SIMULTANEOUS MULTI-ELEMENT (INCLUDING FLUORINE) ANALYSIS OF VARIOUS BIO-MEDICAL SAMPLES

2005 ◽  
Vol 15 (03n04) ◽  
pp. 169-180 ◽  
Author(s):  
K. SERA ◽  
T. TERASAKI ◽  
J. ITOH ◽  
S. FUTATSUGAWA ◽  
Y. SAITOH ◽  
...  
Keyword(s):  
Toxic Elements ◽  
Elemental Concentration ◽  
Urine Analysis ◽  
Arsenic Concentration ◽  
Measuring System ◽  
Clinical Samples ◽  
Fluorine Concentration ◽  
Titanium Concentration ◽  
Quantitative Analyses ◽  
Contaminate Environment

We have measured fluorine concentration in samples taken from humans, such as sweat, saliva, snivel and tear in addition to hair, nail and urine, together with those of other elements by means of a three-detector measuring system. Fluorine has been known as one of the most toxic elements as well as arsenic, lead, mercury and cadmium which contaminate environment over the wide area. This system allowed us to discuss about fluorine concentration related to other elements'. A standard-free method established by us has been applied to quantitative analyses of these samples. By means of these methods, quantitative analysis becomes possible for samples of less than 1mg or 1μl and it is quite suited to tear, snivel and sweat. As one of the conclusion, sweat, snivel and tear give useful information in addition to the samples which have been traditionally analyzed. It is found that titanium concentration in a body is well estimated by analyses of sweat, snivel and saliva, arsenic concentration can be estimated by sweat analysis in addition to urine analysis, and nickel is well evaluated by sweat and tear. In this way, it is required to estimate elemental concentration in a human body by measuring various clinical samples. Especially, correlation between fluorine and arsenic is found in a few bio-medical samples.

STUDIES ON DAILY CHANGES OF ELEMENTAL CONCENTRATION IN BEARD SAMPLES BY MEANS OF THE STANDARD-FREE METHOD

2006 ◽  
Vol 16 (03n04) ◽  
pp. 169-181 ◽  
Author(s):  
K. SERA ◽  
T. SASAKI ◽  
J. ITOH ◽  
Y. SAITOH
Keyword(s):  
Toxic Elements ◽  
Elemental Concentration ◽  
Arsenic Concentration ◽  
Essential Elements ◽  
The Body ◽  
Clear Correlation ◽  
Essential Information ◽  
Daily Ingestion ◽  
The Face ◽  
Daily Changes

We developed and reported a standard-free method for beard (including mustache and whiskers) samples that enables us to quantitatively analyze powdered beard samples of extremely small quantity. In order to investigate intake of essential elements and also exposure to toxic elements, daily changes of elemental concentration in the body give us essential information. Firstly, we have measured dependence of elemental concentration in beard, mustache and whiskers on the collecting regions in the face. Then, daily changes of elemental concentration in the body, which reflect daily ingestion of foods and waters, have been estimated by means of quantitative analyses of beard samples. These beard samples were taken from three persons everyday over successive 7, 14 and 33 days, respectively. As a result, some elements show long-term changes and a few toxic elements such as arsenic and lead exhibit changes in a period of a few days. We have also measured daily changes of elemental concentration in urine and beard taken from the same person at the same time every half day over 10 days, and clear correlation of daily changes of the arsenic concentration between urine and beard samples was observed. It is found that the standard-free method is quite effective for beard samples of very small quantities, and that beard analyses are quite suited to studies on daily changes of elemental concentration in the human body in comparison with the other samples depending on the elements.

