Stereostructures of inunal and isoalloalantolactone, two biologically active sesquiterpene lactones from Inula racemosa

1985 ◽  
Vol 24 (9) ◽  
pp. 2007-2010 ◽  
Author(s):  
Baljit Kaur ◽  
P.S. Kalsi
Keyword(s):  
Sesquiterpene Lactones ◽  
Biologically Active ◽  
Inula Racemosa

Stereostructures of two biologically active sesquiterpene lactones from Inula racemosa

1989 ◽  
Vol 28 (8) ◽  
pp. 2093-2096 ◽  
Author(s):  
S. Kalsi ◽  
Rita Goyal ◽  
K.K. Talwar ◽  
B.R. Chhabra
Keyword(s):  
Sesquiterpene Lactones ◽  
Biologically Active ◽  
Inula Racemosa

scholarly journals Biologically active substances from Achillea nobilis L.

2020 ◽  
Vol 100 (4) ◽  
pp. 52-59
Author(s):  
А.S. Kishkentayeva ◽  
◽  
S.N. Mantler ◽  
М.М. Zhakanov ◽  
S.М. Adekenov ◽  
...  
Keyword(s):  
Climatic Factors ◽  
Raw Materials ◽  
Sesquiterpene Lactones ◽  
Component Composition ◽  
Hot Water ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Phytochemical Study ◽  
Plant Raw Materials ◽  
Active Substances

The review summarizes data on biologically active compounds of Achillea nobilis L. and methods of their isolation. From Achillea nobilis L., collected in different places of growth, the following have been isolated: essential oil, the main components of which are monoterpene compounds; sesquiterpene lactones estafiatin, hanphyllin, anobin, chrysartemine A, canin, anolide and tanapartin-β-peroxide; the steroid acetyleucanbin; flavonoids: 3,5-dihydroxy-6,7,8-trimethoxyflavone, 5-hydroxy-3,6,7,4’-tetramethoxyflavone and 5,3’-di-hydroxy-3,6,7,4’-tetramethoxyflavone. It has been determined that the component composition of the essen-tial oil of Achillea nobilis L. largely depends on the soil and climatic factors in the places of its growth, the phase of the growing season and the method of its extraction from plant raw materials, and the extractant used (chloroform, ethanol, hot water, diethyl ether). Antibacterial, antimicrobial, antioxidant, antiparasitic activi-ties are characteristic both for the sums of extractive substances from Achillea nobilis L. and for individual compounds isolated from them. Methods for the isolation of biologically active substances from Achillea nobilis L. for the development of new drug substances are described. The main aim of this work was a com-parative analysis of the available research results on the phytochemical study of Achillea nobilis L.

Comparative Histochemical analysis of above-ground parts of Filipendula vulgaris and Filipendula ulmaria growing in Central Kazakhstan

2021 ◽  
pp. 4863-4867
Author(s):  
Yerbolat Tulebayev A. ◽  
Margarita Ishmuratova Yu. ◽  
Irina Losseva V. ◽  
Wirginia Kukuła-Koch ◽  
Ewa Poleszak ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Raw Materials ◽  
Sesquiterpene Lactones ◽  
Biologically Active ◽  
Histochemical Analysis ◽  
Filipendula Ulmaria ◽  
Plant Raw Materials ◽  
Related Substances ◽  
Histochemical Tests ◽  
The Republic

The histochemical analysis of medicinal plants and raw materials makes it possible to establish the presence of certain groups of active and related substances or products of their metabolism, as well as to study their localization in tissues. The article presents the results of histochemical analysis of leaves, flowers, petioles and stems of Filipendula vulgaris and Filipendula ulmaria. These types of plant are used in traditional medicine as an anti-inflammatory, antipyretic and bactericidal agent. Our research objective - to determine the peculiarities of the localization features of individual groups of secondary metabolites in the aerial part of meadowsweet and meadowsweet growing in the territory of Central Kazakhstan at the microscopic level. Materials and Methods. Transverse sections of petioles, stem and whole flower; transverse and superficial sections of leaves of Filipendula vulgaris and Filipendula ulmaria were fixed in Strauss-Fleming solution, after which histochemical reactions were carried out to locate and identify essential oils, phenolic acids, flavonoids, sesquiterpene lactones, polysaccharides and alkaloids. The study of microscopic signs, as well as histochemical tests were carried out according to the methods of the State Pharmacopoeia of the Republic of Kazakhstan using a light microscope Biomed-4. Results and Discussion. The localization of biologically active substances in the studied types of plant raw materials was determined by histochemical methods using light microscopy. The presence of phenolic compounds, flavonoids, traces of essential oil, alkaloids and sesquiterpene lactones was established. The absence of polysaccharides in the investigated micropreparations was established. Conclusions. For the first time, the localization of secondary metabolites in the tissues of Filipendula vulgaris and Filipendula ulmaria was studied by histochemical tests. The results of histochemical studies can be used to confirm the authenticity, identification and standardization of the aerial parts of Filipendula vulgaris and Filipendula ulmaria.

scholarly journals THE RED BLOOD CELLS CATALASE ACTIVITY IS INFLUENCED BY TARAXACUM OFFICINALE

InterConf ◽  
2021 ◽  
pp. 167-177
Author(s):  
Ala Fulga ◽  
Valeriana Pantea ◽  
Svetlana Protopop ◽  
Olga Tagadiuc ◽  
Mihail Todiras ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Catalase Activity ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Sesquiterpene Lactones ◽  
Natural Antioxidants ◽  
Taraxacum Officinale ◽  
Biologically Active ◽  
Ability To Act ◽  
Leaves And Roots

