Smoking, Sun Exposure Flag Melanoma Risk in Older Patients

2009 ◽  
Vol 40 (8) ◽  
pp. 17
Author(s):  
RENÉE MATTHEWS
Keyword(s):  
Older Patients ◽  
Sun Exposure ◽  
Melanoma Risk

Nonfamilial Cutaneous Melanoma Incidence in Women Associated With Sun Exposure Before 20 Years of Age

PEDIATRICS ◽  
1989 ◽  
Vol 84 (2) ◽  
pp. 199-204
Author(s):  
Martin A. Weinstock ◽  
Graham A. Colditz ◽  
Walter C. Willett ◽  
Meir J. Stampfer ◽  
Ben A. Bronstein ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
White Women ◽  
Conditional Logistic Regression ◽  
Sun Exposure ◽  
Study Cohort ◽  
Control Analysis ◽  
Melanoma Risk ◽  
Equatorial Latitude ◽  
First Degree Relatives ◽  
History Of

Despite strong evidence that sun exposure causes malignant melanoma, the details of this relation remain unclear. A nested case-control analysis was conducted within the Nurses' Health Study cohort to examine the relation between timing of severe sun exposure and incidence of melanoma. The subjects were 130 white women aged 38 to 65 years with confirmed cutaneous melanoma (other than acral lentigenous) who reported no history of melanoma in first-degree relatives. The control subjects were 300 women matched by race, date of birth, and cycle of questionnaire who also reported no history of melanoma in first-degree relatives. We used conditional logistic regression to evaluate the relation of sun damage after 30 years of age and sun damage from 15 to 20 years of age to the incidence of melanoma. Blistering sunburns between 15 to 20 years of age were associated with risk of melanoma (relative risk = 2.2 for five or more burns vs none, 95% confidence interval 1.2 to 3.8). This association persisted when a history of burns after 30 years of age was controlled in the analysis. No material association was found between blistering sunburns after 30 years of age and melanoma. Similarly, a more equatorial latitude of residence between 15 and 20 years of age was positively associated with melanoma; latitude after 30 years of age was less strongly and not significantly related to melanoma risk. Sun exposure prior to 20 years of age is more closely associated with melanoma risk than sun exposure after 30 years of age.

scholarly journals Clinical Characteristics in Early Childhood Associated with a Nevus-Prone Phenotype in Adults from Tropical Australia: Two Decades of Follow-Up of the Townsville Preschool Cohort Study

2020 ◽  
Vol 17 (22) ◽  
pp. 8680
Author(s):  
Ramez Barsoum ◽  
Simone L. Harrison
Keyword(s):  
Longitudinal Research ◽  
Sun Exposure ◽  
Cost Effective ◽  
Risk Groups ◽  
Melanoma Risk ◽  
Bottom Quartile ◽  
Targeted Screening ◽  
History Of ◽  
Tropical Australia

Having numerous melanocytic nevi increases melanoma risk. Few studies have enumerated nevi in children and re-examined them as adults. We aimed to determine if childhood nevus-counts predict nevus-prone adults, and further explore the relevance of host-factors and sun-exposure. Fifty-one Caucasian residents of Townsville (19.16° S, Queensland, Australia) had full-body nevus-counts aged 1–6 and 21–31 years-old. Sun-exposure was determined from questionnaires. Children in the upper-quartile of nevus-counts acquired nevi more rapidly than those in the bottom-quartile (13.3 versus 4.7 nevi/year; p < 0.0005). Children sunburnt before 7 years-old acquired more incident nevi by adulthood (238 versus 126, p = 0.003) particularly if sunburn was severe (321 versus 157.5, p = 0.003) or erythema occurred annually (380 versus 132, p = 0.008). Fair-skinned, freckled children with some nevi ≥ 3 mm, solar lentigines, or a family history of melanoma acquired more incident nevi than children without these attributes. Nevus-prone adults exhibit distinguishing features earlier in life (<7 years-old in Queensland) than has been shown previously. In addition to intervening with sun-protection counselling early enough to reduce risk, being able to reliably triage children into high- and low melanoma-risk groups may inform more efficacious and cost-effective targeted-screening in melanoma-prone populations. Further longitudinal research is needed to confirm that these attributes can reliably separate risk-groups.

scholarly journals Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls

2009 ◽  
Vol 38 (3) ◽  
pp. 814-830 ◽  
Author(s):  
Y.-m. Chang ◽  
J. H. Barrett ◽  
D. T. Bishop ◽  
B. K. Armstrong ◽  
V. Bataille ◽  
...  
Keyword(s):  
Sun Exposure ◽  
Pooled Analysis ◽  
Melanoma Risk

scholarly journals Biologic markers of sun exposure and melanoma risk in women: Pooled case-control analysis

2010 ◽  
Vol 129 (3) ◽  
pp. 713-723 ◽  
Author(s):  
Catherine M. Olsen ◽  
Michael S. Zens ◽  
Adele C. Green ◽  
Therese A. Stukel ◽  
C. D'Arcy J. Holman ◽  
...  
Keyword(s):  
Sun Exposure ◽  
Case Control ◽  
Control Analysis ◽  
Melanoma Risk ◽  
Biologic Markers ◽  
Case Control Analysis

scholarly journals Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate

2011 ◽  
Vol 47 (5) ◽  
pp. 732-741 ◽  
Author(s):  
Julia A. Newton-Bishop ◽  
Yu-Mei Chang ◽  
Faye Elliott ◽  
May Chan ◽  
Susan Leake ◽  
...  
Keyword(s):  
Case Control Study ◽  
Sun Exposure ◽  
Case Control ◽  
Temperate Climate ◽  
Melanoma Risk ◽  
Control Study ◽  
Large Case