Elemental concentration in the hair taken from healthy people for the past 20 years — 2. Sex-specific differences and changes with age

2016 ◽  
Vol 26 (01n02) ◽  
pp. 29-43 ◽  
Author(s):  
K. Sera ◽  
S. Goto ◽  
T. Hosokawa ◽  
C. Takahashi ◽  
J. Itoh ◽  
...  
Keyword(s):  
Toxic Elements ◽  
Calcium Concentration ◽  
Elemental Concentration ◽  
Essential Elements ◽  
Healthy People ◽  
The Past ◽  
Iron Copper ◽  
Calcium Magnesium ◽  
Copper Zinc ◽  
Iwate Prefecture

A standard-free method for untreated hairs has been applied to quantitative analysis of the hairs taken from 1256 healthy people living in the Iwate prefecture, Japan. It was found that there are clear sex-specific differences in the concentration of some elements. Concentrations of many essential elements, such as calcium, magnesium, iron, copper, zinc and bromine, are clearly higher for female. In particular, calcium concentration is 2.6 times higher for female in comparison with that for male. Contrarily, concentrations of some toxic elements such as chromium, arsenic and mercury are higher for male. On the other hand, concentrations of many elements vary with age. Those of calcium, magnesium and zinc start to increase in the middle of teens and reach maximum in the middle of twenties for female. Mercury concentration increases as the ages advance, while those of chromium, arsenic and lead show no clear changes with age.

QUANTITATIVE AND QUALITATIVE ANALYSIS OF FLUORIDE AND MULTI ELEMENTS OF SHARK TEETH BY PIXE

2008 ◽  
Vol 18 (03n04) ◽  
pp. 123-129
Author(s):  
S. SAKURAI ◽  
R. ASAKAWA ◽  
F. HIROTA ◽  
T. SATO ◽  
K. SERA ◽  
...  
Keyword(s):  
Elemental Concentration ◽  
Good Accuracy ◽  
Preparation Method ◽  
Fluorine Concentration ◽  
X Ray Diffraction ◽  
Sample Preparation Method ◽  
X Ray ◽  
Shark Teeth ◽  
South Of Japan ◽  
Near Future

Biomineralization has two types, biologically induced mineralization (BIM) and biologically controlled mineralization (BCM). Shark teeth is a typical representative of BCM. We have measured concentrations of fluorine and multi elements in shark teeth collected in the south of Japan. As a result, it was confirmed that the sample preparation method, which was established for the biological samples, is applicable to the shark teeth samples and the elemental concentration was obtained in good accuracy and reproducibility. Moreover, we clarified that the shark teeth is composed of Fluorapatite by the combination with X-ray Diffraction. Fluorine concentration is found to be 5500 µg/g in the shark teeth. We have 100 samples of Shark teeth and are planning on reporting the findings of a study with larger samples in the near future.

scholarly journals Comparison of qualitative and quantitative analyses of COVID-19 clinical samples

2020 ◽  
Vol 510 ◽  
pp. 613-616
Author(s):  
Yan Dang ◽  
Ning Liu ◽  
Chianru Tan ◽  
Yingmei Feng ◽  
Xingxing Yuan ◽  
...  
Keyword(s):  
Clinical Samples ◽  
Qualitative And Quantitative ◽  
Quantitative Analyses

scholarly journals POTENTIAL TOXIC ELEMENTS (PTES) IN GROUND AND SPRING WATERS, SOILS AND SEDIMENTS: AN INTERDISCIPLINARY STUDY IN ANTHEMOUNTAS BASIN, N. GREECE

2017 ◽  
Vol 50 (4) ◽  
pp. 2171
Author(s):  
N. Kazakis ◽  
N. Kantiranis ◽  
M. Kaprara ◽  
M. Mitrakas ◽  
G. Vargemezis ◽  
...  
Keyword(s):  
Toxic Elements ◽  
Arsenic Concentration ◽  
Normal Faults ◽  
Geothermal Waters ◽  
Potential Toxic Elements ◽  
Geothermal Fluids ◽  
Porous Aquifer ◽  
Soils And Sediments ◽  
Ophiolitic Rocks ◽  
Interdisciplinary Study

