Urine Analysis May Help Predict Response to Biologics

2012 ◽  
Vol 43 (6) ◽  
pp. 26
Author(s):  
SARA FREEMAN
Keyword(s):  
2020 ◽  
Vol 41 (S1) ◽  
pp. s154-s154
Author(s):  
Hanish Jain ◽  
Elizabeth Hartigan ◽  
Joseph Tschopp ◽  
Paul Suits ◽  
Kristopher Paolino

Background: CAUTIs remain one of the most common hospital-acquired infections (HAIs) accounting for prolonged hospital stay and increased healthcare costs. According to the NHSN, the standardized infection ratio (SIR) at our institution was 1.6 compared to national average of 0.84 in 2018. We highlight the interventions implemented in our institution to prevent CAUTIs. These interventions have shown a reduction in the rate of CAUTIs, the SIR, Foley catheter days, and institutional cost. Methods: In addition to standard CAUTI prevention practices, we hypothesized that we could decrease CAUTIs through the daily implementation of specific practices. We developed a comprehensive interdisciplinary team which included the staff or charge registered nurse (RN), the unit manager, an infection preventionist, an advanced practice registered nurse (APRN), a pharmacist with an antimicrobial focus, and a physician from the infectious disease department who would conduct daily rounds on different units in the institution for education and assessment of catheter indications. A detailed review and analysis of the urine culture orders for patients with a Foley catheter was performed. A nurse-driven Foley catheter removal protocol before urine culture collection was initiated. We implemented a Foley catheter bundle that has guidelines for Foley insertion, best practice competency, and urinary catheter best practice algorithm and advocated alternative use of male or female external catheter. We educated physicians about ordering a reflexive urine analysis test followed by urine culture instead of testing either individually after removal of a Foley catheter. Lastly, we performed a root-cause analysis on all reported CAUTIs. These policies were implemented in a 435-bed tertiary-care center in November 2018, and we present data from 1-year before and after the interventions. Results: At our institution, we had 71 CAUTIs, with an SIR of 1.6, a standardized utilization ratio (SUR) of 0.92, 27,621 Foley days, and institutional cost of $979,303 compared to 40 CAUTIs with an SIR of 1, an SUR of 0.88, 24,193 Foley days, and institutional cost $537,927 after implementing our interventions. Conclusions: CAUTIs can be reduced by implementing specific measures that include infection control team rounds, nurse-driven protocol, and the use of Foley catheter bundles. Measures should be undertaken to prioritize these practices as part of a protocol. We advocate further studies to evaluate these measures. Education programs for healthcare professionals concerning CAUTIs and its complications can be implemented to carry out the prevention methods efficiently.Funding: NoneDisclosures: None


2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Stephen J. Genuis ◽  
Kevin Lane ◽  
Detlef Birkholz

Background. Many individuals have been exposed to organochlorinated pesticides (OCPs) through food, water, air, dermal exposure, and/or vertical transmission. Due to enterohepatic reabsorption and affinity to adipose tissue, OCPs are not efficiently eliminated from the human body and may accrue in tissues. Many epidemiological studies demonstrate significant exposure-disease relationships suggesting OCPs can alter metabolic function and potentially lead to illness. There is limited study of interventions to facilitate OCP elimination from the human body. This study explored the efficacy of induced perspiration as a means to eliminate OCPs.Methods. Blood, urine, and sweat (BUS) were collected from 20 individuals. Analysis of 23 OCPs was performed using dual-column gas chromatography with electron-capture detectors.Results. Various OCPs and metabolites, including DDT, DDE, methoxychlor, endrin, and endosulfan sulfate, were excreted into perspiration. Generally, sweat samples showed more frequent OCP detection than serum or urine analysis. Many OCPs were not readily detected in blood testing while still being excreted and identified in sweat. No direct correlation was found among OCP concentrations in the blood, urine, or sweat compartments.Conclusions. Sweat analysis may be useful in detecting some accrued OCPs not found in regular serum testing. Induced perspiration may be a viable clinical tool for eliminating some OCPs.


2021 ◽  
pp. 114284
Author(s):  
Damian Garbicz ◽  
Tomasz Pilżys ◽  
Iga Wiśniowska ◽  
Małgorzata Grzesiuk ◽  
Radosław Cylke ◽  
...  

Metabolomics ◽  
2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Loïc Mervant ◽  
Marie Tremblay-Franco ◽  
Emilien L. Jamin ◽  
Emmanuelle Kesse-Guyot ◽  
Pilar Galan ◽  
...  

2013 ◽  
Vol 221 ◽  
pp. S64 ◽  
Author(s):  
Julien Boccard ◽  
Fabienne Jeanneret ◽  
Olivier Sorg ◽  
Jean-Hilaire Saurat ◽  
Stepanka Vlckova ◽  
...  

