Freeze-Dried Matrices for Buccal Administration of Propranolol in Children: Physico-Chemical and Functional Characterization

2020 ◽  
Author(s):  
Angela Abruzzo ◽  
Alessandra Crispini ◽  
Cecilia Prata ◽  
Rosanna Adduci ◽  
Fiore Pasquale Nicoletta ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Physico Chemical ◽  
Freeze Dried

The redispersibility and physico-chemical properties of freeze-dried colloidal microgels

1998 ◽  
Vol 137 (1-3) ◽  
pp. 155-164 ◽  
Author(s):  
C.B. Agbugba ◽  
B.A. Hendriksen ◽  
B.Z. Chowdhry ◽  
M.J. Snowden
Keyword(s):  
Chemical Properties ◽  
Physico Chemical ◽  
Freeze Dried

scholarly journals Design and Characterization of Glyceryl Monooleate-Nanostructures Containing Doxorubicin Hydrochloride

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1017
Author(s):  
Agnese Gagliardi ◽  
Donato Cosco ◽  
Betty P. Udongo ◽  
Luciana Dini ◽  
Giuseppe Viglietto ◽  
...  
Keyword(s):  
Liquid Crystal ◽  
Multidrug Resistant ◽  
Lyotropic Liquid Crystal ◽  
Poloxamer 407 ◽  
Breast Cancer Cell Lines ◽  
Doxorubicin Hydrochloride ◽  
Glyceryl Monooleate ◽  
Physico Chemical ◽  
Freeze Dried ◽  
Remote Loading

Glyceryl monooleate (GMO) is one of the most popular amphiphilic lipids, which, in the presence of different amounts of water and a proper amount of stabilizer, can promote the development of well defined, thermodynamically stable nanostructures, called lyotropic liquid crystal dispersions. The aim of this study is based on the design, characterization, and evaluation of the cytotoxicity of lyotropic liquid crystal nanostructures containing a model anticancer drug such as doxorubicin hydrochloride. The drug is efficiently retained by the GMO nanosystems by a remote loading approach. The nanostructures prepared with different non-ionic surfactants (poloxamers and polysorbates) are characterized by different physico-chemical features as a function of several parameters, i.e., serum stability, temperature, and different pH values, as well as the amount of cryoprotectants used to obtain suitable freeze-dried systems. The nanostructures prepared with poloxamer 407 used as a stabilizer show an increased toxicity of the entrapped drug on breast cancer cell lines (MCF-7 and MDA-MB-231) due to their ability to sensitize multidrug-resistant (MDR) tumor cells through the inhibition of specific drug efflux transporters. Moreover, the interaction between the nanostructures and the cells occurs after just a few hours, evidencing a huge cellular uptake of the nanosystems.

Sulfation of Aegle marmelos gum: Synthesis, physico-chemical and functional characterization

2013 ◽  
Vol 92 (2) ◽  
pp. 1660-1668 ◽  
Author(s):  
Manish Jindal ◽  
Vikas Rana ◽  
Vineet Kumar ◽  
Ram S. Singh ◽  
John F. Kennedy ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Aegle Marmelos ◽  
Physico Chemical

scholarly journals Physico-chemical and rheological properties of gelatinized/freeze-dried cereal starches

2017 ◽  
Vol 31 (3) ◽  
pp. 357-365 ◽  
Author(s):  
Magdalena Krystyjan ◽  
Wojciech Ciesielski ◽  
Dorota Gumul ◽  
Krzysztof Buksa ◽  
Rafał Ziobro ◽  
...  
Keyword(s):  
Rheological Properties ◽  
Binding Capacity ◽  
Uniform Structure ◽  
High Porosity ◽  
Water Binding ◽  
Molecular Weights ◽  
Physico Chemical ◽  
Lower Viscosity ◽  
Freeze Dried ◽  
Modified Starches

AbstractThe influence of gelatinization and freeze-drying process on the physico-chemical and rheological properties of cereal starches was evaluated, and it was observed that modified starches revealed an increased water binding capacity and solubility when compared to dry starches, while exhibiting the same amylose and fat contents. The molecular weights of starches decreased after modification which resulted in the lower viscosity of dissolved modified samples in comparison to native starch pastes. As it was observed by scanning electron microscopy modified starches were characterized by an expanded surface, a uniform structure and high porosity.