Ground and spring waters, soils and sediments of Anthemountas basin in Northern G reece were analyzed for Potential Toxic Elements (PTEs). In total, twenty three soil and sediment samples, three groundwater (boreholes) and two spring water samples, were analyzed. Contents of Ni in soils and sediments can be as high as 2169 mg/kg. The high correlation coefficient of Ni and Cr, indicates the geogenic origin of Ni, which originates from ophiolitic rocks. Arsenic concentration ranges from 3 to 110 mg/kg in soils and sediments, with the highest contents observed in travertine. The spring waters are characterized by elevated concentrations of As (up to 235 μg/L), N a, K, Fe and Zn, indicating that hydrothermal fluids are responsible for feldspar alte ration of the Monopigado granodiorite. On the contrary, in groundwaters, As conten ts are low (up to 18 μg/L). Electrical resistivity tomographies performed around the groundwater boreholes, revealed the presence of normal faults, locally allowing the mixing of geothermal fluids with the shallow porous aquifer (SPA). The presence of As in the SPA is probably due to inputs from geothermal waters through normal faulting.

scholarly journals The utility of measurement uncertainty in medical laboratories

2020 ◽  
Vol 58 (9) ◽  
pp. 1407-1413 ◽  
Author(s):  
Federica Braga ◽  
Mauro Panteghini
Keyword(s):  
Measurement Uncertainty ◽  
Metrological Traceability ◽  
Measuring System ◽  
Medical Laboratory ◽  
Management Tool ◽  
Clinical Samples ◽  
Traceability Chain ◽  
Medical Laboratories

AbstractThe definition and enforcement of reference measurement systems, based on the implementation of metrological traceability of patient results to higher-order (reference) methods and/or materials, together with a clinically acceptable level of measurement uncertainty (MU), are fundamental requirements to produce accurate and equivalent laboratory results. The MU associated with each step of the traceability chain should be governed to obtain a final combined MU on clinical samples fulfilling the requested performance specifications. MU is useful for a number of reasons: (a) for giving objective information about the quality of individual laboratory performance; (b) for serving as a management tool for the medical laboratory and in vitro diagnostics (IVD) manufacturers, forcing them to investigate and eventually fix the identified problems; (c) for helping those manufacturers that produce superior products and measuring systems to demonstrate the superiority of those products; (d) for identifying analytes that need analytical improvement for their clinical use and ask IVD manufacturers to work for improving the quality of assay performance and (e) for abandoning assays with demonstrated insufficient quality. Accordingly, the MU should not be considered a parameter to be calculated by medical laboratories just to fulfill accreditation standards, but it must become a key quality indicator to describe both the performance of an IVD measuring system and the laboratory itself.

scholarly journals Optimizing Available Tools for Achieving Result Standardization: Value Added by Joint Committee on Traceability in Laboratory Medicine (JCTLM)

2021 ◽  
Author(s):  
Mauro Panteghini ◽  
Federica Braga ◽  
Johanna E Camara ◽  
Vincent Delatour ◽  
Katleen Van Uytfanghe ◽  
...  
Keyword(s):  
Task Force ◽  
Certified Reference Materials ◽  
Clinical Sample ◽  
Metrological Traceability ◽  
Value Added ◽  
Higher Order ◽  
Measuring System ◽  
Clinical Samples ◽  
Field Methods ◽  
Reference Measurement