Personal melanoma risk awareness versus intrinsic risk.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 9069-9069
Author(s):  
Caroline Robert ◽  
Céleste Lebbé ◽  
Sevrine Ricard ◽  
Philippe Saiag ◽  
Florent Grange ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Family History ◽  
Sun Exposure ◽  
Risk Level ◽  
Control Group ◽  
Melanoma Risk ◽  
Protection Measures ◽  
Frequent Use ◽  
History Of

9069 Background: Intrinsic risk factors for melanoma include personal and family history of the condition, a high number of naevi and a light skin phototype (I or II). The objective of this study was to evaluate the correlation between personal awareness of melanoma risk and objective risk factors and to analyze the elements associated with under-or over-evaluation of the actual risk. Methods: EDIFICE melanoma, a nationwide French observational survey, was conducted through phone interviews on a representative sample of 1502 subjects aged ≥ 18 using typical quotas. The survey took place from 28th Sept 2011 to 20th Oct 2011. Results: 393 subjects (26%) had at least one melanoma risk factor: personal: 1%; family history: 11%; high number of naevi: 8% and phototype I-II: 11%. 1109 (74%) had no risk factor. 1029 (73%) had a correct perception of their risk level, 135 (10%) overestimated their risk and 241 (17%) underestimated it. Compared to the control group (correct perception), the population overestimating the melanoma risk is characterised by a higher percentage of individuals living alone (32% vs. 24%, p<0.05), socio-professional category + (38% vs. 28%, p<0.01) and greater alcohol consumption (45% vs. 34%, p<0.02). They are also more likely to expose themselves to the sun (89% vs. 78%, p<0.004) and less likely to use sunscreen protection (58% vs. 44%, p<0.003). A greater proportion of them participates in melanoma screening programmes (21% vs. 14%, p<0.04). The population that underestimates the risk is characterised by lower educational attainment (11% vs. 7%, p<0.05), greater use of high SPF sunscreen (41% vs. 29%, p<0.0004) and a more frequent use of UV sunbeds (9% vs. 6%, p<0.06). Conclusions: Overall, the French have a fair perception of their personal likelihood of developing melanoma. Interestingly, subjects overestimating their intrinsic risk do not behave appropriately with respect to sun protection measures (more sun exposure and less sunscreen protection). On the other hand, subjects underestimating their risk use UV sunbeds more extensively.

scholarly journals Current Data on Risk Factor Estimates Does Not Explain the Difference in Rates of Melanoma between Hispanics and Non-Hispanic Whites

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Sonia Kamath ◽  
Kimberly A. Miller ◽  
Myles G. Cockburn
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Current Knowledge ◽  
Sun Exposure ◽  
Incidence Rates ◽  
Melanoma Risk ◽  
Similar Frequency ◽  
Red Hair ◽  
Melanoma Incidence ◽  
The Difference

United States Hispanics have seven times lower melanoma incidence rates than non-Hispanic whites (NHW). It is unclear whether this difference can be explained solely by phenotypic risk factors, like darker skin, or whether modifiable risk factors, like sun exposure, also play a role. The purpose of this paper is to summarize what is currently known about melanoma risk factors among Hispanics and NHWs, and whether or not those differences could explain the difference in melanoma incidence. Through literature review, relative risks and prevalence of melanoma risk factors in Hispanics and NHWs were identified and used to calculate the expected rate in Hispanics and rate ratio compared to NHWs. We found that melanoma risk factors either have similar frequency in Hispanics and NHWs (e.g., many large nevi) or are less frequent in Hispanics but do not explain a high proportion of disease variation (e.g., red hair). Considering current knowledge of risk factor prevalence, we found that melanoma incidence rates in the two groups should actually be similar. Sun exposure behavior among Hispanics may contribute to the explanation for the 7-fold difference in melanoma rates. Currently, limited data exist on sun exposure behavior among Hispanics, but possibilities for improving primary prevention by further studying these practices are substantial.

Premenopausal Use of Progestogens and Cutaneous Melanoma Risk: A French Prospective Cohort Study

2019 ◽  
Vol 189 (4) ◽  
pp. 314-329
Author(s):  
Iris Cervenka ◽  
Marie Al Rahmoun ◽  
Yahya Mahamat-Saleh ◽  
Marie-Christine Boutron-Ruault ◽  
Agnès Fournier ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prospective Cohort ◽  
Strong Influence ◽  
Sun Exposure ◽  
Melanoma Risk ◽  
Confounding Effect ◽  
Cox Models ◽  
Sunscreen Use ◽  
Show Evidence ◽  
Using Data

Abstract We investigated the influence of premenopausal use of progestogens on melanoma using data from E3N (Etude Epidémiologique Auprès de Femmes de l’Education Nationale), a prospective cohort of 98,995 French women, aged 40–65 years at inclusion. We used Cox models to adjust for age and melanoma risk factors. Over 1992–2008, 540 melanoma cases were ascertained among 79,558 women. We found a modest association between self-reported progestogen use and melanoma risk (hazard ratio (HR) = 1.23, 95% confidence interval (CI) = 1.02, 1.47), which was reduced after adjustment for melanoma risk factors (HR = 1.15, 95% CI: 0.95, 1.39). There was no heterogeneity across types of progestogens (P = 0.22), and use of multiple progestogens was positively associated with melanoma risk (HR = 1.33, 95% CI: 1.04, 1.70). Among users, we found no relationship with duration of progestogen use, age at start and last use, and time since first and last use. Although our results did not show evidence of a confounding effect of sun exposure, progestogen users had lower levels of residential sun exposure and were more likely to report sunscreen use, suggesting specific sun exposure profiles in users. Our findings do not support a strong influence of progestogens on melanoma risk. Further research is needed to confirm these results.

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