Genetic instability in grossly normal pancreatic duct cells from patients with chronic pancreatitis and pancreatic cancer

2000 ◽  
Vol 118 (4) ◽  
pp. A196
Author(s):  
Alyssa M. Brown ◽  
Mary P. Bronner ◽  
Teri Brentnall ◽  
Peter S. Rabinovitch ◽  
Katie R. Carter ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Pancreatic Duct ◽  
Genetic Instability ◽  
Duct Cells ◽  
Pancreatic Duct Cells

800f Even Pancreatic Duct Cells Can Serve As a Cell of Origin for Pancreatic Cancer: Requirement for Cooperating Genetic Lesions

2015 ◽  
Vol 148 (4) ◽  
pp. S-1192-S-1193
Author(s):  
Jennifer M Bailey ◽  
Audrey M. Hendley ◽  
Conover Talbot ◽  
Christine A Iacobuzio-Donahue ◽  
Steven Leach
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Duct ◽  
Cell Of Origin ◽  
Duct Cells ◽  
Pancreatic Duct Cells ◽  
A Cell

scholarly journals Bile Acids Selectively Activate Iberiotoxin-sensitive Potassium Channels In Native Pancreatic Duct Cells

2009 ◽  
Vol 96 (3) ◽  
pp. 536a-537a
Author(s):  
Viktoria Venglovecz ◽  
Peter Hegyi ◽  
Zoltan Rakonczay ◽  
Barry Argent ◽  
Michael A. Gray
Keyword(s):  
Potassium Channels ◽  
Pancreatic Duct ◽  
Bile Acids ◽  
Duct Cells ◽  
Pancreatic Duct Cells

scholarly journals Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3

2002 ◽  
Vol 159 (2) ◽  
pp. 303-312 ◽  
Author(s):  
Yves Heremans ◽  
Mark Van De Casteele ◽  
Peter in't Veld ◽  
Gerard Gradwohl ◽  
Palle Serup ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Pancreatic Duct ◽  
Endocrine Pancreas ◽  
Notch Pathway ◽  
Neuroendocrine Differentiation ◽  
Β Cell ◽  
Neurogenin 3 ◽  
Adult Human ◽  
Duct Cells ◽  
Pancreatic Duct Cells

Regulatory proteins have been identified in embryonic development of the endocrine pancreas. It is unknown whether these factors can also play a role in the formation of pancreatic endocrine cells from postnatal nonendocrine cells. The present study demonstrates that adult human pancreatic duct cells can be converted into insulin-expressing cells after ectopic, adenovirus-mediated expression of the class B basic helix-loop-helix factor neurogenin 3 (ngn3), which is a critical factor in embryogenesis of the mouse endocrine pancreas. Infection with adenovirus ngn3 (Adngn3) induced gene and/or protein expression of NeuroD/β2, Pax4, Nkx2.2, Pax6, and Nkx6.1, all known to be essential for β-cell differentiation in mouse embryos. Expression of ngn3 in adult human duct cells induced Notch ligands Dll1 and Dll4 and neuroendocrine- and β-cell–specific markers: it increased the percentage of synaptophysin- and insulin-positive cells 15-fold in ngn3-infected versus control cells. Infection with NeuroD/β2 (a downstream target of ngn3) induced similar effects. These data indicate that the Delta-Notch pathway, which controls embryonic development of the mouse endocrine pancreas, can also operate in adult human duct cells driving them to a neuroendocrine phenotype with the formation of insulin-expressing cells.

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