Circadian rhythm characteristics of serum cortisol and dehydroepiandrosterone sulfate in healthy Chinese men aged 30 to 60 years. A cross-sectional study

Abstract Background: Adolescent sexual debut and non-consensual sex have been linked to higher sexual risk and STI infection in adulthood among men who have sex with men (MSM) in high-income countries. This study aimed to examine adolescent and non-consensual anal sexual debut among Chinese MSM and to evaluate factors associated with adolescent sexual debut and non-consensual anal sex.Methods: A cross-sectional study was conducted recently among Chinese men assigned male sex at birth, ≥18 years old, and who had ever engaged in anal sex with a man. Participants answered questions regarding socio-demographics, condomless sex, age at anal sexual debut with a man, and whether the first anal sex was consensual. Factors associated with an adolescent sexual debut (<18 years old) and non-consensual sex at sexual debut were evaluated. We defined adolescent sexual debut as having anal sex with another man at 17 years old or younger, and the participants were asked whether their first male-to-male anal sex was non-consensual.Results: Overall, 2031 eligible men completed the survey. The mean age of sexual debut was 20.7 (SD=4.3) years old. 17.6% (358/2031) of men reported adolescent sexual debut, and 5.0% (101/2031) reported a non-consensual sexual debut. The adolescent sexual debut was associated with having more male sexual partners (adjusted OR 1.10, 95% CI 1.06–1.15) and condomless anal sex in the last three months (AOR=1.71, 95% CI 1.34-2.18). MSM whose sexual debut was non-consensual were more likely to have condomless anal sex (AOR=1.76, 95% CI 1.17-2.66), and to have reported an adolescent sexual debut (AOR=2.72, 95% CI 1.75-4.21).Conclusions: Many Chinese MSM reported adolescent sexual debut and non-consensual sex, both of which are associated with sexual risk behaviors and drive STI transmission. These findings highlight the need for designing tailored interventions for MSM who experienced adolescent sexual debut and non-consensual sex at debut.

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Low serum albumin, aspartate aminotransferase, and body mass are risk factors for frailty in elderly people with diabetes: possible mechanistic role of dehydroepiandrosterone sulfate – a cross-sectional study

10.21203/rs.2.22681/v1 ◽

2020 ◽

Author(s):

Toshihiko Yanase ◽

Ikumi Yanagita ◽

Yuya Fujihara ◽

Chikayo Iwaya ◽

Yuichi Kitajima ◽

...

Keyword(s):

Risk Factors ◽

Regression Analysis ◽

Serum Albumin ◽

Body Mass ◽

Aspartate Aminotransferase ◽

Dehydroepiandrosterone Sulfate ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Independent Risk Factors

Abstract Background: Relatively low dehydroepiandrosterone sulfate (DHEA-S) and high cortisol/DHEA ratio have been suggested to be associated with frailty, evaluated using a physical scale. However, the significance of these two hormones for frailty in elderly patients with type 2 diabetes mellitus (T2DM) has not been assessed using a wider range of measures of frailty, including physical, mental, and social indices. Methods: We performed a cross-sectional study to investigate the significance of these two hormones for frailty in elderly T2DM patients (n=148; ≥65 years), using a broad assessment, the clinical frailty scale, and to reevaluate the risk factors for frailty in elderly T2DM patients. We compared parameters between the non-frail and frail groups using the unpaired t and Mann-Whitney U tests. The Jonckheere-Therpstra test was used to identify relationships with the severity of frailty and risk factors were identified using binary regression analysis. Results: Simple regression analysis identified a number of significant risk factors for frailty, including DHEAS <70 µg/dL and cortisol/DHEA-S ratio ≥0.2. Multiple regression analysis showed that low albumin (<4.0 g/dl) (odds ratio [OR]=5.79, p <0.001), low aspartate aminotransferase (AST) activity (<25 IU/L) (OR=4.34, p =0.009), and low body mass (BM) (<53 kg) (OR=3.85, p =0.012) were independent risk factors for frailty. A significant decrease in DHEA-S and a significant increase in the cortisol/DHEA-S ratio occurred alongside increases in the severity of frailty. DHEA-S concentration positively correlated with both serum albumin and BM. Conclusions: Hypoalbuminemia, low AST, and low BM are independent risk factors for frailty in elderly T2DM patients, strongly implying relative malnutrition in these frail patients. DHEA-S may be important for the maintenance of liver function and BM. A decrease in DHEA-S and an increase in the cortisol/DHEAS ratio may be involved in the mechanism of the effect of malnutrition in elderly T2DM patients.

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Relationship between blood lipid profiles and pancreatic islet β cell function in Chinese men and women with normal glucose tolerance: a cross-sectional study

BMC Public Health ◽

10.1186/1471-2458-12-634 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 12

Author(s):

Tianpeng Zheng ◽

Yun Gao ◽

Haoming Tian

Keyword(s):

Cell Function ◽

Blood Lipid ◽

Normal Glucose Tolerance ◽

Cross Sectional Study ◽

Sectional Study ◽

Β Cell ◽

Cross Sectional ◽

Chinese Men ◽

Normal Glucose ◽

Β Cell Function

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Factors that influence in vitro fertilization treatment outcomes of Chinese men: A cross-sectional study

Applied Nursing Research ◽

10.1016/j.apnr.2016.07.003 ◽

2016 ◽

Vol 32 ◽

pp. 222-226 ◽

Cited By ~ 4

Author(s):

Dan Chen ◽

Jing Ping Zhang ◽

Ling Jiang ◽

Huayan Liu ◽

Ling Shu ◽

...

