Up-regulation of L1CAM in Pancreatic Duct Cells Is Transforming Growth Factor β1– and Slug-Dependent: Role in Malignant Transformation of Pancreatic Cancer

2009 ◽  
Vol 69 (10) ◽  
pp. 4517-4526 ◽  
Author(s):  
Claudia Geismann ◽  
Mascha Morscheck ◽  
Dorothee Koch ◽  
Frank Bergmann ◽  
Hendrik Ungefroren ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Growth Factor ◽  
Pancreatic Duct ◽  
Malignant Transformation ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Duct Cells ◽  
Pancreatic Duct Cells

Genetic instability in grossly normal pancreatic duct cells from patients with chronic pancreatitis and pancreatic cancer

2000 ◽  
Vol 118 (4) ◽  
pp. A196
Author(s):  
Alyssa M. Brown ◽  
Mary P. Bronner ◽  
Teri Brentnall ◽  
Peter S. Rabinovitch ◽  
Katie R. Carter ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Pancreatic Duct ◽  
Genetic Instability ◽  
Duct Cells ◽  
Pancreatic Duct Cells

Bmi1 combines with oncogenic KRAS to induce malignant transformation of human pancreatic duct cells in vitro

Tumor Biology ◽  
2016 ◽  
Vol 37 (8) ◽  
pp. 11299-11309 ◽  
Author(s):  
Shao-jie Chen ◽  
Yin-ting Chen ◽  
Lin-juan Zeng ◽  
Qiu-bo Zhang ◽  
Guo-da Lian ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Malignant Transformation ◽  
Duct Cells ◽  
Pancreatic Duct Cells

scholarly journals Genes and Proteins Differentially Expressed during In Vitro Malignant Transformation of Bovine Pancreatic Duct Cells

Neoplasia ◽  
2007 ◽  
Vol 9 (2) ◽  
pp. 136-146 ◽  
Author(s):  
R. Jesnowski ◽  
Dmitri Zubakov ◽  
Ralf Faissner ◽  
Jörg Ringel ◽  
Jörg D. Hoheisel ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Malignant Transformation ◽  
Differentially Expressed ◽  
Duct Cells ◽  
Pancreatic Duct Cells

800f Even Pancreatic Duct Cells Can Serve As a Cell of Origin for Pancreatic Cancer: Requirement for Cooperating Genetic Lesions

2015 ◽  
Vol 148 (4) ◽  
pp. S-1192-S-1193
Author(s):  
Jennifer M Bailey ◽  
Audrey M. Hendley ◽  
Conover Talbot ◽  
Christine A Iacobuzio-Donahue ◽  
Steven Leach
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Duct ◽  
Cell Of Origin ◽  
Duct Cells ◽  
Pancreatic Duct Cells ◽  
A Cell

scholarly journals HDGF supports anti-apoptosis and pro-fibrosis in pancreatic stellate cells of pancreatic cancer

2018 ◽  
Author(s):  
Yi-Ting Chen ◽  
Tso-Wen Wang ◽  
Tsung-Hao Chang ◽  
Teng-Po Hsu ◽  
Jhih-Ying Chi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Transforming Growth Factor ◽  
Hypoxia Inducible Factor ◽  
Stellate Cells ◽  
Transforming Growth Factor Β1 ◽  
Pancreatic Stellate Cells ◽  
Pancreatic Cancer Cells ◽  
Tgf Β1

ABSTRACTPancreatic cancer is refractory and characterized by extensively surrounding- and intra-tumor fibrotic reactions that are contributed by activated pancreatic stellate cells (PSCs). Activation of PSCs plays a pivotal role for developing fibrotic reactions to affect themselves or pancreatic cancer cells (PCCs). In the current study, we demonstrated that hepatoma-derived growth factor (HDGF) was secreted from transforming growth factor-β1 (TGF-β1)-treated PSCs. We found that HDGF contributed to anti-apoptosis of PSCs and led to synthesis and depositions of extracellular matrix proteins for stabilizing PSCs/PCCs tumor foci. CCAAT/enhancer binding protein δ (CEBPD) responds to TGF-β1 through a reciprocal loop regulation and further activated hypoxia inducible factor-1α (HIF-1α) contributed to up-regulation ofHDGFgene. It agrees with the observation that severe stromal growth positively correlated with stromal HDGF and CEBPD in pancreatic cancer specimens. Collectively, the identification of TGF-β1-activated CEBPD/HIF-1α/HDGF axis provides new insights for the novel discoveries of HDGF in anti-apoptosis and pro-fibrosis of PSCs and outgrowth of pancreatic cancer cells.

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