Safety of green coffee oil in cosmetic formulations: From in vitro to clinical studies

2013 ◽  
Vol 221 ◽  
pp. S231 ◽  
Author(s):  
Tais A.L. Wagemaker ◽  
Ana Sofia Fernandes ◽  
Catarina Rosado ◽  
Patricia Rijo ◽  
Patricia Maia Campos ◽  
...  
Keyword(s):  
Clinical Studies ◽  
Green Coffee ◽  
Cosmetic Formulations ◽  
Coffee Oil

scholarly journals Evaluation of antioxidant and antimicrobial activities of green coffee oil in cosmetic formulations

2012 ◽  
Vol 9 (2) ◽  
pp. 207-214 ◽  
Author(s):  
Tais A. L. Wagemaker ◽  
Ana S. Fernandes ◽  
Patrícia Maia Campos ◽  
Luís Monteiro Rodrigues ◽  
Patrícia Rijo
Keyword(s):  
Antimicrobial Activities ◽  
Green Coffee ◽  
Cosmetic Formulations ◽  
Coffee Oil ◽  
Antioxidant And Antimicrobial Activities

Integrated approach in the assessment of skin compatibility of cosmetic formulations with green coffee oil

2015 ◽  
Vol 37 (5) ◽  
pp. 506-510 ◽  
Author(s):  
T. A. L. Wagemaker ◽  
P. Rijo ◽  
L. M. Rodrigues ◽  
P. M. B. G. Maia Campos ◽  
A. S. Fernandes ◽  
...  
Keyword(s):  
Integrated Approach ◽  
Green Coffee ◽  
Cosmetic Formulations ◽  
Coffee Oil ◽  
Skin Compatibility

scholarly journals Microencapsulation by spray drying of emulsified green coffee oil with two-layered membranes

2014 ◽  
Vol 61 ◽  
pp. 236-245 ◽  
Author(s):  
A.G.S. Carvalho ◽  
V.M. Silva ◽  
M.D. Hubinger
Keyword(s):  
Spray Drying ◽  
Green Coffee ◽  
Coffee Oil

scholarly journals In Vitro,In Vivo, and Clinical Studies of Tedizolid To Assess the Potential for Peripheral or Central Monoamine Oxidase Interactions

2013 ◽  
Vol 57 (7) ◽  
pp. 3060-3066 ◽  
Author(s):  
S. Flanagan ◽  
K. Bartizal ◽  
S. L. Minassian ◽  
E. Fang ◽  
P. Prokocimer
Keyword(s):  
Blood Pressure ◽  
Monoamine Oxidase ◽  
Clinical Research ◽  
Systolic Blood Pressure ◽  
Clinical Studies ◽  
Geometric Mean ◽  
Interaction Study ◽  
Mao B ◽  
Mao A

ABSTRACTTedizolid phosphate is a novel oxazolidinone prodrug whose active moiety, tedizolid, has improved potency against Gram-positive pathogens and pharmacokinetics, allowing once-daily administration. Given linezolid warnings for drug-drug and drug-food interactions mediated by monoamine oxidase (MAO) inhibition, including sporadic serotonergic toxicity, these studies evaluated tedizolid for potential MAO interactions.In vitro, tedizolid and linezolid were reversible inhibitors of human MAO-A and MAO-B; the 50% inhibitory concentration (IC50) for tedizolid was 8.7 μM for MAO-A and 5.7 μM for MAO-B and 46.0 and 2.1 μM, respectively, with linezolid. Tedizolid phosphate was negative in the mouse head twitch model of serotonergic activity. Two randomized placebo-controlled crossover clinical studies assessed the potential of 200 mg/day tedizolid phosphate (at steady state) to enhance pressor responses to coadministered oral tyramine or pseudoephedrine. Sensitivity to tyramine was determined by comparing the concentration of tyramine required to elicit a ≥30-mmHg increase in systolic blood pressure (TYR30) when administered with placebo versus tedizolid phosphate. The geometric mean tyramine sensitivity ratio (placebo TYR30/tedizolid phosphate TYR30) was 1.33; a ratio of ≥2 is considered clinically relevant. In the pseudoephedrine study, mean maximum systolic blood pressure was not significantly different when pseudoephedrine was coadministered with tedizolid phosphate versus placebo. In summary, tedizolid is a weak, reversible inhibitor of MAO-A and MAO-Bin vitro. Provocative testing in humans and animal models failed to uncover significant signals that would suggest potential for hypertensive or serotonergic adverse consequences at the therapeutic dose of tedizolid phosphate. Clinical studies are registered atwww.clinicaltrials.govas NCT01539473 (tyramine interaction study conducted at Covance Clinical Research Center, Evansville, IN) and NCT01577459 (pseudoephedrine interaction study conducted at Vince and Associates Clinical Research, Overland Park, KS).

scholarly journals Advances in bacterial specific imaging

2005 ◽  
Vol 48 (spe2) ◽  
pp. 145-152 ◽  
Author(s):  
David Wareham ◽  
J. Michael ◽  
Satya Das
Keyword(s):  
Nuclear Medicine ◽  
Clinical Studies ◽  
Human Disease ◽  
Diagnostic Technique ◽  
Sterile Inflammation ◽  
Microbial Infection ◽  
Course Of Disease ◽  
Wide Range ◽  
Diagnosis Of Infection

