Sex differences in face recognition memory in patients with temporal lobe epilepsy, patients with generalized epilepsy, and healthy controls

2006 ◽  
Vol 9 (4) ◽  
pp. 593-600 ◽  
Author(s):  
T. Bengner ◽  
C. Fortmeier ◽  
T. Malina ◽  
M. Lindenau ◽  
B. Voges ◽  
...  
Keyword(s):  
Sex Differences ◽  
Face Recognition ◽  
Recognition Memory ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Healthy Controls ◽  
Generalized Epilepsy

scholarly journals Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study

2020 ◽  
Vol 6 (47) ◽  
pp. eabc6457
Author(s):  
Sara Larivière ◽  
Raúl Rodríguez-Cruces ◽  
Jessica Royer ◽  
Maria Eugenia Caligiuri ◽  
Antonio Gambardella ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Strong Influence ◽  
Healthy Controls ◽  
Negative Effects ◽  
Idiopathic Generalized Epilepsy ◽  
Cross Sectional ◽  
Distinct Disease ◽  
The Common ◽  
Generalized Epilepsy

Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.

scholarly journals Network-based atrophy modelling in the common epilepsies: a worldwide ENIGMA study

2020 ◽  
Author(s):  
Sara Larivière ◽  
Raúl Rodríguez-Cruces ◽  
Jessica Royer ◽  
Maria Eugenia Caligiuri ◽  
Antonio Gambardella ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Analytical Methods ◽  
Strong Influence ◽  
Healthy Controls ◽  
Idiopathic Generalized Epilepsy ◽  
Cross Sectional ◽  
Distinct Disease ◽  
The Common ◽  
Generalized Epilepsy

SUMMARYEpilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1,021 adults with epilepsy compared to 1,564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy co-localized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Indices of progressive atrophy further revealed a strong influence of connectome architecture on disease progression in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients, and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided novel insights into the macroscale features that shape the pathophysiology of common epilepsies.

scholarly journals Elevated IL-6 and IL-1β are associated with temporal lobe epilepsy: A study in Chinese patients

2018 ◽  
Vol 16 ◽  
pp. 205873921877893 ◽  
Author(s):  
Li Xia ◽  
Song-Qing Pan ◽  
Qiu-Min Zhang ◽  
Qin Zhou ◽  
Lu Xia ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Chinese Patients ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
Temporal Epilepsy ◽  
Tnf Α ◽  
Plasma Cytokines ◽  
Proinflammatory Molecules ◽  
Positive Correlations

Activation of proinflammatory cytokines in seizures has been well characterized. However, role of cytokines in epilepsy and association with different clinical phenotype has not been well investigated. Reports on possible link between proinflammatory molecules and epilepsy are very limited. In this study, we performed a hospital-based case control study to investigate the association of plasma cytokines and their expression with different clinical categories of epilepsy. Patients admitted to Neurology Department of Renmin Hospital were enrolled in this study after clinical investigations. In all, 92 patients with temporal lobe epilepsy (TLE) and 45 with extra-temporal lobe epilepsy (XTLE) were included in this study. Furthermore, we included 86 healthy controls from the similar geographical population. Plasma levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β were quantified by enzyme-linked immunosorbent assay (ELISA). All plasma cytokines were elevated in TLE and XTLE compared to healthy controls ( P < 0.0001). Furthermore, IL-6 and IL-1β were significantly higher in TLE when compared to extra-temporal epilepsy. Incidentally, no difference in mean plasma TNF-α levels was noticed among TLE and XTLE. Positive correlations were observed between all plasma proinflammatory molecules (TNF-α, IL-6, and IL-1β) investigated in this study. Epilepsy patients displayed higher proinflammatory molecules, namely, IL-6, IL-1β, and TNF-α. Plasma IL-6 and IL-1β can be use as biomarkers for differentiation of TLE from XTLE.

scholarly journals An Exploratory Study of the Relationship between Face Recognition Memory and the Volume of Medial Temporal Lobe Structures in Healthy Young Males

