scholarly journals Role of tight junction proteins in zebrafish liver morphogenesis

2009 ◽  
Vol 331 (2) ◽  
pp. 492
Author(s):  
Isla D. Cheung ◽  
Didier Stainier
Keyword(s):  
Tight Junction ◽  
Tight Junction Proteins ◽  
Zebrafish Liver ◽  
Junction Proteins

Role of AMPK in the expression of tight junction proteins in heat-treated porcine Sertoli cells

2018 ◽  
Vol 121 ◽  
pp. 42-52 ◽  
Author(s):  
Wei-Rong Yang ◽  
Ting-Ting Liao ◽  
Zi-Qiang Bao ◽  
Cai-Quan Zhou ◽  
Hong-Yan Luo ◽  
...  
Keyword(s):  
Tight Junction ◽  
Sertoli Cells ◽  
Tight Junction Proteins ◽  
Heat Treated ◽  
Junction Proteins

scholarly journals ROLE OF PROTECTIVE TOPICAL AGENTS IN THERAPY OF CHRONIC DERMATOSES

2014 ◽  
Vol 11 (3) ◽  
pp. 47-52
Author(s):  
A N KHLEBNIKOVA
Keyword(s):  
Tight Junction ◽  
Combined Therapy ◽  
Skin Barrier ◽  
Tight Junction Proteins ◽  
Barrier Dysfunction ◽  
Epidermal Barrier ◽  
Junction Proteins

Epidermal barrier insufficiency results in skin dryness and fissures in different chronic dermatoses. Barrier dysfunction is due either to genetic problems or lipid deficiency or damage of tight junction proteins. Here we discuss various abnormalities of epidermal barrier in eczema and psoriasis which necessitate to prescribe pro- tective and moisturizing agents to restore skin barrier. We give our own practice data of using Bariederm cream and balm in combined therapy of dyshidrotic eczema, plantar eczema and palmoplantar psoriasis.

scholarly journals The Role of β-Carotene in Colonic Inflammation and Intestinal Barrier Integrity

2021 ◽  
Vol 8 ◽  
Author(s):  
Junrui Cheng ◽  
Emilio Balbuena ◽  
Baxter Miller ◽  
Abdulkerim Eroglu
Keyword(s):  
Epithelial Cells ◽  
Tight Junction ◽  
Signaling Pathway ◽  
Tight Junction Proteins ◽  
Colonic Epithelial Cells ◽  
Colonic Inflammation ◽  
Tlr4 Signaling Pathway ◽  
Β Carotene ◽  
Junction Proteins

Background: Carotenoids are naturally occurring pigments accounting for the brilliant colors of fruits and vegetables. They may display antioxidant and anti-inflammatory properties in humans besides being precursors to vitamin A. There is a gap of knowledge in examining their role within colonic epithelial cells. We proposed to address this research gap by examining the effects of a major dietary carotenoid, β-carotene, in the in vitro epithelial cell model.Methods: We examined the function of β-carotene in the lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4) signaling pathway. We conducted western blotting assays to evaluate expressions of TLR4 and its co-receptor, CD14. We also examined NF-κB p65 subunit protein levels in the model system. Furthermore, we studied the impact of β-carotene on the tight junction proteins, claudin-1, and occludin. We further carried out immunocytochemistry experiments to detect and visualize claudin-1 expression.Results: β-Carotene reduced LPS-induced intestinal inflammation in colonic epithelial cells. β-Carotene also promoted the levels of tight junction proteins, which might lead to enhanced barrier function.Conclusions: β-Carotene could play a role in modulating the LPS-induced TLR4 signaling pathway and in enhancing tight junction proteins. The findings will shed light on the role of β-carotene in colonic inflammation and also potentially in metabolic disorders since higher levels of LPS might induce features of metabolic diseases.

scholarly journals Heat Stress and Gut Health in Broilers: Role of Tight Junction Proteins

2017 ◽  
Vol 3 (1) ◽  
pp. e1-e4 ◽  
Author(s):  
Guillermo Tellez Jr. ◽  
◽  
Guillermo Tellez-Isaias ◽  
Sami Dridi ◽  
◽  
...  
Keyword(s):  
Heat Stress ◽  
Tight Junction ◽  
Tight Junction Proteins ◽  
Gut Health ◽  
Junction Proteins

scholarly journals Role of tight junction proteins in gastroesophageal reflux disease

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Klaus Mönkemüller ◽  
Thomas Wex ◽  
Doerthe Kuester ◽  
Lucia C Fry ◽  
Arne Kandulski ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Tight Junction ◽  
Reflux Disease ◽  
Tight Junction Proteins ◽  
Junction Proteins

scholarly journals The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus

2008 ◽  
Vol 82 (7) ◽  
pp. 3555-3560 ◽  
Author(s):  
Laurent Meertens ◽  
Claire Bertaux ◽  
Lisa Cukierman ◽  
Emmanuel Cormier ◽  
Dimitri Lavillette ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Tight Junction ◽  
Tight Junction Proteins ◽  
Junction Protein ◽  
Cellular Factors ◽  
Cd81 Tetraspanin ◽  
Junction Proteins

ABSTRACT Hepatitis C virus (HCV) is a major cause of liver disease in humans. The CD81 tetraspanin is necessary but not sufficient for HCV penetration into hepatocytes, and it was recently reported that the tight junction protein claudin-1 is a critical HCV entry cofactor. Here, we confirm the role of claudin-1 in HCV entry. In addition, we show that claudin-6 and claudin-9 expressed in CD81+ cells also enable the entry of HCV pseudoparticles derived from six of the major genotypes. Whereas claudin-1, -6, and -9 function equally well as entry cofactors in endothelial cells, claudin-1 is more efficient in hepatoma cells. This suggests that additional cellular factors modulate the ability of claudins to function as HCV entry cofactors. Our work has generated novel and essential means to investigate the mechanism of HCV penetration into hepatocytes and the role of the claudin protein family in HCV dissemination, replication, and pathogenesis.

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