scholarly journals Possible involvement of proteolytic degradation of tyrosinase in the regulatory effect of fatty acids on melanogenesis

1999 ◽  
Vol 40 (7) ◽  
pp. 1312-1316 ◽  
Author(s):  
Hideya Ando ◽  
Yoko Funasaka ◽  
Masahiro Oka ◽  
Akiko Ohashi ◽  
Minao Furumura ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Proteolytic Degradation ◽  
Regulatory Effect

Fatty acids regulate the proteolytic degradation of tyrosinase

1998 ◽  
Vol 16 ◽  
pp. S102
Author(s):  
Hideya Ando ◽  
Yoko Funasaka ◽  
Masahiro Oka ◽  
Minao Furumura ◽  
Jun Matsunaga ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Proteolytic Degradation

scholarly journals Effect of Polyunsaturated Fatty Acids on Homocysteine Metabolism through Regulating the Gene Expressions Involved in Methionine Metabolism

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Tao Huang ◽  
Xiaojie Hu ◽  
Nicholas Khan ◽  
Jing Yang ◽  
Duo Li
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Mrna Expression ◽  
Control Group ◽  
Methionine Metabolism ◽  
Regulatory Effect ◽  
Sprague Dawley ◽  
Gene Expressions ◽  
Sprague Dawley Rats ◽  
Key Genes

The objective was to investigate the regulatory effect of polyunsaturated fatty acids (PUFAs) on mRNA expression of key genes involved in homocysteine (Hcy) metabolism. Eighty male Sprague Dawley rats were randomly divided into eight groups. The oils were orally administered daily for 8 weeks. Plasma Hcy, phospholipids fatty acids, and mRNA expression were determined. Compared with the control group, plasma Hcy was significantly decreased in the 22:6n-3and conjugated linoleic acid (CLA) groups; mRNA expression ofMthfrwas significantly upregulated in the 22:6n-3, 20:5n-3, and 18:3n-3groups and downregulated in the 18:2n-6and stearolic acid (SO) groups.Mat1awas upregulated in the 22:6n-3, 20:5n-3, 18:3n-3, and CLA groups. In addition,Cbswas upregulated in the 22:6n-3, 20:5n-3, 18:3n-3and CLA groups while downregulated in 18:2n-6and SO groups. Dietary 22:6n-3and CLA decrease the plasma concentration of Hcy. mRNA expression ofMthfr, Mat1a, CbsandPemt, Gnmt, Mtrr, andBadis upregulated byn-3PUFA and downregulated byn-6PUFA. CLA upregulates mRNA expression ofMat1aandCbs.

Paracrystalline Aggregates of Psoriatic Keratin and Their Relation to Normal Keratin Structure

1985 ◽  
Vol 43 ◽  
pp. 680-681
Author(s):  
S. Trachtenberg ◽  
P.M. Steinert ◽  
B.L. Trus ◽  
A.C. Steven
Keyword(s):  
Cell Death ◽  
Stratum Corneum ◽  
Intermediate Filament ◽  
Skin Disease ◽  
Amorphous Matrix ◽  
Terminal Differentiation ◽  
Proteolytic Degradation ◽  
Horny Layer ◽  
Chronic Skin ◽  
Chronic Skin Disease

During terminal differentiation of vertebrate epidermis, certain specific keratin intermediate filament (KIF) proteins are produced. Keratinization of the epidermis involves cell death and disruption of the cytoplasm, leaving a network of KIF embedded in an amorphous matrix which forms the outer horny layer known as the stratum corneum. Eventually these cells are shed (desquamation). Normally, the processes of differentiation, keratinization, and desquamation are regulated in an orderly manner. In psoriasis, a chronic skin disease, a hyperkeratotic stratum corneum is produced, resulting in abnormal desquamation of unusually large scales. In this disease, the normal KIF proteins are diminished in amount or absent, and other proteins more typical of proliferative epidermal cells are present. There is also evidence of proteolytic degradation of the KIF.

Fatty Acids and Glycerides

1979 ◽  
Vol 7 (4) ◽  
pp. 813-814
Author(s):  
J. L. HARWOOD
Keyword(s):  
Fatty Acids
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