Nuclear medicine is a powerful diagnostic technique able to detect inflammatory foci in human disease. A wide range of agents have been evaluated for their ability to distinguish lesions due to microbial infection from those due to sterile inflammation. Advances continue to be made on the use of radiolabelled antibiotics which as well as being highly specific in the diagnosis of infection may be useful in monitoring the treatment and course of disease. Here we provide an update on in-vitro and clinical studies with a number of established and novel radiopharmaceuticals

scholarly journals Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

Planta Medica ◽  
2018 ◽  
Vol 85 (03) ◽  
pp. 239-248 ◽  
Author(s):  
Anju Benny ◽  
Jaya Thomas
Keyword(s):  
Essential Oils ◽  
Clinical Studies ◽  
Symptomatic Relief ◽  
Memory Loss ◽  
Clinical Trial Data ◽  
In Vivo Studies ◽  
Scientific Databases ◽  
Preclinical And Clinical Studies

AbstractAlzheimerʼs disease is a multifarious neurodegenerative disease that causes cognitive impairment and gradual memory loss. Several hypotheses have been put forward to postulate its pathophysiology. Currently, few drugs are available for the management of Alzheimerʼs disease and the treatment provides only symptomatic relief. Our aim is to review the relevant in vitro, in vivo, and clinical studies focused toward the potential uses of essential oils in the treatment of Alzheimerʼs disease. Scientific databases such as PubMed, ScienceDirect, Scopus, and Google Scholar from April 1998 to June 2018 were explored to collect data. We have conducted wide search on various essential oils used in different models of Alzheimerʼs disease. Out of 55 essential oils identified for Alzheimerʼs intervention, 28 have been included in the present review. A short description of in vivo studies of 13 essential oils together with clinical trial data of Salvia officinalis, Salvia lavandulifolia, Melissa officinalis, Lavandula angustifolia, and Rosmarinus officinalis have been highlighted. In vitro studies of remaining essential oils that possess antioxidant and anticholinesterase potential are also mentioned. Our literary survey revealed encouraging results regarding the various essential oils being studied in preclinical and clinical studies of Alzheimerʼs disease with significant effects in modulating the pathology through anti-amyloid, antioxidants, anticholinesterase, and memory-enhancement activity.

scholarly journals Abbas Dawwas Matter Al-Maliki Investigation of Biochemical Effect of Phenols Extract Isolated from Coriandrum sativum Seeds Against Echinococcus granulosus Parasite in Vitro

2008 ◽  
pp. 2-9
Keyword(s):  
Echinococcus Granulosus ◽  
Hydatid Disease ◽  
Clinical Studies ◽  
Coriandrum Sativum ◽  
Biochemical Effect ◽  
Extract Concentration ◽  
The Third ◽  
Viability Percentage

This study was carried out to investigate effect of phenols extract isolated from Coriandrum sativum seeds extract against Echinococcus granulosus parasite gotten from livers of sheep infected by hydatid disease in Basrah abattoir . It was found that increase of concentration of extract led to decrease of protoscolices viability and the number of dead protoscolices increased with increase of days . Also the concentration of (0.75 gm/ml) had the higher effect on viability of protoscolices where it was noticed that this concentration killed all protoscolices after three days of treatment wheras the concentration of (0.25 gm/ml) was the less effect where it led to kill protoscolices after seven days of treatment with extract . The viability percentage reached to zero at concentration of (0.75 gm/ml) in the third day but at concentrations (0.5 and 0.6 gm/ml) was zero in the fourth day . Also it was found that protoscolices viability percentage was zero in the seventh day of treatment by using concentration of (0.25 gm/ml) . Therefore phenols extract concentration of (0.75 gm/ml) can be used as a medicinal herbal substitute instead of antibiotics but it needs further clinical studies .

scholarly journals Preclinical and clinical validation of a novel injected molded swab for molecular assay detection of SARS-CoV-2 virus

2021 ◽  
Author(s):  
Chiara Elia Ghezzi ◽  
Devon R Hartigan ◽  
Justin Hardick ◽  
Rebecca Gore ◽  
Miryam Adelfio ◽  
...  
Keyword(s):  
Health Care Providers ◽  
Medical Devices ◽  
Clinical Studies ◽  
Nasal Swab ◽  
Cost Effective ◽  
Slight Reduction ◽  
Care Providers ◽  
Significant Difference ◽  
Injection Molded

During the COVID-19 public health emergency, many actions have been undertaken to help ensure that patients and health care providers had timely and continued access to high-quality medical devices to respond effectively. The development and validation of new testing supplies and equipment, including collection swab, help expand the availability and capability for various diagnostic, therapeutic, and protective medical devices in high demand during the COVID-19 emergency. Here, we report the validation of a new injection-molded anterior nasal swab, ClearTip™, that was experimentally validated in a laboratory setting as well as in independent clinical studies in comparison to gold standard flocked swabs. We have also developed an in vitro anterior nasal tissue model, that offers an efficient and clinically relevant validation tool to replicate with high fidelity the clinical swabbing workflow, while being accessible, safe, reproducible, time and cost effective. ClearTi™ displayed a greater efficiency of release of inactivated virus in the benchtop model, confirmed by greater ability to report positive samples in a clinical study in comparison to flocked swabs. We also quantified in multi-center pre-clinical and clinical studies the detection of biological materials, as proxy for viral material, that showed a statistically significant difference in one study and a slight reduction in performance in comparison to flocked swabs. Taken together these results underscore the compelling benefits of non-absorbent injected molded anterior nasal swab for COVID-19 detection, comparable to standard flocked swabs. Injection-molded swabs, as ClearTip™, could have the potential to support future swab shortage, due to its manufacturing advantages, while offering benefits in comparison to highly absorbent swabs in terms comfort, limited volume collection, and potential multiple usage.

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