
Ehab Mostafa Ali ◽  
Koki Kanehira ◽  
Akiyoshi Taniguchi
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Titanium Dioxide ◽  
Surface Modification ◽  
Titanium Dioxide Nanoparticles ◽  
Crystalline Form ◽  
Cellular Mechanisms ◽  
Oxidative Stresses ◽  
Wide Range ◽  
Crystalline Forms

Titanium dioxide nanoparticles (TiO2NPs) are manufactured worldwide for use in a wide range of applications. There are two common crystalline forms of TiO2anatase and rutile with different physical and chemical characteristics. We previously demonstrated that an increased DNA damage response is mediated by anatase crystalline form compared to rutile. In the present study, we conjugated TiO2NPs with polyethylene glycol (PEG) in order to reduce the genotoxicity and we evaluated some oxidative stress parameters to obtain information on the cellular mechanisms of DNA damage that operate in response to TiO2NPs different crystalline forms exposure in hepatocarcinoma cell lines (HepG2). Our results indicated a significant increase in oxidative stress mediated by the anatase form of TiO2NPs compared to rutile form. On the other hand, PEG modified TiO2NPs showed a significant decrease in oxidative stress as compared to TiO2NPs. These data suggested that the genotoxic potential of TiO2NPs varies with crystalline form and surface modification.

scholarly journals Titanium dioxide nanoparticle-induced oxidative stress triggers DNA damage and hepatic injury in mice

Nanomedicine ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. 1423-1434 ◽  
Author(s):  
Ritesh K Shukla ◽  
Ashutosh Kumar ◽  
Naga Veera Srikanth Vallabani ◽  
Alok K Pandey ◽  
Alok Dhawan
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Titanium Dioxide ◽  
Hepatic Injury ◽  
Titanium Dioxide Nanoparticle

Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells

2008 ◽  
Vol 180 (3) ◽  
pp. 222-229 ◽  
Author(s):  
Eun-Jung Park ◽  
Jongheop Yi ◽  
Kyu-Hyuck Chung ◽  
Doug-Young Ryu ◽  
Jinhee Choi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles

Titanium dioxide nanoparticles promote oxidative stress, autophagy and reduce NLRP3 in primary rat astrocytes

2020 ◽  
Vol 317 ◽  
pp. 108966 ◽  
Author(s):  
José Antonio Pérez-Arizti ◽  
José Luis Ventura-Gallegos ◽  
Roberto Erasmo Galván Juárez ◽  
María del Pilar Ramos-Godinez ◽  
Zaira Colín-Val ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Rat Astrocytes

scholarly journals Titanium Dioxide Nanoparticles Induce DNA Damage and Genetic Instability In vivo in Mice

2009 ◽  
Vol 69 (22) ◽  
pp. 8784-8789 ◽  
Author(s):  
B. Trouiller ◽  
R. Reliene ◽  
A. Westbrook ◽  
P. Solaimani ◽  
R. H. Schiestl
Keyword(s):  
Dna Damage ◽  
Titanium Dioxide ◽  
Genetic Instability ◽  
Titanium Dioxide Nanoparticles

scholarly journals Internalization of Titanium Dioxide Nanoparticles Is Cytotoxic for H9c2 Rat Cardiomyoblasts

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1955 ◽  
Author(s):  
Elizabeth Huerta-García ◽  
Iván Zepeda-Quiroz ◽  
Helen Sánchez-Barrera ◽  
Zaira Colín-Val ◽  
Ernesto Alfaro-Moreno ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Death ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Membrane Integrity ◽  
The Body ◽  
Potential Health ◽  
Tio2 Nps

Titanium dioxide nanoparticles (TiO2 NPs) are widely used in industry and daily life. TiO2 NPs can penetrate into the body, translocate from the lungs into the circulation and come into contact with cardiac cells. In this work, we evaluated the toxicity of TiO2 NPs on H9c2 rat cardiomyoblasts. Internalization of TiO2 NPs and their effect on cell proliferation, viability, oxidative stress and cell death were assessed, as well as cell cycle alterations. Cellular uptake of TiO2 NPs reduced metabolic activity and cell proliferation and increased oxidative stress by 19-fold measured as H2DCFDA oxidation. TiO2 NPs disrupted the plasmatic membrane integrity and decreased the mitochondrial membrane potential. These cytotoxic effects were related with changes in the distribution of cell cycle phases resulting in necrotic death and autophagy. These findings suggest that TiO2 NPs exposure represents a potential health risk, particularly in the development of cardiovascular diseases via oxidative stress and cell death.

Sign in / Sign up

Export Citation Format

Share Document