Keyword(s):

In Vitro Fertilization ◽

Treatment Outcomes ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Vitro Fertilization ◽

Chinese Men

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SALIVARY CORTISOL AND METABOLIC SYNDROME COMPONENT’S ASSOCIATION

ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) ◽

10.1590/0102-672020180001e1351 ◽

2018 ◽

Vol 31 (1) ◽

Cited By ~ 1

Author(s):

Grasiane Izidorio GARBELLOTTO ◽

Fernanda Jardim REIS ◽

Ana Maria Pandolfo FEOLI ◽

Carla Haas PIOVESAN ◽

Andréia da Silva GUSTAVO ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Metabolic Syndrome ◽

Circadian Rhythm ◽

Salivary Cortisol ◽

Cross Sectional Study ◽

Elevated Blood ◽

Sectional Study ◽

Cross Sectional ◽

Pituitary Adrenal Axis

ABSTRACT Background: Actually the lifestyle exposes the population to several risk factors related to alimentary habits and less physical activity that contributes to chronic diseases appearance worldwide. Aim: To analyze the association between salivary cortisol and the components of metabolic syndrome. Methods: This is a cross-sectional study. As part of it, 28 individuals aged 30-59 years presenting three or more of the following findings: CA: ≥88 cm for women and ≥102 cm for men; SBP>130 mmHg and DBP>85 mmHg; GL>100 mg/dl; TG>150 mg/dl; HDL<40 mg/dl for men and <50 mg/dl for women. Was performed analysis of salivary cortisol (by radioimmunoassay) from 25 salivary samples collected throughout the day, for evaluating changes in the circadian rhythm of this hormone (8AM, noon and 8PM). Results: 28 evaluated individuals had a mean age of 51.9±7.5 years, mostly women (64.3%) and a mean of BMI 33.6±3.2 kg/m². The cortisol level from the 8AM averaged 18.7±4.8 ng/dlL. Individuals with FPG>110mg/dl, have significantly lower average levels of cortisol than ones with FPG <110 (12.8±5,2 vs. 17.3±4.2). Significant correlations were HOMA vs. WC (r=0,465; p˂0,005) and TG (r=0,473; p˂0,005), WC vs. FG (r=0,446; p˂0,005) and BMI (r=0,730; p˂0.0001); TG vs. HDL (r=0,441 p˂0,005) and FG (r=0,440; p˂0,005). Conclusion: Morning salivary cortisol in subjects with chronically elevated blood glucose can represent a downregulation of the hypothalamic-pituitary adrenal axis. This is an important finding not yet well investigated.

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Early and non-consensual sexual debut among Chinese men who have sex with men: a cross-sectional study

10.21203/rs.3.rs-25389/v1 ◽

2020 ◽

Author(s):

Weiming Tang ◽

Yehua Wang ◽

Wenting Huang ◽

Dan Wu ◽

Fan Yang ◽

...

Keyword(s):

Sexual Debut ◽

Cross Sectional Study ◽

Sectional Study ◽

Anal Sex ◽

Cross Sectional ◽

Early Sexual Debut ◽

Chinese Men ◽

Factors Associated ◽

Consensual Sex ◽

Sex With Men

Abstract Background Early sexual debut and non-consensual sex have been linked to higher sexual risk and STI infection among men who have sex with men (MSM) in high-income countries. This study aimed to examine early and non-consensual sexual debut among Chinese MSM and to evaluate factors associated with early sexual debut and non-consensual sex. Methods A cross-sectional study was conducted in 2016 among Chinese men born biologically male, ≥ 18 years old, and who had ever engaged in anal sex with a man. Participants answered questions regarding socio-demographics, condomless sex, age at anal sexual debut with a man, and whether the first anal sex was consensual sex. Factors associated with an early sexual debut (< 18 years old) and non-consensual sex at sexual debut were evaluated. Results Overall, 2031 eligible men completed the survey. The mean age of sexual debut was 20.7 (SD = 4.3) years old. 17.6% (358/2031) of men reported early sexual debut, and 5.0% (101/2031) reported a non-consensual sexual debut. Early sexual debut was associated with having more male sexual partners (adjusted OR 1.10, 95% CI 1.06–1.15) and condomless anal sex in last three months (AOR = 1.71, 95% CI 1.34–2.18) in last three months. MSM whose sexual debut was non-consensual were more likely to have condomless anal sex (AOR = 1.76, 95% CI 1.17–2.66), and to have reported an early sexual debut (AOR = 2.72, 95% CI 1.75–4.21). Conclusions Many Chinese MSM reported early sexual debut and non-consensual sex, both of which are associated with sexual risk behaviors and drive STI transmission. These findings highlight the need for improving sexual health education among young people.

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