2005 ◽  
Vol 15 (03n04) ◽  
pp. 169-180 ◽  
Author(s):  
K. SERA ◽  
T. TERASAKI ◽  
J. ITOH ◽  
S. FUTATSUGAWA ◽  
Y. SAITOH ◽  
...  

We have measured fluorine concentration in samples taken from humans, such as sweat, saliva, snivel and tear in addition to hair, nail and urine, together with those of other elements by means of a three-detector measuring system. Fluorine has been known as one of the most toxic elements as well as arsenic, lead, mercury and cadmium which contaminate environment over the wide area. This system allowed us to discuss about fluorine concentration related to other elements'. A standard-free method established by us has been applied to quantitative analyses of these samples. By means of these methods, quantitative analysis becomes possible for samples of less than 1mg or 1μl and it is quite suited to tear, snivel and sweat. As one of the conclusion, sweat, snivel and tear give useful information in addition to the samples which have been traditionally analyzed. It is found that titanium concentration in a body is well estimated by analyses of sweat, snivel and saliva, arsenic concentration can be estimated by sweat analysis in addition to urine analysis, and nickel is well evaluated by sweat and tear. In this way, it is required to estimate elemental concentration in a human body by measuring various clinical samples. Especially, correlation between fluorine and arsenic is found in a few bio-medical samples.


Author(s):  
S.A. Amansakhatov ◽  
◽  
A.P. Yalkabova ◽  

Purpose. To study the structure of hospital incidence of uveitis on the basis of a retrospective analysis of case histories of the International Center for Eye Diseases. Material and мethods. A retrospective analysis of the case histories of 896 patients with various forms of uveitis for 10 years (from 2011 to 2020) was carried out. Standard ophthalmological examination: visiometry, refractometry, tonometry, biomicroscopy, ophthalmoscopy,USB, OCT. Laboratory examination: general blood and urine analysis, biochemical and immunological blood tests. Results. The hospital incidence of uveitis was 6.5% with a slight predominance of females (53.3%) and a predominance of people living in rural areas (62.4%). Clinically and anatomically, the most common in the age groups from 31 to 60 years was the most common anterior uveitis 39.4% (n=353), followed by posterior uveitis in frequency – 38.3% (n=343), average uveitis – 7.9% (n=71) and panuveitis 2.2% (n=20). Unilateral lesion in 68.9% of patients. The etiological factor was established in 29.3% of patients, of which the largest group was infectious uveitis – 20.6% of cases. Most often, herpesvirus and cytomegalovirus were infectious agents (91.4%). Conclusion. The results of the study showed the need for expanding diagnostic methods, correcting the treatment strategy and tactics of managing this category of patients. Key words: uveitis, clinical features, morbidity.


2021 ◽  
Vol 66 (5) ◽  
pp. 33-38
Author(s):  
P. Skopin ◽  
A. Ivashin ◽  
Yu. Skopina ◽  
Yu. Kozina ◽  
R. Zukov ◽  
...  

Results: To develop a method for reducing the frequency and severity of early radiation reactions in patients with cancer of the uterus or cervix. Material and methods: We analyzed the results of treatment of 60 patients with cancer of the uterus and cervix, patients received a postoperative course of external beam radiotherapy combined with the intramuscular administration of the Derinat® radioprotector (sodium deoxyribonucleate); in the second arm, they received a postoperative course of external beam radiotherapy and standard therapy in case of radiation cystitis. The assessment of radiation reactions severity was performed with the EORTC QLQ-C30 criteria, WBC count, IPSS scale, urine analysis and cystoscopic examination evaluated with the developed by us scale. Results: Evaluation of the quality of life in patients with cervical or uterine cancer at the final stage of treatment using the IPSS scale showed that in the arm of patients with sodium deoxyribonucleate, there was a 30.4 % (p> 0.05) decrease in the symptoms of urinary disorders. The use of the radioprotector sodium deoxyribonucleate also statistically significantly reduced the incidence of radiation cystitis by 73 %. According to cystoscopy, the total bladder injury score at the end of treatment was 147 % lower. The number of leukocytes in the urine analysis at the end of treatment was 116.3 % lower (p≤0.01) in those who received sodium deoxyribonucleate Conclusion: The data obtained indicate the radioprotective efficacy of sodium deoxyribonucleate and make it possible to recommend its intramuscular administration to patients with cancer of the uterus and cervix against the background of external beam radiation therapy to reduce the frequency and severity of acute radiation cystitis in patients with cancer of the uterus or cervical cancer receiving external beam radiation therapy.


Sign in / Sign up

Export Citation Format

Share Document