Lurasidone Gets Nod Based on Short-Term Data

2010 ◽  
Vol 38 (11) ◽  
pp. 6
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  
Short Term ◽  
Term Data

Prediction of Long Term Stress Rupture Data for 2124

2006 ◽  
Vol 519-521 ◽  
pp. 1041-1046 ◽  
Author(s):  
Brian Wilshire ◽  
H. Burt ◽  
N.P. Lavery
Keyword(s):  
Q Methodology ◽  
Fracture Behavior ◽  
Stress Rupture ◽  
Creep Data ◽  
Short Term ◽  
Rupture Data ◽  
Term Creep ◽  
Term Data ◽  
Short Term Creep

The standard power law approaches widely used to describe creep and creep fracture behavior have not led to theories capable of predicting long-term data. Similarly, traditional parametric methods for property rationalization also have limited predictive capabilities. In contrast, quantifying the shapes of short-term creep curves using the q methodology introduces several physically-meaningful procedures for creep data rationalization and prediction, which allow straightforward estimation of the 100,000 hour stress rupture values for the aluminum alloy, 2124.

scholarly journals Research on Aiming and Tracking Ability Evaluation Model of Laser-guided Missile

2021 ◽  
Vol 2083 (4) ◽  
pp. 042074
Author(s):  
Wuzhou Li ◽  
Shicong Lin ◽  
Zehui Liu
Keyword(s):  
Evaluation Model ◽  
Continuous Process ◽  
Laser Guidance ◽  
Short Term ◽  
Tracking Ability ◽  
Verification Model ◽  
Coordinate Data ◽  
Operational Data ◽  
Term Data ◽  
Ability Evaluation

Abstract Laser guidance is a continuous process, during which a lot of operational data and corresponding changes are generated. Aiming at the live-fire drill shooting training and assessment evaluation of a certain type of laser-guided missile, this paper analyzes the principle of laser guidance, studies the weighting system of the information field based on the importance of characteristic intervals, integrates and processes the data and outputs the aiming effect picture and sheet, and constructs the aiming and tracking ability evaluation model. Stationary targets and moving targets are tested respectively, and the verification model can realize the calculation of laser information field, the integration of coordinate data, the output of aiming effect diagram, and the evaluation of the shooter’s aiming and tracking ability expressed in a percentage system. The model realizes data collection, integration and processing based on MATLAB software, and builds graph and table output ports, which can realize low delay processing of a large amount of short-term data.

scholarly journals A Multi-Year Examination of Gardening Experience and Fruit and Vegetable Intake During College

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2088 ◽  
Author(s):  
Daniel Staub ◽  
Sarah E. Colby ◽  
Melissa D. Olfert ◽  
Kendra Kattelmann ◽  
Wenjun Zhou ◽  
...  
Keyword(s):  
Vegetable Intake ◽  
Fruit And Vegetable Intake ◽  
Farmers Markets ◽  
Fruit And Vegetable ◽  
Short Term ◽  
Second Year ◽  
Locally Grown ◽  
Term Data ◽  
Time Point

Gardening has been positively associated with fruit and vegetable (FV) consumption based on short-term studies among children, but long-term data among adolescents and young adults are lacking. This investigation sought to elucidate the association between gardening experience and FV intake among college students over a two-year period. Students (N = 593) from eight universities were assessed at the end of their freshman (Y1) and sophomore (Y2) years during the springs of 2016 and 2017, respectively. At each time point, participants completed the NCI FV Screener and questions related to gardening experience and FV-related attitudes and behaviors. Students were then categorized into four groups based on gardening experience: Gardened only during the first or second year (Y1 only and Y2 only gardeners), gardened both years (Y1+Y2 gardeners), and non-gardeners. While both Y1 only and Y1+Y2 gardeners reported significantly higher FV intake relative to non-gardeners at Y1 (2.3 ± 0.9 and 2.6 ± 0.7 versus 1.9 ± 0.6 cup equivalents (CE)/day, respectively; p < 0.01), only Y1+Y2 gardeners differed from non-gardeners at Y2 (2.4 ± 0.6 versus 1.8 ± 0.5 CE/day; p < 0.001). Additionally, Y1+Y2 gardeners reported more frequent engagement of several FV-related behaviors, including shopping at farmers’ markets, eating locally grown foods, and cooking from basic ingredients; and were five times more likely to have gardened during childhood (OR: 5.2, 95%, CI: 3.5–8.8; p < 0.001). Findings suggest that while isolated gardening experiences during college are associated with FV intake, reoccurring experience may be essential for sustained benefit.

