An integrative approach to investigate the association among high-sensitive C-reactive protein, body fat mass distribution, and other cardiometabolic risk factors in young healthy women

The objective of this study was to analyze the association of nutritional status (Body Mass Index, waist circumference, waist-hip ratio, and body fat mass) and blood pressure with inflammation status which was assessed by blood C-reactive protein level in dyslipidemic subjects. The study design was cross sectional survey involving 81 dyslipidemic subjects in Bogor. The study showed that there were significant correlations between BMI, waist-hip ratio, body fat mass, and diastolic blood pressure with blood CRP level (p<0.05). In conclusion, the higher percentage of over nutritional status, body fat mass, and diastolic blood pressure, the higher status of inflammation.<br />Keywords:

Download Full-text

Body Fat Distribution in Trunk and Legs Are Associated With Cardiometabolic Risk Clustering Among Chinese Adolescents Aged 10-18 Years Old

10.21203/rs.3.rs-93841/v1 ◽

2020 ◽

Author(s):

Qingmei Yang ◽

Ping Ma ◽

Hao Zhang ◽

Rongrong Cai ◽

Yangyang Dong ◽

...

Keyword(s):

Risk Factors ◽

Body Fat ◽

Fat Mass ◽

Cardiometabolic Risk ◽

Fat Body ◽

Fat Distribution ◽

Body Fat Distribution ◽

Chinese Adolescents ◽

Cardiometabolic Risk Factors ◽

Body Fat Mass

Abstract Background: The association between total fat, body fat distribution and cardiometabolic risk factors are highly controversial among adolescents. The aim of the present study was to evaluate the association of body fat distribution with cardiometabolic risk factors clustering among Chinese adolescents.Methods: In this cross-sectional study a total of 1175 adolescents aged 10 to 18 years underwent a comprehensive assessment of cardimetabolic risk factors. Body fat analysis was performed with Bioelectrical impedance analysis. Results: Individuals with the CVRFs ≥1 or CVRFs ≥2 had higher indices of body fat distribution such as body fat mass(BFM) compared to those with normal CVRFs (all P<0.001). The prevalence of CVRFs ≥1, CVRFs ≥2 increased with increasing of the quartile of BFM, TBFM, ABFM, LBFM, PBF, VFL compared to normal subjects. After adjusted for age and sex, the study indicated an linear relationship between TBFM(β=0.693, 95%CI:0.363,1.023), LBFM(β=-1.471, 95%CI:-2.768,-0.175) and CVRFs z-score. Logistic regression models suggested TBFM was associated with CVRFs≥1 and CVRFs≥2 by higher odds. Lower odds of LBFM was associated with CVRFs≥2. Conclusions A significant association between body fat mass of trunk(TBFM), body fat mass of leg(LBFM) and cluster of cardiometabolic risk factors was showed in the study. It suggested to reduce body fat mass of trunk and increase body fat mass of leg were essential for adolescents to prevent cardiovascular risk factors clustering.

Download Full-text

Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women

Cardiology Research and Practice ◽

10.4061/2011/904878 ◽

2011 ◽

Vol 2011 ◽

pp. 1-9

Author(s):

O. A. Matvienko ◽

D. L. Alekel ◽

S. N. Bhupathiraju ◽

H. Hofmann ◽

L. M. Ritland ◽

...

Keyword(s):

Risk Factors ◽

Postmenopausal Women ◽

Fat Mass ◽

Cardiometabolic Risk ◽

Soy Isoflavones ◽

Dietary Quality ◽

C Reactive Protein ◽

Reactive Protein ◽

Cardiometabolic Profile ◽

Biologic Factors

We hypothesized that soy isoflavones would attenuate the anticipated increase in androidal fat mass in postmenopausal women during the 36-month treatment, and thereby favorably modify the circulating cardiometabolic risk factors: triacylglycerol, LDL-C, HDL-C, glucose, insulin, uric acid, C-reactive protein, fibrinogen, and homocysteine. We collected data on 224 healthy postmenopausal women at risk for osteoporosis (45.8–65 y, median BMI 24.5) who consumed placebo or soy isoflavones (80 or 120 mg/d) for 36 months and used longitudinal analysis to examine the contribution of isoflavone treatment, androidal fat mass, other biologic factors, and dietary quality to cardiometabolic outcomes. Except for homocysteine, each cardiometabolic outcome model was significant (overall -values from ≤.0001 to .0028). Androidal fat mass was typically the strongest covariate in each model. Isoflavone treatment did not influence any of the outcomes. Thus, androidal fat mass, but not isoflavonetreatment, is likely to alter the cardiometabolic profile in healthy postmenopausal women.

Download Full-text

Association of high-sensitivity C-reactive protein with cardiometabolic risk factors and micronutrient deficiencies in adults of Ouagadougou, Burkina Faso

British Journal Of Nutrition ◽

10.1017/s0007114512003182 ◽

2012 ◽

Vol 109 (7) ◽

pp. 1266-1275 ◽

Cited By ~ 5

Author(s):

Augustin N. Zeba ◽

Hélène F. Delisle ◽

Clémentine Rossier ◽

Genevieve Renier

Keyword(s):