Evaluation of physico-chemical properties of tomato powder produced by an optimized freeze drying process

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Zeyu Wu ◽  
Haiyan Wang ◽  
Li Zhang ◽  
Zhaojun Xian ◽  
Honghong Li ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Freeze Drying ◽  
Binding Capacity ◽  
Chemical Properties ◽  
Soluble Solids ◽  
Drying Process ◽  
Total Acid ◽  
Physico Chemical ◽  
Freeze Dried ◽  
Tomato Powder

Abstract In this study, the physico-chemical properties of tomato powder produced by an optimized freeze drying process (FDP) were evaluated. With the lycopene content as the dependent variable, the optimum FDP conditions (i.e., thermal cracking time of 62 s, ascorbic acid addition amount [0.13%], and particle size [Dv90] of 163 μm) were obtained through response surface methodology (RSM). The results showed that the content of lycopene in the prepared tomato powder was higher than that in two commercial products. Aldehydes were the main components among 25 kinds of aromatic substances detected in tomato powder. The values of a * and a */b *, the hydration properties including water holding capacity (WHC) and oil binding capacity (OBC), and the content of total acid, ascorbic acid, and soluble solids were improved compared to commercial spray dried and freeze dried samples. All the above results suggested that FDP was an adequate procedure for the production of high-quality tomato powder.

scholarly journals How Do the Different Types of Carrier and Drying Techniques Affect the Changes in Physico-Chemical Properties of Powders from Chokeberry Pomace Extracts?

Foods ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1864
Author(s):  
Anna Michalska-Ciechanowska ◽  
Aleksandra Hendrysiak ◽  
Jessica Brzezowska ◽  
Aneta Wojdyło ◽  
Agnieszka Gajewicz-Skretna
Keyword(s):  
Freeze Drying ◽  
Chemical Properties ◽  
Temperature Treatment ◽  
High Temperature Treatment ◽  
Physico Chemical ◽  
Freeze Dried ◽  
Drying Techniques ◽  
Different Types ◽  
Plant Sources ◽  
By Products

Chokeberry fruit, one of the richest plant sources of bioactives, is processed into different foodstuffs, mainly juice, which generates a considerable amount of by-products. To follow the latest trends in the food industry considering waste management, the study aimed to produce chokeberry pomace extract powders and conduct experimental and chemometric assessment of the effect of different carriers and drying techniques on the physico-chemical properties of such products. The PCA analysis showed that the examined powders were classified into two groups: freeze-dried (variation in case of moisture content, water activity, colour, and browning index) and vacuum-dried (bulk density). No clear pattern was observed for the physical properties of carrier added products. The sum of polyphenolics (phenolic acids, anthocyanins and flavonols) ranged from 3.3–22.7 g/100 g dry matter. Drying techniques had a stronger effect on the polyphenols profile than the type of carrier. Hydroxymethyl-L-furfural formation was enhanced by inulin addition during high-temperature treatment. Overall, the addition of maltodextrin and trehalose mixture for freeze drying and vacuum drying at 90 °C caused the highest retention of polyphenolics and the lowest formation of hydroxymethyl-L-furfural; however, an individual and comprehensive approach is required when the obtainment of high-quality chokeberry powders is expected.

COMPARATIVE ANALYSIS OF FREEZE DRIED AND SPRAY DRIED BEET-ROOT POWDER ACCORDING TO PHYSICO-CHEMICAL, FUNCTIONAL AND COLOR PROPERTIES

2021 ◽  
Vol 14(63) (1) ◽  
pp. 153-162
Author(s):  
Niharika KAPOOR ◽  
Ashish M. MOHITE ◽  
Neha SHARMA ◽  
Dipti SHARMA
Keyword(s):  
Comparative Analysis ◽  
Water Activity ◽  
Proximate Analysis ◽  
Drying Process ◽  
Beet Root ◽  
Physico Chemical ◽  
Freeze Dried ◽  
Powder Properties ◽  
Spray Dried ◽  
Research Endeavour

The aim of the research endeavour was to evaluate the powder properties of freeze dried and spray dried beet-root powders.The physical, proximate, color and functional properties such as water activity, wettability, solubility and hygroscopicity were studied. From the comparative analysis between freeze and spray dried beet root powder, better results were found for freeze-dried samples in terms of color, wettability and hygroscopicity. Freeze-dried samples required a longer amount of time to obtain into powder form as compared to spray dried samples. Whereas the solubility and water activity values were found slightly higher in spray dried samples as compared to freeze dried samples. The proximate analysis, such as crude fiber, crude fat, ash and carbohydrate values recorded better result for freeze dried samples as compared to spray dried samples. It can be concluded from this study that the beet root, when dried in the freeze drying process, has better results as compared to the spray drying process.

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