Abstract Background The JCTLM created a Task Force on Reference Measurement System Implementation (TF-RMSI) to provide guidance on metrological traceability implementation for the in vitro diagnostics (IVD) community. Content TF-RMSI investigated the reference measurement systems (RMS) for 13 common measurands by applying the following procedural steps: (a) extracting data from the JCTLM database of available certified reference materials (CRMs) and reference measurement procedures (RMPs); (b) describing the RMS to which each recruited CRM or RMP belongs; (c) identifying the intended use of the CRMs, and, if used as a common calibrator for IVD measuring systems and/or trueness assessment of field methods was included, checking the CRM’s certificate for information about commutability with clinical samples; and (d) checking if the CRM or RMP measurement uncertainty (MU) has the potential to be small enough to avoid significantly affecting the analytical performance specifications (APS) for MU of clinical sample results when the MU from the IVD calibrator and from the end-user measuring system were combined. Summary We produced a synopsis of JCTLM-listed higher-order CRMs and RMPs for the selected measurands, including their main characteristics for implementing traceability and fulfilling (or not) the APS for suitable MU. Results showed that traceability to higher-order references can be established by IVD manufacturers within the defined APS for most of the 13 selected measurands. However, some measurands do not yet have suitable CRMs for use as common calibrators. For these measurands, splitting clinical samples with a laboratory performing the RMP may provide a practical alternative for establishing a calibration hierarchy.

FLUORINE AND MULTI-ELEMENT ANALYSIS OF MUSHROOM SAMPLES BY MEANS OF PIXE SYSTEM

2005 ◽  
Vol 15 (03n04) ◽  
pp. 285-291 ◽  
Author(s):  
J. ITOH ◽  
S. FUTATSUGAWA ◽  
Y. SAITOH ◽  
K. SERA
Keyword(s):  
Elemental Concentration ◽  
Good Accuracy ◽  
Preparation Method ◽  
Clear Correlation ◽  
Fluorine Concentration ◽  
Element Analysis ◽  
Measured Concentration ◽  
Specific Element ◽  
Iwate Prefecture ◽  
Multi Element Analysis

We have measured concentration of multi elements including fluorine in mushrooms collected in Iwate prefecture, Japan. As a result, it was confirmed that the sample preparation method, which was established for the plant samples, is applicable to the mushroom samples and the elemental concentration was obtained in good accuracy and reproducibility. Moreover, it becomes clear that the mushroom takes a specific element selectively depending on its species, and it is found that to analyze various kinds of mushrooms is of great use as a way of monitoring environmental pollution. Fluorine concentration is found to be 7-68 ppm in the mushroom samples. However, clear correlation of fluorine and other elements was not observed in each sample in this study.

scholarly journals Contamination of cosmetics with toxic elements and risk assessment for consumers’ health

2020 ◽  
Vol 52 (1) ◽  
pp. 40-44
Author(s):  
T.F. Kharchenko ◽  
S.S. Isaeva ◽  
A.H. Kudriavtseva ◽  
O.A. Kharchenko ◽  
A.M. Stroy ◽  
...  
Keyword(s):  
Toxic Elements ◽  
Inductively Couple Plasma ◽  
Arsenic Concentration ◽  
Atomic Emission ◽  
Atomic Emission Spectrometry ◽  
Emission Spectrometry ◽  
Couple Plasma Atomic Emission ◽  
Plasma Atomic Emission Spectrometry ◽  
Study Results ◽  
The Given

The aim of the Research. To study the content of toxic elements (lead, arsenic and mercury) in decorative cosmetics. Methods and Materials. The study included lipsticks, mascara, children’s decorative cosmetics from domestic and foreign manufacturers (Ukraine, Finland, France, Latvia, Japan) and pigments used in manufacturing. The content of toxic elements was determined using inductively couple plasma atomic emission spectrometry on JCPE-9820-2015 device. Advanced mathematical and statistical methods were applied to analyze the findings of the study. Results and Discussion. The findings of the study indicate that decorative cosmetics products in the Ukrainian market may contain lead and arsenic concentration resulting in undesirable health outcomes. Conclusions. The study on toxic elements contents in decorative cosmetics products proves the necessity for these products mandatory control by the given indicators. Thorough sanitary and chemical control over their production and selling will prevent access of low quality and hazardous to human health cosmetic products to the Ukrainian market. Key Words: decorative cosmetics, hazard, lead, arsenic and mercury concentration.

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