Risk Factors ◽

Burkina Faso ◽

Cardiometabolic Risk ◽

High Sensitivity ◽

Sub Saharan Africa ◽

Micronutrient Deficiencies ◽

C Reactive Protein ◽

Reactive Protein ◽

Sub Saharan ◽

Hs Crp

Increasing evidence suggests that high-sensitivity C-reactive protein (hs-CRP) is associated with cardiometabolic risk factors (CMRF) while being also related to micronutrient deficiencies. As part of a project on the double burden of under- and overnutrition in sub-Saharan Africa, we assessed the relationship between hs-CRP and both CMRF and micronutrient deficiencies in a population-based cross-sectional study carried out in the Northern district of Ouagadougou, the capital city of Burkina Faso. We randomly selected 330 households stratified by income tertile. In each income stratum, 110 individuals aged 25–60 years and having lived in Ouagadougou for at least 6 months were randomly selected, and underwent anthropometric measurements and blood sample collection. The prevalence of high hs-CRP was 39·4 %, with no sex difference. Vitamin A-deficient subjects (12·7 %) exhibited significant risk of elevated hs-CRP (OR 2·5;P= 0·015). Serum ferritin was positively correlated with log hs-CRP (r0·194;P= 0·002). The risk of elevated hs-CRP was significant in subjects with BMI ≥ 25 kg/m2(OR 6·9; 95 % CI 3·6, 13·3), abdominal obesity (OR 4·6; 95 % CI 2·2, 7·3) and high body fat (OR 10·2; 95 % CI 5·1, 20·3) (P< 0·001, respectively). Independent predictors of hs-CRP in linear regression models were waist circumference (β = 0·306;P= 0·018) and serum TAG (β = 0·158;P= 0·027). In this sub-Saharan population, hs-CRP was consistently associated with adiposity. Assuming that plasma hs-CRP reflects future risk of cardiovascular events, intervention which reduces CRP, or chronic and acute nutrition conditions associated with it, could be effective in preventing their occurrence particularly in sub-Saharan Africa.

Download Full-text

BMI, body fat mass and plasma leptin level in relation to cardiovascular diseases risk factors among adolescents in Taitung

Obesity Research & Clinical Practice ◽

10.1016/j.orcp.2015.08.009 ◽

2016 ◽

Vol 10 (4) ◽

pp. 432-441 ◽

Cited By ~ 4

Author(s):

Ya-Ke Wu ◽

Nain-Feng Chu ◽

Ya-Hsien Huang ◽

Jhu-Ting Syu ◽

Jin-Biou Chang

Keyword(s):

Risk Factors ◽

Cardiovascular Diseases ◽

Body Fat ◽

Fat Mass ◽

Body Fat Mass ◽

Plasma Leptin

Download Full-text

Interactions of genetic and environmental risk factors with respect to body fat mass in children: Results from the ALSPAC study

Obesity ◽

10.1002/oby.20196 ◽

2013 ◽

Vol 21 (6) ◽

pp. 1238-1242 ◽

Cited By ~ 8

Author(s):

Christina Riedel ◽

Rüdiger von Kries ◽

Nora Fenske ◽

Konstantin Strauch ◽

Andrew R. Ness ◽

...

Keyword(s):

Risk Factors ◽

Body Fat ◽

Fat Mass ◽

Environmental Risk ◽

Environmental Risk Factors ◽

Body Fat Mass

Download Full-text

Strategies for reducing body fat mass: effects of liposuction and exercise on cardiovascular risk factors and adiposity

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s12143 ◽

2011 ◽

pp. 141 ◽

Cited By ~ 17

Author(s):

F B Benatti

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Body Fat ◽

Fat Mass ◽

Body Fat Mass ◽

Mass Effects

Download Full-text

Increased C-Reactive Protein in Brazilian Children: Association with Cardiometabolic Risk and Metabolic Syndrome Components (PASE Study)

Cardiology Research and Practice ◽

10.1155/2019/3904568 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10 ◽

Cited By ~ 6

Author(s):

Lara Gomes Suhett ◽

Helen Hermana Miranda Hermsdorff ◽

Naruna Pereira Rocha ◽

Mariane Alves Silva ◽

Mariana De Santis Filgueiras ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Cardiometabolic Risk ◽

Disease Risk ◽

Elevated Serum ◽

Cardiometabolic Risk Factors ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp ◽

Brazilian Children

C-reactive protein (CRP) is a marker of subclinical inflammation that has been found to be associated with cardiovascular disease risk. However, few studies have investigated the relationship between CRP and cardiometabolic markers in a representative sample of prepubescent children. The objective was to evaluate the high-sensitive CRP (hs-CRP) and its association with traditional and nontraditional cardiometabolic risk factors, as well as metabolic syndrome (MetS) components in Brazilian children. This is a cross-sectional representative study, with participants of the Schoolchildren Health Assessment Survey (PASE). Children from 8 to 9 years old (n=350) enrolled in public and private schools in the municipality of Viçosa, Minas Gerais, Brazil, were evaluated. Sociodemographic evaluation was performed through a semistructured questionnaire. Anthropometric, body composition, clinical, and biochemical measures were analyzed for cardiometabolic risk assessment. The total mean of serum hs-CRP concentration was 0.62 (±1.44) mg/L. hs-CRP was significantly correlated with several anthropometric, biochemical, and clinical parameters in this population (P<0.05). hs-CRP was positively associated with the accumulation of cardiometabolic risk factors and MetS components (P<0.05). Children with excessive weight; abdominal obesity; increased gynoid and android body fat; low HDL-c; hyperglycemia; and elevated uric acid, homocysteine, and apoB had higher chances of presenting increased hs-CRP (P<0.05). In this study, Brazilian children with cardiometabolic risk already presented elevated serum hs-CRP concentration. hs-CRP was associated with the increase of traditional and nontraditional cardiometabolic risk factors, as well as the accumulation of MetS components.

Download Full-text