1998 ◽  
Vol 11 (1) ◽  
pp. 3-20 ◽  
Author(s):  
Clare E. Mackay ◽  
Neil Roberts ◽  
Andrew R. Mayes ◽  
John J. Downes ◽  
Jonathan K. Foster ◽  
...  
Keyword(s):  
Face Recognition ◽  
Recognition Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Multiple Comparisons ◽  
Cerebral Hemispheres ◽  
Parahippocampal Gyrus ◽  
Bonferroni Correction ◽  
Temporal Pole ◽  
The Right

A rigorous new methodology was applied to the study of structure function relationships in the living human brain. Face recognition memory (FRM) and other cognitive measures were made in 29 healthy young male subjects (mean age = 21.7 years) and related to volumetric measurements of their cerebral hemispheres and of structures in their medial temporal lobes, obtained using the Cavalieri method in combination with high resolution Magnetic Resonance Imaging (MRI. Greatest proportional variability in volumes was found for the lateral ventricles (57%) for the cerebral hemispheres (8%) in the mean volumes of the hippocampus, parahippocampal gyrus, amygdala, caudate nucleus, temporal pole and temporal lobe on the right and left sides of the brain. The volumes of the right and left parahippocampal gyrus, temporal pole, temporal lobe, and left hippocampus were, prior to application of the Bonferroni correction to take account of 12 multiple comparisons, significantly correlated with the volume of the corresponding hemisphere (p< 0.05). The volumes of all structures were highly correlated (p< 0.0002 for all comparisons) between the two cerebral hemispheres. There were no positive relationships between structure volumes and FRM score. However, the volume of the right amygdala was, prior to application of the Bonferroni correction to take account of 38~multiple comparisons, found to be significantly smaller in the five most consistent high scorers compared to the five most consistent low scorers (t= 2.77,p= 0.025). The implications for possible relationships between healthy medial temporal lobe structures and memory are discussed.

Verbal Recognition Memory Performance in Unilateral Temporal Lobe Epilepsy

1993 ◽  
Vol 44 (2) ◽  
pp. 191-200 ◽  
Author(s):  
M. Seidenberg ◽  
B. Hermann ◽  
A. Haltiner ◽  
A. Wyler
Keyword(s):  
Recognition Memory ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Memory Performance ◽  
Verbal Recognition ◽  
Recognition Memory Performance

scholarly journals Transcriptionally Less Active Prodynorphin Promoter Alleles are Associated with Temporal Lobe Epilepsy: A Case-Control Study and Meta-Analysis

2008 ◽  
Vol 24 (3) ◽  
pp. 135-140 ◽  
Author(s):  
Marcelo A. Kauffman ◽  
Damián Consalvo ◽  
Moron Dolores Gonzalez ◽  
Silvia Kochen
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Fixed Effects ◽  
Association Studies ◽  
Hippocampal Sclerosis ◽  
Meta Analysis ◽  
Case Control ◽  
Healthy Controls ◽  
Fixed Effects Model ◽  
Familial Predisposition

We performed an association study in a population of patients with Mesial Temporal Lobe Epilepsy (TLE) with Hippocampal Sclerosis (MTEHS) together with a systematic revision of the literature to investigate the role of transcriptionally less active polymorphic alleles of Prodynorphin (PDYN) gene in this pathology. We included 102 patients with a diagnosis of MTEHS and 86 healthy controls. The positive antecedent of family history for epileptic events defined a TLE subgroup with familial predisposition for epileptic disorders. The PDYN promoter polymorphism was genotyped by means of a PCR assay. For meta-analysis, we identified case-control association studies between TLE and PDYN by searching PUBMED. The pooled OR was estimated using a fixed effects model under dominant and co-dominant heredity models. No differences in genotypic and allelic frequencies were found between cases and controls (p= 0.61) in our population, neither in the whole cohort nor in the analysis limited to TLE with familial predisposition (p= 0.71). The Meta-Analysis included 591 TLE patients and 1117 healthy controls. We found an association between L allele (p= 0.003; OR = 1.40; IC 95 = 1.12–1.74) and a modestly higher risk to develop TLE in the group of patients with familial predisposition. Therefore, functional allelic variants in the PDYN promoter might modify the risk to develop TLE in subjects with familial predisposition.

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