Lurasidone and risk for metabolic syndrome: results from short- and long-term clinical studies in patients with schizophrenia

CNS Spectrums ◽  
2020 ◽  
pp. 1-11
Author(s):  
Michael Tocco ◽  
John W. Newcomer ◽  
Yongcai Mao ◽  
Andrei Pikalov ◽  
Antony Loebel
Keyword(s):  
Metabolic Syndrome ◽  
Dose Range ◽  
Dose Effect ◽  
Short Term ◽  
Open Label ◽  
Quetiapine Xr ◽  
Long Term Treatment ◽  
Short And Long Term ◽  
Term Data

Abstract Objective To assess the effects of treatment with lurasidone on risk for metabolic syndrome (MetS) in patients with schizophrenia. Methods Rates of metabolic syndrome during treatment with lurasidone (40-160 mg/d) were analyzed using pooled, short-term data from three randomized, double-blind, placebo-controlled studies (vs olanzapine and quetiapine XR); long-term data from two active-comparator-controlled studies (vs risperidone and quetiapine XR); and data from two open-label studies in which patients were switched from olanzapine or risperidone to lurasidone. Results MetS was defined based on the National Cholesterol Education Program criteria. In short-term studies, the odds of meeting criteria for MetS at week 6 LOCF (adjusted for baseline metabolic syndrome status) was similar for the lurasidone and placebo groups (OR = 1.18; [95% CI, 0.81-1.71]; P = .39), but the odds (vs placebo) were significantly greater for olanzapine (OR = 2.81; [95% CI, 1.53-5.15]; P < .001) and quetiapine (OR = 3.49; [95% CI, 1.93-6.29]; P < .0001). No dose effect was observed for lurasidone across the dose range of 40-160 mg/d. In long-term studies, the odds of MetS after 12 months of treatment was significantly higher for risperidone compared with lurasidone (OR = 2.12; 95% CI, 1.15-3.90; P = .016) and for quetiapine XR compared with lurasidone (OR = 3.92; 95% CI, 1.15-13.40; P = .029). In open-label extension studies, the rate of MetS decreased in patients switched to lurasidone after 6 weeks of treatment with olanzapine or 12 months of treatment with risperidone. Conclusion In this analysis of lurasidone clinical trials, the odds of developing metabolic syndrome were minimal during short- and long-term treatment with lurasidone (40-160 mg/d).

scholarly journals A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards

2009 ◽  
Vol 37 (6) ◽  
pp. 714-732 ◽  
Author(s):  
Alan R. Boobis ◽  
Samuel M. Cohen ◽  
Nancy G. Doerrer ◽  
Sheila M. Galloway ◽  
Patrick J. Haley ◽  
...  
Keyword(s):  
Health And Environmental Sciences ◽  
Human Cancer ◽  
Carcinogenic Risk ◽  
Hazard Identification ◽  
Testing Strategy ◽  
Short Term ◽  
Kidney Tumors ◽  
Key Events ◽  
Potential Cancer ◽  
Term Data

The two-year cancer bioassay in rodents remains the primary testing strategy for in-life screening of compounds that might pose a potential cancer hazard. Yet experimental evidence shows that cancer is often secondary to a biological precursor effect, the mode of action is sometimes not relevant to humans, and key events leading to cancer in rodents from nongenotoxic agents usually occur well before tumorigenesis and at the same or lower doses than those producing tumors. The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) hypothesized that the signals of importance for human cancer hazard identification can be detected in shorter-term studies. Using the National Toxicology Program (NTP) database, a retrospective analysis was conducted on sixteen chemicals with liver, lung, or kidney tumors in two-year rodent cancer bioassays, and for which short-term data were also available. For nongenotoxic compounds, results showed that cellular changes indicative of a tumorigenic endpoint can be identified for many, but not all, of the chemicals producing tumors in two-year studies after thirteen weeks utilizing conventional endpoints. Additional endpoints are needed to identify some signals not detected with routine evaluation. This effort defined critical questions that should be explored to improve the predictivity of human carcinogenic risk.

The assessment of short term data of pipe corrosion in drinking water—II. Copper

1993 ◽  
Vol 34 (10) ◽  
pp. 1595-1606 ◽  
Author(s):  
J.J. Royuela ◽  
E. Otero
Keyword(s):  
Drinking Water ◽  
Short Term ◽  
Term Data
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