Natural antioxidants protect cells against oxidative stress, which is directly involved in ageing processes and in the pathogenesis of cardiovascular, neurodegenerative and neoplastic diseases. Taraxacum officinale (TO) due to its rich content of biologically active ingredients has been commonly used in traditional medicine. It contains a wide spectrum of compounds with antioxidant activity. The content depends of parts of this plant. The roots are rich in phenolic and terpene compounds, sesquiterpene lactones, fructosans and inulin, while leaves are rich in substances belonging to flavonoids, phenolic acids, coumarins and vitamins, especially vitamin A. The literature results prove that antioxidant activity of TO depends on several factors including the plant part, the solvent used, as well as the duration of extraction. The aim of this study was to evaluate and to compare the action of alcoholic extracts of roots and leaves of TO on RBC’s catalase activity. Material and methods. Raw Taraxacum officinale plant material consisted of dried leaves and roots were harvested from a natural site. The extracts for analysis were prepared using 20, 25, 40, 50 and 80% (v/v) ethanol mixtures used as solvents. The catalase activity was established by using RBC of healthy persons. Conclusions. Phytotherapeutic herbs and plants continue to play an important role in the discovery and development of drugs. Leaves and roots of dandelion represent a rich source of bioactive compounds for potential exploitation in nutraceuticals and pharmacological sectors. Taraxacum officinale has a high ability to act as an antioxidant. The highest influence on RBC’s catalase activity was reported in case of roots ethanolic extracts of 25%. These actions are realized due to multiple substances, whose content probably depends of ethanol’s concentration. Additional studies are needed to characterize biological activities of these extracts.

scholarly journals Evaluation of supercritical plant extracts on volatile and non volatile biologically active lipophil components

2001 ◽  
Vol 7 (2) ◽  
Author(s):  
É. Lemberkovics ◽  
Á. Kéry ◽  
B. Simándi ◽  
T. Sz. Kristó ◽  
A. Kakasy ◽  
...  
Keyword(s):  
Volatile Compounds ◽  
Steam Distillation ◽  
Sesquiterpene Lactones ◽  
Biologically Active ◽  
Solvent Fractionation ◽  
Salvia Fruticosa ◽  
Soxhlet Apparatus ◽  
Common Dandelion ◽  
Two Stages ◽  
Bounded Form

Authors dealt more than ten years with the analysis of supercritical extracts. For extraction (SFE) carbon dioxide was used as supercritical solvent. Fractionation of extracts was carried out by releasing the separations pressure at two stages. The extracts were collected as separate samples successively in time. The traditional extractions were carried out with steam distillation or by using n-hexane and ethanol in Soxhlet apparatus. For the analysis of volatile compounds GC, GC-MS; of non volatile compounds TLC-densitometry and spectroscopic methods were used. The following general characteristics were established comparing the composition of steam distillated oils with that of volatile SFE fractions. The SFE fractions were richer in monoterpene-esters and poorer in alcohols than the essential oils prepared by traditional way (clary sage, lavandel). Regarding the distributi,n of the monoterpene and sesquiterpene compounds, the SFE fractions contained sesquiterpene hydrocarbon in higher percentage than the distillated oils (e.g. 13-caryophyllene in Salvia fruticosa, (3-caryophyllene, y­muurolene, y-cadinene in Ochnum basilicum). Further the proportion of sesquiterpenes increased in SFE fractions collected successively in time.Significant difference was remarkable in respect of the optical rotationability of lovage oil and SFE fraction which was probably caused by the different ratio between the two ligustilid enantiomers. It was verified in some cases that a part of mono- and sesquiterpenes were present originally in a bounded form (glycosides) in plants. Therefore they appeared in essential oil fractions only after previous acidic treatment (Thymus, Origanum species). During the supercritical extraction the azulenogene sesquiterpene lactones did not transform to azulenes (in chamomile, yarrow), but the non volatile SFE fractions of some Asteraceae plant contained sesquiterpene--lacton of unchanged structure in high quantity (e.g. cnicin in blessed thistle, parthenolide in feverfew). Authors obtained also SFE fractions which were rich in triterpenoids and phytosterols (marigold, common dandelion).  

scholarly journals Comparison of Different Techniques for Extraction of Biologically Active Compounds from Achillea Millefolium Proa

2008 ◽  
Vol 3 (9) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Antoaneta Trendafilova ◽  
Milka Todorova
Keyword(s):  
Sesquiterpene Lactones ◽  
Solvent Polarity ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Achillea Millefolium ◽  
Total Phenolic ◽  
Ultrasound Assisted Extraction ◽  
Total Extract ◽  
Active Compounds ◽  
Assisted Extraction

The effect of ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE) and conventional extraction (CE) on the extraction of biologically active compounds from Achillea millefolium Proa has been investigated. The extracts were analyzed by spectrophotometric methods. The influence of the extraction time and the solvent on the yields of total extract (TEC), total phenolic compounds (TPhC), flavonoids (FC) and sesquiterpene lactones (SLC) has been studied. It was found that TEC and TPhC increased with increasing the solvent polarity in order CHCl3, MeOH and 80% MeOH. The extraction with MeOH gave maximum amount of flavonoids, while the SLC was found to be almost equal in all used solvents. UAE for 60 min and MAE for 60 s afforded higher or almost equal TEC, TPhC and FC than those obtained by CE for 24 h. The best extraction of sesquiterpene lactones was achieved with CHCl3 for 20 min of ultrasound treatment and 20 s of microwave irradiation.

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